Risk Factors for Multidrug-resistant Tuberculosis by Cleopas Martin Rumende

“…Previous studies showed that a major mechanism for the emergence of drugs resistance in TB bacilli is random mutation in the bacterial genome and the pressure of selection by anti-TB drugs. Pulmonary TB in diabetic patients usually show higher mycobacterial loads at the initiation of treatment, hence they may have higher chance of bacillary mutation and the emergence of MDR-TB with the presenting of higher bacterial loads, longer treatment is needed to clear the bacteria. …”
Get full text

Compassionate Use of Omadacycline in a Down Syndrome Pre-Schooler With Critically Ill Atypical Pneumonia Caused by Macrolide-Resistant Mycoplasma Pneumoniae by Wu D, Xie FJ, Wang YJ, Jiang XH, Zhang GL, Zhang H, Zhu YC, Zhang Y, Tang YJ, Lin YL, Xu JX, Zhang JN, Liu BW, Kang K, Gao Y

“…The treatment achieved a favourable therapeutic effect without any related adverse events (AEs) during hospitalization and follow-up.Conclusion: In clinical practice, rapid and accurate identification of causative organisms should be a priority for prompt initiation of pathogen-targeted antibiotics, in which tNGS possesses enormous potential, particularly for difficult-to-culture MP. …”
Get full text

Design and validation of a new questionnaire with a gender perspective to measure medication adherence for secondary prevention of ischaemic heart disease: study protocol by Leticia Fernandez-Friera, Rauf Nouni-Garcia, Concepcion Carratala-Munuera, Domingo Orozco-Beltran, Adriana Lopez-Pineda, Virtudes Pérez-Jover, Vicente Bertomeu-González, Pablo Martinez Perez, Alberto Cordero, Jose A Quesada, Jose Maria Castellano-Vazquez, Andreu Nolasco, Vicente F Gil Guillén, Alvaro Carbonell-Soliva, José Joaquin Mira-Solves, Jose Verdú Soriano, Julio Osende-Olea, Avelino Pereira-Expósito, Silvia Guillén-García, Eduardo Paya-Mora, Joaquina Díaz-Torres, Francisco González-Llopis

“…Patient will answer the initial questionnaire and adherence to aspirin and statin will be measured using a direct method (drug concentration analysis in blood) and other questionnaires. …”
Get full text

Development of a Synthetic Medium to Investigate the Role of Buffer Capacity and Metabolites on the Fermentation Chemistry of Cucumber Juice by Allison Anthony, Caitlin Skinner, Neeraj Katare, David Guydan, Suzanne Johanningsmeier, Fred Breidt

“…Malic acid was found to be the principal buffer in this pH range, and the initial concentration correlated with sugar utilization and final medium pH. …”
Get full text

Effects of preoperative and postoperative resistance exercise interventions on recovery of physical function in patients undergoing abdominal surgery for cancer: a systematic revie... by David Stephensen, Ferhana Hashem, Kevin Corbett, Amanda Bates, Michelle George, Ralph Peter Hobbs, Malcolm Hopkins, Irena Hutchins, David Peter Lowery, Tracy Pellatt-Higgins, Charitini Stavropoulou, Ian Swaine, Lee Tomlinson, Hazel Woodward, Haythem Ali

“…Objective To systematically review the effects of preoperative and postoperative resistance exercise training on the recovery of physical function in patients undergoing abdominal surgery for cancer.Data sources A systematic review of English articles using Medline, Physiotherapy Evidence Database, CINAHL and the Cochrane Library electronic databases was undertaken.Eligibility criteria for selecting studies Studies were included if they used a randomised, quasi-randomised or controlled trial study design and compared the effects of a muscle-strengthening exercise intervention (±other therapy) with a comparative non-exercise group; involved adult participants (≥18 years) who had elected to undergo abdominal surgery for cancer; and used muscle strength, physical function, self-reported functional ability, range of motion and/or a performance-based test as an outcome measure.Results Following screening of titles and abstracts of the 588 publications retrieved from the initial search, 24 studies met the inclusion criteria and were accessed for review of the full-text version of the article, and 2 eligible studies met the inclusion criteria and were included in the review. …”
Get full text

