Prevalence of visual impairment and outcomes of cataract surgery in Chaonan, South China. by Xiujuan Zhang, Emmy Y Li, Christopher Kai-Shun Leung, David C Musch, Xin Tang, Chongren Zheng, Mingguang He, David F Chang, Dennis Shun-Chiu Lam

“…<h4>Method</h4>A two-stage cluster sampling procedure was used to select 3700 participants aged ≥50 years from 74 clusters of Chaonan Region. …”
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Validation of a deep learning–based AI system for HER2-targeted breast cancer assessment using ultrasound imaging in a clinical setting by Kathryn Malherbe

“…BackgroundThis study evaluates the performance of a deep learning–based artificial intelligence (AI) system developed under the Stradexa (a branded form of doxorubicin used regionally in South Africa) initiative, designed for real-time risk stratification and treatment monitoring in HER2-positive breast cancer. …”
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Using machine learning models to plan HIV services: Emerging opportunities in design, implementation and evaluation by T Dzinamarira, E Mbunge, I Chingombe, D F Cuadros, E Moyo, I Chitungo, G Murewanhema, B Muchemwa, G Rwibasira, O Mugurungi, G Musuka, H Herrera

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Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4 by Brian Wong, Dirk G Brockstedt, Lisa A Marshall, Sachie Marubayashi, Aparna Jorapur, Scott Jacobson, Mikhail Zibinsky, Omar Robles, Dennis Xiaozhou Hu, Jeffrey J Jackson, Deepa Pookot, Jerick Sanchez, Martin Brovarney, Angela Wadsworth, David Chian, David Wustrow, Paul D Kassner, Gene Cutler, Oezcan Talay

“…But some patients fail to respond or initially respond but later relapse as they develop resistance to immune therapy. …”
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Identification of a risk model for prognostic and therapeutic prediction in bladder urothelial carcinoma based on infiltrating CD8+ T cells by Ligang Ma, Ruixin Li, Junjie Su, Qiong Cao, Haojie Wang, Zhihao Wei, Chengliang Wang, Chengdong Zhang, Guanyu Li, Wang Qin, Zheng Zhang, Chu Wang, Yingao Zhu, Jingjing Zhao, Shiyong Xin, Jun Ma

“…This study aims to thoroughly characterize tumor-infiltrating immune cells in bladder cancer (BLCA) and identify key immune cells and gene models associated with prognosis and therapeutic outcomes in BLCA. Methods: Initially, we assessed the relationship between the abundance of infiltrating immune cells and prognosis, CD8+T cell was selected to establish the risk model, which was constructed based on five key genes. …”
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Cyclobrachycoumarin from <i>Gerbera piloselloides</i> Inhibits Colorectal Cancer In Vitro and In Vivo by Limei Fan, Xiansheng Ye, Qian Fang, Xiaoxuan Li, Haiping Wang, Binlian Sun, Xiji Shu, Xiaoying Hou, Yuchen Liu

“…Among them, the compound cyclobrachycoumarin showed a significant inhibitory effect on colorectal cancer (CRC) cell proliferation and was selected for further investigation. Cyclobrachycoumarin was found to induce CRC cell apoptosis and cell cycle arrest in a dose-dependent manner. …”
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Analysis of genetic diversity and phylogenetic relationships among Indonesian native cattle breeds using microsatellite markers: A review by Rini Hastarina, Agung Purnomoadi, Sutopo Sutopo, Dela Ayu Lestari, Fatmawati Mustofa, Putu Novia Gariri, Pupus Galau Prahara, Firda Tasya Kamila, Syaddad Verahry Philco, Maulida Arkaan Muhammad Da’i, Asep Setiaji

