Deciphering the morpho–physiological traits for high yield potential in nitrogen efficient varieties (NEVs): A japonica rice case study by Kuan-yu ZHU, Jia-qian YAN, Yong SHEN, Wei-yang ZHANG, Yun-ji XU, Zhi-qin WANG, Jian-chang YANG

“…These improved agronomic and physiological traits were positively and significantly correlated with grain yield and internal NUE, which could be used to select and breed N-efficient rice varieties.…”
Get full text

Identification of Potential Sepsis Therapeutic Drugs Using a Zebrafish Rapid Screening Approach by Mark Widder, Chance Carbaugh, William van der Schalie, Ronald Miller, Linda Brennan, Ashley Moore, Robert Campbell, Kevin Akers, Roseanne Ressner, Monica Martin, Michael Madejczyk, Blair Dancy, Patricia Lee, Charlotte Lanteri

“…Food and Drug Administration (FDA) and other active pharmaceutical ingredients (APIs) known to affect pathways implicated in the initiation and progression of sepsis in humans (i.e., inflammation, mitochondrial dysfunction, coagulation, and apoptosis). …”
Get full text

Pediatric medication management barriers faced by providers serving underserved populations and proposed solutions by Tiranun Rungvivatjarus, Tiranun Rungvivatjarus, Maria Z. Huang, Maria Z. Huang, Britanny Winckler, Britanny Winckler, Erin S. Fisher, Erin S. Fisher, Kyung E. Rhee, Kyung E. Rhee

“…This study explores provider-reported barriers and proposed solutions to improving medication management.MethodsFocus group discussions were selected to obtain data as they can provide rich insight into participants’ perspectives. …”
Get full text

External release of entropy by synchronized movements of local secondary structures drives folding of a small, disulfide-bonded protein. by Atsushi Sato, Andre Menez

“…The second process was the activation process to establish the global mutual relationships of the native protein in the selected candidate. This activation process was initiated and propagated by a positive feedback process between efficient entropy release and well-packed local structures, which moved in synchronization. …”
Get full text

Effects of school-based interventions on all 24-hour movement behaviours in young people: a systematic review and meta-analysis of randomised controlled trials by José Francisco López-Gil, Javier Rodrigo-Sanjoaquín, Miguel Ángel Tapia-Serrano, Javier Sevil-Serrano

“…The study was registered in International Prospective Register of Systematic Reviews (PROSPERO) (ID: removed for peer review).Results Of the 5141 records initially identified, 41 studies remained for full-text review. …”
Get full text

PROTAC-Based Antivirals for Respiratory Viruses: A Novel Approach for Targeted Therapy and Vaccine Development by Amith Anugu, Pankaj Singh, Dharambir Kashyap, Jillwin Joseph, Sheetal Naik, Subhabrata Sarkar, Kamran Zaman, Manpreet Dhaliwal, Shubham Nagar, Tanishq Gupta, Prasanna Honnavar

“…These are small molecules that can selectively degrade target proteins via the ubiquitin–proteasome pathway. …”
Get full text

Extracellular vesicle digital scoring assay for assessment of treatment responses in hepatocellular carcinoma patients by Chen Zhao, Yi-Te Lee, Andrew Melehy, Minhyung Kim, Jacqueline Ziqian Yang, Ceng Zhang, Jina Kim, Ryan Y. Zhang, Junseok Lee, Hyoyong Kim, Yong Ju, Yuan-Jen Tsai, Xianghong Jasmine Zhou, Steven-Huy B. Han, Saeed Sadeghi, Richard S. Finn, Sammy Saab, David S. Lu, Jason Chiang, Jae-Ho Park, Todd V. Brennan, Steven A. Wisel, Manaf Alsudaney, Alexander Kuo, Walid S. Ayoub, Hyunseok Kim, Hirsh D. Trivedi, Yun Wang, Aarshi Vipani, Irene K. Kim, Tsuyoshi Todo, Justin A. Steggerda, Georgios Voidonikolas, Kambiz Kosari, Nicholas N. Nissen, Rola Saouaf, Amit G. Singal, Myung Shin Sim, David A. Elashoff, Sungyong You, Vatche G. Agopian, Ju Dong Yang, Hsian-Rong Tseng, Yazhen Zhu

