NSC-derived extracellular vesicles-mediates neuronal plasticity enhancement in vascular dementia via transferring miR-210 by Qunwen Pan, Yan Wang, Zhi Xiang, Yulan Yin, Yuyan Deng, Kesheng Xiao, Xiaobing Xu, Yahong Wang, Ganwen Deng, Xiaoxia Wang, Wangtao Zhong, Xiaotang Ma

“…This interaction enhances the secretion of NSC-EVs under hypoxic condition. …”
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HR+HER2− breast cancers with growth factor receptor–mediated EMT have a poor prognosis and lapatinib downregulates EMT in MCF-7 cells by Krisha Desai, Radhika Aiyappa, Jyothi S Prabhu, Madhumathy G Nair, Patrick Varun Lawrence, Aruna Korlimarla, Anupama CE, Annie Alexander, Rohini S Kaluve, Suraj Manjunath, Marjorrie Correa, BS Srinath, Shekhar Patil, Anjali Kalamdani, MSN Prasad, TS Sridhar

“…The results suggest that synergistic interactions between growth factor receptors and integrin β6 could mediate epithelial-to-mesenchymal transition and migration in a subset of luminal breast cancers and lapatinib might be effective in disrupting this interaction.…”
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Research on the Spatiotemporal Characteristics and Influencing Mechanisms of Sustainable Plateau Urban Building Carbon Emissions: A Case Study of Qinghai Province by Haifa Jia, Bo Su, Jianxun Zhang, Pengyu Liang, Wanrong Li, Shuai Wu, Shan Wang

“…Key findings include: (1) The XGBoost model exhibits robust predictive performance (R² > 0.9, MSE < 0.1, RMSE < 0.3), validating its effectiveness for plateau urban systems. (2) Socioeconomic structure and urban expansion characteristics significantly positively influence building carbon emissions, with GDP, per capita GDP, and built-up areas being particularly influential. (3) The interaction between climate and terrain increases carbon emissions in urban buildings. (4) While socioeconomic structure is a common factor affecting BCEs across different types of plateau urban buildings, other factors, such as urban population density, the housing construction area, and the urban shape index, exhibit variability. …”
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In silico design of a multi-epitope vaccine against Mycobacterium avium subspecies paratuberculosis by Weiqi Guo, Weiqi Guo, Xinyu Wang, Jiangang Hu, Beibei Zhang, Luru Zhao, Luru Zhao, Guangdong Zhang, Jingjing Qi, Zuzhang Wei, Yanqing Bao, Mingxing Tian, Shaohui Wang

“…This research developed a multi-epitope vaccine targeting MAP through pan-genomes and reverse vaccinology methods, offering innovative strategies for creating effective vaccines against MAP.…”
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Probing marine macroalgal phlorotannins as an antibacterial candidate against Salmonella typhi: Molecular docking and dynamics simulation approach by Arun Kumar Malaisamy, Balamuralikrishnan Balasubramanian, Pon Yazhine Tamilselvan, Venkatesh Sakthivel, Santhi Venkatachalapathi, Haripriya Kuchi Bhotla

“…The increasing prevalence of drug-resistant bacterial strains, including multidrug-resistant Salmonella typhi, has raised significant concerns about the effectiveness of traditional antimicrobial treatments. …”
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Endometrial stromal Menin supports endometrial receptivity by maintaining homeostasis of WNT signaling pathway through H3K4me3 during WOI by Xin Xu, Yichen Han, Keer Jin, Weina Xu, Huanyu Zhang, Yana Ma, Xiangjuan Li, Haibin Wang, Mengying Liu, Xiaona Lin

“…Menin, the unique subunit of the H3K4 methyltransferase complex, exhibits cell-specific effects on gene expression through chromatin modification by histone 3 lysine 4 trimethylation (H3K4me3). …”
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Dimensional control of interface coupling-induced ferromagnetism in CaRuO3/SrCuO2 superlattices by Li Zhe, Shi Wenxiao, Zhang Jine, Zheng Jie, Wang Mengqin, Zhu ZhaoZhao, Han Furong, Zhang Hui, Xie Liming, Yunzhong Chen, Fengxia Hu, Baogen Shen, Yuansha Chen, Jirong Sun

“…Understanding and controlling the coupling effects at the oxide interface are prerequisites for designing emergent interfacial phases with desired functionalities. …”
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Molecular Dynamics Simulation of Lipid Nanoparticles Encapsulating mRNA by Zhigang Zhang, Dazhi Cheng, Wenqin Luo, Donling Hu, Tiantian Yang, Kaixuan Hu, Li Liang, Wei Liu, Jianping Hu

“…Upon mixing with nucleic acids in acidic conditions, LNPs undergo disassembly, during which protonated SM-102 encapsulates mRNA through electrostatic interactions, forming stable hydrogen bonds. Cluster structure analysis revealed that the four lipid components of LNPs are distributed sequentially from the outside inwards as DMG-PEG 2000, DSPC, cholesterol, and protonated SM-102. …”
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Punica granatum leaf extract as a natural antibacterial agent explored by experimental and computational methods by Faria Tasnim, Md. Eram Hosen, Al Riyad Hasan, Md. Taohid Hasan, Md. Mizanur Rahaman, Md. Motaher Hossain, Md. Abdulla Al Jubayed, Md. Aktaruzzaman, Mansour Altayyar, Endalamaw Yihune, Md. Tarikul Islam, Magdi E. A. Zaki