Influence of P(V3D3-co-TFE) Copolymer Coverage on Hydrogen Detection Performance of a TiO₂ Sensor at Different Relative Humidity for Industrial and Biomedical Applicatio... by Mihai Brinza, Lynn Schwäke, Lukas Zimoch, Thomas Strunskus, Thierry Pauporté, Bruno Viana, Tayebeh Ameri, Rainer Adelung, Franz Faupel, Stefan Schröder, Oleg Lupan

“…They exhibit excellent hydrogen selectivity, particularly in environments with high humidity. …”
Get full text

Long-term neurocognitive and behavioral outcomes in survivors of pediatric brain tumors: a systematic review by Tirath Patel, Pulkit Johar, Vaishnavi Kanisetti, Sahithi Talacheru, Vadali Avinash, Arghadip Das, Sweta Sahu, Abhishek Goyal, Megan W. Szobody, Tori Sayers, Sriya Gullapalli, Murali M. Yallapu, Mushfiq H. Shaikh, Nikhilesh Anand, Kelsey Potter-Baker, Bharathi S. Gadad

“…Duplicates were removed, and 14 studies were finally selected following the PRISMA guidelines. Initial observations noted significant variations in the study methodologies and inclusion criteria.ResultsOur study showed that children treated with proton radiotherapy experienced better neurocognitive and academic results than those treated with photon radiotherapy. …”
Get full text

Data Preprocessing Techniques for AI and Machine Learning Readiness: Scoping Review of Wearable Sensor Data in Cancer Care by Bengie L Ortiz, Vibhuti Gupta, Rajnish Kumar, Aditya Jalin, Xiao Cao, Charles Ziegenbein, Ashutosh Singhal, Muneesh Tewari, Sung Won Choi

“…Three major categories of preprocessing techniques were identified: data transformation (used in 12/20, 60% of selected studies), data normalization and standardization (used in 8/20, 40% of the selected studies), and data cleaning (used in 8/20, 40% of the selected studies). …”
Get full text

The Consolidated Approach to Intervention Adaptation (CLARION): Developing and undertaking an empirically and theoretically driven intervention adaptation by Lydia Ould Brahim, Sylvie D. Lambert, Nancy Feeley, Jane McCusker, Dan Bilsker, Mark J. Yaffe, Rosetta Antonacci, Stephanie Robins, John William Kayser, Christine Genest, Haida Paraskevopoulos, Jessica Blair, Andrea Laizner

“…However, the scoping review indicated that M-PACE lacked three critical steps: selecting a candidate intervention, understanding its core components, and pre-testing the adapted intervention. …”
Get full text

Antecedents and consequences of professional competence of school administrators with emphasis on environmental sustainability and sustainable development by mohamadreza rasouli, ghafar tari, hossein Baghaei

“…After combining the initial codes, 61 codes were identified, which were transformed into 13 sub-categories. …”
Get full text

Understanding the relationship between adolescents with tuberculosis and health services: an indepth qualitative study from Cape Town by Graeme Hoddinott, James Seddon, Khanyisa Mcimeli, Stephanie Jacobs, Dillon Timothy Wademan, Zara Kavalieratos, Mfundo Mlomzale, Arlene J Marthinus, Lucia N Jola

“…Initial misdiagnoses and delayed TB diagnoses were reported, despite seeking help from multiple healthcare providers at different facilities. …”
Get full text

Synergistic Adsorption and Fluorescence in Porous Aromatic Frameworks for Highly Sensitive Detection of Radioactive Uranium by Suming Zhang, Siyu Wu, Cheng Zhang, Doudou Cao, Yingbo Song, Yue Zheng, Jiarui Cao, Lu Luo, Yajie Yang, Xiangjun Zheng, Ye Yuan

“…The unique N-O chelating pockets on the 4-bromo-1-<i>H</i>-indole-7-carboxylic acid gave rise to high coordination affinity toward uranyl ions, which enabled the fast adsorption rate of uranyl ions and a uranyl ion adsorption capacity of 44.88 mg·g⁻¹ at 298 K with an initial pH value of 6.0 and the uranyl concentration of 10 ppm. …”
Get full text

First Brazilian consensus on the management of localized and locally advanced urothelial bladder cancer: a SBU-SBOC-SBRT-LACOG-GU panel review by Lucas Nogueira, Icaro Thiago de Carvalho, Ary Adamy, Daher Chade, Luis Felipe Piovesan, Ricardo Favaretto, Allisson Bruno Barcelos Borges, Arthur Accioly, Diogo Assed Bastos, Diogo Augusto Rodrigues da Rosa, Fernando C Maluf, Andrey Soares

