A collaboratively-derived science-policy research agenda. by William J Sutherland, Laura Bellingan, Jim R Bellingham, Jason J Blackstock, Robert M Bloomfield, Michael Bravo, Victoria M Cadman, David D Cleevely, Andy Clements, Anthony S Cohen, David R Cope, Arthur A Daemmrich, Cristina Devecchi, Laura Diaz Anadon, Simon Denegri, Robert Doubleday, Nicholas R Dusic, Robert J Evans, Wai Y Feng, H Charles J Godfray, Paul Harris, Sue E Hartley, Alison J Hester, John Holmes, Alan Hughes, Mike Hulme, Colin Irwin, Richard C Jennings, Gary S Kass, Peter Littlejohns, Theresa M Marteau, Glenn McKee, Erik P Millstone, William J Nuttall, Susan Owens, Miles M Parker, Sarah Pearson, Judith Petts, Richard Ploszek, Andrew S Pullin, Graeme Reid, Keith S Richards, John G Robinson, Louise Shaxson, Leonor Sierra, Beck G Smith, David J Spiegelhalter, Jack Stilgoe, Andy Stirling, Christopher P Tyler, David E Winickoff, Ron L Zimmern

“…These participants consulted with colleagues and submitted 239 questions. An initial round of voting was followed by a workshop in which 40 of the most important questions were identified by further discussion and voting. …”
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The mechanism of discriminative aminoacylation by isoleucyl-tRNA synthetase based on wobble nucleotide recognition by Bingyi Chen, Fang Yi, Zhiteng Luo, Feihu Lu, Hongwei Liu, Siting Luo, Qiong Gu, Huihao Zhou

“…C34 of unmodified tRNAIle(CAU) (behaves like tRNAMet) lacks a relevant H-bond acceptor, which disrupts key H-bonding interactions and structural adaptations and suspends the ScIleRS·tRNAIle(CAU) complex in an initial non-reactive state. This wobble nucleotide recognition-based structural adaptation provides mechanistic insights into selective tRNA aminoacylation by AARSs.…”
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A roadmap to implementing outpatient administration of bispecific antibodies in multiple myeloma by Alfred L. Garfall, Rahul Banerjee, Laurent Frenzel, Cyrus Khandanpour, Cyrus Khandanpour, Cyrus Khandanpour, Yi Lin, Erica Ottoni, Robert Rifkin, Sarah Rockwell, Cesar Rodriguez, Humberto Villefort, Elena Zamagni, Elena Zamagni

“…This report provides actionable guidance to implement safe and effective administration of BsAbs for patients with RRMM in outpatient and community settings.MethodsThree clinician advisory workshops were held in the United States, Europe, and Latin America to discuss key factors to operationalize BsAb use in outpatient and community settings, focusing on the critical phases of practice setup, treatment initiation, and ongoing management.ResultsBsAb administration in outpatient and community settings requires careful planning, a well-prepared multidisciplinary team (MDT) of healthcare professionals, and clear protocols, including MDT composition, roles/responsibilities, capacity planning, patient selection criteria, step-up dosing procedure, admission processes, patient/caregiver education requirements, and adverse event (AE) monitoring/management. …”
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Wide-Field Kerr Microscopy and Magnetometry on Cr₂Ge₂Te₆ Exfoliated van-der-Waals Flakes by Ivan Soldatov, Burak Ozer, Saicharan Aswartham, Sebastian Selter, Louis Veyrat, Bernd Buchner, Rudolf Schafer

“…We derived this characteristic thickness from the initial susceptibility of the hysteresis loops and used it to estimate the specific domain wall energy to be <inline-formula> <tex-math notation="LaTeX">$2.7\cdot 10^{-\mathrm {4}}$ </tex-math></inline-formula>J/m&#x00B2;. …”
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Advocacy by nonprofit scientific institutions needs to be evidence-based: a case study by François Gonon, Henri Gouraud, André Gillibert, Bruno Falissard, Lisa Cosgrove, Kasper P. Kepp, Ioana A. Cristea, Florian Naudet

“…The foundation has claimed that an initial assessment at any of its Expert Centers led to a 50 % reduction in hospitalization days. …”
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The Role of Interferon in the Management of BCG Refractory Nonmuscle Invasive Bladder Cancer by Andres F. Correa, Katherine Theisen, Matthew Ferroni, Jodi K. Maranchie, Ronald Hrebinko, Benjamin J. Davies, Jeffrey R. Gingrich

“…Combination BCG plus interferon-α2B remains a reasonably safe alternative treatment for select patients with BCG refractory disease prior to proceeding to radical cystectomy.…”
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Effects of Lay-up Protective Agent on Water and Steam TOCi During Unit Start-up and Lay-up Processes by Yuqiang DENG, Ji QI, Qiliang WANG, Dongdong QI, Fei SONG, Haiyang LI, Jiaqing CHENG, Dongmei WANG, Yanbin MA

“…Therefore, the protective agent free of chained carbon component should be selected whenever possible. If organic agents had to be a choice, the TOCi and cation conductivity must be placed under supervisory control during shutdown or initial start-up processes so as to provide directions for the addition of agents as well as the system flushing operation. …”
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An analysis of mitochondrial variation in cardiomyopathy patients from the 100,000 genomes cohort: m.4300A>G as a cause of genetically elusive hypertrophic cardiomyopathy by Luis R. Lopes, William L. Macken, Seth Du Preez, Huafrin Kotwal, Konstantinos Savvatis, Neha Sekhri, Saidi A. Mohiddin, Renata Kabiljo, Robert D. S. Pitceathly

