A review of molecular investigations on traditional Chinese medicinal plant-based therapies in multidrug-resistant tuberculosis by Robin Raj, Arpan Kumar Tripathi, P. Saranya, Jaskiran kaur, Rashmi Saxena Pal, Kuldeep Singh, Divya Jain, MVNL Chaitanya, Shivendra Kumar

“…Results: Through an integrative analysis of recent research, we explored the multifaceted interactions between phytochemicals and various molecular targets within Mycobacterium tuberculosis (Mtb). …”
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Theoretical Insights into the Chemical Bonding, Electronic Structure, and Spectroscopic Properties of the Lanarkite Pb₂SO₅ Structure by Guilherme S. L. Fabris, Mateus M. Ferrer, Claudio R. R. Almeida, Carlos A. Paskocimas, Julio R. Sambrano, Felipe A. La Porta

“…Also, a complete topological analysis based on Bader’s Quantum Theory of Atoms in Molecules (QTAIM) was applied to identify atom–atom interactions in the covalent and non-covalent interactions of the PSO structure. …”
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Research Progress and Prospects on Risk Assessment and Early Warning for Embankment Safety in Estuarine and Coastal Areas by ZHU Yong-hui, LI Meng-yu, LUAN Hua-long, QU Geng, YUAN Yuan, WU Wei-wei, GE Jian-zhong, GUO Jun

“…By employing field surveys, dynamic monitoring, flume experiments, numerical simulation, machine learning, and theoretical analysis, it clarifies three key relationships driven by the evolution mechanism of the flood-tide disaster chains: the “fluid-structure interaction”, “causal relationship between disaster-causing factors and risk assessment”, and “coordination between habitat safety and dynamic early warning”. …”
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Microbial metabolism in laboratory reared marine snow as revealed by a multi-omics approach by Lei Hou, Zihao Zhao, Barbara Steger-Mähnert, Nianzhi Jiao, Gerhard J. Herndl, Yao Zhang

“…Conclusions Our findings shed light on the essential metabolic interactions within marine snow-degrading microbial consortia, which employ complementary physiological mechanisms and survival strategies to effectively scavenge marine snow. …”
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Merits and limits of SWAT-GL: application in contrasting glaciated catchments by T. Schaffhauser, F. Hofmeister, F. Hofmeister, G. Chiogna, F. Merk, Y. Tuo, J. Machnitzke, L. Alcamo, J. Huang, M. Disse

“…In addition, a sensitivity analysis using elementary effects (or the Morris method) is performed to give a detailed picture of the importance of the introduced glacier processes, as well as the relevance of the interactions with the already-existing snow routine. …”
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Dose-dependent immunotoxic mechanisms of celastrol via modulation of the PI3K-Akt signaling pathway by Shaohui Geng, Jingqi Wen, Chunli Shen, Li Liu, Yijin Jiang, Jingyuan Fu, Yiwei Guan, Zi Ye, Yuanhao Wu, Chen Li, Guangrui Huang

“…Network toxicology mapped key pathways, and molecular docking predicted interactions with immune-related proteins. High-dose celastrol (10 mg/kg) was administered to C57BL/6J mice, followed by a histopathological analysis of the thymus and spleen. …”
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Foot-and-mouth disease dynamics in multi-species livestock systems at the interface of African protected areas by Oriane Ploquin, Vladimir Grosbois, Mthabisi Ndlovu, Simbarashe Ndozore, Martin Munzamba, Emildah Porovha, Khanyile Nkomo, Oriane Basso, Gaelle Corbel, Richard Shumba, Masocha D. Mhlanga, Ellen Mwandirigana, Benjamin Musekiwa, Elijah Takayindisa, Anais Loisier, Hervé Fritz, Florian Liégeois, Alexandre Caron, Franck Prugnolle, Eve Miguel

“…Multi-species epidemiological systems are characterized by populations that interact and perform different functions in pathogen transmission and maintenance. …”
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Perspectives on and Experiences With Remote Monitoring and Patient-Initiated Care Among Norwegian Patients With Axial Spondyloarthritis: Qualitative Study by Christine Hillestad Hestevik, Cecilie Varsi, Nina Østerås, Anne Therese Tveter, Jon Skandsen, Hedda Eik

