Improved robustness for deep learning-based segmentation of multi-center myocardial perfusion cardiovascular MRI datasets using data-adaptive uncertainty–guided space-time analysis... by Dilek M. Yalcinkaya, MS, Khalid Youssef, PhD, Bobak Heydari, MD, Janet Wei, MD, C. Noel Bairey Merz, MD, Robert Judd, PhD, Rohan Dharmakumar, PhD, Orlando P. Simonetti, PhD, Jonathan W. Weinsaft, MD, Subha V. Raman, MD, Behzad Sharif, PhD

“…In our approach, dubbed data-adaptive uncertainty–guided space-time (DAUGS) analysis, a given test case is segmented by all members of the DNN pool and the resulting uncertainty maps are leveraged to automatically select the “best” one among the pool of solutions. …”
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Beyond BMI: a comprehensive approach to pediatric obesity assessment by Norma Cipatli Ayuzo Del Valle, Norma Cipatli Ayuzo Del Valle, Perla Pérez-Treviño, Ana Carla Cepeda Lopez, Ana Carla Cepeda Lopez, Regina M. Murillo-Torres, Elena Cristina Castillo, Diego Gutierrez-Cantu, Oscar Tamez-Rivera, Oscar Tamez-Rivera, Mayela Paez Flores, Isabella Flores-Ayuzo, Luis Alberto Luévano-Martinez, Sergio Javier Fernandez Ortiz, Sergio Javier Fernandez Ortiz, Noemí García, Leonardo Mancillas-Adame

“…Conversely, four participants initially categorized as obese by BMI were reclassified as non-obese, reflecting elevated lean mass rather than adiposity. …”
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High expression of SOX10 is correlated with poor prognosis and immune infiltrates in skin cutaneous melanoma by Xu Sun, Yi-ming Cheng, Meng-wei Sun, Xu-dong Zhang, Xiao-yu Yu, Hai-bo Wang, Yi-fei Wang, Ning Li

“…Screening was performed by LASSO coefficients to select non-zero variables that satisfied the coefficients of lambda, and 8 genes were screened out. …”
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Two decades of insecticide resistance in Benin: a retrospective analysis of evolution and drivers by Steve Zinsou Hougbe, Razaki A. Ossé, Roseric Azondékon, Casimir Kpanou, Minassou Juvénal Ahouandjinou, Zul-kifl Affolabi, Koffi Djigbodi Koumodji, Hermann Sagbohan, Esdras Mahoutin Odjo, Constantin Adoha, Boulais Yovogan, Serge Akpodji, Linda Towakinou, Bruno Akinro, Albert Salako, Filémon Tokponnon, Germain Gil Padonou, Lamine Baba-Moussa, Martin Akogbeto

“…Resistance to pyrethroids was first observed in 1999, initially limited in scope. However, from 2010 to 2024, resistance to all pyrethroids spread across all regions of Benin, reaching high levels. …”
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Patient-reported outcome measures for fatigue in patients with chronic kidney disease: a systematic review by Angela Ju, Karine Manera, Armando Teixeira-Pinto, Germaine Wong, Martin Howell, Adeera Levin, Chandana Guha, David C Wheeler, Allison Jauré, Anastasia Hughes, Rosanna Cazzolli, Luca G Torrisi, Rebecca Wu

“…Objective Fatigue is a common and debilitating symptom that is associated with an increased risk of mortality, dialysis initiation and hospitalisation among patients with chronic kidney disease (CKD). …”
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Retinal progenitor cells (jCell) for retinitis pigmentosa by Jing Yang, Jing Yang, Baruch D. Kuppermann, David Liao, Mitul C. Mehta, Chinhui Hsiang, Chinhui Hsiang, Steven Menges, Steven Menges, David S. Boyer, Henry Klassen, Henry Klassen

“…Initially, subjects received the lowest dose (0.5 × 106 RPCs) in the worse-seeing eye. …”
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Molecular and immunological features associated with long-term benefits in metastatic NSCLC patients undergoing immune checkpoint blockade by Pedro Rocha, Rafael Bach, Laura Masfarré, Sharia Hernandez, Nil Navarro-Gorro, Adrià Rossell, Xavier Villanueva, Mario Giner, Ignacio Sanchéz, Miguel Galindo, Raúl Del Rey-Vergara, Albert Iñañez, Beatriz Sanchéz-Espiridion, Wei Lu, Ariadna Acedo-Terrades, Pau Berenguer-Molins, Albert Sánchez-Font, Roberto Chalela, Victor Curull, Álvaro Taus, Max Hardy-Werbin, Mark Sausen, Andrew Georgiadis, James White, Jennifer B Jackson, Laura Moliner, Sergi Clavé, Beatriz Bellosillo, Ana Rovira, Ignacio Wistuba, Luisa M Solis Soto, Júlia Perera-Bel, Edurne Arriola