“…Conclusion These data support the inclusion of MT-TI in the initial genetic testing panel for (non-syndromic) HCM.…”
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Identification and purification of a novel bacteriophage T7 endonuclease from the Kogelberg Biosphere Reserve (KBR) biodiversity hotspot by Priyen Pillay, Maabo Moralo, Sibongile Mtimka, Taola Shai, Kirsty Botha, Lusisizwe Kwezi, Tsepo L. Tsekoa

“…An initial approach was employed where the process was scaled up to 3 L with IPTG concentration of 0.1 mM at 30 °C and purified via immobilised metal affinity chromatography (IMAC). …”
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In-silico drug repositioning studies of Candida albicans Nitrogen permease reactivator 1 (Npr1) kinase by Sanjib Das, Arka Bagchi, Analava Bera, Arunima Biswas, Analabha Roy, Rik Ganguly, Amalesh Mondal, Deepanjan Chattopadhyay, Paromita Saha Mondal, Tanushree Mondal, Subhasree Samanta, Achintya Mohan Goswami, Tanima Saha

“…Among the compounds, Indacaterol was selected on the basis of high safety profile, binding affinity score value of − 9.3 kcal/mol, as well as its DFG-motif interaction. …”
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The use of nano-structured cellulose to improve plywood: A review by L.C. Lirya Silva, F.O. Lima, S.N. Monteiro, A.R.G. Azevedo, A.L. Christoforo, B.S. Ferreira, D. Goveia, C.I. de Campos

“…The main authors were selected for an in-depth analysis of their results. …”
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Water Tourism: A Solution for Sustainable Development and Water Resource Conservation in Qazvin Province by Sayedh Marzie Hosseini, mohammad hasan saeedi motlagh, Seyedeh Samin Farabi, Fatemeh Borzoo Jirandehi, Shima Kabiri, Behzad Ghiasi

“…Based on their characteristics, strengths, and weaknesses, the best option was selected.Results: According to the quantitative analysis conducted, the Ab Anbar (water reservoir), which is essentially a hallmark of Qazvin Province, was identified as the top potential. …”
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Effects of Heat Treatment on Microstructures and Corrosion Properties of Al<i>_x</i>CrFeNi Medium-Entropy Alloy by Pushan Guo, Yuan Pang, Qingke Zhang, Lijing Yang, Zhenlun Song, Yi Zhang

“…Synergistic analysis of post-corrosion morphology (through electrochemical testing and in-situ immersion) combined with XPS analysis of the passive films revealed that the initial stage of corrosion was primarily pitting. …”
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Introducing entrustable professional activities for postgraduate medical training in Switzerland by Pinilla, Severin, Bauer, Werner, Breckwoldt, Jan, Burkhart, Christoph S., Hennel, Eva K., Marty, Adrian P., von Wartburg, Urs, Brodmann Maeder, Monika, Huwendiek, Sören

“…In the Swiss context, such a reform has been successfully initiated. Continuous evaluations of the ongoing projects will provide further insights for competency-based graduate medical education reforms.…”
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Antioxidants on the thermodynamic properties and radical evolution in coal by Pan Shu, Yanni Zhang, Lan Yu, Xuanhong Du, Yating Zhang, Binde Qin, Nianqiang Li

“…Three antioxidants-tea polyphenols, melatonin, and β-carotene were selected for this research. Initially, quantum chemistry methods were employed to analyze the reactive sites and the quantity of key free radicals within the antioxidant molecules. …”
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The Architectural Language of Biophilic Design After Architects Use Text-to-Image AI by Chaniporn Thampanichwat, Tarid Wongvorachan, Limpasilp Sirisakdi, Panyaphat Somngam, Taksaporn Petlai, Sathirat Singkham, Bhumin Bhutdhakomut, Narongrit Jinjantarawong

“…The 30 selected images were used to help architects develop the architectural language to describe the characteristics of biophilic design across 10 categories: Form, Space, Movement, Light, Color, Material, Object, View, Sound, and Weather. …”
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Addressing industrial waste heat supply variability with Organic Rankine Cycle systems incorporating thermal energy storage by Bipul Krishna Saha, El Mouatez Billah Messini, Pramod Kumar

“…Among these, eight fluids (Butane, Heptane, Hexane, Pentane, Neopentane, R-134a, R-245fa, and Toluene) were selected. The initial findings indicate that the ORC-RORC achieves its highest net power output (27 kW and 37 kW) when the turbine input temperature is maintained at 200 °C. …”
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Evaluation of reproducible and transparent research practices in pulmonology by C.A. Smith, J. Nolan, D.J. Tritz, T.E. Heavener, J. Pelton, K. Cook, M. Vassar

“…Here, we analyzed the reproducibility of studies in the field of pulmonology.Methods 500 pulmonology articles were randomly selected from an initial PubMed search for data extraction. …”
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Primary Immunodeficiency Registry System: The Minimum Data Set Designing Phase—A Systematic Review and Quantitative Delphi Study by Saman Mohammadpour, Hassan Emami, Sima Shokri, Rafat Bagherzadeh, Soqrat Omari Shekaftik, Zanko Hosseini

“…Results In the first stage, the initial minimum data set consisted of 198 data elements, which were categorized into two categories: administrative and clinical. …”
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Enhancing CO₂ adsorption kinetics in direct air capture: The role of steam desorption in amine-based anion exchange sorbents by Florian M. Chimani, Josef Fuchs, Andreas Wallmüller, Jean Pierre Matriciani, Gerhard Schöny, Stefan Müller

“…Amine-based sorbents are highly selective for CO₂ and effective in capturing it at low ambient concentrations, making them ideal for DAC. …”
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