Mechanism of activation of TLR4/NF-κB/NLRP3 signaling pathway induced by heat stress disrupting the filtration barrier in broiler by Hui-li Dong, Xing-yue Wu, Fei-yao Wang, Hao-xiang Chen, Si-liang Feng, Chen-yang Zhou, Zhan-qin Zhao, Li-fang Si

“…Conclusions It demonstrated that heat stress caused detrimental effects on both the morphological structure and function of the renal filtration barrier, and the initiation of the TLR4/NF-κB/NLRP3 signaling pathway exacerbated the inflammatory damage, leading to increased thermal damage to renal tissues and glomerular filtration barriers; however, with the prolongation of heat stress, broilers gradually developed heat tolerance, and the damage to the renal tissues and filtration barriers triggered by heat stress was mitigated.…”
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Optimizing Radiation Dose and Image Quality in Stroke CT Protocols: Proposed Diagnostic Reference Levels for Multiphase CT Angiography and Perfusion Imaging by Robert Forbrig, Christoph G. Trumm, Paul Reidler, Wolfgang G. Kunz, Konstantinos Dimitriadis, Lars Kellert, Johannes Rückel, Thomas Liebig, Robert Stahl

“…CTP should be limited to selected patients.…”
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Socio‐ecological correlates of wildlife species identification across rural communities in northern Tanzania by Justin Raycraft, Reilly Becchina, Danielle Bettermann, Stephen Koester, Elana Kriegel, Kiana Lindsay, Edwin Maingo Ole, Emily Ramirez, Bryan Spizuco, Christian Kiffner

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Therapeutic potential of interleukin 6 inhibitors in difficult-to-treat patients with rheumatoid arthritis (results of a retrospective study) by I. V. Pozharov, E. V. Zhilyaev, A. A. Klimenko

“…Comparison of the group that achieved LDA (LDA+, n = 172; 35.5 %) with the group that did not achieve LDA (LDA–, n = 312; 64.5 %) revealed that the LDA+ was characterized by younger age of RA onset (p = 0.005), later initiation of DMARD (p = 0.005) and JAKi/bDMARDs (p = 0.034) therapies from the onset of RA, and more frequent presentation with stage IV radiological findings per Steinbroker (p = 0.007). …”
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Volumetric 3D Reconstruction of Large Osteochondral Lesions of the Talus Being Reconstructed with Viable Osteochondral Allograft Combined with Autograft by Nathaniel Zona BA, Daniel Moon MD, MS, MBA

“…Surgically, the OLTs were initially inspected arthroscopically then converted to open debridement. …”
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Presenting a Leadership Empowerment Model through Sense-making by Using the Cognitive and Behavioral Scripts by Hamid Zare, Aliasghar Pourezzat, Hasan Zareei Matin, Arezoo Salmani

“…In this extensive study, a total of 111 randomly selected groups operating at various organizational levels within companies active in the pharmaceutical industry were meticulously examined to gather a broad spectrum of insights. …”
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Knowledge, attitude, and practices regarding antibiotic use and antimicrobial resistance among urban slum dwellers in Uganda by Regina Ndagire, Ekwaro A. Obuku, Ivan Segawa, Fiona Atim, Catherine Nassozi Lwanira, Rachel Nante Wangi, Moses Ocan

“…Antimicrobial stewardship initiatives should trickle down to the local citizen.…”
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Association between female genital mutilation/cutting and caesarean delivery in singleton births across Sub-Saharan Africa by Demisu Zenbaba, Sylvester Okeke, Deborah Okeke-Obayemi, Sanni Yaya

“…The study targeted women aged 15–49 with a total sample of 28,176. Initially, bivariate analysis was conducted to assess the association between FGM/C and C-Section, as well as other covariates. …”
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Immunoinformatic-driven design and evaluation of multi-epitope mRNA vaccine targeting HIV-1 gp120 by Muhammad Zeeshan Ahmed, Muhammad Zeeshan Ahmed, Tazeen Rao, Zeeshan Mutahir, Sarfraz Ahmed, Najeeb Ullah, Suvash Chandra Ojha

“…The viral envelope protein (gp120) selectively interacts with CD4 and chemokine receptors on the surface of target cells. …”
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Technologies for Interoperable Internet of Medical Things Platforms to Manage Medical Emergencies in Home and Prehospital Care: Scoping Review by Mattias Seth, Hoor Jalo, Åsa Högstedt, Otto Medin, Bengt Arne Sjöqvist, Stefan Candefjord

