The role of neutrophil extracellular traps in cancer progression and thrombosis development by J. Kh. Khizroeva, Z. D. Aslanova, A. G. Solopova, V. O. Bitsadze, А. V. Vorobev, А. Yu. Tatarintseva, J.-С. Gris, I. Elalamy, N. А. Makatsariya, D. V. Blinov

“…Introduction. Initially discovered as a mechanism to protect host neutrophils from pathogens and prevent spread of infection outside inflammatory site, neutrophil extracellular traps (NETs) have been implicated in progression of other diseases associated with sterile inflammation such as autoimmune diseases, diabetes, and cancer. …”
Get full text

Sociocultural determinants of health-associated quality of life among Afghan refugees in Pakistan: evidence from a multi-stage cross-sectional study by Atta Ur Rehman, Rubeena Zakar, Ume Hani, Florian Fischer

“…Therefore, this study was initiated to assess the sociocultural determinants influencing health-associated quality of life among Afghan refugees in Pakistan. …”
Get full text

Anlotinib plus camrelizumab and chemotherapy as first-line treatment in patients with advanced esophageal squamous cell carcinoma by Mingfang Xu, Yu Pu, Yuzhu Jiang, Yingda Liu, Yan Feng, Xiaodong Zhao, Mengxia Li

“…This is an open-label, investigator-initiated, phase 2, non-randomized clinical trial enrolled patients from August 3, 2020, to August 10, 2022. …”
Get full text

‘They went for the test together but came back separately’: a constructivist grounded theory perspective on male engagement in antenatal HIV testing in Bamenda, Cameroon by Lily Haritu Foglabenchi, Nancy Manigha Nyahkeh, Heidi Stöckl, Tanya Marchant

“…Also, couple communication was rare or subtle—mostly initiated by women who suspected spousal infidelity. …”
Get full text

Mapping stakeholders, services, data, and the information system for adolescent health in the West Bank by Aisha Shalash, Maysaa Nemer, Niveen Abu-Rmeileh, Mohammad Kittaneh, Dervla Kelly, Khalifa Elmusharaf

“…These services were primarily delivered through healthcare facilities, educational institutions, youth centers, and select population-based programs, including vaccination initiatives and the 121 hotline, which provides free psychological support to victims of violence. …”
Get full text

Knowledge, Attitude, and Practice of Breast-Self Examination Among Female Students of Niger Delta University by Deborah Oboli, Oluchi Mkpae, Monica Anurika Gbuchie, Tonte Gbuchie

Get full text

Selisistat, a SIRT1 inhibitor, enhances paclitaxel activity in luminal and triple-negative breast cancer: in silico, in vitro, and in vivo studies by Anna Wawruszak, Jarogniew Luszczki, Damian Bartuzi, Joanna Kalafut, Estera Okon, Arkadiusz Czerwonka, Andrzej Stepulak

“…Accumulative evidence suggests that each sirtuin possesses individual character, implicating its role in the regulation of multifaceted biological functions leading to BC initiation, progression and metastasis. Selisistat (EX527) is a potent, cell permeable, highly selective SIRT1 inhibitor. …”
Get full text

The role of the mTOR pathway in breast cancer stem cells (BCSCs): mechanisms and therapeutic potentials by Chen Zhang, Shu Xu, Chuanzheng Yin, Shaobo Hu, Pian Liu

“…The review further examines various therapeutic strategies targeting the mTOR pathway in BCSCs, encompassing selective PI3K/Akt/mTOR inhibitors, monoclonal antibodies, natural products, and innovative approaches such as nanoparticle-mediated drug delivery. …”
Get full text

Site-specific growth dynamics and yield patterns in Populus deltoides against edaphic variability over seven age-gradations. by Ashok Kumar Dhakad, Tarsem Singh, Avtar Singh, Kuldip Singh

“…Current Annual Increment (CAI) values for tree growth variables increased initially but declined after the third age-gradation. …”
Get full text

Curcumin Improved The Sperm Motility of Oligo-Asthenoteratozoospermia Patients during Cryopreservation by Regulating Mitochondrial Apoptotic Pathway Genes and Improving The Antioxi... by Farnoush Naseri, Seyed Abdolhamid Angaji, Elham Siasy, Maryam Peyvandi

“…The aim of this study is to reduce male infertility through sperm preservation.Materials and Methods: In this experimental study, thirty OAT patients meeting the inclusion criteria were selected for the current research. Initially, the patients were studied by karyotyping, and all of them were normal 46 XY. …”
Get full text