“…Analysis of multiple studies reveals that geographical isolation, selective breeding, and human-mediated practices have shaped the genetic structure of these populations. …”
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What should be measured and reported in clinical trials for the treatment of patients with acute pancreatitis? A study protocol for establishing a core outcome set by Wei Huang, Ling Li, Xin Sun, Chen Hu, Lihui Deng, Ping Zhu, Qing Xia, Weiwei Chen, Yuxin Shen, Zhiyao Chen, Ziqi Lin, Qingyuan Tan

“…However, due to heterogeneous and selective outcome reporting across trials of interventions, it is hard to combine or compare the trial results compromising systematic evaluations of effectiveness and safety. …”
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Evaluating the knowledge, roles, and skills of health cadres in stunting prevention: A mixed-method study in Indonesia by Restuning Widiasih, Deni Kurniadi Sunjaya, Laili Rahayuwati, Binahayati Rusyidi, Ermiati, Citra Windani Mambang Sari, Mardani, Rusdi, Serene En Hui Tung

“…However, structured assessments and follow-up initiatives to enhance their participation remain limited. …”
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May the Extensive Farming System of Small Ruminants Be Smart? by Rosanna Paolino, Adriana Di Trana, Adele Coppola, Emilio Sabia, Amelia Maria Riviezzi, Luca Vignozzi, Salvatore Claps, Pasquale Caparra, Corrado Pacelli, Ada Braghieri

“…The review of the technologies involved and the main fields of application can help identify the most suitable systems for managing grazing sheep and goats and contribute to selecting more sustainable and efficient solutions in line with current environmental and welfare concerns.…”
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Exploring perceptions and awareness of artificial light: A qualitative study among medical and non-medical college students in an urban area of Southern India by Mithra Prasanna, Thapar Rekha, Mallya Ajay, Prabhakar Madhu Malar, Pandey Sonali, Agrawal Yash, Vats Anmol, Agarwal Shreya, Maurya Sarthak, Patel Sneha, Mohanty Marmit, Hooda Divya

“…Conclusion: The findings emphasise the need for greater awareness of the implications of artificial light use, promoting healthier practices and informed decisions among students. Educational initiatives and public health strategies should focus on promoting healthier practices and informed decisions to mitigate its risks. …”
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<i>Cassia grandis</i> L.f. Pods as a Source of High-Value-Added Biomolecules: Optimization of Extraction Conditions and Extract Rheology by Filipe M. M. Cordeiro, Salomé G. Bedoya, Daniel A. P. Santos, Rebeca S. Santos, Thomas V. M. Bacelar, Filipe S. Buarque, George Simonelli, Ana C. M. Silva, Álvaro S. Lima

“…Thus, this work aims to optimize the extraction of these biomolecules present in the pods of <i>Cassia grandis</i> L.f. Initially, the effect of choline-based ionic liquids—ILs (choline chloride [Ch]Cl, dihydrogen citrate [Ch][DHC], and bitartrate [Ch][BIT]) as extracting agents for phenolic compounds and flavonoids was evaluated based on their efficiency and selectivity. …”
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Barriers to breast cancer treatment in Brazil: A study on migration and regional disparities by Marcelo Antonini, Gabriela Moreira Santos, André Mattar, Marina Diogenes Teixeira, Andressa Gonçalves Amorim, Marina Fleury de Figueiredo, Marcellus do Nascimento Moreira Ramos, Francisco Pimentel Cavalcante, Eduardo Camargo Millen, Antonio Luis Frasson, Felipe Zerwes, Odair Ferraro, Fabricio Palermo Brenelli, Juliana Francisco, Luiz Henrique Gebrim

“…The study evaluated patient migration rate for treatment, with information obtained from the DATASUS - SISCAN/Cancer Information System database. The selected analysis period was from 2017 to 2022, during which all necessary variables were available. …”
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The symbiont Wolbachia increases resistance to bifenthrin in Ectropis grisescens by regulating the host detoxification function by Tian Gao, Yong Zhang, Wanpeng Sun, Qiangkun Li, Xueyu Huang, Dian Zhi, Huabin Zi, Ruijie Ji, Yanhua Long, Chunmei Gong, Yunqiu Yang

