Chicken interferon-induced transmembrane proteins inhibit Newcastle disease virus infection by affecting viral entry and W protein expression by Jing Chen, Peiheng Li, Wancheng Zou, Ju Li, Yuhang Jiang, Letian Li, Pengfei Hao, Zihan Gao, Jiayi Hao, Xiaoshuang Shi, Chang Li

“…In summary, our results provide the initial comprehensive analysis of the antiviral effects of chIFITMs against NDV. …”
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MAPT-A152T mutation drives neuronal hyperactivity through Fyn-NMDAR signaling in human iPSC-Derived neurons: Insights into Alzheimer's pathogenesis by Maika Itsuno, Hirokazu Tanabe, Etsuko Sano, Takashi Sasaki, Chisato Oyama, Hiroko Bannai, Koichi Saito, Kazuhiko Nakata, Setsu Endoh-Yamagami, Hideyuki Okano, Sumihiro Maeda

“…In addition, the A152T mutation increased the interaction between tau and Fyn. These findings suggest that the tau-Fyn interaction plays a critical role in regulating neuronal activity under physiological conditions, while the A152T mutation enhances neuronal activity by strengthening this endogenous interaction between tau and Fyn. …”
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dyphAI dynamic pharmacophore modeling with AI: a tool for efficient screening of new acetylcholinesterase inhibitors by Yasser Hayek-Orduz, Dorian Armando Acevedo-Castro, Dorian Armando Acevedo-Castro, Juan Sebastián Saldarriaga Escobar, Brandon Eli Ortiz-Domínguez, María Francisca Villegas-Torres, Paola A. Caicedo, Álvaro Barrera-Ocampo, Natalie Cortes, Edison H. Osorio, Andrés Fernando González Barrios

“…Therapeutic strategies for Alzheimer’s disease (AD) often involve inhibiting acetylcholinesterase (AChE), underscoring the need for novel inhibitors with high selectivity and minimal side effects. A detailed analysis of the protein-ligand pharmacophore dynamics can facilitate this. …”
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A framework for dynamic assessment of soil erosion and detection of driving factors in alpine grassland ecosystems using the RUSLE-InVEST (SDR) model and Geodetector: A case study... by Hucheng Li, Jianjun Chen, Ming Ling, Zizhen Chen, Yanping Lan, Qinyi Huang, Xinhong Li, Haotian You, Feng Wang, Xiaowen Han, Guoqing Zhou

“…Understanding the spatiotemporal patterns and key drivers of soil erosion in alpine grassland regions is crucial for developing effective conservation and restoration strategies in ecologically vulnerable areas. …”
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Determinants of vaccine hesitancy in Switzerland: study protocol of a mixed-methods national research programme by Claudine Burton-Jeangros, Michael J. Deml, Kristen Jafflin, Sonja Merten, Benedikt Huber, Andrea Buhl, Eleonora Frau, Valérie Mettraux, Joanna Sonderegger, Paulina Kliem, Rachele Cattalani, Daniel Krüerke, Constanze Pfeiffer, Philip E. Tarr

“…We aim to provide a detailed characterisation of vaccine hesitancy, including CAM and biomedical perspectives, patient–provider interactions, and sociocultural factors, to establish the mediating effects of vaccine hesitancy on underimmunisation, and to design an intervention to improve vaccination communication and counselling among physicians, parents and adolescents.Methods and analysis Our transdisciplinary team employs a sequential exploratory mixed-methods study design. …”
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A novel peptide targeting CCR7 inhibits tumor cell lymph node metastasis by Yixuan Sun, Yuzhen Qian, Lu Qiu, Xueqin Zhu, Haoming Ning, Liwei Pang, Xiaoshuang Niu, Yi Liu, Xiuman Zhou, Guanyu Chen, Wenjie Zhai, Yanfeng Gao

“…Subsequently, we successfully identified a CCR7 binding peptide TC6 by phage display biopanning, which specifically blocks the interaction of CCR7/CCL19 and CCR7/CCL21. Further, the D-amino acids were introduced to substitute the N- and C-terminus of TC6 peptide to obtain the proteolysis-resistant TC6-D3 peptide, which decreased tumor cell migration in vitro via ERK1/2 pathway and inhibited tumor growth and lymph nodes metastasis in vivo, as well as effectively restored T cells cytotoxicity in both primary tumors and lymph nodes. …”
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M1-Polarized Macrophages Promote Self-Renewing Phenotype of Hepatic Progenitor Cells with Jagged1-Notch Signalling Involved: Relevance in Primary Sclerosing Cholangitis by Heli Li, Shiran Sun, Qing Lei, Ping Lei, Xiong Cai, Chidan Wan, Guanxin Shen

