C1QL1 inhibits breast cancer through the HSP90α/VCP-ERS/UPR axis by Ningning Zhang, Qing Shao, Xinni Xiang, Chun Yan, Dan Tao, Qian Li, Huan Rong, Yi Zhao, Tingxiu Xiang, Xiaohua Zeng

“…Here public database analyses, quantitative PCR with reverse transcription, western blot, immunohistochemistry and quantitative methylation-specific PCR were used to analyze C1QL1 expression and promoter methylation. The effects of C1QL1 on BrCa proliferation, cell cycle, apoptosis and metastasis were assessed using the Cell Counting Kit-8, flow cytometry analysis, terminal deoxynucleotidyl transferase dUTP nick end labeling assays, transwell in vitro and nude mice experiments in vivo. …”
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Application of the Fitness and Nutrition Program for Seniors (FANS) to improve Physical Activity and Kinanthropometric Measures among Community-Dwelling Older Adults living with Fr... by Pei-Shan Li, Chia-Jung Hsieh, Nae-Fang Miao, Chuan-Hsiu Tsai, Chieh-Yu Liu, Hung-Ru Lin, Shu-Fang Vivienne Wu, Jordan Koh

“…This research aimed to investigate the effectiveness of this intervention on physical activity and kinanthropometric measures. …”
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Gamma-radiation insulating performance of AlON-hardened Na2O–Bi2O3–SiO2–BaO–Fe2O3–ZrO2 glasses by Jamila S. Alzahrani, Z. A. Alrowaili, I. O. Olarinoye, Chahkrit Sriwunkum, Imen Kebaili, M. S. Al-Buriahi

“…Abstract Aside high radiation cross-section, high mechanical strength is an essential quality for durable and effective glass shields. Many emerging glass shields are brittle with low strength parameters; consequently, limiting their longstanding applications. …”
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Impact of national and supranational policies on social inequalities in major NCDs and related risk factors in Europe: a scoping review protocol by Mall Leinsalu, Rainer Reile, Norun Hjertager Krog, Digo Chakraverty, Gerd Monika Flodgren, Julia Doetsch, Trude Robsahm, Astri Syse, Kadri Tammur, Julia Waldhauer

“…Concept: any national or supranational policy directly targeting social inequalities in NCDs and/or their risk factors, or NCDs or their risk factors in general, while reporting effects on inequalities or targeting root causes of social inequality. …”
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Preparation of Phosphorus-Doped Boron Nitride Aerogel and Its Heavy Metal Ion Adsorption Properties by Junzhong ZHANG, Zheng LIU, Bo LIU, Yanlong LI

“…Furthermore, the scalable synthesis using low-toxicity precursors (boric acid, melamine, and red phosphorus) and the ultralight density of the material <1 mg/cm3 enable cost-effective fabrication and integration into dynamic filtration systems for large-scale wastewater treatment. …”
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Timosaponin B-II suppresses gastric cancer cell proliferation and induces apoptosis via the Nrf2/miR-455-3p/KLF6 pathway by Qiaoyan Cui, Ruijie Zhang, Shiqiao Zhao, Jian Wang, Yafen Dong, Xuesong Bai, Ye Chen, Yan Qiu

“…Furthermore, the expression levels of nuclear factor erythroid 2-related factor 2(Nrf2), miR-455-3p, and KLF6 were quantified to elucidate the mechanisms underlying TB-II’s effects. To confirm the interaction between miR-455-3p and KLF6, as well as Nrf2 and miR-455-3p, bioinformatics analysis, luciferase assays, and ChIP-PCR were conducted. …”
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LIPUS Responsive Dopamine-Modified PVDF Piezoelectric Nanofiber Membrane for Full-Thickness Skin Wound Healing by Zhang Z, Liu L, Wang H, Xie W, Zhai W, Wen L, Zhang B, Liu K, Zhang X, Liu S, Huang L, Li D, Zhou Y

“…Finally, the effects of DA/PVDF membranes on full-thickness skin defect healing were tested in a mouse model. …”
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Genetic line-specific immune profiles and immunometabolic responses to intramuscular lipopolysaccharide injection by Kayla M. Elmore, Susan J. Lamont, Elizabeth A. Bobeck

“…Cloacal temperature was recorded at baseline, 2 hpi, and 24 hpi, while blood was collected for flow cytometry and metabolic analysis. Data were analyzed using the SAS 9.4 MIXED procedure with genetic line, injection status, and interaction as fixed effects, with significance at p ≤ 0.05. …”
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Buyang Huanwu Decoction Alleviates Ischemic Stroke Injury by Inhibiting Ferroptosis via the Nrf2/GPX4 Pathway by Huang H, Liu S, Wu J, Zhu J, Xu J, Yu S, Bei L, Zhang B, Luo Y

“…Nrf2 inhibitor experiments confirmed BHD’s effects are Nrf2-mediated.Conclusion: In pre-clinical studies, BHD exerts neuroprotective effects in ischemic stroke by inhibiting ferroptosis through the Nrf2/GPX4 pathway. …”
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Phage-mediated virulence loss and antimicrobial susceptibility in carbapenem-resistant Klebsiella pneumoniae by Yanshuang Yu, Mengzhu Wang, Liuying Ju, Minchun Li, Mengshi Zhao, Hui Deng, Christopher Rensing, Qiu E. Yang, Shungui Zhou

“…These insights advance our understanding of phage-host interactions in clinical settings, potentially inspiring new approaches akin to an “arms race” model to combat multidrug-resistant crises effectively.…”
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METHODS FOR ORGANIZATION OF CONTEXTUAL TRAINING OF FUTURE GEOGRAPHY TEACHERS by Karpenko Tetiana, Lakomova Olena, Shyian Daria

