Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis by Jianyu Yan, Tianyu Wang, Ruizhi Yu, Lijuan Xu, Hongming Shao, Tengfei Li, Zhe Wang, Xudong Cha, Zhenyuan Miao, Chengguo Xing, Ke Xu, Huanhai Liu, Chunlin Zhuang

Get full text

Pre-frailty is associated with higher risk of gastroesophageal reflux disease: a large prospective cohort study by Lei Peng, Xueqin Li, Jinfeng Qi, Yangang Shan, Liming Zhang, Zhenqing Yang, Xucheng Wu, George O. Agogo, Zuyun Liu, Genxiang Mao, Honglei Wu

Get full text

Enteroaggregative Escherichia coli foodborne outbreak in Shandong Province, China (2023): comprehensive epidemiology and genomic resistance profiling by Lu Liu, Lu Liu, Shuang Wang, Shuang Wang, Xiaolin Yu, Xiaolin Yu, Yuzhen Chen, Yuzhen Chen, Yanru Chen, Yanru Chen, Gaoxiang Sun, Gaoxiang Sun, Ziqing Liu, Ziqing Liu, Lixiao Cheng, Lixiao Cheng, Huaning Zhang, Huaning Zhang, Zengqiang Kou, Zengqiang Kou

Get full text

Psilocybin-Assisted suppoRtive psychoTherapy IN the treatment of prolonged Grief (PARTING) trial: protocol for an open-label pilot trial for cancer-related bereavement by Jerome Sarris, Rachel E Neale, Jörg Strobel, Stephen Parker, Fiona Maccallum, Margaret Ross, Vanessa L Beesley, Susan L Rossell, Tom J Kennedy, Renee Harvey, Daniel Perkins, James Bennett-Levy, Shevaugn Johnson, Hanna Beebe, Natalie Roset

“…All sessions will be delivered by a psychologist and either a nurse or Indigenous Therapist. An artificial intelligence-assisted tool will be used to create an artwork of participants’ psychedelic experience.Outcomes will be investigated over a 12-month follow-up period. …”
Get full text

Telemonitoring for Chronic Heart Failure: Narrative Review of the 20-Year Journey From Concept to Standard Care in Germany by Sebastian Spethmann, Gerhard Hindricks, Kerstin Koehler, Stefan Stoerk, Christiane E Angermann, Michael Böhm, Birgit Assmus, Sebastian Winkler, Martin Möckel, Mirja Mittermaier, Monika Lelgemann, Daniel Reuter, Ralph Bosch, Alexander Albrecht, Stephan von Haehling, Thomas M Helms, Stefan Sack, Tarek Bekfani, Jan Wolfgang Gröschel, Magdalena Koehler, Christoph Melzer, Jan Wintrich, Bettina Zippel-Schultz, Georg Ertl, Claus Vogelmeier, Nikolaos Dagres, Jasmin Zernikow, Friedrich Koehler

“…Ongoing research on artificial intelligence applications for prioritizing and interpreting individual health data will continue to transform digital health care. …”
Get full text

How do we measure dysarthria after stroke? A systematic review to guide the core outcome set for dysarthria by Jamie J Kirkham, Claire Mitchell, Audrey Bowen, Joshua Cheyne, Paul Conroy, Sabrina El Kouaissi, Martha Duncan-Zaleski, Brooke-Mai Whelan, Sarah J Jane Wallace

“…Objectives A consensus study to establish a Core Outcome Set for dysarthria after stroke identified four key outcome domains that should be measured in research and clinical practice: (1) intelligibility of speech, (2) ability to participate in conversations, (3) living well with dysarthria and (4) communication partners skills and knowledge (where relevant). …”
Get full text

Future Proofing Study: a cluster randomised controlled trial evaluating the effectiveness of a universal school-based cognitive–behavioural programme for adolescent depression by Maree Teesson, Helen Christensen, Svetha Venkatesh, Aliza Werner-Seidler, Lara Johnston, Bridianne O’Dea, Michelle Torok, Katharine Steinbeck, Raghu Lingam, Andrew Mackinnon, Yael Perry, Kit Huckvale, Joanne R Beames, Alison L Calear, Kate Maston, Philip J Batterham, Ju Lee Oei, Mark E Larsen, Jennifer L Hudson, Lyndsay Brown, Hiroko Fujimoto, Alexandra Batholomew, Debopriyo Bal, Susan Rachel Skinner, Katherine M Boydell, Susanne Schweizer

