In Vivo PK-PD and Drug–Drug Interaction Study of Dorzagliatin for the Management of PI3Kα Inhibitor-Induced Hyperglycemia by Guanqin Jin, Kewei Zheng, Shihuang Liu, Huan Yi, Wei Wei, Congjian Xu, Xiaoqiang Xiang, Yu Kang

“…<b>Objectives:</b> The anticancer effects of PI3Kα inhibitors (PI3Ki) are constrained by their hyperglycemic side effects, while the efficacy of conventional hypoglycemic agents, such as insulin, metformin, and SGLT-2 inhibitors, in mitigating PI3Ki-induced hyperglycemia remains suboptimal. …”
Get full text

Family sports intergenerational influence effect and related factors analysis in the Yangtze Delta of China by Kun Yang, Wenduo Liu, Zhengxue Song

“…The differences in the occupations of their parents have a significant impact on OSM, Offspring Sports Rating (OSR), and Offspring Sports Condition (OSC), and the sports-related occupations parents have a significant positive effect on the development of their offspring’s sports behavior. …”
Get full text

UAV image analysis for detecting rice seedling gaps and gap effect on grain yield by Sanai Li, Yubin Yang, Jing Zhang, Lloyd T. (Ted) Wilson, Stanley Omar P.B. Samonte, Fugen Dou, Tanumoy Bera, Xin-Gen Zhou, Darlene Sanchez, Jing Wang

Get full text

Multi-Scale Analysis of the Mitigation Effect of Green Space Morphology on Urban Heat Islands by Jie Liu, Xueying Wu, Liyu Pan, Chun-Ming Hsieh

“…Urban green spaces (UGS) serve as critical mitigators of urban heat islands (UHIs), yet the scale-dependent mechanisms through which UGS morphology regulates thermal effects remain insufficiently understood. This study investigates the multi-scale relationships between UGS spatial patterns and cooling effects in Macao, employing morphological spatial pattern analysis (MSPA) to characterize UGS configurations and geographically weighted regression (GWR) to examine city-scale thermal interactions, complemented by patch-scale buffer analyses of area, perimeter, and landscape shape index effects. …”
Get full text

Physiological and Transcriptome Analysis Revealed the Effect of ABA on Promoting Persimmon Fruit Postharvest Deastringency by Han Zhou, Jiao-Jiao Nie, Meng-Lin Ren, Yu-Duan Ding, Ya-Xiu Xu, Qing-Gang Zhu

“…The contents of acetaldehyde and ethanol did not increase during the storage time, indicating that ABA treatment-promoted persimmon fruit deastringency was not due to the acetaldehyde interaction with soluble tannins. Furthermore, the transcriptome analysis showed that 6713 differentially expressed genes (DEGs) were identified, and the WGCNA (weighted gene co-expression network analysis) showed that one module, which comprises 575 DEGs, significantly correlated with the contents of soluble and resoluble tannins. …”
Get full text

Analysis of Thermo-Hydro-Mechanical Coupling of Coal and Gas with Absorption/Desorption Thermal Effect by Jianfeng Hao, Bing Liang, Weiji Sun

Get full text

Time-course analysis of the effect of paraprobiotics ABG0050 on the intestinal immune system of broilers by Hiroya Kondo, Shiori Iino, Takako Fukuda, Mikio Aoki, Yukinori Yoshimura, Naoki Isobe, Takahiro Nii

“…The expression levels of AvBDs and cytokines in the proventricular tissue after LPS stimulation were measured, and a two-way ANOVA was conducted to analyze the effects of LPS and LB. The results showed no significant effects of either factor on AvBDs, but the expression of Th1-type cytokines, including IFN-γ, IL-6, and IL-12, was significantly increased by the LB factor without interaction with LPS, suggesting that the Th1/Th2 balance was shifted towards Th1 dominance regardless of LPS stimulation. …”
Get full text

Establish a simple and quantitative deep learning-based method to analyse complicated intra- and inter-species social interaction behaviour for four stag beetle species by Michael Edbert Suryanto, Petrus Siregar, Tzong-Rong Ger, Chung-Der Hsiao

Get full text

Assessment of the effect of social media use on medical students’ academic performance: cross-sectional study from Jordan by Hana Taha, Hana Taha, Diana Abu-Surrah, Luna Abu-Awadh, Ameen Mahmoud, Tamara Al-Qadi, Layan Al Hamdan, Moumen Hijazi, Abdulla Al Ani, Vanja Berggren

“…The integration of social media platforms into the life of medical students and their effect on their academic performance has not been studied enough.ObjectiveThis study examines the duration of time spent on social media, the type of content medical students is exposed to, the online engagement in study groups, and the influence of the interaction between students and their professors via social media on students’ academic performance.MethodsA cross-sectional study that used structured self-administered online questionnaire to assess the use of social media by a random sample of 429 medical students in Jordan. …”
Get full text

