Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose? by Marka Crittenden, Sandra Demaria, C Norman Coleman, Jonathan Schoenfeld, Arta Monjazeb, Samir Khleif, Seema Gupta, Andrew Sikora, Zachary Morris, Chandan Guha, Stephen Shiao, Silvia Chiara Formenti, Bhadrasain Vikram, Mansoor M Ahmed

“…Divergence of approaches and findings between preclinical studies and clinical trials highlights the need for evaluating the design of future clinical studies with particular emphasis on radiation dose and fractionation, immune biomarkers and selecting appropriate end points for combination radiation/immune modulator trials, recognizing that direct effect on the tumor and potential abscopal effect may well be different. …”
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Insights Into Rapid Identification, Screening and Activity Investigation of Novel Hemp Seed Pancreatic Lipase/Cholesterol Esterase Inhibitory Peptides by Hao YIN, Jiangxiong ZHU, Yu ZHONG, Danfeng WANG, Yun DENG, Minyan ZHANG, Fang ZHAO

“…After identifying the peptide sequences, 136 peptides with higher content and potential activity were selected to establish a candidate peptide library. …”
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Sulfatase 2 inhibition sensitizes triple-negative breast cancer cells to paclitaxel through augmentation of extracellular ATP by Jasmine M. Manouchehri, Jharna Datta, Lynn M. Marcho, Daniel Stover, Ramesh K. Ganju, Bhuvaneswari Ramaswamy, William E. Carson, Arjun Mittra, Xiaoli Zhang, Patrick M. Schnell, Yu Yue, Mark P. Rubinstein, Mathew A. Cherian

“…We examined eATP and cell viability in paclitaxel-treated TNBC and nontumorigenic immortal mammary epithelial MCF-10A cells in the presence of OKN-007, a selective SULF2 inhibitor, and/or heparan sodium sulfate. …”
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Dynamic monitoring of fine-grained ecological vulnerability in dryland urban agglomeration integrating novel remote sensing index and explainable machine learning by Chunqiang Li, Shanchuan Guo, Qin Huang, Haowei Mu, Bo Yuan, Zilong Xia, Hong Fang, Wei Zhang, Pengfei Tang, Peijun Du

“…Over nearly 40 years, DEVI initially increased, then decreased, indicating ecological conditions first deteriorated and then improved, with an overall improvement of 14%. …”
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Heritage grapevines as sources of biological control agents for Botryosphaeria dieback pathogens by Carmen Sanjuana DELGADO-RAMÍREZ, Edgardo SEPÚLVEDA, Edelweiss Airam RANGEL-MONTOYA, Cesar VALENZUELA-SOLANO, Rufina HERNANDEZ-MARTINEZ

“…The most promising isolates belonging to Trichoderma and Bacillus spp. were selected and characterized to determine their modes of action. …”
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Molecular regulatory networks of microplastics and cadmium mediated hepatotoxicity from NAFLD to tumorigenesis via integrated approaches by Yuhan Li, Yulun Jian, Jinjin Zhou, Min Zhang, Yanfeng Zhou, Yang Ge, Hui Wang, Wei Mu

“…Therefore, we introduce regulatory cascades as novel initiating and key events within the Adverse Outcome Pathway (AOP) framework, revealing for the first time the precise mechanisms underlying the inflammation-to-cancer transition driven by Cd-MP co-exposure. …”
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Third delay in care of critically ill patients: a qualitative investigation of public hospitals in Kenya by Mike English, Jacob McKnight, Tim Baker, Carl Otto Schell, Karima Khalid, Elibariki Mkumbo, John Maiba, Onesmus O Onyango, Tamara M Willows, Jacquie N Oliwa

“…We identified suboptimal systems for identification of critical illness, inadequate resources for continuity care and disruption of the flow of care, as the major causes of delays in identification and the initiation of essential care to critically ill patients. …”
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Priming VRC01-precursor B cells with non-envelope immunogens disfavors boosting with HIV-1 envelope by Andrew Wilcox-King, Yu-Hsin Wan, Samuel C. Scharffenberger, Crystal B. Chhan, Amelia R. Davis, Leah J. Homad, Emilie Seydoux, Kellie J. MacPhee, Latha Kallur Siddaramaiah, Mariane Melo, Pia Dosenovic, Darrell J. Irvine, Ollivier Hyrien, Leonidas Stamatatos, Andrew T. McGuire

“…Because it is distinct from Env, we speculated that the ai-mAb will selectively engage naive VRC01 class B cells while limiting B cell responses directed at off-target epitopes on Env during prime-boost regimens. …”
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Single-atom nanozyme-mediated dihydroartemisinin delivery for self-enhanced chemodynamic therapy and ferroptosis by Yuanlong Zhang, Binghong Chen, Penghui Wei, Zhongyuan Shen, Xiyue Wu, Wenzhong Mei, Yang Zhu, Yuanxiang Lin