Implementation of decarbonisation actions in general practice: a systematic review and narrative synthesis by Jeremy Dale, Helen Atherton, Ana Raquel Nunes, Abi Eccles, Rachel Spencer, Helen Twohig, Florence Karaba, Olivia Geddes, Frederik Dahlmann, Michael Gregg, Abi Bickerton

“…However, barriers such as high costs, resource constraints and limited awareness among clinicians and patients highlighted the need for enhanced communication, education and the structured promotion of initiatives to improve patient and community engagement.Conclusions There is limited evidence on the implementation of decarbonisation actions in general practice. …”
Get full text

Towards developing new private sector maternity care models in South Africa: results from a deliberative stakeholder dialogue by Tanya Doherty, Sue Fawcus, Vishal Brijlal, Geetesh Solanki

Get full text

Simultaneous Determination of Six Chromones in Saposhnikoviae Radix via Quantitative Analysis of Multicomponents by Single Marker by Jinhua Zhang, Luxiao Chen, Junna Qiu, Yu Zhang, Lu Wang, Lijuan Jiang, Yanyan Jiang, Bin Liu

“…In the present study, cimifugin (C), 5-O-methylvisamminol (V), hamaudol (H), and their corresponding glycosides, prim-O-glucosylcimifugin (GC), 4′-O-β-D-glucosyl-5-O-methylvisamminol (GV), and sec-O-glucosylhamaudol (GH), were selected as bioactive constituents and indicators for the quality evaluation of SR. …”
Get full text

Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO by Vidya Narayanaswami PhD, Kenneth Dahl PhD, Vadim Bernard-Gauthier PhD, Lee Josephson PhD, Paul Cumming PhD, Neil Vasdev PhD

“…The dynamic and multicellular processes of neuroinflammation are mediated by the nonneuronal cells of the central nervous system, which include astrocytes and the brain’s resident macrophages, microglia. Although initiation of an inflammatory response may be beneficial in response to injury of the nervous system, chronic or maladaptive neuroinflammation can have harmful outcomes in many neurological diseases. …”
Get full text

Predictive value of systemic immune inflammation index combined with coagulation index in traumatic coagulopathy in patients with severe trauma by Chen Wang, Yongyong Huang, Shiyun Liao, Jiming Song

“…Early identification of TIC and its risk factors is vital for initiating timely interventions. The systemic immune inflammation index (SII), a composite marker of inflammation and immune response, alongside conventional coagulation indices, may hold promise in predicting TIC. …”
Get full text

The lack of specificity of sodC-based PCR for the detection of Neisseria meningitidis carriage in pharyngeal swabs from adolescents by Dan Duy Pham-Tran, Lex E. X. Leong, Mark McMillan, Andrew Lawrence, Hassen Mohammed, Adam Finn, Helen S. Marshall

“…Oropharyngeal swab samples collected from adolescents (approximately 15–18 years of age) enrolled in the “B-Part-of-It” cluster-randomized controlled trial (NCT03089086) were selected for this study. Samples were initially screened for the presence of specific N meningitidis porin A gene (porA) using PCR and then preserved by freezing at −80°C. …”
Get full text

Bridging intentions and outcomes: a program theory approach to residency accreditation standards by Dana Tenne-Fishbain, Yehuda L. Danon, Rachel Nissanholz-Gannot

“…The widespread transition to competency-based education and upcoming international recognition initiatives makes systematic evaluation of residency accreditation particularly timely. …”
Get full text

Reorganization of work schedules for better distribution of work demands in home health care – a feasibility study by Maja Vilhelmsen, Tonje Pedersen Ludvigsen, Kristina Thomassen, Charlotte Diana Nørregaard Rasmussen

“…Abstract Background Given the home health care industry’s growth, increasing demand for workers, and complex patient care needs, investigating initiatives to maintain home health care workers’ health and ability to work is crucial. …”
Get full text

Spousal Separation and Use of and Unmet Need for Contraception in Nepal: Results Based on a 2016 Survey by Suresh Mehata, Yuba Raj Paudel, Amit Dhungel, Mohan Paudel, Janak Thapa, Deepak Kumar Karki

Get full text

Predictors of time to unplanned implanon discontinuation in the first year of application at public hospitals in North Shoa, Central Ethiopia: using acceleration failure time model by Befekadu Tesfaye Oyato, Husen Zakir Abasimel, Derara Girma Tufa, Hana Israel Gesisa, Dursa Hussein, Bacha Merga Chuko

“…Data were gathered from the family planning initiation and removal registration books as well as by contacting users directly. …”
Get full text