“…At an optimal cutoff of 0.76 identified in the training set, HCC EV TR Score had high accuracy in detecting viable tumors (sensitivity: 76.5%, specificity: 88.2%) and found residual disease not initially observed on MRI in six patients with a median lead time of 63 days. …”
Get full text

Acute care of aneurysmal subarachnoid hemorrhage: practical consensus statement from a multidisciplinary group of German-speaking neurointensivists and neuroradiologists on behalf... by Rainer Kollmar, Hagen B. Huttner, Yigit Ozpeynirci, Christian Herweh, Jochen A. Sembill, Stefan Gerner, Michael Bender, Patrick Schramm, Ingo Schirotzek, Lisa Maeder, Anisa Myftiu, Marius Hartmann, Juergen Konczalla, Karsten Geletneky, Rainer Kram, Raimund Helbok, Joji B. Kuramatsu, Martin Welte, Amr Abdulazim, Emanuela Keller, Ferdinand Bohmann, Wolf-Rüdiger Schäbitz

“…Methods Senior experts from neurology, neurosurgery, neurocritical care, and interventional neuroradiology were selected for their academic and clinical expertise. …”
Get full text

The hospitalization rate and clinical characteristics of mucormycosis prior and during COVID-19 pandemic: A single-center study by Mehrdad Estakhr, Zahra Ghotbi, Mahtab Rostamihosseinkhani, Etrat Hooshmandi, Masoud Janipour, Vahid Reza Ostovan, Nima Fadakar, Hanieh Bazrafshan, Zahra Bahrami, Abbas Rahimi-Jaberi, Maryam Poursadeghfard, Masoumeh Nazeri, Pariya Kouhi, Peyman Petramfar, Sadegh Izadi, Zohreh Barzegar, Ehsan Nikzadeh, Sarvin Sasannia, Shahram Arsang-Jang, Reza Tabrizi, Behzad Khademi, Mahsa Kohandel-Shirazi, Mohammad Saied Salehi, Nahid Ashjazadeh, Bijan Khademi, Mohammad Javad Ashraf, Owrang Eilami, Amir Roudgari, Mohsen Moghaddami, Kamiar Zomorodian, Hamid Badali, Afshin Borhani-Haghighi

“…In addition, a quadrupled group of hospitalized patients with age and sex-matched SARS-COV-2 infection without any sign of mucormycosis was selected as the control group for COVID-associated mucormycosis. …”
Get full text

Voluntary information and price sharing database – a scoping review of the pricing and procurement landscape across eight Commonwealth Member States by Bridget Kebirungi, Phyllis Ocran, Nduta Kamere, Lynette Keneilwe Mabote, Ngozi Osi, Meghna Joshi-von Heyden, Emily Gilmour, Janneth Mghamba, Layne Robinson, Zaheer-Ud-Din Babar, Helena Rosado, Victoria Rutter

“…Vincent and the Grenadines. Nations were selected to represent diverse health systems, population sizes, and procurement practices. …”
Get full text

Mobile applications as an aid in treating obese and overweight people by Marika Gutowska, Wiktoria Belcarz, Paulina Fijałek, Karolina Kalinowska, Jan Karczmarz, Agnieszka Kosińska, Joanna Orzechowska, Michał Orzechowski, Aleksandra Paprocka, Urszula Świrk

“…The deficits in initiating application are a negative predictor of attrition in adolescents. …”
Get full text

Predictors of Suboptimal Peak Inspiratory Flow in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Clinical Practice by Natalia V. Trushenko, Baina B. Lavginova, Svetlana Yu. Chikina, Natalia E. Obukhova, Iuliia A. Levina, Fedor D. Tkachenko, Galina V. Nekludova, Zamira M. Merzhoeva, Sergey N. Avdeev

“…The most significant predictors were age (odds ratio [OR], 0.89) and FEV1 (OR 0.59). Conclusion Selecting a suitable dry powder inhaler for maintenance therapy in patients with acute exacerbation of COPD requires consideration of the patient's ability to achieve optimal PIF, with special attention to age and severity of functional impairment.…”
Get full text

Uncovering potential causal genes for undiagnosed congenital anomalies using an in-house pipeline for trio-based whole-genome sequencing by Jeong-Min Kim, Hye-Won Cho, Dong Mun Shin, Oc-Hee Kim, Jihyun Kim, Hyeji Lee, Gang-Hee Lee, Joon-Yong An, Misun Yang, Heui Seung Jo, Ja-Hyun Jang, Yun Sil Chang, Hyun-Young Park, Mi-Hyun Park