Get full text

Perceived and endocrine acute and chronic stress indicators in fibromyalgia syndrome by Eva Beiner, Michelle Hermes, Julian Reichert, Kristian Kleinke, Stephanie Vock, Annette Löffler, Leonie Ader, Andrei Sirazitdinov, Sebastian Keil, Tim Schmidt, Anita Schick, Martin Löffler, Michael Hopp, Christian Ruckes, Jürgen Hesser, Ulrich Reininghaus, Herta Flor, Wolfgang Eich, Hans-Christoph Friederich, Jonas Tesarz

Get full text

Assessing Patient-Reported Satisfaction With Care and Documentation Time in Primary Care Through AI-Driven Automatic Clinical Note Generation: Protocol for a Proof-of-Concept Study by Josep Vidal-Alaball, Carlos Alonso, Daniel Hugo Heinisch, Alberto Castaño, Encarna Sánchez-Freire, María Luisa Benito Serrano, Carla Ferrer Pascual, Ignacio Menacho, Ruthy Acosta-Rojas, Odda Cardona Gubert, Rosa Farrés Creus, Joan Armengol Alegre, Carles Martínez Querol, Marina Moreno-Martinez, Mercè Gonfaus Font, Silvia Narejos, Anna Gomez-Fernandez

“… BackgroundRelisten is an artificial intelligence (AI)–based software developed by Recog Analytics that improves patient care by facilitating more natural interactions between health care professionals and patients. …”
Get full text

Swarm learning with weak supervision enables automatic breast cancer detection in magnetic resonance imaging by Oliver Lester Saldanha, Jiefu Zhu, Gustav Müller-Franzes, Zunamys I. Carrero, Nicholas R. Payne, Lorena Escudero Sánchez, Paul Christophe Varoutas, Sreenath Kyathanahally, Narmin Ghaffari Laleh, Kevin Pfeiffer, Marta Ligero, Jakob Behner, Kamarul A. Abdullah, Georgios Apostolakos, Chrysafoula Kolofousi, Antri Kleanthous, Michail Kalogeropoulos, Cristina Rossi, Sylwia Nowakowska, Alexandra Athanasiou, Raquel Perez-Lopez, Ritse Mann, Wouter Veldhuis, Julia Camps, Volkmar Schulz, Markus Wenzel, Sergey Morozov, Alexander Ciritsis, Christiane Kuhl, Fiona J. Gilbert, Daniel Truhn, Jakob Nikolas Kather

Get full text

Effects of Dexmedetomidine as an Adjuvant in Preoperative Ultrasound-Guided Internal Branch of Superior Laryngeal Nerve Block on Postoperative Sore Throat and Hemodynamics in Patie... by Chen Z, Zhang L, Lu G, Zhang Y, Zhao D, Zhao S, Zhang H, Jin Y, Zhao X, Jin Y

“…Ultrasound-guided internal branch of the superior laryngeal nerve block (US-guided iSLNB) presents a potential intervention for POST. In this first randomized controlled trial to date, we aimed to investigate the effects of US-guided iSLNB, with or without perineural dexmedetomidine, on the incidence and severity of POST following DLTs.Methods: A total of 159 patients were randomly assigned to three groups: control, bilateral US-guided iSLNB (2 mL 0.20% ropivacaine + 1 mL saline on each side), and bilateral US-guided iSLNB combined with perineural dexmedetomidine group (2 mL 0.20% ropivacaine + 1 mL 0.5 μg·kg− 1 dexmedetomidine on each side). …”
Get full text

Real-World Effectiveness of a Novel AI-Software Dependent Neuromodulation (ASDN) with Remote Monitoring Capability Field Stimulation Device for Chronic Pain: A 24-Month Analysis of... by Green M, Cabble A, Bailey M, Kappell ML, Billet B, Kim CW, Singh JR, Suthar M, Kalia H, Kappell S, Chakravarthy K

