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  1. 441

    The Influence of Celebrity Endorsers, Viral Marketing, and Brand Image on Purchase Decision of Facetology Sunscreen Products in the Shopee Marketplace (A Study on Students of the U... by Dini Dwi Saputri, Jojok Dwiridotjahjono

    Published 2025-03-01
    “… The development of information technology and the internet has changed traditional business processes to become more dynamic through digital platforms. E-commerce, as one of the innovations in online marketing, makes it easy for consumers to shop practically. …”
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    Assessing the impact of the TB response in Taiwan – the journey towards ending TB by P.-C. Chan, C.-Y. Chiang, P.-H. Lee, H.-Y. Lo, P.-W. Chu, J.-J. Chen, S. Kato, M.C.B. Raviglione

    Published 2025-05-01
    “…During 2005-2024, Taiwan universally adopted new diagnostic tools for drug-resistant TB, shorter regimens and user-friendly platforms for reporting and case management. Nationwide policy innovations included active case finding, and TB infection (TBI) treatment. …”
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  7. 447

    Research advances in immune agonists and their nanoparticles for enhancing the immunotherapeutic efficacy of PD-1 inhibitors in malignancies by Renjie Xia, Renjie Xia, Juan Liang, Jianguo Ma, Jianguo Ma, Xiaoyu Du, Xiaoyu Du, Liangbin Ma, Liangbin Ma, Xiongxiong Han, Xiongxiong Han, Yong Wang, Yong Wang, Jianwei Qin, Long Yan

    Published 2025-08-01
    “…Immune checkpoint blockade (ICB), particularly targeting programmed cell death-1 (PD-1), has revolutionized cancer immunotherapy but remains limited by heterogeneous therapeutic responses and immune-related toxicities. …”
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    Engineered Mycobacterium smegmatis expressing anti-PD-L1/IL-15 immunocytokine induces and activates specific antitumor immunity by Lin Li, Yang Yang, Baorui Liu, Jie Shen, Jie Shao, Fangcen Liu, Yi Mei, Junmeng Zhu, Xiaoxuan Sha, Rutian Li

    Published 2025-05-01
    “…Background Immune checkpoint inhibitors and cytokines have revolutionized tumor treatment but are still limited by dose-dependent toxicity and efficacy. In situ vaccine platforms based on intelligent microbes are promising therapeutic strategies that sustainably deliver drugs locally without causing severe systemic risks.Methods In this study, we have innovatively engineered a non-pathogenic, adjuvant-acting Mycobacterium smegmatis (M. smegmatis) that co-expresses a programmed cell death-ligand 1 (PD-L1) inhibitor and an interleukin-15 (IL-15) cytokine complex containing the interleukin-15 receptor alpha (IL-15Rα) sushi domain (Ms-PDL1scfv-IL15).Results We demonstrate that the fusion protein of PD-L1 inhibitor and IL-15 cytokine systemically binds mouse or human PD-L1 and maintains IL-15 stimulatory activity. …”
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  10. 450

    Salmonella-NLRP3 Inflammasome Crosstalk: Host Defense Activation Versus Bacterial Immune Evasion Strategies by Li Y, Xu Y, Jin C, Qiu J, Jiao X, Pan Z, Guo Y

    Published 2025-04-01
    “…This process also initiates pyroptosis, a highly inflammatory form of programmed cell death characterized by lytic cell lysis. …”
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