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The Influence of Celebrity Endorsers, Viral Marketing, and Brand Image on Purchase Decision of Facetology Sunscreen Products in the Shopee Marketplace (A Study on Students of the U...
Published 2025-03-01“… The development of information technology and the internet has changed traditional business processes to become more dynamic through digital platforms. E-commerce, as one of the innovations in online marketing, makes it easy for consumers to shop practically. …”
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The Use of AI in Elementary School Learning: A Systematic Literature Review
Published 2025-03-01Get full text
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Perception and impact of the COVID-19 pandemic among smallholder farmers in eastern Ethiopia
Published 2023-12-01Get full text
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446
Assessing the impact of the TB response in Taiwan – the journey towards ending TB
Published 2025-05-01“…During 2005-2024, Taiwan universally adopted new diagnostic tools for drug-resistant TB, shorter regimens and user-friendly platforms for reporting and case management. Nationwide policy innovations included active case finding, and TB infection (TBI) treatment. …”
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447
Research advances in immune agonists and their nanoparticles for enhancing the immunotherapeutic efficacy of PD-1 inhibitors in malignancies
Published 2025-08-01“…Immune checkpoint blockade (ICB), particularly targeting programmed cell death-1 (PD-1), has revolutionized cancer immunotherapy but remains limited by heterogeneous therapeutic responses and immune-related toxicities. …”
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448
A Review on the Stability Challenges of Advanced Biologic Therapeutics
Published 2025-04-01Get full text
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Engineered Mycobacterium smegmatis expressing anti-PD-L1/IL-15 immunocytokine induces and activates specific antitumor immunity
Published 2025-05-01“…Background Immune checkpoint inhibitors and cytokines have revolutionized tumor treatment but are still limited by dose-dependent toxicity and efficacy. In situ vaccine platforms based on intelligent microbes are promising therapeutic strategies that sustainably deliver drugs locally without causing severe systemic risks.Methods In this study, we have innovatively engineered a non-pathogenic, adjuvant-acting Mycobacterium smegmatis (M. smegmatis) that co-expresses a programmed cell death-ligand 1 (PD-L1) inhibitor and an interleukin-15 (IL-15) cytokine complex containing the interleukin-15 receptor alpha (IL-15Rα) sushi domain (Ms-PDL1scfv-IL15).Results We demonstrate that the fusion protein of PD-L1 inhibitor and IL-15 cytokine systemically binds mouse or human PD-L1 and maintains IL-15 stimulatory activity. …”
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Salmonella-NLRP3 Inflammasome Crosstalk: Host Defense Activation Versus Bacterial Immune Evasion Strategies
Published 2025-04-01“…This process also initiates pyroptosis, a highly inflammatory form of programmed cell death characterized by lytic cell lysis. …”
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全球教師社群研究之趨勢分析 Analysis of Trends in Global Teacher Community Research
Published 2025-06-01Get full text
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