“…The immunologic interaction between parenchyma cells and encircling inflammatory cells is thought to be the most important mechanism of biliary damage and repair in primary sclerosing cholangitis (PSC). …”
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Unveiling the diagnostic and pro-inflammatory role of crohn’s disease: insights from 16 S-guided discovery and species-specific validation by Yao Xu, Runxiang Xie, Yuqing Weng, Yewei Fang, Huimin Chen, Shuan Tao, He Zhang, Yawen Ye, Xinyu Deng, Axiang Han, Qi Jiang, Wei Liang

“…Abstract Background The rising incidence of Crohn’s disease (CD) in Asia underscores the need to explore its underlying mechanisms. The interaction between gut microbiota and the host is strongly linked to CD onset and progression, yet the precise mechanisms remain unclear. …”
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Mechanism study on the treatment of ulcerative colitis by Gegen Qinlian nano-preparation through promoting M2 macrophage polarization by Jilei Li, Jiarui Cao, Zhenyu Zhang, Sizhe Wang, Meng Zhu, Lili Yang, Wenhui Ouyang, Chunzheng Ma

“…We aimed to investigate whether GGQL nano-preparation could promote M2 macrophage polarization, correct intestinal inflammation, and treat UC.MethodsWe used databases to identify M2 macrophage-related gene targets for GGQL nano-preparation in UC. Protein-protein interaction networks, topological analysis, and GO/KEGG enrichment analyses revealed GGQL nano-preparation‘s potential regulation of macrophage polarization via a specific pathway. …”
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Functional-structural co-dependent brain mapping of metamemory in amnestic mild cognitive impairment by Juan-Juan Lu, Jie Ma, Mou-Xiong Zheng, Jia-Jia Wu, Yun-Ting Xiang, Jing Jin, Qi-Hao Guo, Xu-Yun Hua, Jian-Guang Xu

“…Amplitude of low-frequency fluctuation (ALFF) of left parahippocampal gyrus (PHG.L) (P = 0.026) and mediodorsal medial magnocellular (ltMDm) (P = 0.001), along with group × ALFF interaction effects in right cuneus (P = 0.010) and inferior parietal gyrus (P = 0.011) affected metamemory. …”
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Super‐Enhancer–Driven Syndecan‐4 Regulates Intercellular Communication in Hypoxic Pulmonary Hypertension by Xiaoying Wang, Xiangrui Zhu, Wei Huang, Zhaosi Wang, Jian Mei, Langlin Ou, Yunwei Chen, Cui Ma, Lixin Zhang

“…The effects of syndecan‐4 and its underlying mechanisms were subsequently elucidated using Western blot, coimmunoprecipitation, and cell coculture assays. …”
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Exogenous pyruvate is therapeutic against colitis by targeting cytosolic phospholipase A2 by Sadaf Hasan, Nabil Ghani, Xiangli Zhao, Julia Good, Chuan-ju Liu

“…Growing evidence indicates the molecular interactions between the cellular metabolites and different phases of inflammation. …”
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A state of the art review on geotechnical reinforcement with end life tires by M. Shariati, M. Afrazi, H. Kamyab, S. Rouhanifar, E. Toghroli, M. Safa, Sh. Chelliapan, H. Afrazi

“…Additionally, the article delves into modeling approaches that simulate the intricate behavior of these mixtures, facilitating better design and analysis. The economic feasibility of incorporating scrap tires is investigated, emphasizing the cost-effectiveness achieved through reduced material costs and enhanced infrastructure durability. …”
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Challenges and barriers to physician decision-making for prescribing and deprescribing among patients with multimorbidity in eastern China’s primary care settings: a qualitative st... by Ming Yan, Zhijie Xu, Andrew Farmer, Yu Xia, Mi Yao, Lingyan Wu, Xinmei Zhou, Liyan Han

