A Hidden Metastasis with a Bloomy Rind Sign: Carcinomatous Meningitis from Metastatic Lung Adenocarcinoma with Unusual Cranial Nerve Involvement by Tanvi Joshi, Adrian Jacob, Swetha Narla, M Balamurugan

“…While the prognosis remains poor, early intervention can potentially improve quality of life and extend survival in selected cases.…”
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Risk factors and diagnostic markers for acute coronary syndrome in chronic kidney disease by L. A. Kamyshnikova, D. S. Pisankina, K. S. Gorbachevskaya, G. V. Biryukov, M. S. Sviridova, I. V. Kalashnikova

“…In addition, CKD itself is the initiator of acute coronary syndrome (ACS), the prevalence of which is greater, the more pronounced the impairment of kidney function and the more concomitant risk factors in the patient.Aim. …”
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HIV Replication Under High-Level Cabotegravir Is Associated with the Appearance of 3′-PPT Mutations, Circular DNA Transcription and Recombination by Xierong Wei, Jonathan T. Lipscomb, Ariana Santos Tino, Mian-er Cong, Susan Ruone, Meghan L. Bentz, Mili Sheth, Gerardo Garcia-Lerma, Jeffrey A. Johnson

“…The HIV integrase inhibitor, dolutegravir (DTG), in the absence of eliciting integrase (int) resistance, has been reported to select mutations in the virus 3′-polypurine tract (3′-PPT) adjacent to the 3′-LTR U3. …”
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A network analysis of carbapenem-resistant Klebsiella pneumoniae among healthcare facilities by Courtney L. Luterbach, Dana K. Pasquale, Heather I. Henderson, Eric Cober, Sandra S. Richter, Robert A. Salata, Robert C. Kalayjian, Richard R. Watkins, Andrea M. Hujer, Kristine M. Hujer, T. Nicholas Domitrovic, Yohei Doi, Keith S. Kaye, Scott Evans, Vance G. Fowler, Robert A. Bonomo, Barry Kreiswirth, Liang Chen, Cesar A. Arias, James Moody, David van Duin, for the Antibacterial Resistance Leadership Group

“…Thus, controlling spread necessitates integrated surveillance and control initiatives at regional and national levels in addition to institution-specific approaches.…”
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Identification of potential dual α-amylase and α-glucosidase inhibitory peptides from Humulus scandens through multi-step virtual screening, molecular docking, ligand efficiency an... by De Xin Dang, Shi Qi Xu, Desheng Li, Huan Wang, Xinhua Xia, Shaoyong Xu

“…A total of 2499 peptides were initially generated, among which 42 were predicted to possess biological activity. …”
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Game-Based Telerehabilitation on Motor Function in Stroke Patients by Kimia Moradiani, Vahideh Moradi, Gholamreza Hassanzadeh, Hamid Reza Asgari, Ardalan Shariat

“…Out of 118 articles initially identified, duplicates and articles published before 2018 were excluded. …”
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Key influencers in an aneurysmal thrombosis model: A sensitivity analysis and validation study by Qiongyao Liu, Toni Lassila, Fengming Lin, Michael MacRaild, Tufail Patankar, Fathallah Islim, Shuang Song, Huanming Xu, Xiang Chen, Zeike A. Taylor, Ali Sarrami-Foroushani, Alejandro F. Frangi

“…Here, we conduct a global sensitivity analysis on a previously developed thrombosis model, utilizing thrombus composition, the flow-induced platelet index, and the bound platelet concentration as output metrics. These metrics are selected for their relevance to thrombus stability. …”
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Exploring pesticide risk in autism via integrative machine learning and network toxicology by Ling Qi, Jingran Yang, Qiao Niu, Jianan Li

“…Using the LASSO algorithm, 23 key targets were initially selected. Each combination of 1–23 targets was used to construct predictive models using eight different machine learning algorithms. …”
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Age dependent susceptibility and immune responses to La Crosse virus infection in non-human primates by Clayton W. Winkler, Tyson A. Woods, Aaron B. Carmody, Katherine G. Taylor, Rachel LaCasse, Dana Scott, Patrick W. Hanley, Jamie Lovaglio, Karin E. Peterson

“…Marmoset were selected due to their susceptibility to viral encephalitis. …”
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Progressive damage mechanism of rock-anchoring interface under cyclic impact loading by Peng Wang, Nong Zhang, Jiaguang Kan, Zhengzheng Xie, Guangzhen Cui, Feng Guo, Chuang Cao, Zhe Xiang, Changliang Han

“…Changes in elastic potential energy dominate the failure process, which follows a characteristic progression: fissure compression, initiation, propagation, penetration, and final rupture. …”
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An Auto-Adjusting Algorithm to Enhance Indoor Localization Accuracy: A Real-Time Experimental Analysis by Othman A. Alfahad, Husham Saied, Emad Malaekah, Ahmed Al Rashdi, Mohammed Emam, Mohsen Bakouri

“…The proposed method initially succeeded in reducing the error caused by fixed coefficients and RSSI by 28.03%. …”
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CaRcd1 positively regulates pepper (Capsicum annuum L.) regeneration by interacting with the transcription factor CaGATA26 to inhibiting CaTMKL1 expression by Han Qiao, Mingxuan Li, Yan Chen, Xiangyun Cui, Ruiquan Ye, Sujun Liu, Han Hui, Liang Sun, Qing Cheng, Huolin Shen

