A novel patient-derived cutaneous melanoma cell line reveals key features of metastatic melanoma by Ana Tomás, Ana Tomás, Lúcia Roque, Inês Francisco, Ana Luísa Silva, Hugo Nunes, Emanuel Gouveia, Elisabete Carvalho, Victor Farricha, Cecília Moura, Joaninha Costa Rosa, Pedro Miguel Garrido, Cristina Albuquerque, Patrícia M. Pereira, M. Guadalupe Cabral, Marta Pojo

“…RET S649L was also identified in an earlier metastatic lesion, possibly conferring a selective advantage, and highlighting this mutation as a potential therapeutic target. …”
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Computational Analysis Method for Multi-subject Behavior in Public Spaces Based on Targeted Computer Vision Tracking by Chao YAN, Siyan LIU, Shanshu HE, Leiqing XU

“…Video data is recorded from selected angles based on spatial conditions, ensuring adequate representation of spatial-temporal dynamics. …”
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Development and Comparison of Interrupt-Based and Analog-to-Digital Converter Algorithms for Seed Counting in Precision Planters by A. Ghaffarnezhad, H. Navid, H. Karimi

“…Consequently, the analog-to-digital converter-based algorithm was selected as the superior choice for this research.AcknowledgmentThe authors express appreciation for the financial support provided by the University of Tabriz.…”
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Motives of Freud's essay Das Unheimliche in the collection of stories Žena koja zaustavlja satove by Kornelije Kvas by Lazić-Gavrilović Aleksandra M.

“…In the selected works, Greek tragedies will feature prominently. …”
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Clinical and morphological features in patients with advanced endometrial cancer treated with immunotargeting therapy by L. A. Kolomiets, M. N. Stakheeva, O. N. Churuksaeva, A. B. Villert, A. L. Chernyshova, V. G. Sisakyan, I. Yu. Lots, N. M. Chernorubashkina, V. N. Zhurman, A. A. Grechkina, E. N. Aleksandrova, N. E. Musaeva, O. V. Diduk, N. A. Bulygina, D. A. Pyatina, I. L. Obraz, A. V. Krechetova, M. A. Danilova, M. A. Khodzhakhova, A. A. Malsteva, N. A. Ermak

“…PFS was defined as the time from the ITT initiation until progression or death against the background of treatment. …”
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The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology by Jennifer Stables, Reiss Pal, Barry M. Bradford, Dylan Carter-Cusack, Isis Taylor, Clare Pridans, Nemat Khan, Trent M. Woodruff, Katharine M. Irvine, Kim M. Summers, Neil A. Mabbott, David A. Hume

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Evaluation Indicators of Science, Technology, and Innovation: A Comparative Study of Iran, Australia, and New Zealand by Leila Namdarian

“…Australia and New Zealand were selected as benchmarks due to their leadership in STI evaluation practices. …”
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Soil humus and aluminum—iron interactions enhance carbon sequestration and yield sustainability after long-term fertilization in three different soils by Philip T. Singbah, Jing Huang, Imtiaz Ahmed, Mahmoud Abdelaziz, Kiya Adare Tadesse, Nano Alemu Daba, Jiwen Li, Jun Yan, Shujun Liu, Lisheng Liu, Huimin Zhang

“…Methods: A long-term field experiment initiated in 1982 at Qiyang Red Soil Experimental Station in southern China was selected. …”
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Navigating Rarity: Pathological Challenges and Diagnostic Ambiguity in Rare Gliomas—A Case Series with a Focus on Personalized Treatment and Quality of Life by Nadja Grübel, Anika Wickert, Felix Sahm, Bernd Schmitz, Anja Osterloh, Rebecca Kassubek, Ralph König, Christian Rainer Wirtz, Jens Engelke, Andrej Pala, Mona Laible

