The relationship between oxidative balance score, depression, and survival among adult cancer survivors in the United States by Qu Zhang, Qu Zhang, Yemei Wu, Qianyu Fan, Wenxi Zhou, Wenxi Zhou, Min Liu

“…BackgroundDepression and oxidative balance score (OBS) are linked to disease risk, yet their combined effects on cancer survival remain unclear. This study assessed OBS, depression, and mortality in cancer survivors.MethodsUtilizing a prospective, population-based cohort design, this analysis enrolled 1,455 adult cancer survivors (age ≥20 years) through the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. …”
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A new method for predicting essential proteins based on participation degree in protein complex and subgraph density. by Xiujuan Lei, Xiaoqin Yang

“…Identification of essential proteins from protein-protein interaction (PPI) networks can be applied to pathway analysis and function prediction, furthermore, it can contribute to disease diagnosis and drug design. …”
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Deciphering key nano-bio interface descriptors to predict nanoparticle-induced lung fibrosis by Jiayu Cao, Yuhui Yang, Xi Liu, Yang Huang, Qianqian Xie, Aliaksei Kadushkin, Mikhail Nedelko, Di Wu, Noel J. Aquilina, Xuehua Li, Xiaoming Cai, Ruibin Li

“…Results The nano-bio interactions induced diverse changes in the 4 characteristics of MeONPs and had variable effects on the 14 cellular functions, which were quantitatively evaluated in chemico and in vitro. …”
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Isoetin from Isoetaceae Exhibits Superior Pentatransferase Inhibition in Breast Cancer: Comparative Computational Profiling with FDA-Approved Tucatinib by Abdulaziz H. Al Khzem, Mansour S. Alturki, Ohood K. Almuzaini, Saad M. Wali, Mohammed Almaghrabi, Mohammed F. Aldawsari, Maram H. Abduljabbar, Reem M. Alnemari, Atiah H. Almalki, Thankhoe A. Rants’o

“…In addition, molecular interaction fingerprints and pharmacokinetic profiling were evaluated. …”
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Unlocking the Potential of <i>Curcumae Rhizoma</i> Aqueous Extract in Stress Resistance and Extending Lifespan in <i>Caenorhabditis elegans</i> by Linyao Jing, Yanlin Zhao, Lijun Jiang, Fei Song, Lu An, Edmund Qi, Xueqi Fu, Jing Chen, Junfeng Ma

“…This study integrates network pharmacology and in vivo analysis to investigate the mechanisms and effects of <i>Curcumae Rhizoma</i> (<i>C. …”
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CORN 2.0 - Condition Orientated Regulatory Networks 2.0 by Ricky Wai Tak Leung, Xinying Zhang, Zhuobin Chen, Yuyun Liang, Simei Huang, Zixin Yang, Xueqing Zong, Xiaosen Jiang, Runming Lin, Wenbin Deng, Yaohua Hu, Jing Qin

“…TRSNs are more stable and practical for analysis, making them ideal for studying gene regulation under specific conditions. …”
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CO₂-ECBM from a Full-Chain Perspective: Mechanism Elucidation, Demonstration Practices, and Future Outlook by Yinan Cui, Chao Li, Yuchen Tian, Bin Miao, Yanzhi Liu, Zekun Yue, Xuguang Dai, Jinghui Zhao, Hequn Gao, Hui Li, Yaozu Zhang, Guangrong Zhang, Bei Zhang, Shiqi Liu, Sijian Zheng

“…It highlights the complex multi-physics processes involved, including competitive adsorption–desorption, diffusion and seepage, thermal effects, stress responses, and geochemical interactions. …”
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EPHX2 overexpression deters the advancement of clear cell renal cell carcinoma via lipid metabolism reprogramming by Bo Guan, Cong Huang, Cong Huang, Cong Huang, Jun He, Jun He, Jun He, Weimin Shan, Di Cui, Xiaowei Li, Chaozhao Liang, Chaozhao Liang, Chaozhao Liang, Zongyao Hao, Zongyao Hao, Zongyao Hao

“…EPHX2, a metabolic regulator with tumor-suppressive properties, not only influences cell cycle dynamics but also interacts with multiple signaling pathways to inhibit tumor growth. …”
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PARP-1 serves as a novel molecular marker for hepatocellular carcinoma in a Southern Chinese Zhuang population by Jiatong Li, Dongwei Dou, Ping Li, Wenqi Luo, Wenxin Lv, Chengdong Zhang, Xiaowei Song, Yuan Yang, Yuening Zhang, Yanzhen Xu, Feifan Xiao, Yan Wei, Jian Qin, Hongtao Li, Xiaoli Yang

“…Higher PARP-1 level was associated with a higher tumor stage (p < 0.05), without correlation with age, gender, smoking, drinking, tumor size, serum alpha-fetoprotein level, hepatitis B virus infection, metastasis, and invasion (p > 0.05). Further analysis suggested that H2AX , a PARP-1 protein interaction partner, was coordinated with PARP-1 in hepatocellular carcinoma tumorigenesis. …”
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Deep learning enabled integration of tumor microenvironment microbial profiles and host gene expressions for interpretable survival subtyping in diverse types of cancers by Haohong Zhang, Xinghao Xiong, Mingyue Cheng, Lei Ji, Kang Ning

“…Additionally, we identified potential interactions between microbes and host genes that may play roles in survival. …”
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Differential expression of nickel nanoparticles of Lactobacillus plantarum on VDR/LncRNA EIF3J-DT in Colorectal cancer by Saradhadevi Muthukrishnan, Anjali K Ravi, S Ajay, Gayathiri Gunasangkaran, Hemalatha Senthilkumar, Vijaya Anand Arumugam, Velayuthaprabhu Shanmugam, Sakthivel Kunnathur Murugesan, Gurusaravanan Packiaraj, Arun Muthukrishnan, Ashokkumar Kaliyaperumal