“…Chemodynamic therapy (CDT), leveraging intracellular iron ions (Fe2+) and hydrogen peroxide (H2O2), is a highly selective therapeutic strategy with significant potential. …”
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Unveiling the Dark Side of Ultraviolet/Optical Bright Galaxies: Optically Thick Dust Absorption by Yingjie Cheng, Mauro Giavalisco, Bren E. Backhaus, Rachana Bhatawdekar, Nikko J. Cleri, Luca Costantin, Emanuele Daddi, Mark Dickinson, Steven L. Finkelstein, Michaela Hirschmann, Benne W. Holwerda, Anton M. Koekemoer, Ray A. Lucas, Fabio Pacucci, Pablo G. Pérez-González, Giulia Rodighiero, Lise-Marie Seillé, Katherine E. Whitaker, L. Y. Aaron Yung, Pablo Arrabal Haro, Micaela B. Bagley, Jeyhan S. Kartaltepe, Casey Papovich, Nor Pirzkal

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The Impact of Social Capital on Sustainable Development of Agriculture in Rural Areas (Case Study: Kermanshah Province Villages) by Vakil Haidari Sareban, Sohyla Bakhtar, Mina Ziarati

“…The statistical society is Kermanshah province villages those 84 villages and 441 people were selected as samples. Field methods were used to collect data. …”
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Assessment and recalibration of seventeen lung cancer risk prediction models in approximately one million Chinese population utilising healthcare big data: a retrospective cohort a... by Ziqing Ye, Yexiang Sun, Yueqi Yin, Liya Liu, Miao Cui, Longyao Zhang, Yuantao Hao, David C. Christiani, Hongbo Lin, Peng Shen, Yongyue Wei

“…The five-year incidence rates observed in the model-selected population, ranging from 0.81% (95% CI 0.64%–0.96%) to 1.29% (1.08%–1.48%), were consistently higher than that observed in the criteria-selected population (0.75%, 95% CI 0.59%–0.90%). …”
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Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) study. Ten years later by S. A. Boytsov, O. M. Drapkina, E. V. Shlyakhto, A. O. Konradi, Yu. A. Balanova, Yu. V. Zhernakova, V. A. Metelskaya, E. V. Oshchepkova, O. P. Rotar, S. A. Shalnova

“…Realization of this threat led to initiation of epidemiological study by the Russian Ministry of Health to investigate the prevalence of CVDs and their risk factors, since it is CVDs that specify the high allcause mortality in Russia. …”
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A hybrid epithelial-mesenchymal transition program enables basal epithelial cells to bypass stress-induced stasis and contributes to a metaplastic breast cancer progenitor state by Joseph A. Caruso, Chira Chen-Tanyolac, Thea D. Tlsty

“…From these cultures, rare variants emerge from the basal epithelial population, re-initiating growth. Variants exhibit pre-malignant properties, including an aberrant epigenetic program that enables continued proliferation and acquisition of genetic changes. …”
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Impact of iatrogenic alterations on adjacent segment degeneration after lumbar fusion surgery: a systematic review by Moritz Jokeit, Christos Tsagkaris, Franziska C. S. Altorfer, Frédéric Cornaz, Jess G. Snedeker, Mazda Farshad, Jonas Widmer

“…Although it is not possible to definitively advocate for one or more techniques, the principle of selecting the most tissue-sparing approach needs to be scaled across surgical planning and execution. …”
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Impaired instance acquisition as a cause of the comorbidity of learning disorders in young adults by Chiara Valeria Marinelli, Giuliana Nardacchione, Marialuisa Martelli, Vincenza Tommasi, Marco Turi, Paola Angelelli, Pierpaolo Limone, Pierluigi Zoccolotti, Pierluigi Zoccolotti

“…Subsequently, we reclassified the sample into three groups based on the type of deficit: one without procedural/instance deficits (“Control” group), one with selective deficits in “procedural” tasks (“Poor procedural” group), and one with deficits in instance-based tasks (“Poor instance” group). …”
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Assessing male involvement in childcare and associated factors among fathers of below two in Toke Kutaye district, Central Ethiopia, 2024: a community-based cross-sectional study by Gemechu Ganfure, Jiregna Darega, Latera Debebe Kitila

“…A total of 605 fathers with children under 2 years were randomly selected for interviews. Data on male involvement in child care were collected using a structured questionnaire. …”
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OXIDATIVE-ANTIOXIDANT CHANGES OF LOW-DENSITY LIPOPROTEINS AND THEIR ASSOCIATION WITH ATHEROSCLEROTIC RISK FACTORS IN MALE NOVOSIBIRSK POPULATION by Yu. I. Ragino, A. S. Krivchun, M. V. Ivanova, L. V. Shcherbakova, S. K. Malyutina, Yu. P. Nikitin, M. I. Voevoda

“…To investigate the parameters of oxidative-antioxidant changes of low-density lipoproteins (LDL) in a male population, and to study their association with selected risk factors of atherosclerosis and coronary heart disease (CHD). …”
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Analisis Adopsi Pengguna Kelompok Usia Muda pada Integrasi Layanan Pembayaran Gopay di Aplikasi Tokopedia Menggunakan Model UTAUT2 & TTF by Hanifa Putri Rahima, Buce Trias Hanggara, Widhy Hayuhardhika Nugraha Putra

“…A sample of 100 respondents aged 17-24 years was selected, and the SEM-PLS method was employed for empirical data analysis. …”
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Assessment of binary prediction of fraudulent advertisements in ATS candidate tracking cloud systems by V. V. Ligi-Goryaev, G. A. Mankaeva, T. B. Goldvarg, S. S. Muchkaeva, E. N. Dzhakhnaeva

“…Ultimately, the most effective model can be selected based on these evaluation metrics and deployed in a production environment, where it can classify job advertisements as fraudulent or legitimate. …”
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