SGLT2 inhibitors across various patient populations in the era of precision medicine: the multidisciplinary team approach by Patrick McLean, Josiah Bennett, Edward “Trey” Woods, Sanjay Chandrasekhar, Noah Newman, Yusuf Mohammad, Muzamil Khawaja, Affan Rizwan, Riyan Siddiqui, Yochai Birnbaum, Carl J. Lavie, Salim Virani, Karim El Hachem, W. H. Wilson Tang, Tania Ahuja, Scott Isaacs, Chayakrit Krittanawong

“…Abstract Sodium-glucose cotransporter-2 inhibitors have revolutionized the management of a variety of diseases. Initially developed to address glycemic control in diabetes, sodium-glucose cotransporter-2 inhibitors were identified for their ability to inhibit glucose reabsorption in the kidneys. …”
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Gain of Function Research: the Clairvoyant Lens on Pandemics by Sudhir BHANDARI, Amitabh DUBE, Bhoopendra PATEL, Amit TAK, Minal KACHHAWA, Jitendra Kumar GUPTA, Kapil GUPTA, Shivankan KAKKAR

“…This mechanism consists of the practice of serial passaging of microorganisms to increase their transmissibility, virulence, immunogenicity, and host tropism through the inclusive feature of selective pressure of culture medium. Although, the GoFR can be a double-edged sword that has the potential to give an insight and better appreciation of current and future pandemics with antecedent apprehension of initiating a pandemic, itself. …”
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Hydrodynamic coefficients identification of ship simplified modular model based on support vector regression by Lifei SONG, Yuqing WANG, Wei PENG, Peiyong LI, Yushan LIu, Yongfeng ZHANG

“…Further, Lasso regression is introduced to select the most influential hydrodynamic coefficients and alleviate multicollinearity. …”
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System-Level Assessment of Ka-Band Digital Beamforming Receivers and Transmitters Implementing Large Thinned Antenna Array for Low Earth Orbit Satellite Communications by Giovanni Lasagni, Alessandro Calcaterra, Monica Righini, Giovanni Gasparro, Stefano Maddio, Vincenzo Pascale, Alessandro Cidronali, Stefano Selleri

“…In this paper, we present a system-level model of a digital multibeam antenna designed for Low Earth Orbit satellite communications operating in the Ka-band. We initially develop a suitable array topology, which is based on a thinned lattice, then adopt it as the foundation for evaluating its performance within a digital beamforming architecture. …”
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Interruption of mitochondrial symbiosis is associated with the development of osteoporosis by Haoling Zhang, Haoling Zhang, Haoling Zhang, Rui Zhao, Xuemei Wang, Yaqian Qi, Doblin Sandai, Wei Wang, Zhijing Song, Zhijing Song, Qiudong Liang

“…This selective interruption of endosymbiosis as early as 2 billion years ago allowed mitochondria to become intracellular signaling hubs. …”
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GRP78/BIP/HSPA5 as a Therapeutic Target in Models of Parkinson’s Disease: A Mini Review by Adaze Bijou Enogieru, Sylvester Ifeanyi Omoruyi, Donavon Charles Hiss, Okobi Eko Ekpo

“…Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by selective loss of dopamine neurons in the substantia nigra pars compacta of the midbrain. …”
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Innovation and Technology in Urban Transformation: An Analysis of Frameworks, Stakeholders, and Key Performance Indicators for the Development of Smart Cities by González Rubio Isaura, Rolón Julio C., López-Leyva Santos, Bermúdez Juan Carlos

“…Additionally, we analyze different smart city approaches, and the roles of stakeholders involved in planning and implementing these initiatives. Based on this analysis, we outline adaptable frameworks for potential application in Mexican cities, identifying priority areas and criteria for selecting and prioritizing key performance indicators (KPIs) like technology use, energy efficiency, and social inclusion. …”
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Tracheobronchial Amyloidosis Mimicking Tracheal Tumor by Elif Tanrıverdi, Mehmet Akif Özgül, Oğuz Uzun, Şule Gül, Mustafa Çörtük, Zehra Yaşar, Murat Acat, Naciye Arda, Erdoğan Çetinkaya

“…Herein, we report a case of a 68-year-old man admitted with progressive dyspnea to our institution for further evaluation and management. He was initially diagnosed with and underwent management for bronchial asthma for two years but had persistent symptoms despite optimal medical therapy. …”
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Cross-Modal Hashing Retrieval Based on Density Clustering by Xiaojun Qi, Xianhua Zeng, Hongmei Tang

“…DCCH utilizes the global density correlation between different modalities to select representative instances to replace the entire data precisely. …”
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Pedagogical interventions in augmentative and alternative communication (AAC): therapeutic benefits in healthcare and quality of life. A systematic review by David Gómez-Asencio, Francisco-Javier Gago-Valiente, Francisco-Javier Gago-Valiente, Cristina Arana-Álvarez, María-Isabel Mendoza-Sierra, María-Isabel Mendoza-Sierra, María-José López-López, Emilia Moreno-Sánchez, Emilia Moreno-Sánchez

“…The study was registered in the International Prospective Register of Systematic Reviews (PROSPERO), and its quality was evaluated with the Effective Public Health Practice Project (EPHPP) instrument.ResultsAmong the 256 articles that were initially selected, only a total of 10 studies met the established eligibility criteria after performing a more exhaustive analysis with abstract and full text reading. …”
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Research on the evaluation index system for happy rivers and lakes: a case study of Xinchang County in Zhejiang Province, China by Xiaoyu Li, Chenxi Cui, Bonian Shui, Chengye Hu, Zhou Ye, Yong Zhang