“…These compounds also showed favorable pharmacokinetic and toxicity profiles in ADMET analysis, indicating their potential as safe and effective therapeutic agents. …”
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Perception of economic inequality and its association with depressive symptoms and suicide ideation among young adults in South Korea by Minjae Choi, Joshua Kirabo Sempungu, Joon Hee Han, Mi-Hyui Kim, Eun Hae Lee, Yo Han Lee

“…Objective measures explain the effects of socioeconomic disparities, but individuals may perceive inequality differently. …”
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Daidzein-rich isoflavone aglycones inhibit 17β-hydroxysteroid dehydrogenase 1 and increase estrogen sulfotransferase in endometriosis by Yosuke Tarumi, Osamu Takaoka, Yuko Izumi, Akihisa Katayama, Koki Shimura, Hiroyuki Okimura, Hisashi Kataoka, Fumitake Ito, Izumi Kusuki, Jo Kitawaki, Taisuke Mori

“…This study aims to investigate the effects of DRIAs on the enzymes involved in estrogen metabolism in endometriosis.Study design Stromal cells isolated from ovarian endometriomas (OESCs) were cultured with DRIAs. …”
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Oxidation-induced destabilization of polymorphic α-synuclein fibrils: insights from molecular dynamics by Tohir Akramov, Tohir Akramov, Parthiban Marimuthu, Parthiban Marimuthu, Mukhriddin Makhkamov, Mukhriddin Makhkamov, Aamir Shahzad, Rasulbek Mashalov, Jamoliddin Razzokov, Jamoliddin Razzokov, Jamoliddin Razzokov

“…Free Energy Landscape (FEL) analysis highlights a shift toward more flexible and less compact conformations upon oxidation. …”
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Repetitive magnetic stimulation with iTBS600 induces persistent structural and functional plasticity in mouse organotypic slice cultures by Han Lu, Shreyash Garg, Maximilian Lenz, Andreas Vlachos

“…Understanding these interactions may help refine stimulation protocols to optimize therapeutic outcomes.…”
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The Proteolytic Activity of Neutrophil-Derived Serine Proteases Bound to the Cell Surface Arming Lung Epithelial Cells for Viral Defense by Akmaral Assylbekova, Maiya Allayarova, Moldir Konysbekova, Amanbek Bekturgan, Aiya Makhanova, Samantha Brown, Norbert Grzegorzek, Hubert Kalbacher, Ruslan Kalendar, Timo Burster

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Energy, water and food nexus in the west region of Cameroon: Case of the Tchouadeng watershed by Nasse Fetio Ngoune, Boris Merlain Kanouo Djousse, Grisseur Henri Djoukeng, Sibelle Tsague Mouafo, Arthur L Tagny Tapa, Jospin Gouana Tedongmo, Junior GB Khenzo, Martin Tchoffo

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Systematic free energy insights into the enhanced dispersibility of myofibrillar protein in low-salt solutions through ultrasound-assisted enzymatic deamidation by Yating Liu, Zongyun Yang, Zhen Li, Juan Shen, Xia Wang, Ru Li, Ye Tao, Xinglian Xu, Peng Wang

“…This work aimed to investigate the effects of ultrasound assisted enzymatic deamidation by protein-glutaminase (PG) on the dispersion of myofibrillar protein (MP) in low-salt solutions. …”
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Structure-guided design of partial agonists at an opioid receptor by Balazs R. Varga, Sarah M. Bernhard, Amal El Daibani, Saheem A. Zaidi, Jordy H. Lam, Jhoan Aguilar, Kevin Appourchaux, Antonina L. Nazarova, Alexa Kouvelis, Ryosuke Shinouchi, Haylee R. Hammond, Shainnel O. Eans, Violetta Weinreb, Elyssa B. Margolis, Jonathan F. Fay, Xi-Ping Huang, Amynah Pradhan, Vsevolod Katritch, Jay P. McLaughlin, Susruta Majumdar, Tao Che

“…Functional studies reveal that C6-Quino shows differential activity at G-protein and arrestin pathways and interacts with the sodium binding pocket, confirmed through cryo-EM analysis. …”
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Carbon-based nanocomposites for sensing applications-a review by Davood Peyrow Hedayati, Stefania Termine, Christopher Bascucci, Paul Al Malak, Paolo Bondavalli, Dionisis Semitekolos, Frank Clemens, Costas Charitidis, Robert Böhm

“…A critical analysis of current challenges and prospects is also presented, outlining potential avenues for further research and innovation. …”
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Study on the Compatibility of C₆F₁₂O Gas Mixture with EPDM by Shuangshuang TIAN, Benli LIU, Guangyu DENG, Xiaoxing ZHANG, Huihui LI, Weihao LIU, Hui CHEN

“…The increase in temperature and the addition of O₂ will reduce the interaction parameters and mixing energy of the C₆F₁₂O/EPDM and CO₂/EPDM binary blends, making it easier to interact with EPDM.…”
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Smartphone intervention for pregnancy smoking cessation with peer support: the study protocol of the SmokeFree Together 2.0 (SFT 2.0) randomised controlled trial by Ken Resnicow, Kristie Foley, Daniel Muresan, Oana M Blaga, Marina D Dascal, Alexandra Onișor, Teodora Frățilă, Andreea Morar, Dan Mihu, Cristian I Iuhas, Gabriela Caracostea, Cristian I Meghea

“…Herein, we report the methods used to develop, implement and test the feasibility and effectiveness of a novel adaptive mobile pregnancy tobacco cessation app-based intervention using deep tailoring and a self-nominated supporter.Methods and analysis The study is a type II hybrid effectiveness-implementation randomised controlled trial. …”
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