“…However, knowledge about how patients with axSpA perceive and experience these approaches is limited. To effectively implement these strategies in clinical practice, understanding patient perspectives is crucial. …”
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Applying affect coding and dynamical systems mathematical modeling to understanding the role of emotional expression on the therapeutic relationship across an entire course of subs... by Gina Cipriano, Paul R. Peluso, Emma Bright, Blanka Hutarkova

“…The findings aim to improve therapeutic outcomes by providing a deeper understanding of these emotional interactions, ultimately contributing to more effective substance abuse interventions.MethodThis study utilized the APA-produced DVD series Psychotherapy Over Time, featuring Dr. …”
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Green One-Step Synthesis and Characterization of Fluorescent Carbon Quantum Dots from PET Waste as a Dual-Mode Sensing Probe for Pd(II), Ciprofloxacin, and Fluoxetine via Fluoresce... by Christian Ebere Enyoh, Qingyue Wang, Weiqian Wang, Miho Suzuki, Go Masuda, Daisuke Nakajima, Senlin Lu

“…For Pd²⁺, the fluorescence emission intensity at 470 nm was quenched proportionally to the increasing concentration, while CIP and FLX induced fluorescence enhancement. The Stern–Volmer analysis confirmed strong interaction between the analytes and PET-FCQDs, distinguishing dynamic quenching for Pd²⁺ and static interactions for CIP and FLX. …”
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Pragmatic performance, its relationship with symptom severity, and early clinical predictors of pragmatics in 5 ~ 6-year-old children with autism spectrum disorder by Lu Qian, Ning Ding, Hui Fang, Ting Xiao, Bei Sun, HuiYun Gao, XiaoYan Ke

“…Abstract Background Pragmatic language refers to using spoken language to convey messages effectively across diverse social communication contexts. …”
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Protocol of the Nutritional, Psychosocial, and Environmental Determinants of Neurodevelopment and Child Mental Health (COINCIDE) study [version 2; peer review: 2 approved] by Eunice Lobo, Jyothi S. Menon, Deepa R., Supriya Bhavnani, Onno CP van Schayck, Shweta Dixit, Prashanth Nuggehalli Srinivas, Aditi Roy, Sumathi Swaminathan, Ruby Gupta, Poornima Prabhakaran, Prashanth Thankachan, Giridhara Rathnaiah Babu, Debarati Mukherjee, Siddhartha Mandal, Gauri Divan

“…While previous studies have examined the independent effects of nutritional status, psychosocial adversities, and environmental pollutants on children’s outcomes, little is known about their interaction and cumulative effects. …”
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Therapeutic potential of the neutralizing monoclonal antibody 45G3 against encephalomyocarditis virus by Yanfang Zhang, Zhiying Wang, Yaohui Fang, Qiong Zhu, Jie Fu, Sijing Hu, Jiayin Jin, Min Zhou, Xijia Liu, Danna Zhang, Shouwei Huang, Yali Deng, Lingling Xie, Shu Shen, Jing Ye, Fei Deng, Shengbo Cao

“…Additionally, posttreatment analysis revealed reduced tissue damage and a markedly decreased inflammatory response in the brain, indicating that the 45G3 antibody effectively blocked viral infection, thereby mitigating tissue damage and enhancing survival. …”
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Evaluating the multitargeted potency of Pixuvri against cell cycle regulation proteins in cervical cancer by Mohammed Ali Alshehri, Hadil Alahdal, Akram Ahmed Aloqbi, Afnan Mohammed Shakoori, Ghadir Sindi, Rehab M. Bagadood, Nida Alsaffar, Mohammad Ahmad Alobaidy, Noof Abdulrahman Alrabiah, Md Khursheed, Abeer Al Tuwaijri, Abeer Al Tuwaijri

