Long-Term Response to PD-1 and CTLA-4 Blockade in an SCLC Patient with Negative PD-L1 Expression on Biopsy: A Case Report by Marco Cefalì, Francesco Martucci, Patrizia Frösch

“…While immune checkpoint inhibition has revolutionized the treatment of non-small cell histologies, results in SCLC have shown overall less favorable evolution, and despite initial data from different trials showing potential for development, the lack of reliable biomarkers for patient selection is a major hindrance to their use. …”
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New insights of cultural cannibalism amongst Magdalenian groups at Maszycka Cave, Poland by Francesc Marginedas, Palmira Saladié, Marta Połtowicz-Bobak, Thomas Terberger, Dariusz Bobak, Antonio Rodríguez-Hidalgo

“…BP) is part of this ongoing debate. Although initial research in the 1990s suggested cannibalism, more recent studies challenge this interpretation arguing that the low incidence of human activity rule out the likelihood of processing for the purpose of consumption and proposing skull selection as a funerary practice. …”
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Study on a Rapid Aerodynamic Optimization Method of Flying Wing Aircraft for Conceptual Design by Chenhao Wei, Jun Huang, Lei Song

“…Secondly, the surrogate model was constructed based on the points selected by the optimization Latin square method. Thirdly, the surrogate model combined with a multi-island genetic algorithm was used for the preliminary solution of global optimum, and then, the Nonlinear Programming by Quadratic Lagrangian method combined with a vortex lattice method was used for searching the nearest exact best point from the initial best point. …”
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The Personalized Approach to the Chronic Central Serous Chorioretinopathy Treatment Based on the Navigated Micropulse Laser Technology by P. L. Volodin, A. V. Doga, E. V. Ivanova, V. A. Pismenskaya, Iu. I. Kukharskaya, E. S. Khrisanfova

“…Before laser treatment were individually selected the optimal energy parameters for each patient. …”
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Effect of Working Fluid on Characteristics of Organic Rankine Cycle with Medium Temperature Geothermal Water by Zvonimir Guzović, Zlatko Bačelić Medić, Marina Budanko

“…While many studies on working fluid selection exist, each geothermal source is unique due to its specific temperature and local cooling fluid (water or air). …”
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An EfficientNet integrated ResNet deep network and explainable AI for breast lesion classification from ultrasound images by Kiran Jabeen, Muhammad Attique Khan, Ameer Hamza, Hussain Mobarak Albarakati, Shrooq Alsenan, Usman Tariq, Isaac Ofori

“…This technique selects the best features and fuses using a new parallel zero‐padding maximum correlated coefficient features. …”
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Linear regressive weighted Gaussian kernel liquid neural network for brain tumor disease prediction using time series data by Firoz Khan, Sardar Irfanullah Amanullah, Shitharth Selvarajan

“…The proposed LRWGKLNN model comprises four major steps, namely data acquisition, preprocessing, feature selection, and classification. In the initial step, a large volume of time-series data samples is collected from a comprehensive dataset. …”
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A Comprehensive Evaluation of Soybean Germplasm Resources for Salt Tolerance During Germination by Lei Han, Lerong Ge, Lin Fei, Chengwei Huang, Yilin Li, Wentan Fan, Dan Zhu, Longgang Zhao

“…Future research utilizing this approach can aid in the selection of soybean varieties with salinity tolerance.…”
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Application of machine learning for predicting the incubation period of water droplet erosion in metals by Khaled AlHammad, Mamoun Medraj, Moussa Tembely

“…The incubation period—the initial phase before visible material loss occurs—is particularly crucial for maintenance planning and material selection yet remains challenging to predict accurately due to the complex interplay of material properties and impact conditions. …”
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Management practices and mortality predictors among Klebsiella pneumoniae infections across Lebanese hospitals: a multicenter retrospective study by Rania Itani, Hani M. J. Khojah, Hamza Raychouni, Rahaf Kibrit, Patricia Shuhaiber, Carole Dib, Mariam Hassan, Tareq L. Mukattash, Abdalla El-Lakany

“…Around one-third of the patients (32.9%) received inappropriate initial antimicrobial therapy. The 30-day mortality rate was 14.4%. …”
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Core Outcome Sets for Pain Disorders: A Systematic Review of Research and Reporting Quality by Cui Y, Li B, Jiang S, Li Y, Wang S