“…Recognizing the evident benefit of cross-domain interoperability, we advocate a stronger focus on collaborative initiatives and technologies to achieve higher levels of interoperability. …”
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Insights Into How mHealth Applications Could Be Introduced Into Standard Hypertension Care in Germany: Qualitative Study With German Cardiologists and General Practitioners by Susann May, Frances Seifert, Dunja Bruch, Martin Heinze, Sebastian Spethmann, Felix Muehlensiepen

“…The study found that acceptance of mHealth apps could be significantly increased through targeted educational initiatives, enhanced data quality, and better integration of these tools into existing clinical workflows. …”
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Risk barriers and sustainability in payment for ecosystem service implementation in smallholder forestry by A. Ibrahim, S. Withaningsih, R. Kinseng, Parikesit ., D. Muhamad

“…A total of 40 pertinent studies were selected due to the intricate array of obstacles and uncertainties that hinder the effective implementation of payment for ecosystem services initiatives. …”
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Nanoformulations Downregulating METTL16 Combined with mRNA Tumor Vaccines Suppress Triple-Negative Breast Cancer and Prevent Metastasis by Wang R, Zhang Y, Du S, Li Y, Ren Y, Lin J

“…Initially, the antitumor properties of LNP/siMETTL16 were evaluated at the cellular level. …”
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A Personal History in Black – A Portrait of a Historian in her Youth in Belgrade (1979-1991) by Jelena Mrgić

“…Popular culture grew in influence, and I was able to select the elements of my ‘second skin’, constructing a gothic image as close as possible to the original. …”
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Prevalence, Appropriateness, and Outcomes of Colistin Use in Multidrug-Resistant <i>Pseudomonas aeruginosa</i> Infections: Insights from Hospital Data by Rana K. Abu-Farha, Savana Sobh, Khawla Abu Hammour, Feras Darwish El-Hajji, Sireen A. Shilbayeh, Rania Itani

“…<i>Conclusions</i>: This study demonstrated that colistin was selectively initiated in high-risk patients, particularly those with XDR <i>P. aeruginosa</i>. …”
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Spatial variation of HIV testing and associated factors among pregnant women: a Spatial and multilevel analysis, DHS of sub-Saharan African countries by Mihret Getnet, Desalegn Anmut Bitew, Lemlemu Maru, Ephrem Tesfaye, Dagnew Getnet Adugna

“…Deviance (-2LL) was applied to select the best fitted model. Results HIV testing among pregnant women accounts about 87% in this study. …”
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An Online Transverse Study of Humble Leadership and Team Performance by Majd T. Mrayyan, Abdullah Algunmeeyn

“…The individuals involved in quality initiatives in academic and healthcare settings demonstrated higher levels of humble leadership ( p  = .01). …”
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Overexpression of multiple cytochrome P450 genes with and without knockdown resistance mutations confers high resistance to deltamethrin in Culex quinquefasciatus by Saowanee Chamnanya, Benyapa Kiddela, Jassada Saingamsook, Woottichai Nachaiwieng, Nongkran Lumjuan, Pradya Somboon, Jintana Yanola

“…This study supports sustainable public health initiatives in Thailand to address the evolving challenges of insecticide resistance.…”
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The peers expanding engagement in stimulant harm reduction with contingency management study: a protocol paper by Alexis Cooke, Erin Stack, Linda Peng, Ryan Cook, Bryan Hartzler, Gillian Leichtling, Christi Hildebran, Judith M. Leahy, Kelsey Smith Payne, Lynn E. Kunkel, Kim Hoffman, P. Todd Korthuis

“…Every 2 months, two sites are randomly assigned to initiate the experimental CM condition of incentives for achieving client-directed harm reduction activities. …”
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The identification and validation of histone acetylation-related biomarkers in depression disorder based on bioinformatics and machine learning approaches by Lu Zhang, Lu Zhang, YuJing Lv, Mengqing Ma, Jile Lv, Jie Chen, Shang Lei, Yi Man, Guimei Xing, Yu Wang

“…Candidate genes were selected by intersecting DEGs, key module genes, and HAC-RGs, followed by functional analysis. …”
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