“…Future research could develop and evaluate implementation strategies to address specific challenges and barriers to allow PCPs to make effective medication decisions for patients with multimorbidity.…”
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Selective Reduction of Iron from Iron–Manganese Ore of the Keregetas Deposit Using Hydrogen by Nurlybai Kosdauletov, Assylbek Nurumgaliyev, Bakyt Zhautikov, Bakyt Suleimen, Galymzhan Adilov, Bauyrzhan Kelamanov, Konstantin Smirnov, Talgat Zhuniskaliyev, Yerbol Kuatbay, Gulzat Bulekova, Assylbek Abdirashit

“…The findings demonstrate that hydrogen is an effective and environmentally friendly reducing agent, enabling selective reduction of iron. …”
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Spatial Transcriptomic Signatures of Early Acute T Cell–mediated Rejection in Kidney Transplants by Minji Kang, BS, Haeyoon Kwon, Jeongin Song, BS, Yunyoung Jang, BS, Seung Hee Yang, PhD, Seung-Min Cha, BS, Ji Hwan Moon, PhD, Yong Chul Kim, MD, PhD, Hyun Je Kim, MD, PhD

“…Kidney transplantation significantly improves the quality of life for those with end-stage renal failure, yet allograft rejection resulting from immune cell interactions remains a persistent challenge. Although T cell–directed immunosuppressive drugs effectively contain graft rejection in most patients, a notable proportion still experiences acute T cell–mediated rejection (TCMR). …”
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Combining Fluconazole with Benzo[<i>a</i>]phenoxazine Derivatives as a Promising Strategy Against Fluconazole-Resistant <i>Candida</i> Species by Maria Inês Pacheco, Bárbara Guimarães, Patrícia Pereira-Silva, Augusto Costa-Barbosa, M. Sameiro T. Gonçalves, Maria João Sousa, Paula Sampaio

“…This study evaluates the antifungal activity of four benzo[<i>a</i>]phenoxazine derivatives (<b>C34</b>, <b>C35</b>, <b>A42</b>, and <b>A44</b>) against 14 <i>Candida</i> strains following EUCAST standards. Fluconazole interactions are analysed through fractional inhibitory concentration index (FICI) calculation and response surface analysis based on the Bliss model. …”
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Exploring faculty perceptions and concerns regarding artificial intelligence Chatbots in nursing education: potential benefits and limitations by Zyad T. Saleh, Majdi Rababa, Rami A. Elshatarat, Muna Alharbi, Bandar Naffaa Alhumaidi, Majed S. Al-Za’areer, Reem Ahmad Jarrad, Tahany Fareed Al Niarat, Wesam T. Almagharbeh, Khaled Mohammed Al-Sayaghi, Doaa El Sayed Fadila

“…However, concerns about misinformation, reduced faculty-student interaction, and inadequacies in addressing complex clinical scenarios were prevalent. …”
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Polygenic prediction of human longevity on the supposition of pervasive pleiotropy by M. Reza Jabalameli, Jhih-Rong Lin, Quanwei Zhang, Zhen Wang, Joydeep Mitra, Nha Nguyen, Tina Gao, Mark Khusidman, Sanish Sathyan, Gil Atzmon, Sofiya Milman, Jan Vijg, Nir Barzilai, Zhengdong D. Zhang

“…We tracked allele frequency changes as a function of viability across different age bins and prioritized 34 variants with an immediate implication on lipid metabolism, body mass index (BMI), and cognitive performance, among other traits, revealed by PheWAS analysis in the UK Biobank. Given the highly complex and non-linear interactions between the genetic determinants of longevity, we reasoned that a composite polygenic score would approximate a substantial portion of the variance in lifespan and developed the integrated longevity genetic scores (iLGSs) for distinguishing exceptional survival. …”
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Pathogenomic Insights into <i>Piscirickettsia salmonis</i> with a Focus on Virulence Factors, Single-Nucleotide Polymorphism Identification, and Resistance Dynamics by Sk Injamamul Islam, Khandker Shahed, Md Imtiaz Ahamed, Luu Tang Phuc Khang, Won-Kyo Jung, Papungkorn Sangsawad, Nguyen Dinh-Hung, Patima Permpoonpattana, Nguyen Vu Linh

“…Effective control of bacterial infections remains a significant challenge in aquaculture. …”
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