“…Recent studies suggest that insect symbionts play a role in influencing insecticide resistance, however, their specific involvement in E. grisescens remains unclear. Here, we initially selected appropriate antibiotic mixtures at a concentration of 300 μg ml−1. …”
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Impact of a glutamine-enriched peptide formula on gastrointestinal toxicity and on the interruption of oncologic treatment in patients with adenocarcinoma of the rectum by Bárbara Gabriela Salas-Salas, Laura Ferrera-Alayón, Laura Ferrera-Alayón, Alicia Calleja-Fernández, Rodolfo Chicas-Sett, Eva Nogués-Ramia, Juan Zafra-Martín, Marta Lloret, Marta Lloret, Marta Lloret

“…Intestinal toxicity was evaluated with the CTCAE 5.0 scale, functionality with the ECOG scale and nutritional status with GLIM criteria.ResultsFifty-four patients were initially selected, although 51 were finally enrolled: 25 in the PD group and 26 in the DA group. …”
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Data-Driven Approach for Intelligent Classification of Tunnel Surrounding Rock Using Integrated Fractal and Machine Learning Methods by Junjie Ma, Tianbin Li, Roohollah Shirani Faradonbeh, Mostafa Sharifzadeh, Jianfeng Wang, Yuyang Huang, Chunchi Ma, Feng Peng, Hang Zhang

“…Subsequently, crucial parameters affecting surrounding rock quality were analyzed and selected, including rock strength, the fractal dimension of discontinuity, the discontinuity condition, the in-situ stress condition, the groundwater condition, and excavation orientation. …”
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Transformation metabolites of phthalate esters (PAEs) inhibited rice growth through jasmonic acid signaling pathway by Yingying Sun, Jie Chen, Wei Wang, Lizhong Zhu

“…MBP conjugated with isoleucine, and the conjugate subsequently mimicked a JA bioactivator (JA-isoleucine conjugate) to occupy the binding site of COI1-JAZ co-receptor protein, thereby initiating the JA signaling pathway. These JA-related outcomes and mechanism were consistently evidenced in rice exposed to other four typical PAEs, and the aliphatic chain length of selected PAEs indicated a negative contribution to these observations. …”
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FXR Activation Accelerates Early Phase of Osteoblast Differentiation Through COX-2-PGE₂-EP4 Axis in BMP-2-Induced Mouse Mesenchymal Stem Cells by Ko Fujimori, Yusuke Iguchi, Yukiko Yamashita, Keigo Gohda, Naoki Teno

“…Moreover, treatment with either inhibitor during the first 6 h after initiating osteoblast differentiation repressed FXR-activated osteoblast differentiation to the same extent as did the treatment for 6 d. …”
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The Excretion Period of Triclabendazole Residual and it's Metabolites after Triclafascid Application on Sheep by M. B. Musaev, I. E. Shumakovich, M. S. Khalikov, N. B. Emelyanova, P. P. Kochetkov, N. E. Patyukov, V. E. Abramov

“…Researches were carried out on 12 sheep of Romanov breed at the age of 1 year. The animals selected in the experiment were divided according to the principle of analogues into 4 groups (control and 3 experimental) for 3 animals in every slaughter period. …”
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Characterization of MADS-Box Gene Family in <i>Isatis indigotica</i> and Functional Study of <i>IiAP1</i> in Regulating Floral Transition and Formation by Yanqin Ma, Yanhong Lan, Ju Li, Haicheng Long, Yujie Zhou, Zhi Li, Mingjun Miao, Jian Zhong, Haie Wang, Wei Chang, Ziqin Xu, Liang Yang

“…In flowering plants, MADS-box genes play regulatory roles in flower induction, floral initiation, and floral morphogenesis. <i>Isatis indigotica</i> (<i>I</i>. …”
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