Exploring the inhibitory effect and mechanism of 3,4,5-trihydroxybiphenyl on α-glucosidase: an integrated experimental and computational approach by Ruofan Guo, Ruofan Guo, Guohua Yu, Yuan Li, Youyou Wang, Youyou Wang, Huixia Fan, Shuo Zhang, Chen Wang, Junhui Zhou, Junhui Zhou, Jian Yang, Jian Yang, Feng Gao, Feng Gao, Zhiqiang Luo

“…In this study, we assessed the inhibitory effects of THB on α-glucosidase and explored the mechanism of inhibition through kinetic analysis, multispectral techniques, molecular docking and molecular dynamics simulations. …”
Get full text

Capturing the Complex: An Intraindividual Temporal Network Analysis of Learning Resource Regulation by Bettina Harder, Nick Naujoks-Schober, Manuel D. S. Hopp

“…Understanding a learner’s resources as a system of interacting components, the success of a learning process is determined by the effectiveness of their interactions. …”
Get full text

Unveiling the future: Wavelet- ARIMAX analysis of climate and diarrhea dynamics in Bangladesh’s Urban centers by Md. Waliullah, Md. Jamal Hossain, Md. Raqibul Hasan, Abdul Hannan, Mohammad Mafizur Rahman

“…The outcomes highlight the necessity of employing advanced time-series modeling tools such as Wavelet-ARIMAX to better understand and anticipate climate-health interactions. Wavelet-ARIMAX uses wavelet analysis to identify time-varying patterns in climate-disease interactions, providing useful insights for public health initiatives. …”
Get full text

Study on the Interaction Effects of Landscape Pattern on the Synergistic Trade-Offs of Ecosystem Services Based on Multi-Model Fusion: A Case Study of Chengdu-Chongqing Economic Ci... by Yuhao Jin, Yuanhang Li, Weiping Shen, Hengkang Zhu

“…In a certain range, the degree of landscape agglomeration interacts with the degree of landscape fragmentation to promote synergistic/trade-offs effects of ESs. …”
Get full text

Effects of the Tovertafel® on apathy, social interaction and social activity of people with dementia in long-term inpatient care: results of a non-controlled within-subject-design... by Robert Konrad, Carina Güttler, Natalie Öhl, Christian Heidl, Stefanie Scholz, Christian Bauer

“…Effects on the residents’ social interaction and activity were recorded before (T1), during (T2) and 1 h after (T3) each intervention using the Engagement of a Person with Dementia Scale (EPWDS). …”
Get full text

An Empirical Analysis of Corporate Social Responsibility Effects on Financial Performance for Romanian Listed Companies by Mariana Vuță, Sorin-Iulian Cioacă, Mihai Vuţă, Adrian Enciu

Get full text

AMMI and GGE biplot analysis of maize genotypes for seed yield across different maize growing location in Tanzania by Marco Martin Mwendo, Ernest Rashid Mbega, Joseph Ndunguru, Mashamba Philipo

“…A randomized complete block design (RCBD) with three replication was employed. additive main effects and multiplicative interaction (AMMI) and genotype-by-environment interaction (GGE) analysis was utilized to study the genotype and environment (GE) interactions. …”
Get full text

Peer effects among friends on students' cognitive abilities: An analysis based on emotional distance. by Wenyi Zhou, Junming Xie, Jinsong Kuang, Yongqing Feng, Dag Øivind Madsen

“…Based on the "China Education Tracking Survey" data, we discuss peer effects among friends on students' cognitive abilities from the perspective of Emotional Distance Analysis. …”
Get full text

Effects of Valproic Acid Embryonic Exposure on Zebrafish: A Systematic Review and Meta-Analysis by Bernardo Flores-Prieto, Jorge Manzo-Denes, María Elena Hernández-Aguilar, Genaro Alfonso Coria-Avila, Deissy Herrera-Covarrubias, Gonzalo Emiliano Aranda-Abreu, Fausto Rojas-Durán, César Antonio Pérez-Estudillo, Jorge Suárez-Medellín, María Rebeca Toledo-Cárdenas

“…This article examines the effects of embryonic exposure to VPA in zebrafish on the basis of 39 articles sourced from PubMed and Google Scholar. …”
Get full text

Analysis of the effective propellants of tourism development in Rasht metropolis based on future studies approach by Farhad Javan, Sirous Hojjat, Mohammad Seyfizadeh

Get full text

Reconstructing Risk–Risk Analysis to Support Effective Governance of High-Risk Climate Interventions by Duncan P. McLaren

“…The shortcomings mean ethical questions are not resolved, interaction effects between possible responses are downplayed and other potential exceptional responses ignored. …”
Get full text