“…All users completed at least one therapy session and submitted symptom data via a mobile application.Intervention: EcoAI delivers transcutaneous electrical nerve stimulation (TENS) to modulate afferent pain signaling and electrical muscle stimulation (EMS) to improve local circulation and neuromuscular function. …”
Get full text

Effectiveness and Safety of the TRIO Optimal Health Management Program in Patients With Type 2 Diabetes Mellitus Initiating Basal Insulin Therapy: Prospective Observational Real-Wo... by Chenxi Li, Lixin Guo, Lixin Shi, Li Chen, Liming Chen, Yaoming Xue, Hong Li, Yuzhen Liang, Jing Yang, Weimin Wang, Dalong Zhu

“…Based on this, a data-based and artificial intelligence management system named “TRIO” was developed to provide patients with more personalized intervention methods in stages, in groups, and around the clock. …”
Get full text

High-frequency terahertz stimulation alleviates neuropathic pain by inhibiting the pyramidal neuron activity in the anterior cingulate cortex of mice by Wenyu Peng, Pan Wang, Chaoyang Tan, Han Zhao, Kun Chen, Huaxing Si, Yuchen Tian, Anxin Lou, Zhi Zhu, Yifang Yuan, Kaijie Wu, Chao Chang, Yuanming Wu, Tao Chen

Get full text

Calculation of COVID-19 disease burden using Monte Carlo simulation with dynamic disability weights and analysis of transmission characteristics by Wenxiu Chen, Wei An, Qun Gao, Ji Bai, Hua Li, Song Tang, Wenhui Gao, Zhe Tian, Yu Zhang, Min Yang

Get full text

Immediate effects of high-intensity laser therapy for nonspecific neck pain: a double-blind randomized controlled trial by Yuhua Xie, Yuhua Xie, Yingxiu Diao, Dongyu Wu, Manxia Liao, Linrong Liao, Linrong Liao, Linrong Liao

Get full text

Ethical governance of clinical research on the brain–computer interface for mental disorders: a modified Delphi study by Qing Zhang, Zhen Wang, Jing Chen, Chen Zhang, Tianhong Zhang, Yifeng Xu, Haiqing Ji, Xingchao Wang, Pinan Liu

Get full text

Mapping the future: bibliometric insights into ferroptosis and diabetic nephropathy by Tangwen Wei, Yang Qin, Xiaohui Lin, Xiujuan Wang, Suyi Chen, Xia Chen, Nan Yan, Xinyi Wei, Zhichang Zhang, Bing Wei

Get full text

Machine learning algorithms to predict the risk of admission to intensive care units in HIV-infected individuals: a single-centre study by Jialu Li, Yi Ding, Yiwei Hao, Chengyu Gao, Jinjing Xiao, Ying Liu, Yining Zhao, Qinlan Li, Lulu Xing, Hongyuan Liang, Liang Ni, Fang Wang, Sa Wang, Di Yang, Guiju Gao, Jiang Xiao, Hongxin Zhao

“…The ANN model performed best in internal validation (Brier score = 0.034, ROC-AUC = 0.961, PR-AUC = 0.895) to predict the risk of ICU admission for PLWHs. 11 important features were identified to predict predict ICU admission risk by the Shapley plot: respiratory failure, multiple opportunistic infections in the respiratory system, AIDS defining cancers, baseline viral load, PCP, baseline CD4 cell count, and unexplained infections. An intelligent healthcare prediction system could be developed based on the medical records of PLWHs, and the ANN model performed best in effectively predicting the risk of ICU admission, which helped physicians make timely clinical interventions, alleviate patients suffering, and reduce healthcare cost. …”
Get full text

Gut metagenomic characteristics of ADHD reveal low Bacteroides ovatus-associated host cognitive impairment by Yan Li, Haiting Sun, Yufen Huang, Anqi Yin, Linjuan Zhang, Jiao Han, Yixuan Lyu, Xiangzhao Xu, Yifang Zhai, Huan Sun, Ping Wang, Jinyang Zhao, Silong Sun, Hailong Dong, Feng Zhu, Qiang Wang, Luis Augusto Rohde, Xuefeng Xie, Xin Sun, Lize Xiong

Get full text