“…Selected R60 as the variety with superior regeneration capacity through pharmacological and RNA-seq analyses of the typical features of dedifferentiation and redifferentiation. …”
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EFFECTIVENESS OF ORAL MEDICATIONS IN THE PERIOPERATIVE PERIOD OF ROTATOR CUFF INJURIES - SYSTEMATIC REVIEW by Edivando de Moura Barros, Elzir Finizola Costa Junior, Fabio Teruo Matsunaga, Milla Pompilio da Silva, Eiffel Tsuyoshi Dobashi, Marcel Jun Sugawara Tamaoki

“…Material and methods: A systematic review of the literature was carried out, conducting a data search in the Pubmed/Medline, Science Direct and Embase databases. Initially, 1,223 articles were identified where, after detailed analysis, eight studies were selected to compose this research. …”
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Clinical Trial Protocol for Porcine Islet Xenotransplantation in South Korea by Byung-Joon Kim, Jun-Seop Shin, Byoung-Hoon Min, Jong-Min Kim, Chung-Gyu Park, Hee-Jung Kang, Eung Soo Hwang, Won-Woo Lee, Jung-Sik Kim, Hyun Je Kim, Iov Kwon, Jae Sung Kim, Geun Soo Kim, Joonho Moon, Du Yeon Shin, Bumrae Cho, Heung-Mo Yang, Sung Joo Kim, Kwang-Won Kim

“…Background Islet transplantation holds promise for treating selected type 1 diabetes mellitus patients, yet the scarcity of human donor organs impedes widespread adoption. …”
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Discovery of Cyclic Peptide Inhibitors Targeted on TNFα-TNFR1 from Computational Design and Bioactivity Verification by Jiangnan Zhang, Huijian Zhao, Qianqian Zhou, Xiaoyue Yang, Haoran Qi, Yongxing Zhao, Longhua Yang

“…The results indicate that two cyclic peptides, R1_CC4 and α_CC8, exhibit the strongest binding free energies. α_CC8 was selected for further optimization using virtual mutations through in vitro activity and toxicity experiments due to its optimal biological activity. …”
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Cyberbullying victimization predicts substance use and mental health problems in adolescents: data from a large-scale epidemiological investigation by Cláudio Romualdo, Wanderlei Abadio de Oliveira, Luciana Bertoldi Nucci, José Eugenio Rodríguez Fernández, Laura Soares da Silva, Evelin Moreira Freires, Amanda Severo Lins Vitta, Fernando Ferreira Semolini, Lucas da Rosa Ferro, Denise de Micheli, André Luiz Monezi Andrade

“…The CYB group also exhibited significant alcohol and tobacco consumption, as well as the initiation of these substances at a younger average age compared to the nCYB group. …”
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Case Report: Durable complete response of advanced-stage hepatocellular carcinoma to DEB−TACE combined with lenvatinib and camrelizumab by Baiguo Xu, Baiguo Xu, Baiguo Xu, Baiguo Xu, Baiguo Xu, Yufeng Cui, Yufeng Cui, Yufeng Cui, Yufeng Cui, Yufeng Cui, Ning Wang, Ning Wang, Ning Wang, Ning Wang, Ning Wang, Zhongsong Gao, Zhongsong Gao, Zhongsong Gao, Zhongsong Gao, Zhongsong Gao, Qing Ye, Qing Ye, Qing Ye, Qing Ye, Qing Ye, Huiling Xiang, Huiling Xiang, Huiling Xiang, Huiling Xiang, Huiling Xiang

“…These findings suggest that integrating MKIs and ICIs may represent a potential treatment approach for select advanced HCC cases, warranting further validation in larger studies.…”
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Aurora 2.0: A fluorogenic dye library for expanding the capability of protein-adaptive differential scanning fluorimetry (paDSF) by Annemarie F. Charvat, Kayleigh Mason-Chalmers, Aneta Grabinska-Rogala, Shloka Shivakumar, Zachary Gale-Day, Taiasean Wu, Zoe Millbern, Jonathan B. Grimm, Emma C. Carroll, K․ Peter R․ Nilsson, Luke D. Lavis, Nelson R. Vinueza, Jason E. Gestwicki

“…To assess performance, these dyes were screened against a panel of ∼100 proteins, which were selected, in part, to represent the most challenging targets (e.g. small size). …”
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Immunohistochemical Investigation of Cyclooxygenase-2 Expression in Rabbit Uterine Adenocarcinoma and the Potential Use of COX-2 Inhibitors in Cancer Therapy by Emanuela Vaccaro, Luigi Navas, Martina Ercolano, Giuseppe Piegari, Evaristo Di Napoli, Serenella Papparella, Donato Inverso, Barbara Brunetti, Orlando Paciello, Valeria Russo

“…Cyclooxygenase-2 (COX-2) is overexpressed in many human and animal cancers. Selective COX-2 inhibitors have shown antitumoral effects in tumors with a high expression of COX-2. …”
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The Level of Meningococcal Carriage and Genotyping of N. meningitidis Strains in the Group of Labor Migrants by M. A. Koroleva, M. I. Gritsay, K. O. Mironov, N. N. Fomkina, I. S. Koroleva, I. I. Gaponova, A. S. Esman, V. P. Bulanenko, Yu. G. Yanushevich, A. A. Shelenkov, V. V. Kaptelova, Yu. V. Mikhailova

“…Population migration can play a crucial role in the spread of invasive strains of meningococcus, initiating outbreaks of meningococcal infection, and changing the incidence at the local level.Aim. …”
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