“…The fourth case presents a young woman with neurofibromatosis type 1, initially misdiagnosed with glioblastoma based on histopathological findings. …”
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Single intravenous administration of oncolytic adenovirus TILT-123 results in systemic tumor transduction and immune response in patients with advanced solid tumors by Elise Jirovec, Dafne C. A. Quixabeira, James H. A. Clubb, Santeri A. Pakola, Tatiana Kudling, Victor Arias, Lyna Haybout, Katriina Jalkanen, Tuomo Alanko, Tine Monberg, Amir Khammari, Brigitte Dreno, Inge Marie Svane, Matthew S. Block, Daniel A. Adamo, Johanna Mäenpää, Claudia Kistler, Suvi Sorsa, Otto Hemminki, Anna Kanerva, João M. Santos, Victor Cervera-Carrascon, Akseli Hemminki

“…Methods Patients with advanced solid tumors initially received a single i.v. dose of TILT-123 ranging from 3 × 109 to 4 × 1012 viral particles (VP). …”
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Transcriptome dynamics along with expression analysis of key genes involved in fiber development between Gossypium barbadense and Gossypium darwinii by Allah Ditta, Xiaoyan Cai, Muhammad Shehzad, Sajid Fiaz, Yanchao Xu, Yuqing Hou, Zunaira Anwar, Aqsa Ijaz, Najla B. S. Al-Saud, Fang Liu, Kunbo Wang, Baohua Wang, Baohong Zhang, Ahmed M. Ramadan, Muhammad Kashif Riaz Khan, Zhongli Zhou

“…Owing to excellent fiber quality of both Gossypium barbadense and Gossypium darwinii and information obtained via Simple Sequence Repeat (SSR) markers, two lines: Xh-18 and darwinii 5–7 were selected for transcriptome sequencing during developmental stages i.e., fiber initiation, elongation, and secondary cell wall (SCW) biosynthesis followed by 0 day after anthesis (DPA), 5DPA, 10DPA, 15DPA and 25DPA, respectively. …”
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Dual disease co-expression analysis reveals potential roles of estrogen-related genes in postmenopausal osteoporosis and Parkinson’s disease by Dongdong Yu, Dongdong Yu, Jian Kang, Chengguo Ju, Qingyan Wang, Ye Qiao, Ye Qiao, Long Qiao, Long Qiao, Dongxiang Yang

“…Additionally, three hub genes—WT1, CCNB1, and SMAD7—were selected from the PPI network utilizing Cytoscape software. …”
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Pretreatment CT-based machine learning radiomics model predicts response in unresectable hepatocellular carcinoma treated with lenvatinib plus PD-1 inhibitors and interventional th... by Haihong Zhu, Xuan Luo, Zhixian Sun, Yonglin Hua, Yuxin Xiao, Huilong Li, Xiaowu Ma, Wenliang Tan, Zhiqin Xie, Ziyu Zhang, Chenwei Tang, Hongkai Zhuang, Weikai Xu, Yajin Chen, Changzhen Shang

“…The objective response rate, disease control rate, and conversion resection rates were 47.7, 78.1 and 23.2%. 14 features were selected from the initially extracted 1223 for radiomics model construction. …”
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Microbial Indicators Show the Rehabilitation Flow of Soil Microbiota After the Brumadinho Dam Collapse by Paulo Wilson Goulart, Amanda Tristão Santini, Lutecia Rigueira Medina, Alan Emanuel Silva Cerqueira, Alex Castro Gazolla, Wiane Meloni Silva, Igor Rodrigues de Assis, Diego Aniceto, Sergio Oliveira de Paula, Cynthia Canêdo da Silva

“…The results indicated that the reference area initially outperformed the affected area on all evaluated bioindicators, highlighting environmental stress in the affected zone. …”
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Prolonged storage reduces viability of Peptacetobacter (Clostridium) hiranonis and core intestinal bacteria in fecal microbiota transplantation preparations for dogs by Bruna Correa Lopes, Jonathan Turck, M. Katherine Tolbert, Paula R. Giaretta, Jan S. Suchodolski, Rachel Pilla, Rachel Pilla