“…It has been pointed out that both models emphasize the importance of the context in the assimilation of effective knowledge and the formation of competence in their application in practice. …”
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User Intent to Use DeepSeek for Health Care Purposes and Their Trust in the Large Language Model: Multinational Survey Study by Avishek Choudhury, Yeganeh Shahsavar, Hamid Shamszare

“…The model assessed direct and indirect effects, including potential quadratic relationships. …”
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Comparison of Yield and some Physiological Characteristics of Wheat Cultivars under Cut Irrigation Levels in Shahriar Region by Reza Afsharianzadeh, Eslam Majidi Heravan, Mohammad Nasri, Hossein Heidari sharifAbad, Ghorban NourMohammadi

“…The main factor of irrigation treatment in three levels including: normal irrigation I0, cut irrigation in flowering stage I1 and cut irrigation in grain filling stage I2 and cultivars in 21 levels as a sub-factor including; Chamran, star, Sirvan, Sivand ,Arg, Parsi, Barat, Narin, Heidary, Ofogh, Rakhshan, Baharan, Sepahan, Aflak, Mihan, Zare, Gonhad, Orum, Saison, Gascogen and Mehregan. The results of analysis of variance showed that 1000-seed weight, grain yield, total yield, stomatal conductance, canopy temperature, leaf proline, cell membrane stability, grain gluten, SOD antioxidant enzyme and MDA degradation biomarker were affected by the main effects of irrigation levels and cultivarsand interactions were significant at the level of 5% and 1%. …”
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Hematological toxicity of [225Ac]Ac-PSMA-617 and [177Lu]Lu-PSMA-617 in RM1-PGLS syngeneic mouse model by Meryl Maria Vilangattil, Abir Swaidan, Jonathan Godinez, Marco F. Taddio, Johannes Czernin, Christine E. Mona, Giuseppe Carlucci

“…Treatments like chemotherapy, immunotherapy, and PSMA-targeted radioligand therapy (RLT) show promise, but challenges remain with tumor resistance, side effects, and dose-limiting toxicity in kidneys and bone marrow. …”
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Investigating the Factors Governing the Informativeness of Stock Prices Using the DEMATEL Approach by Mohammad Hossein Ramazani Zare, Meysam Arabzadeh, Ali Namaki, Mohammad Alipour

“…Companies proficient in effectively communicating and disseminating information to investors tend to achieve superior performance in the capital market, often resulting in an increase in their stock prices. …”
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Assessment of the impact of power business intelligence on adenoma detection rate: a prospective observational trial by Ya-Hui Hsu, Chia-Hsin Cheng, Ping-Hung Ko, Chia-Pei Tang, Chih-Wei Huang, Chih-Wei Tseng

“…Feedback to endoscopists has been shown to improve ADRs; however, many feedback systems lack automation and real-time interactivity. This study evaluates the effectiveness of Power Business Intelligence (Power BI) on ADR enhancement. …”
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Understanding “Alert Fatigue” in Primary Care: Qualitative Systematic Review of General Practitioners Attitudes and Experiences of Clinical Alerts, Prompts, and Reminders by Illin Gani, Ian Litchfield, David Shukla, Gayathri Delanerolle, Neil Cockburn, Anna Pathmanathan

“…This review offers much-needed insight into GP attitudes toward the deployment, design, and overall effectiveness of CRs. ObjectiveThis systematic review aims to synthesize current qualitative research on GPs’ attitudes toward CRs, enabling an exploration of the interacting influences on the occurrence of alert fatigue in GPs, including the deployment, design, and perceived efficacy of CRs. …”
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Midpalatal suture osteotomy combined with microimplant-assisted rapid palatal expansion for adult maxillary transverse deficiency treatment: a study protocol of a randomised contro... by Lei Zhang, Yifeng Qian, Wenyi Zhang, Miri Chung, Yanfei Zhu, Lingyong Jiang

“…A series of linear and angular parameters will be measured in the pre- and post-coronal planes before treatment (T0), immediately after expansion (T1) and 6 months after expansion (T2) to evaluate the efficacy of skeletal expansion and dental side effects. The study aims to compare the clinical and cost-effectiveness of SARPE and that of MSO-MARPE. …”
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Novel treatment strategy targeting interleukin-6 induced by cancer associated fibroblasts for peritoneal metastasis of gastric cancer by Ema Mitsui, Satoru Kikuchi, Tomohiro Okura, Hiroshi Tazawa, Yuta Une, Noriyuki Nishiwaki, Shinji Kuroda, Kazuhiro Noma, Shunsuke Kagawa, Toshiaki Ohara, Junko Ohtsuka, Rieko Ohki, Toshiyoshi Fujiwara

“…We conducted immunohistochemical analysis of IL-6 and α-smooth muscle (α-SMA) expressions in clinical samples of GC and PM, and investigated the interactions between CAFs and GC cells in vitro. …”
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Identification and Classification of Prescription Errors at a Tertiary Hospital in Southeast Nigeria by Patricia Uche Ogbo, Chioma Assumpta Okonkwo, Collins Chukwuemeka Magbo, Chidimma Maryrose Ononugbo, Cyndi Chinelo Ofolebe, Nathaniel Chinonso Okafor, Charles Chiemela Nwaobilor, Ogochukwu Ifeoma Ugwuede, Chimezie William Nnaji

“… Background: Prescription errors are the most common type of medication errors that occur in healthcare settings, and they are risk factors to adverse effects, drug therapy problems and failure in therapeutic goals. …”
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