Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing. by Laura C Greaves, Marco Nooteboom, Joanna L Elson, Helen A L Tuppen, Geoffrey A Taylor, Daniel M Commane, Ramesh P Arasaradnam, Konstantin Khrapko, Robert W Taylor, Thomas B L Kirkwood, John C Mathers, Douglass M Turnbull

“…However the dynamics of this process and when these mtDNA mutations occur initially are poorly understood. Using human colorectal epithelium as an exemplar tissue with a well-defined stem cell population, we analysed samples from 207 healthy participants aged 17-78 years using a combination of techniques (Random Mutation Capture, Next Generation Sequencing and mitochondrial enzyme histochemistry), and show that: 1) non-pathogenic mtDNA mutations are present from early embryogenesis or may be transmitted through the germline, whereas pathogenic mtDNA mutations are detected in the somatic cells, providing evidence for purifying selection in humans, 2) pathogenic mtDNA mutations are present from early adulthood (<20 years of age), at both low levels and as clonal expansions, 3) low level mtDNA mutation frequency does not change significantly with age, suggesting that mtDNA mutation rate does not increase significantly with age, and 4) clonally expanded mtDNA mutations increase dramatically with age. …”
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Towards net-zero carbon emissions: A systematic review of carbon sustainability reporting based on GHG protocol framework by Hussein H. Sharaf-Addin

“…Furthermore, it proposes valuable recommendations for advanced initiatives towards a carbon-neutral future.…”
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Minimizing Blood Loss in Bladder Cancer: Efficacy of Preoperative Embolization before Transurethral Resection of Bladder Tumor by Hojun Lee, Hoon Kwon, Chang Won Kim

“…Materials and Methods Initially, 1707 patients diagnosed with bladder cancer were selected using CT and MRI between January 2018 and October 2023. …”
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A life-saving collaborative network: repairing ventilators in Brazil by Luis Vasconcellos, Fernando Coelho Ferreira, Carlos Sakuramoto

“…Design/methodology/approach – A qualitative approach was used in a single case study with semi-structured interviews. The interviewee selection process was non-probabilistic through snowball sampling. …”
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Unfavorable Tumor Responses to Immunotherapy in the Liver: Lessons Learned from Clinical and Preclinical Studies by Li-Chun Lu, Gen-Sheng Feng, Chih-Hung Hsu

“…Data Sources and Study Selection: We enrolled relevant clinical and preclinical studies conducted by our groups and others. …”
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Nexus of women’s participation in smallholder financial inclusion programs and economic efficiency: implications for poverty alleviation by Shangao Wang, Gershom Endelani Mwalupaso, Asma Akter, Asma Akter

“…This study addresses this gap using data from 436 farm households in Zambia. Employing sample-selection stochastic cost frontier analysis, we find that WP in RUSACCOs significantly enhances EE. …”
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Relationship between Vessel Diameter and Time to Maturation of Arteriovenous Fistula for Hemodialysis Access by M. Khavanin Zadeh, F. Gholipour, Z. Naderpour, M. Porfakharan

“…A prospective cross-sectional study carried out during 2006-2007 on 96 hemodialysis patients from Hasheminejad Kidney Center with non probability selection, all of them with end to side native AVF. …”
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A Clustering-Based Dimensionality Reduction Method Guided by POD Structures and Its Application to Convective Flow Problems by Qingyang Yuan, Bo Zhang

“…In contrast, clustering methods are effective for nonlinear feature extraction, yet their application in dimensionality reduction methods is hindered by unstable cluster initialization and inefficient mode sorting. To address these issues, we propose a clustering-based dimensionality reduction method guided by POD structures (C-POD), which uses POD preprocessing to stabilize the selection of cluster centers. …”
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The role of reviewers in the era of systematic reviews and meta-analysis: A practical guide for researchers by Emir Begagić, Faruk Skenderi, Semir Vranić

“…Best practices are summarized for protocol registration, comprehensive search strategies, study selection and data extraction, risk-of-bias evaluation, and context-appropriate statistical modeling, with a specific focus on heterogeneity, small-study effects, and data transparency. …”
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Application of SGLT-2 inhibitors in non-diabetic CKD: mechanisms, efficacy, and safety by Bing Zhang, Liufei Deng

“…Sodium-glucose cotransporter 2 (SGLT-2) inhibitors, initially developed for diabetes management, have recently demonstrated remarkable renal and cardiovascular protective effects in patients with non-diabetic CKD. …”
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Northern bobwhite response to habitat restoration in eastern oklahoma by Andrew D. Crosby, R. Dwayne Elmore, David M. Leslie

“…We found no significant treatment effect. Model selection showed that occupancy was best explained by the combination of overstory canopy cover and habitat area at both the local and landscape scales. …”
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A review of organizational arrangements in microfinance and health programs by Jenny Ruducha, Meena Jadhav

“…Recently published reviews have summarized the changes in health behaviors and health outcomes due to the effective layering of health interventions with microfinance initiatives. However, a large gap remains in defining and understanding the organizational strategies for implementing effective health programs and services that improve the health and social well-being of women and their families…”
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Response Surface Methodology-Based optimization of Inulinase Production from New Bacillus Isolates by Selmihan Şahin, Sercan Özbek Yazıcı, Bahadır Törün, İsmail Özmen, Hacı Halil Bıyık

“…Both inulinases sustained 50% of their initial activity at 30°C for 9 days.. The results point out that bacteria are an important source as inulinase producer. …”
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Relationships between Lecturer Performance, Organizational Culture, Leadership, and Achievement Motivation by Yusdi Anra, Martinis Yamin

“…There were 255 lecturers selected from initial population of 706 individuals based on a simple random technique as the sample. …”
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Hydrochar Production from Cigarette Butts and Tobacco for Dye Adsorption by Elif Hatice Gürkan, Selim Ceylan, Semra Çoruh, Sevda Esma Darama

“…Malachite green was selected as the dye material for the project. Adsorption experiments were conducted at different initial concentrations, adsorbent doses, and contact times. …”
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Variant Design of Modular Products Using Functional Modelling and Multi-Criteria Evaluation Method by Mirko Pastović, Mirko Karakašić, Željko Ivandić, Ivan Grgić

“…A multi-criteria evaluation of the working principles was used to select those working principles that received the highest rating. …”
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Evaluating ERD Models and RAID-Based Storage for Query Performance Optimization in Relational Databases by Juanda Hakim Lubis, Sri Handayani, Herman Mawengkang, Yuliska

“…Designing a database is the initial step in creating a system with optimal performance. …”
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Misdiagnosed as Ankylosing Spondylitis: An Unusual Case of Acute Promyelocytic Leukemia with Myeloid Sarcoma by Mostafa Kamandi, Sama Barati

“…Extramedullary manifestations in APL are rare at initial diagnosis and exhibit unique biological characteristics. …”
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Sustainability in project risk management methodologies through the AHP-TOPSIS method applied to logistics and supply chain management by Patricia Navascués Vega, Urtzi Llano Castresana

“…The results show a low average score in sustainability among all the selected methods, with only one standing out favorably. …”
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Waste to energy: A STEM-ESD approach to improve student awareness and action in converting waste into eco-friendly energy by Rini Solihat, Baharudin Yusuf Haqiqi, Ari Widodo

“…This study provides an initial perspective on the potential of STEM-ESD project-based learning to enhance students' awareness and practical engagement in sustainable waste management practices.…”
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