“…Among them, 10 variants of seven coding genes were selected as possible causal variants by variant pathogenicity, genotype–phenotype analysis, and a multidisciplinary team. …”
Get full text

Application of Theoretical Solubility Calculations and Thermal and Spectroscopic Measurements to Guide the Processing of Triamcinolone Acetonide by Hot-Melt Extrusion by Pedro A. Granados, Idejan P. Gross, Patrícia Medeiros-Souza, Livia L. Sá-Barreto, Guilherme M. Gelfuso, Tais Gratieri, Marcilio Cunha-Filho

“…<b>Methods</b>: Using Hansen solubility parameters, seven hot-melt extrusion (HME)-grade polymers and four plasticizers were initially screened for miscibility with TA. Based on Δδt values, four polymers—Eudragit^® L100 (EUD), Parteck^® MXP (PVA), Plasdone^® S-630 (PVPVA), and Aquasolve™ AS-MG (HPMCAS)—along with triethyl citrate (TEC), were selected for experimental evaluation. …”
Get full text

Investigation into the synergism and interaction for waste valorization via co-pyrolysis of milk packet and Parthenium hysterophorus through thermogravimetric analysis by Rahul Lanjewar, Jitendra Choudhary, Manoj Kumar Tripathi, Sankar Chakma

“…The physicochemical characteristics, thermal behavior, synergetic effects, and kinetic parameters of the selected feedstock and their mixture were analyzed using the thermal gravimetric (TGA) technique. …”
Get full text

Freeze‐Up Ice Jams and Channel Hydraulics Cause Hazardous Open Water Zones Within Winter Ice Cover on the Kuskokwim and Yukon Rivers and Their Tributaries by Christopher D. Arp, Dana N. Brown, Allen C. Bondurant, Karin L. Bodony, Melanie Engram, Katie V. Spellman, Sarah J. Clement, Matthew C. Scragg

“…To better understand the distribution, variability, and mechanisms of OWZs, we selected nine reaches totaling 380 river‐km for remote sensing analysis and field studies in western Alaska. …”
Get full text

Study on the driving factors of watershed runoff change in Zuli River by Budyko hypothesis and soil and water assessment tool model by Yun Zhao, Rui Zhang, Heping Shu, Yaxian Li, Zhi Xu, Qiang Wang

“…Therefore, the significance of human activities must be taken into account in ecological protection and water-related initiatives within the Loess Plateau gully region, so as to formulate effective sustainable development strategies for the future integrated management of the basin.…”
Get full text

Overall survival of patients with non-small cell lung cancer after surgery treatment by Lončarević Olivera, Aćimović Slobodan, Vuković Jelena, Stojisavljević Marko, Marić Nebojša, Lončarević Slobodan, Petrović Marina, Milivojević Ivana, Ignjić Gordana, Milić Gordana, Mirilo Leonida, Rančić Nemanja

“…This retrospective case series study included all patients with NSCLC admitted to the Military Medical Academy in Belgrade in the period 2010–2015. A total number of selected patients was 85 (27 females and 58 males). …”
Get full text

Biofeedback for Motor and Cognitive Rehabilitation in Parkinson’s Disease: A Comprehensive Review of Non-Invasive Interventions by Pierluigi Diotaiuti, Giulio Marotta, Salvatore Vitiello, Francesco Di Siena, Marco Palombo, Elisa Langiano, Maria Ferrara, Stefania Mancone

“…EEG neurofeedback targeted abnormal cortical oscillations, such as beta-band overactivity and reduced frontal theta, and was associated with improvements in motor initiation, executive functioning, and cognitive flexibility. …”
Get full text

Ultrasound Imaging and Machine Learning to Detect Missing Hand Motions for Individuals Receiving Targeted Muscle Reinnervation for Nerve-Pain Prevention by Anna Rita E. Moukarzel, Justin Fitzgerald, Marcus Battraw, Clifford Pereira, Andrew Li, Paul Marasco, Wilsaan M. Joiner, Jonathon Schofield

“…Targeted muscle reinnervation (TMR) was initially developed as a technique for bionic prosthetic control but has since become a widely adopted strategy for managing pain and preventing neuroma formation after amputation. …”
Get full text