Research on the multi-agent motivation coupling evolution and synergy improvement for farmland ecological protection in China by Adila Ainiwaerjiang, Xueying Jin, Zhen Xie, Tian Tian, Yuxuan Dang

“…Employing a coupling and coordination model to assess the collaborative effectiveness among these actors, this study identifies a downward trend in synergistic effectiveness across three phases: primary coupling, approaching decoupling, and mild decoupling. …”
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Characterization of gut microbiota and metabolites in renal transplant recipients during COVID-19 and prediction of one-year allograft function by Zijie Wang, Xiang Gao, Hongsheng Ji, Ming Shao, Bin Ni, Shuang Fei, Li Sun, Hao Chen, Ruoyun Tan, Mulong Du, Min Gu

“…GEE further identified 12 genera and 181 metabolites closely associated with these trajectories; a multivariable model incorporating gut metabolites of 1-Caffeoylquinic Acid and PMK was found to effectively predict one-year allograft function. Conclusions Our study indicates a possible interaction between the composition of the gut microbiota and metabolites community and COVID-19 in renal transplant recipients, particularly in relation to disease severity and the prediction of one-year allograft function.…”
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Evaluation of the immobilized enzymes function in soil remediation following polycyclic aromatic hydrocarbon contamination by Babar Hussain, Hongqing Zhu, Chunyu Xiang, Luo Mengfei, Bowei Zhu, Shibin Liu, Hui Ma, Shengyan Pu

“…Moreover, previous research has not adequately covered this topic, despite the employment of several immobilized enzymes in aqueous solution cultures to remediate other types of organic pollutants. Bibliometric analysis further highlighted the research trends from 2000 to 2023 on this field of growing interest and identified important challenges regarding enzyme stability and interaction with soil matrices. …”
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Contextual drivers of climate-smart agroforestry adoption in Bugesera and Rulindo agroecosystems of Rwanda by Donatien Ntawuruhunga, Edwin Estomii Ngowi, Halima Omari Mangi, Raymond John Salanga, Kenneth Lynch Leonard

“…This study examined 381 farmers from two regions in Rwanda to investigate how contextual factors at the field level interact with climate-smart agroforestry (CSAF) practices. …”
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SOX9 mediates the phenotypic transformation of vascular smooth muscle cells in restenosis after carotid artery injury by Chuan Jiang, Chuan Jiang, Jiasen Ye, Jie Huang, Yang Gao, Hong Chen, Fuqiang Guo, Lei Guo, Xiaofan Yuan

“…Elucidating the mechanisms underlying ISR is essential for developing effective preventive and therapeutic strategies. In this study, we identified SOX9, a transcription factor, as a key factor involved in the pathogenesis of ISR. …”
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Arginase 1 drives mitochondrial cristae remodeling and PANoptosis in ischemia/hypoxia-induced vascular dysfunction by Han She, Jie Zheng, Guozhi Zhao, Yunxia Du, Lei Tan, Zhe-Sheng Chen, Yinyu Wu, Yong Li, Yiyan Liu, Yue Sun, Yi Hu, Deyu Zuo, Qingxiang Mao, Liangming Liu, Tao Li

“…Multi-omics approaches revealed arginase 1 (Arg1) upregulation in ischemic VSMCs, confirmed by in vivo and in vitro knockout models showing Arg1’s protective effects on mitochondrial cristae, mitochondrial and vascular function, and limited the release of mtDNA. …”
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Diversity in Hydrogen-rich Envelope Mass of Type II Supernovae. III. The Mass-loss and Evolutionary Pathways of the Red Supergiant Progenitors by Qiliang Fang, Takashi J. Moriya, Keiichi Maeda, Andris Dorozsmai, Javier Silva-Farfán

“…Using MESA + STELLA , we compute an extensive grid of SN II light-curve models originating from RSG with effective temperatures T _eff around 3650 K and hydrogen-rich envelopes artificially stripped to varying degrees. …”
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RIPK2 promotes colorectal cancer metastasis by protecting YAP degradation from ITCH-mediated ubiquitination by Chen Lu, Hongda Liu, Tianyu Liu, Sizheng Sun, Yanan Zheng, Tao Ling, Xiagang Luo, Yiming E, Yuting Xu, Jie Li, Lei Liu, Lin Miao, Zhengxia Liu, Chunzhao Yu

“…In this study, we identified receptor-interacting protein kinase 2 (RIPK2) as an independent risk factor for poor CRC prognosis. …”
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Association of life’s crucial 9 score with benign prostatic hyperplasia: a cross-sectional study by Haoran Wang, Runhua Tang, Shuhang Luo, Huimin Hou, Jianyong Liu, Ming Liu, Jianye Wang

“…The association demonstrated a linear dose-response relationship, with the inflection point at an LC9 score of 72.5. Subgroup analysis revealed stronger protective effects in participants with lower socioeconomic deprivation. …”
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A multi-ancestry genome-wide association study identifies novel candidate loci in the RARB gene associated with hypertensive disorders of pregnancy by Jasmine A. Mack, Adam Burkholder, Farida S. Akhtari, John S. House, Ulla Sovio, Gordon C.S. Smith, Charles P. Schmitt, David C. Fargo, Janet E. Hall, Alison A. Motsinger-Reif