“…Pixuvri is approved for non-Hodgkin lymphoma and exhibits minimal cardiotoxicity compared to anthracyclines. Interaction fingerprints highlighted key residues (4GLN, 4GLU, 3TRP), while pharmacokinetics, DFT computations, and WaterMap hydration site analysis supported its potential. …”
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Compounds from Cyclocarya paliurus leaves inhibit binary division of methicillin-resistant Staphylococcus aureus by disrupting FtsZ dynamic by Wenlong Chen, Shuixian Zhang, Chunxu Huang, Zhiming Hu, Ting Cao, Jun Mou, Xinxia Gu, Meiling Sun, Jie Liu, Jie Liu

“…Despite these divergent effects on polymerization and distinct binding modes, all compounds ultimately disrupted Z-ring assembly and septum formation. …”
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Therapeutic potential of Medical Nutrition Therapy (MNT) in Non-Alcoholic Fatty Liver Disease (NAFLD) by Abdul-Malik Bawah, Kasim Abdulai, Priscilla Cecilia Akpene Amenya

“…Key clinical data, including liver function tests (ALT, AST, GGT), metabolic markers (BMI, weight, fasting glucose, lipid profile), and inflammatory markers (C-reactive protein [CRP], tumor necrosis factor-alpha [TNF-α]), were collected at baseline and after 12 months. Regression analysis with interaction terms assessed the impact of educational level and occupational type on MNT outcomes. …”
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Improving healthy food recommender systems through heterogeneous hypergraph learning by Jing Wang, Jincheng Zhou, Muammer Aksoy, Nidhi Sharma, Md Arafatur Rahman, Jasni Mohamad Zain, Mohammed J.F. Alenazi, Aliyeh Aminzadeh

“…These devices generate vast amounts of dynamic, personalized data, which traditional Graph Neural Network (GNN) models — limited to simple pairwise connections — fail to capture effectively. For example, IoT sensors tracking daily nutrient intake require complex, multi-faceted analysis that traditional methods struggle to handle. …”
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Spatiotemporal monitoring of water storage in the North China Plain from 2002 to 2022 based on an improved GRACE downscaling method by Jinze Tian, Yu Chen, Shuai Wang, Xinlong Chen, Huibin Cheng, Xiaolong Tian, Xue Wang, Kun Tan

“…Study focus: The coupling effects of key drivers on water storage dynamics were quantitatively analyzed, integrating frequency-domain correlation analysis to identify lag effects, which were incorporated into a Random Forest (RF) downscaling method. …”
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Examining Specific Theory-of-Mind Aspects in Amnestic and Non-Amnestic Mild Cognitive Impairment: Their Relationships with Sleep Duration and Cognitive Planning by Areti Batzikosta, Despina Moraitou, Paschalis Steiropoulos, Georgia Papantoniou, Georgios A. Kougioumtzis, Ioanna-Giannoula Katsouri, Maria Sofologi, Magda Tsolaki

“…The HC group consistently outperformed both MCI groups in these tasks, with aMCI showing higher performance than naMCI. Mediation analysis applied to examine potential direct and indirect effects of sleep duration on ToM tasks indicated that total sleep time had significant indirect effects through cognitive planning—mainly as rule violation total score—on specific ToM aspects. …”
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Ziziphus spina-christi alleviates paracetamol-induced hepatorenal toxicity in rats through in vivo and computational approaches by Ehsan Kh. M. Khedre, Amany M. M. Hegab, Amira A. El-Mahis, Amina A. S. Abdel Rahman, Sherien H. B. Elwakeel, Ali S. Abdelhameed, Vittorio Calabrese, Ursula M. Jacob, Eman S. G. Hassan

“…Molecular docking showed that rosmarinic acid, a major phenolic acid in ZSC, had strong binding affinities with the studied apoptotic and inflammatory targets through various hydrophilic and hydrophobic interactions. ZSC demonstrates significant protective effects against PCM-induced liver and kidney damage, likely through modulation of apoptotic and inflammatory signaling pathways including NF-κB/TNF-α, Bcl-2/Bax/caspase-3, and ERK/JNK/p38 MAPK. …”
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