“…After 3 months, P. hiranonis was undetectable by culture in 83% (5/6) of the frozen samples without glycerol.DiscussionWhile the lyophilization procedure initially reduced P. hiranonis abundance, P. hiranonis viability was stable thereafter for up to 6 months at −20°C. …”
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A new evaluation methodology study - Integrating ‘ancient literature - clinical research - expert consensus’ firstly proposes eight elements for taking Chinese medicine decoctions... by Feiyu Li, Jing Shang, Yixuan Li, Guoxiu Liu, Sijin Zhao, Jiankun Wu, Hongmei Chen, Wanlin Wu, Xuelong Zhao, Huaqiang Zhai

“…We aim to establish a comprehensive and standardised reference standard comprising key elements of Chinese medicine decoctions.MethodsThis study was conducted using the method of “Ancient Literature - Clinical Research - Expert Consensus”. (1) Ancient literature analysis: Systematically analysed 1,019 records of Chinese medicine decoctions in “Bijiqi Qianjin Yaofang”, and initially extracted the elements related to the efficacy of the medicine. (2) Clinical research: A questionnaire covering the knowledge and demand of medication was designed and distributed to medical institutions in 12 regions, including Beijing and Shanghai, and 87 valid data were collected. …”
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Association between Alzheimer's disease pathologic products and age and a pathologic product-based diagnostic model for Alzheimer's disease by Weizhe Zhen, Yu Wang, Hongjun Zhen, Weihe Zhang, Wen Shao, Yu Sun, Yanan Qiao, Shuhong Jia, Zhi Zhou, Yuye Wang, Leian Chen, Jiali Zhang, Dantao Peng, Dantao Peng

“…Through a machine learning approach, we constructed an AD diagnostic model with excellent performance based on the selected features.…”
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Genome-Wide Methylation Sequencing to Identify DNA Methylation Markers for Early-stage Hepatocellular Carcinoma in Liver and Blood by Siyu Fu, Ruben G. Boers, Joachim B. Boers, Pam E. van der Meeren, Jean Helmijr, Vanja de Weerd, Michail Doukas, Maurice Jansen, Bettina E. Hansen, Roeland F. de Wilde, Dave Sprengers, Joost Gribnau, Saskia M. Wilting, José D. Debes, Andre Boonstra

“…The selected DMMs with and without ASAP/GAAD score were further evaluated in 180 blood samples. …”
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Knowledge towards health impacts of climate change among Amhara Sayint community, Northeastern Ethiopia by Genanew Mulugeta Kassaw, Asmamaw Malede, Adinew Gizeyatu, Metadel Adane, Asha Embrandiri, Awoke Keleb, Gete Berihun, Abebe Kassa Geto, Belachew Tekleyohannes Wogayehu, Gebremeskel Kibret Abebe, Tibebu Habtie Zewde, Sisay Abebe Debela, Solomon Seyoum, Amana Ogeto Luke, Gashaw Wondaya, Atitegeb Abera Kide, Mekonnen Moges, Denise Metoyer, Mesfin Gebrehiwot

“…Its findings are crucial for guiding future research and developing targeted public health strategies and educational initiatives.…”
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Effectiveness and feasibility of a theory-informed intervention to improve Mediterranean diet adherence, physical activity and cognition in older adults at risk of dementia: the Me... by A. Jennings, O. M. Shannon, R. Gillings, V. Lee, R. Elsworthy, R. Bundy, G. Rao, S. Hanson, W. Hardeman, S-M. Paddick, M. Siervo, S. Aldred, J. C. Mathers, M. Hornberger, A. M. Minihane

“…Conclusions The intervention was successful in initiating and maintaining dietary behaviour change for up to 12 months which resulted in cognitive benefits. …”
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