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Suggested Topics within your search.
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2-Benzazolyl-4-Piperazin-1-Ylsulfonylbenzenecarbohydroxamic Acids as Novel Selective Histone Deacetylase-6 Inhibitors with Antiproliferative Activity.
Published 2015-01-01“…Whereas compounds bearing a para substituted hydroxamic acid (9a-d) were active HDAC inhibitors, the meta substituted analogues (8a-d) were appreciably inactive. Compounds 9a-d selectively inhibited HDAC6 (IC50 = 0.1-1.0 μM) over HDAC1 (IC50 = 0.9-6 μM) and moreover, also selectively inhibited the growth of lung cancer cells vs. patient matched normal cells. …”
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863
Strategy Selection to Enhance Customer Data Quality using AHP: Case Study of General Insurance Company (PT XYZ)
Published 2024-10-01“…The Analytical Hierarchy Process (AHP) is utilized to select the optimal strategy from available alternatives. …”
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864
A Two-Stage Feature Selection Approach Based on Artificial Bee Colony and Adaptive LASSO in High-Dimensional Data
Published 2024-12-01“…High-dimensional datasets, where the number of features far exceeds the number of observations, present significant challenges in feature selection and model performance. This study proposes a novel two-stage feature-selection approach that integrates Artificial Bee Colony (ABC) optimization with Adaptive Least Absolute Shrinkage and Selection Operator (AD_LASSO). …”
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865
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Suitability of Electrodialysis with Monovalent Selective Anion-Exchange Membranes for Fractionation of Aqueous Mixture Containing Reactive Dye and Mineral Salt
Published 2025-03-01“…Standard cation-exchange membranes (CM membranes) and monovalent selective anion-exchange membranes (MVA membranes) were used in the electrodialysis (ED) stack. …”
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867
Hybrid optimization method for optimal site selection and sizing of a hybrid photovoltaic water pumping/diesel/battery system
Published 2025-01-01“…In this paper, a hybrid optimization method based on a technique for order of preference by similarity to an ideal solution (TOPSIS) is used for the simultaneous site selection and sizing of a hybrid photovoltaic (PV) water pumping/diesel generator energy system. …”
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868
The Survival of Bifidobacterium infantis 20088 and Physicochemical Changes During Refrigeration Storage of Selected Fermented Traditional Sudanese Fruit Beverages
Published 2015-10-01“…This study was carried out to evaluate survival of Bifidobacterium infantis 20088 in fermented beverage formulated from selected traditional Sudanese fruits Gudaim and dom. …”
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869
Global Optimal Solving Algorithm for Power Distribution Based on Selective Harmonic Elimination in Cascaded H-Bridge Multilevel Inverters
Published 2025-06-01“…To address the above issues, a novel power distribution based on the selective harmonic elimination (PD–SHE) strategy is proposed to achieve arbitrary power distribution and selective harmonic elimination but with low switching frequency and single carrier cycle. …”
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870
Historical Manuscripts Analysis: A Deep Learning System for Writer Identification Using Intelligent Feature Selection with Vision Transformers
Published 2025-06-01“…The initial preprocessing phase involves thorough document refinement using bilateral filtering for denoising and Otsu thresholding for binarization, ensuring document clarity and consistency for subsequent feature detection. …”
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871
A Novel Energy Control Digital Twin System with a Resource-Aware Optimal Forecasting Model Selection Scheme
Published 2025-07-01“…To solve this problem, we propose a novel energy control digital twin system with a resource-aware optimal forecasting mode selection scheme. The system dynamically selects optimal forecasting models by integrating statistical features of the input time series with available resources. …”
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872
Selective killing of homologous recombination-deficient cancer cell lines by inhibitors of the RPA:RAD52 protein-protein interaction.
Published 2021-01-01“…The FluorIA was used to rank the compounds by their ability to inhibit the RPA:RAD52 PPI and showed mitoxantrone and doxorubicin to be the most effective. Initial studies using the three FDA-approved drugs showed selective killing of BRCA1-mutated breast cancer cells (HCC1937), BRCA2-mutated ovarian cancer cells (PE01), and BRCA1-mutated ovarian cancer cells (UWB1.289). …”
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873
To what extent do we learn from past epidemics: a mobile phone survey of selected villages in Liberia
Published 2024-01-01“…We interviewed 600 respondents three times over seven years, sampled by an initial list of 2,265 respondents in 571 villages across all of Liberia selected through Random Digit Dialing (RDD) in 2015-2016. …”
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874
Validity of inferring size-selective mortality and a critical size limit in Pacific salmon from scale circulus spacing.
Published 2018-01-01“…Through simulation we found that the percentage of adults that displayed a SCSI value greater than the maximum observed in the juvenile sample was highly dependent on the initial juvenile sample size and size-selective mortality rate. …”
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875
Clinical outcome of chronic haematogenous osteomyelitis of the femur or tibia in adults using selective segmental osteotomy and induced membrane technique
Published 2025-04-01“…Visual Analogue Scale (VAS) score, Self-rated Anxiety Scale (SAS) score, and Hospital for Special Surgery (HSS) score improved at 3 months after the second stage of surgery and at the final follow-up compared with initial admission (P < 0.05). For adult patients with CHOM of femur and tibia, selective segmental osteotomy with induced membrane technique is a feasible and effective treatment method.…”
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876
Postoperative abdominal sepsis induces selective and persistent changes in CTCF binding within the MHC-II region of human monocytes.
Published 2021-01-01“…<h4>Results</h4>Compared to a matched surgical control cohort, postoperative sepsis was associated with selective and enduring increase in CTCF binding within the MHC-II. …”
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877
Policy Instruments for Managing EU Road Safety Targets: Road Safety Impact Assessment
Published 2012-03-01“…Road Safety Impact Assessment (RSIA) is an initial part of road infrastructure safety management systems. …”
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878
Recovery of Samarium from Waste SmCo Magnets via Selective Precipitation with Ammonium Bicarbonate: Optimization of Process Efficiency
Published 2024-11-01“…This was followed by selective Sm precipitation in the pH range of 5–6.5 using NH<sub>4</sub>HCO<sub>3</sub>. …”
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C-reactive protein orchestrates acute allograft rejection in vascularized composite allotransplantation via selective activation of monocyte subsets
Published 2025-06-01“…Results: Our findings demonstrate that CRP expedites allograft rejection and diminishes allograft survival by selectively activating non-classical monocytes. Therapeutic stabilization of CRP abrogates this activating effect on monocytes, thereby attenuating acute allograft rejection. …”
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880
Optimisation of the cultured ELISpot/Fluorospot technique for the selective investigation of SARS-CoV-2 reactive central memory T cells
Published 2025-04-01“…CCR7+ cell depletion was used to demonstrate our optimised protocol to selectively demonstrate central memory T-cell responses. …”
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