“…The “Happy Rivers and Lakes” initiative is an important measure to systematically address the complex water issues in China. …”
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Innovative Strategies and Transformations in the Montilla–Moriles Wine-Production Area: Adaptation and Success in the Global Market by Fernando J. Fuentes-García, Sandra M. Sánchez-Cañizares, Miguel González-Mohíno, L. Javier Cabeza-Ramírez

“…The findings of this study reveal that despite the industry’s challenges, innovative initiatives can thrive by leveraging global market opportunities.…”
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Pathologic function and therapeutic potential of extracellular vesicle miRNA in sepsis by Rou Deng, Xiayu Cui, Runze Zhang, Changya Liu, Jielian Luo, Liang Liu, Wen Zhang, Wen Zhang, Bangjiang Fang, Bangjiang Fang

“…Sepsis is a systemic inflammatory response initiated by an infection, which can lead to multi-organ dysfunction. …”
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PUR-GEN: A web server for automated generation of polyurethane fragment libraries by Katarzyna Szleper, Mateusz Cebula, Oksana Kovalenko, Artur Góra, Agata Raczyńska

“…The use of PUR-GEN in molecular docking of 414 generated oligomers provides an example of the pipeline for initiation of the PUR degrading enzymes discovery.…”
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SARS-CoV-2 seroprevalence and COVID-19 vaccination coverage in two states of Nigeria from a population based household survey by Nwachukwu William Enyereibe, Elsie Ilori, Laura Steinhardt, Kristen Stafford, Chioma Dan-Nwafor, Chinwe Lucia Ochu, Dalhatu Ibrahim, Matthias Alagi, Baffa Sule Ibrahim, Iwara Emem Iwara, Nwando Mba, Zainab Ibrahim, Rabiatu Aliyu Ahmed, Iliya Botson, Stanley Uche Ogbonna, Ehimario Igumbor, Jafiya Abubakar, Nasir Ahmed, Gloria Ogochukwu Nwiyi, Chima Emmanuel Ihemeje, Catherine Okoi, Doris John, Matthew Ashikeni, Basheer Lawan Muhammad, Nnaemeka C. Iriemenam, Olumide Okunoye, Stacie M. Greby, Orji Bassey, McPaul Okoye, Natalia Blanco, Andrew Mitchell, Oladipupo Ipadeola, Gladys S. Antonza, Augustine Mpamugo, Favour Makava, Manhattan Charurat, Sylvia Adebajo, Mahesh Swaminathan, Adetifa Ifedayo, Chikwe Ihekweazu

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MER4 endogenous retrovirus correlated with better efficacy of anti-PD1/PD-L1 therapy in non-small cell lung cancer by Francois Ghiringhelli, Romain Boidot, Caroline Truntzer, Bertrand Routy, Philippe Joubert, Julie Lecuelle, Laure Favier, Cléa Fraisse, Aurélie Lagrange, Coureche Kaderbhai, Sandy Chevrier

“…The secondary endpoint was overall survival (OS) from ICI initiation. We studied expression of 6205 ERVs. Multivariate Cox regression model with lasso penalty was estimated on the training set to select ERVs significantly associated with survival. …”
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An AI recognition method for children's clinical operative pain by skin potential (SP) signal by Mingxuan Huang, Cangcang Fu, Linbo Chui, Jiadong He, Xiaozhi Wang, Jikui Luo, Bin Wu, Yonggang Chen, Shaohua Hu, Jihua Zhu, Yubo Li

“…Then, we applied wavelet transform (WT) to capture the time-frequency characteristics of the signals and extract energy features and created a feature set comprising 30 features and selected 10 most relevant ones using the “SelectKBest” function.We compared six algorithms, optimized their parameters, and evaluated the stability and fitting performance of each algorithm. …”
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Bromelain Supplementation in the Management of Otitis Media with Effusion in Children by Francesco Martines, Ginevra Malta, Emanuele Cannizzaro, Theodoridou Kelly, Pietro Salvago, Fulvio Plescia

“…All patients selected before initiating pharmacological treatment underwent thorough screening regarding the functionality of the tympanic cavities, otoacoustic emissions, the auditory threshold, and the ear canal’s integrity. …”
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Definitions of determinants of physical activity behaviour: process and outcome of consensus from the DE-PASS expert group by Jan Dygrýn, Javier Brazo-Sayavera, Joana Cruz, Mekdes Kebede Gebremariam, José Carlos Ribeiro, Laura Capranica, Ciaran MacDonncha, Yael Netz

“…In round 1, experts selected the most suitable definition for each of the 41 initially identified determinants. …”
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Petrology, geochemistry and Ar-Ar geochronology of eclogites in Jinshajiang orogenic belt, Gonjo area, eastern Tibet and restriction on Paleo-Tethyan evolution by Yuan Tang, Ya-dong Qin, Xiao-dong Gong, Yong Li, Dong-bing Wang, Bao-di Wang

“…In this paper, eclogites developed in the Jinshajiang suture zone in Gonjo area, eastern Tibet, are selected as specific research objects, and petrological, geochemical and Ar-Ar geochronological analyses are carried out. …”
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