“…Longitudinal blood specimens were collected before ICB treatment initiation and early-on treatment. Plasma ctDNA next-generation sequencing panel (NGS) and serum proteomics were performed. …”
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Impacts of Ecological Restoration Projects on Ecosystem Carbon Storage of Tongluo Mountain Mining Area, Chongqing, in Southwest China by Lei Ma, Manyi Li, Chen Wang, Hongtao Si, Mingze Xu, Dongxue Zhu, Cheng Li, Chao Jiang, Peng Xu, Yuhe Hu

“…For future restoration initiatives, it is advisable to select suitable vegetation types based on the local dominant species for a comprehensive approach.…”
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Establishment and optimization of a system for the detection of Candida albicans based on enzymatic recombinase amplification and CRISPR/Cas12a system by Xiaotong Zeng, Qiuyang Jiang, Fo Yang, Qianlin Wu, Tingyao lyu, Qi Zhang, Jin Wang, Feng Li, Dayong Xu

“…After a reaction at 37°C, the temperature is raised to 45°C, melting the wax and allowing the amplification system to merge with the detection system, initiating the reaction. This one-step detection platform simplifies and expedites the procedure, achieving a sensitivity level on par with that of two-step methods. …”
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A Delphi-based framework for optimizing nurse staffing in Chinese hospitals by Waner Wang, Waner Wang, Gege Li, Jiangfeng Pu, Tiemei Shen, Zhanghao Xie, Lifang Chen, Hong Cui, Peng Xu, Huigen Huang, Huigen Huang

“…ObjectiveThe objective of this study was to develop an evaluation system for the allocation of hospital nursing human resources in hospitals in the context of the Healthy China initiative.AimsThe evaluation system aims to provide a foundation and recommendations for optimizing the allocation of hospital nursing human resources by providing data-driven insights to guide staffing decisions. …”
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Disseminated tumor cells in bone marrow as predictive classifiers for small cell lung cancer patients by Ying Wang, Jingying Nong, Baohua Lu, Yuan Gao, Mingming Hu, Cen Chen, Lina Zhang, Jinjing Tan, Xiaomei Yang, Peter Ping Lin, Xingsheng Hu, Tongmei Zhang

“…Aneuploid CD31- disseminated tumor cells (DTCs) and CD31+ disseminated tumor endothelial cells (DTECs) residing in the bone marrow are generally considered as the initiators of metastatic process. However, the clinical significance of DTCs and DTECs in SCLC remains poorly understood. …”
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A set of plasmatic microRNA related to innate immune response highly predicts the onset of immune reconstitution inflammatory syndrome in tuberculosis co-infected HIV individuals (... by Polidy Pean, Ratana Meng, Eliott Benichou, Eliott Benichou, Pichsivannary Srey, Bunnet Dim, Laurence Borand, Laurence Borand, Olivier Marcy, Didier Laureillard, François-Xavier Blanc, Tineke Cantaert, Yoann Madec, Laurence Weiss, Daniel Scott-Algara

“…BackgroundAfter initiation of combination antiretroviral treatment (cART), HIV-1/tuberculosis coinfected patients are at high risk of developing tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS). …”
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Cryptococcal antigen positivity combined with the percentage of HIV-seropositive samples with CD4 counts <100 cells/μl identifies districts in South Africa with advanced burden of... by Lindi-Marie Coetzee, Naseem Cassim, Charlotte Sriruttan, Mabatho Mhlanga, Nelesh P Govender, Deborah Kim Glencross

“…Reflexed screening for cryptococcal antigen (CrAg) in remnant blood samples was initially piloted at selected CD4 testing laboratories of the National Health Laboratory Service (NHLS) prior to the implementation of a national screening programme using a lateral flow assay (LFA) (IMMY, Norman, OK, USA). …”
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Cervical cancer screening uptake and correlates among HIV-infected women: a cross-sectional survey in Côte d’Ivoire, West Africa by Eugene Messou, Didier K Ekouevi, Boris Tchounga, Simon Pierre Boni, Jean Jacques Koffi, Apollinaire G Horo, Aristophane Tanon, Serge-Olivier Koulé, Innocent Adoubi, Antoine Jaquet