“…The potent bioactive component present in L. plantarum was identified via gas chromatography-mass spectrometry (GC–MS) analysis, and its interaction with VDR, as well as the functional interaction with lncRNA EIF3J-DT, were evaluated using the PyRx program and RPISeq-software, respectively. …”
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Prolyl 4-hydroxylase subunit alpha-2 acts as a TRIM21 ubiquitination substrate to promote papillary thyroid cancer progression via the glycolytic pathway by Fengping Wu, Qian Liu, Jinkang Zhang, Dongkun Xu, Xue Jiang, Kun Zhang, YaZheng Chen, Xuliang Xia, Zhiqiang Jiang, Yuhong Shi, Wenling Tu

“…Conversely, P4HA2 overexpression exerts opposing effects on these cancer cell phenotypes. In vivo assessments confirmed the tumor-promoting effects of P4HA2, including subcutaneous tumor formation and multiple-organ (lung and liver) metastasis. …”
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Exploring potential targets and mechanisms of PCB52-induced cardiotoxicity: Integration of network toxicology and zebrafish experimental evidence by Linhao Zong, Xiaoyang Lu, Yuxin Yang, Jing Zhao, Ziqi Tang, Dake Cao, Linxia Sun, Miao Guan, Shixia Xu

“…Molecular docking was employed to validate the interactions between PCB52 and hub targets. Enrichment analysis focusing on the hub genes indicated oxidative stress, apoptosis, nuclear factor kappa-B (NF-κB) activation, and inflammatory pathways were primary processes involved. …”
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Soil preferential flow dynamics in the southern drylands of India—a watershed based approach by Pushpanjali, K. S. Reddy, Ashish S. Dhimate, K. Karthikeyan, Josily Samuel, A. G. K. Reddy, N. Ravi Kumar, K. V. Rao, Prabhat Kumar Pankaj, Jagriti Rohit, Manoranjan Kumar, V. K. Singh

“…Soil preferential flow has become increasingly important in the face of changing climates, erratic rainfall patterns, and for effective rainwater management. In semi-arid regions, watersheds serve as fundamental hydrologic units, providing a holistic perspective for the study of soil preferential flow. …”
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Does creatine cause hair loss? A 12-week randomized controlled trial by Mohammadyasin Lak, Scott C. Forbes, Damoon Ashtary-Larky, Sahar Dadkhahfar, Reza Mahmoud Robati, Farshid Nezakati, Makan Khajevandi, Sara Naseri, Arvin Gerafiani, Neda Haghighat, Jose Antonio, Grant M. Tinsley

“…There were no group-by-time interactions observed for any hormones or hair-related outcomes (p > 0.05). …”
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Repurposing of propane oxidative-dehydrogenation catalysts to deoxygenation of vegetable oils for green diesel production by S. Lucantonio, G. Di Vito Nolfi, C. Courson, K. Gallucci, A. Di Giuliano, L. Rossi

“…Both catalysts performed promisingly(NiCoMo and ZnCoMo best conversion of 100 %, NiCoMo and ZnCoMo best diesel yields of 73 % and 68 %, respectively). Analysis of Variance was performed on main effects and factor interactions of all measured quantities and performance parameters, obtaining surface responses equations. …”
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Observations of methane net sinks in the upland Arctic tundra by A. Donateo, D. Famulari, D. Giovannelli, D. Giovannelli, D. Giovannelli, D. Giovannelli, D. Giovannelli, A. Mariani, M. Mazzola, S. Decesari, G. Pappaccogli, G. Pappaccogli

“…Non-growing-season emissions accounted for about 58 % of the annual CH<span class="inline-formula">₄</span> budget, characterized by large pulse emissions. The analysis of the impact of thermal anomalies on CO<span class="inline-formula">₂</span> and CH<span class="inline-formula">₄</span> exchange fluxes underscores that high positive (<span class="inline-formula">&gt;5</span> °C) thermal anomalies may contribute to an increased positive flux in both summer and winter periods, effectively reducing the net annual uptake. …”
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A multi methods study to explore the impact of the COVID-19 pandemic on the psychological well-being of cancer nurses across Cheshire and Mersey by Lynda Appleton, Courtney Atkins, Sarah Watmough, Helen Poole

“…Importantly interventions should be evaluated for their effectiveness and barriers to accessing support removed. …”
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Photocatalytic degradation of rhodamine B using zinc oxide/silver nanowire nanocomposite films under ultraviolet irradiation by Noah Jang, June Soo Kim, Hyunjun Kim, Da Ye Kim, Yujin Nam, Maeum Han, Seong Ho Kong

“…The bandgap reduction observed in ZnO/AgNW composites, as confirmed by Tauc plot analysis, is attributed to structural modifications, oxygen vacancy formation and plasmonic interactions that enhance charge transfer and light absorption. …”
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Peony (Paeonia lactiflora) leaf performance of two cultivars in response to ozone exposure by Zaisheng Shao, Liquan Jing, Li Zha, Xiaoyan Lu, Wenhui Huo, Kai Yang, Hengfeng Zhang

“…The total ascorbate (AsA) content was decreased but total antioxidant capacity (TAC), phenolics, and antioxidant enzyme activity showed an increasing trend due to O3. Statistical analysis using ANOVA revealed no significant differences in the responses of leaf indices between the two peony cultivars to O3 stress, as indicated by the absence of significant interaction effects between O3 treatment and cultivar.DiscussionThe above results indicate that under O3 stress, peony leaves exhibit chlorosis and aggravated membrane lipid peroxidation, leading to a decline in Asat and inhibited leaf growth. …”
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