“…Repeated resection is necessary in selected cases and should not delay further treatment. …”
Get full text

Unraveling the CDK9/PP2A/ERK Network in Transcriptional Pause Release and Complement Activation in KRAS‐mutant Cancers by Yafang Wang, Lansong Xu, Lijun Ling, Mingyue Yao, Shangxuan Shi, Chengcheng Yu, Yingnian Li, Jie Shen, Hualiang Jiang, Chengying Xie

“…Abstract Selective inhibition of the transcription elongation factor (P‐TEFb) complex represents a promising approach in cancer therapy, yet CDK9 inhibitors (CDK9i) are currently limited primarily to certain hematological malignancies. …”
Get full text

Резолюция Экспертного совета «Диагностика и лечение больных со сладжем в желчном пузыре» by V. T. Ivashkin, Alexey V. Okhlobystin, Dmitry S. Bordin, M. F. Osipenko, E. Ya. Seleznyova, Yu. O. Shulpekova, S. R. Abdulkhakov, O. P. Alexseyeva, I. G. Bakulin, L. G. Vologjhanina, V. B. Grinevich, N. V. Bakulina, T. A. Kolesova, N. V. Korochanskaya, I. V. Putintseva, A. S. Sarsenbayeva, N. S. Yazenok

“…In the absence of other changes, besides biliary sludge, prescription of initial course of hymecromone combined to ursodeoxycholic acid (UDCA) is indicated. …”
Get full text

Identification of jarosite and other major mineral Fe phases in acidic environments affected by mining-metallurgy using X-ray Absorption Spectroscopy: With special emphasis on the... by Ingrid Nayeli Escobar-Quiroz, Mario Villalobos-Peñalosa, Teresa Pi-Puig, Francisco Martín Romero, Javier Aguilar-Carrillo de Albornoz

“…In this study, the mineral phases were identified by X-ray Absorption Spectroscopy (XAS) and bulk powder X-Ray Diffraction (XRD), and chemically through acid digestions for multielemental quantification, as well as a 3-step selective sequential extraction (SSE) to quantify the types of Fe oxide phases and the contribution of the associated elements. …”
Get full text

A modified decontamination and storage method for sputum from patients with tuberculosis [version 3; peer review: 1 approved, 2 approved with reservations] by Nguyen Thuy Thuong Thuong, Dang Thi Minh Ha, Timothy M. Walker, Nguyen Le Quang, Le Pham Tien Trieu, Guy Thwaites, Do Dang Anh Thu, Nguyen Huu Lan, Nguyen Hong Hanh

“…We assessed the Time to Positivity (TPP) and Growth Unit (GU) data. Results We selected 22 sputum samples to compare two digestion and decontamination methods. …”
Get full text

Depression and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies by Xiaojuan Chen, Xiaoning Liu, Fengjuan Li, Haitian He, Xinying Li, Tianhang Qin, Bin Jiang, Yuge Chen, Yanqi Wang, Yuhao Su, Xiaojie Wang, Lei Liang, Huiling Hua, Jun Wu, Jianping Ma, Fulan Hu, Pei Qin

“…We assessed the methodological quality and evidence quality of the research with A Measurement Tool to Assess Systematic Reviews 2 and Grade of Recommendations, Assessment, Development and Evaluation, classifying studies into four categories based on evidence classification criteria. Results We selected a total of 72 articles from 27,150 resulting in 114 meta-analyses and 109 health outcomes. …”
Get full text

Optimal Management for Primary High Grade Ta Bladder Cancer: Role of re‐staging TURBT and Intravesical Adjuvant Therapy by Tarek Ajami, Sunwoo Han, Ruben Blachman‐Braun, Helen Y. Hougen, Yuval Avda, Mark L. Gonzalgo, Bruno Nahar, Sanoj Punnen, Dipen J. Parekh, Isildinha M. Reis, Chad R. Ritch

“…Cox proportional hazard regression models were used to assess the effect of re‐TURBT and other clinical/treatment‐related predictors on recurrence‐ and progression‐free survivals. The survivals by selected predictors were estimated using Kaplan–Meier method, and groups were compared by the log‐rank test. …”
Get full text

Interest groups in Lithuania: dynamics of development and characteristics of institutionalization by Alvidas Lukošaitis

“…The focus of the study is to identify and analyze tendencies manifested during the initial institutionalization period of the interest group system. …”
Get full text