“…In contrast, the average score for intervention coverage was lowest (15/24), followed by constructing the initial outcome list (18/24). These findings suggest that greater emphasis should be placed on incorporating the perspectives of both professionals and patients during the initial outcome selection process.Conclusion: The development of Core Outcome Sets should adhere closely to guidelines established by the Core Outcome Measures in Effectiveness Trials (COMET) Initiative. …”
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An investigation into the factors associated with pregnancy-associated glycoproteins in milk in seasonal-calving, pasture-based dairy cows by R.C. Doyle, M.M. Herlihy, J. Kenneally, M.C. Lucy, S.T. Butler

“…There was also an association with parity because parity 1 cows had greater milk PAG S-N values than parity 2 and parity 3 cows during the initial peak and nadir stages of the PAG profile. …”
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RECOMBINANT HUMAN LUTEINIZING HORMONE FOR THE TREATMENT OF INFERTILITY: THE GENERATION OF PRODUCER CELL LINES by N. A. Orlova, S. V. Kovnir, Yu. A. Khodak, M. A. Polzikov, I. I. Vorobiev

“…For the initial cell population and for their clonal lines, we used increasing concentrations of methotrexate to amplify the genetic cassettes in the cell genome. …”
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United States racial/ethnic disparities in PGT-A use: an analysis of 2014–2020 SART CORS database by Akailah Mason-Otey, David B. Seifer

“…Abstract Background The use of preimplantation genetic testing for aneuploidy (PGT-A) allows for the selection of euploid embryos and has been thought to improve outcomes in ART, particularly in women ≥ 35 years old. …”
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CREATIVE CORE WITHIN THE SCIENTIFIC RESEARCH OF EDUCATIONAL PROBLEMS by Vladimir I. Zagvyazinsky, Alfia F. Zakirova

“…The creative core of scientific research is considered in close relation to the key aspects of the scientific inquiry: problematics definition, research topic and subject selection, clarification of initial facts and theoretical statements, definition of the conceptual framework, determination of essential novelty. …”
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Predicting receptor-ligand pairing preferences in plant-microbe interfaces via molecular dynamics and machine learning by Erica T. Prates, Omar Demerdash, Manesh Shah, Tomás A. Rush, Udaya C. Kalluri, Daniel A. Jacobson

“…Secreted microbial signaling molecules initiate and mediate symbiosis by binding to structurally compatible plant receptors. …”
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Implementation of Diagnostic Methods of Career Guidance in Computer Systems by Anna P. Sergushicheva

“…The selection of surviving specimens is based on the percentage of success in the development of each of the professions in the list and the fitness function. …”
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Reliability of lateral cephalometric radiographs in the assessment of the upper airway: a systematic review by M. E. Balashova, Z. S. Khabadze, I. A. Voronov, I. N. Bagdasarova, N. N. Fedotova

“…Based on our results, the measurement of the nasopharyngeal space on lateral cephalograms can be used as an initial screening method to estimate the nasopharynx volumes. …”
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Real-world outcomes from the UK IBD Registry on second-line biologic therapy following anti-TNF exposure in Crohn’s disease: results from the BISCUITS study by Frederick Taylor, Giorgio Bartalucci, Catherine Gleave, Liz Dobson, Keith Bodger, Susanna Dodd, Stuart Bloom, Alun Passey, Riikka Nissinen, Daniel Wirth, Andreas Duva, Jennifer Lee, J. R. Fraser Cummings

“…Background: Selection of second-line therapy in Crohn’s disease (CD) patients after failure of first-line TNFα-inhibitor (TNFi) therapy to optimise outcomes remains challenging in real-world clinical practice. …”
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Methicillin‐resistant Staphylococcus aureus and Pseudomonas aeruginosa community acquired pneumonia: Prevalence and locally derived risk factors in a single hospital system by Bradley W. Frazee, Amarinder Singh, Matt Labreche, Partow Imani, Kevin Ha, Jonathan Furszyfer Del Rio, Eugene Kreys, Robert Mccabe

“…We sought to carry out these recommendations in our system, focusing on the emergency department, where CAP diagnosis and initial empiric antibiotic selection usually ooccur. …”
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