“…The aim of this study was to estimate the coverage of cervical cancer screening and associated factors among WLHIV in Abidjan, Côte d’Ivoire.Design Cross-sectional survey conducted from May to August 2017.Settings Outpatient setting in the four highest volume urban HIV clinics of government’s or non-governmental organisation’s sector in Côte d’Ivoire.Participants All WLHIV, aged 25–55 years, followed since at least 1 year, selected through a systematic sampling procedure.Intervention A standardised questionnaire administered to each participant by trained healthcare workers.Outcome Cervical cancer screening uptake.Results A total of 1991 WLHIV were included in the study, aged in median 42 years (IQR 37–47), and a median CD4 count (last known) of 563 (378-773) cells/mm3. …”
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PARP inhibitors enhance antitumor immune responses by triggering pyroptosis via TNF–caspase 8–GSDMD/E axis in ovarian cancer by Ping Jin, Qi Zhang, Xin Li, Yu Xia, Yong Fang, Xiong Li, Ning Jin, Xiang-Ping Yang, Qing-Lei Gao, Zhengmao Zhang, Pu Huang, Yi-yu Qian, Zanhong Wang, Wen Pan, Si-Yuan Wang, Emmanuel Kwateng Drokow, Pingfei Li, Zhiqiang Han

“…On PARP inhibition, the NF-κB signaling pathway was activated, leading to increased secretion of TNF-α and subsequent initiation of the TNFR1–caspase 8 cascade. Impeding pyroptosis through the depletion of Gsdme significantly compromised the tumor-suppressing effects of PARP inhibition and undermined the anti-immune response in the syngeneic ID8 mouse model.Conclusions PARPis induce a specific type of ICD called pyroptosis via TNF–caspase 8–GSDMD/E axis, resulting in an inflamed TIME and augmentation of tumor-targeting immune responses. …”
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Impact of glucocorticoid receptor polymorphism rs6198 on sepsis survival in a prospective multicenter cohort by Christoph Sombetzki, Lars Palmowski, Dominik Ziehe, Hartmuth Nowak, Tim Rahmel, Stefan Felix Ehrentraut, Patrick Thon, Jennifer Orlowski, Lars Bergmann, Michael Adamzik, Björn Koos, Katharina Rump, SepsisDataNet.NRW research group

“…Subgroup analysis demonstrated a particularly pronounced impact among patients with initially high disease severity (HR 6.16, 95% CI 1.66–22.80, p = 0.007). …”
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Early versus delayed enteral nutrition in critically ill children under 12 years of age: A systematic review and meta-analysis of randomised controlled trials by Marianne E. Visser, Roselyn Chipojola, Sarah Gordon, Amanda Brand, Nyanyiwe Mbeye, Gertrude Kunje, Talitha Mpando, Suzgika Lakudzala, Elodie Besnier, Celeste E. Naude

“…Summary: Background &amp; aims: Enteral nutrition (EN) is key to reducing malnutrition risk in critically ill children, with timing of EN initiation being an important consideration. This systematic review aimed to assess the effects of early enteral nutrition (EEN) compared to delayed enteral nutrition (DEN) in critically ill children as part of the Global Evidence, Local Adaptation (GELA) project. …”
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The potential value of fatty acid binding protein 1 in Chronic HBV-related liver disease progression assessment by Shasha Ma, Xiaoyan Li, Chao Wu, Kuerbannisa Wulayin, Mingna Li, Lian Zhou, Shutao Lin, Zhaoxia Hu, Maimaitiaili Tuerxun, Bingliang Lin, Lubiao Chen

“…FABP1 was measured in serum samples collected at admission and some selected liver biopsies. Results Immunohistochemical analysis revealed abundant cytoplasmic expression of FABP1 in hepatocytes. …”
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Novel Patterns of Photosynthetic Activity Within Canopies of Poplar Stands with Different Densities by Taijin Zhang, Xiaoting Liu, Qinhui Zhang, Hui Xiao, Yunong Han, Zhenghua Xing, Fusen Wang, Xiyang Zhao

“…Moreover, water use efficiency (WUE) initially increased and then decreased under an 825 trees·ha⁻¹ (D3) planting density. …”
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A study on the status of myopia and pre-myopia among primary school students in different regions of Shaanxi Province, China by Dong Wei, Dong Wei, Li Yangbing, Liu Chengfei, Liu Chengfei, Zhang Ye, Zhang Ye, Wang Zihao, Wang Zihao, Li Yanying, Li Yanying, He Xiaokang, He Xiaokang, Fu Kunlin, Du Zhaojiang

“…The observed progression patterns suggest critical windows for prevention, advocating for: (1) Preschool-initiated vision protection programs, (2) Establishment of digital refractive registries for high-risk cohorts, and (3) Implementation of regionally tailored myopia control protocols prioritizing northern districts.…”
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