“…Chromatin mapping in FUMA identified a significant interaction within chromosome 3’s enhancer and open chromatin regions, with strong effects observed for RARB and H3P10 gene regulation in mesendoderm cells, mesenchymal stem cells, and trophoblast-like stem cells. …”
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Bridging Simulation and Practice in Medical History Taking: A Comprehensive Needs Assessment of Standardized Patient Competencies in Early Clinical Exposure by SANI BAIMAI, VORAWAN VANICHAROENCHAI, CHERDSAK IRAMANEERAT

“…Standardized patients (SPs) play a crucial role in early clinical exposure (ECE) by providing controlled, realistic patient interactions. However, optimizing SP effectiveness requires a systematic assessment of their competencies.Methods: This study employed a cross-sectional survey design to identify competency gaps in SPs and key areas for improvement to enhance their role in medical training during ECE. …”
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Permanently stationed bacteriobots for surveillance and elimination of nascent tumours by Praneshwar Eswaran

“…Such an approach would revolutionise cancer treatment by significantly reducing cancer incidence and would transform targeted therapy by optimising efficacy while minimising adverse effects. While the basis of the bacteriobot is evidence based and derives principles from existent nanorobot models, experimental validation is necessary to evaluate its feasibility. …”
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Detection of microplastics stress on rice seedling by visible/near-infrared hyperspectral imaging and synchrotron radiation Fourier transform infrared microspectroscopy by Chaojie Wei, Hongxin Xie, Hongxin Xie, Hongxin Xie, Wei Wang, Yu-Feng Li, Yu-Feng Li, Yu-Feng Li, Xiaorong Wang, Ziwei Song, Fajun Chen

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Ethanolic Extract of <i>Ganoderma mexicanum</i> Pat. Mycelium: A Source of Bioactive Compounds with Antiproliferative Activity and Potential PPAR-γ Natural Ligands by Lucia T. Angulo-Sanchez, Max Vidal-Gutiérrez, Heriberto Torres-Moreno, Martín Esqueda, Aldo Gutiérrez, Georgina Vargas, Juan Luis Monribot-Villanueva, José A. Guerrero-Analco, César Muñoz-Bacasehua, Ramón Enrique Robles-Zepeda

“…These compounds showed interactions with the PPAR-γ receptor through molecular docking. …”
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Indoor air quality and airborne transmission under the One Health lens: A scoping review by Gil Correia, Daniela Calheiros, Nuno Rosa, Lisa Rodrigues, Sandra Cunha, Luiz Miguel Santiago, José Costa, Manuel Gameiro da Silva, Teresa Gonçalves

“…Our work maps the topics covered, the methodologies employed, and the evidence gaps identified.Our literature search yielded 8471 articles, from which 18 studies were selected for detailed analysis. Findings indicate that the One Health approach effectively addresses the complex challenge of airborne microbiological contamination. …”
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Targeting B-raf/MEK signaling in melanocytic carcinoma using HPLC-MS/MS characterized metabolites from Valeriana wallichii Rhizome by Charushila V. Balikai, Raviraj M. Kulkarni, Kiran Thabaj, Shankar Gharge, Rohini S. Kavalapure, Shyam S. Desai

“…Target prediction and protein interaction networks further revealed modulation of key nodes such as BRAF and MEK. …”
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β2 integrin regulates neutrophil trans endothelial migration following traumatic brain injury by Lei Li, Ruilong Peng, Cong Wang, Xin Chen, Dilmurat Gheyret, Siyu Guan, Bo Chen, Yafan Liu, Xilei Liu, Yiyao Cao, Cha Han, Jianhua Xiong, Fanjian Li, Taoyuan Lu, Haoran Jia, Kaiji Li, Jinchao Wang, Xu Zhang, Jianye Xu, Yajuan Wang, Xin Xu, Tuo Li, Jianning Zhang, Shu Zhang

“…Finally, it was demonstrated that ITGB2 mediates these effects mainly through its interaction with intercellular adhesion molecule-1 (ICAM 1) of endotheliocyte. …”
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Inability of α-cyclodextrins to accommodate cholesterol potentially underlies their lack of efficacy and ototoxicity in Niemann-Pick disease type C treatment by Yusei Yamada, Mayuko Tanaka, Yusei Ikeda, Yuki Kondo, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Takahiro Seki, Yuki Kurauchi, Hiroshi Katsuki, Katsumi Higaki, Kotaro Matsusaka, Kentaro Minami, Naoki Yoshikawa, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie, Yoichi Ishitsuka

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Chaperones vs. oxidative stress in the pathobiology of ischemic stroke by Vladislav Soldatov, Artem Venediktov, Andrei Belykh, Andrei Belykh, Gennadii Piavchenko, Mukhammad David Naimzada, Mukhammad David Naimzada, Nastasya Ogneva, Natalia Kartashkina, Olga Bushueva, Olga Bushueva

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Spatiotemporal Soil Moisture Prediction Using a Causal-Guided Deep Learning Model by Tingtao Wu, Lei Xu, Ziwei Pan, Ruinan Cai, Jin Dai, Shuang Yang, Xihao Zhang, Xi Zhang, Nengcheng Chen

“…These findings demonstrate that integrating causal knowledge with deep learning models effectively enhances the modeling capabilities of complex spatiotemporal systems, providing a novel solution for broader spatiotemporal prediction tasks.…”
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