Variation in the practice of discontinuing mechanical ventilation in critically ill adults: study protocol for an international prospective observational study by Andrew Jones, Deborah J Cook, Maureen O Meade, Karen E A Burns, Leena Rizvi, Peter Dodek, Arthur S Slutsky, Jesus Villar, Farhad N Kapadia, David J Gattas, Scott K Epstein

“…Research personnel at participating ICUs will collect demographic data, data to characterise the initial strategy or event that facilitated discontinuation of MV (direct extubation, direct tracheostomy, initial successful SBT, initial failed SBT or death before any attempt could be made), clinical outcomes and site information. …”
Get full text

Echocardiographic Screening for Transcatheter Edge-to-Edge Mitral Valve Repair: Correlation Between Transthoracic and Transesophageal Assessment by Michela Bonanni, Fausto Pizzino, Giovanni Benedetti, Rosangela Capasso, Rachele Manzo, Giuseppe Iuliano, Giancarlo Trimarchi, Andreina D’Agostino, Umberto Paradossi, Alessia Gimelli, Sergio Berti, Massimiliano Mariani

“…The study aims to assess whether TTE is as effective as TOE in selecting patients with severe MR who are eligible for M-TEER. …”
Get full text

Metabolic Profile Correction in Patients with Obstructive Sleep Apnea Depends on the Duration of CPAP Therapy Sessions by M. V. Gorbunova, S. L. Babak, O. Yu. Rebrova, M. A. Karnaushkina, A. G. Malyavin

“…The optimal therapeutic level of CPAP therapy was titrated at home using devices for automatic selection of therapeutic pressure (PR System One REMstar Auto CPAP Machine with A-Flex (Philips Respironics, USA)) within 7 days after the diagnostic study. …”
Get full text

An Overview of 20 Years of Pisco Spirit Research: Trends and Gaps Revealed by a Systematic Review by Erick Saldaña, Jennifer Alvarez, Jaime Laqui-Estaña, Karina Eduardo, Juan D. Rios-Mera, César Augusto Napa-Almeyda, Jhony Mayta-Hancco

“…The initial search yielded 360 records. After removing non-original articles (books, book chapters, conference papers, and reviews), 101 articles remained. …”
Get full text

Risk factors and prediction models for recurrent acute ischemic stroke: a retrospective analysis by Liuhua Ke, Hongyu Zhang, Kang Long, Zheng Peng, Yongjun Huang, Xingxuan Ma, Wanjun Wu

“…Methods A total of 114 cases of recurrent acute ischemic stroke patients admitted from July 2017 to March 2021 were selected as the observation group, and another 409 cases of initial ischemic stroke patients from the same period as the control group. …”
Get full text

Synergistic antimicrobial and probiotic activity of lactic acid bacteria isolated from Tarkhineh against Candida albicans by Amir Kiani, Yousef Nami, Anahita Barghi, Melika Salehian, Farjam Goudarzi, Babak Haghshenas

“…Out of 20 isolated strains, five (Ta12, Ta19, Ta37, Ta51, and Ta58) showed a high survival rate (> 94%) under the initial acidity and bile salt screening conditions, which led to their selection for further study. …”
Get full text

El aprendizaje de competencias en los MOOC: una Revisión Sistemática de Literatura / Learning Competencies in MOOCs: A Systematic Literature Review by Juan Francisco Romero-Córdova, Rubén Arriazu-Muñoz

“…All these criteria lead us to an initial sample of 1,766 scientific articles that, finally, after the filtering process was reduced to 43 scientific publications. …”
Get full text

Impact of early and rapid hydration for patients with ischemic stroke within 24 hours of onset by An-Ting Lee, Kuan-Hsin Lee, Chun-Hao Chen, Leng-Chieh Lin, Jiann-Der Lee, Hsu-Huei Weng, Jen-Tsung Yang, Yuan-Hsiung Tsai, Yen-Chu Huang

“…Multivariate analysis showed that age, prior stroke and initial NIHSS were independent predictors of 3-month outcomes. …”
Get full text

Soil Physical Properties, Root Distribution, and “Ponkan” Tangerine Yield Across Different Rootstocks in a Deep Tillage Ultisol by Pedro Antônio Namorato Benevenute, Laura Beatriz Batista Melo, Samara Martins Barbosa, Mariany Isabela Soares Domingues, Isabela Cristina Filardi Vasques, Everton Geraldo de Morais, Lucas Roberto de Castro, Geraldo César de Oliveira, Ester Alice Ferreira, Bruno Montoani Silva

“…Deep soil tillage and proper rootstock selection mitigate the root development limitations in Ultisol’s Bt horizon, enhancing the citrus yield potential. …”
Get full text

Modeling of project activities for UAV modernization to conduct swarm drone attack missions by Oleg Fedorovych, Leonid Malieiev, Oleksii Hubka, Andrei Popov

“…To address this, an optimization model based on integer (Boolean) programming was developed for selecting the most rational UAV component architecture. …”
Get full text

Linking Electronic Health Record Prescribing Data and Pharmacy Dispensing Records to Identify Patient-Level Factors Associated With Psychotropic Medication Receipt: Retrospective S... by Peng Wu, Jillian H Hurst, Alexis French, Michael Chrestensen, Benjamin A Goldstein

“…We fit a least absolute shrinkage and selection operator (LASSO) regression model to evaluate the predictability of a fill. …”
Get full text

Extracellular Vesicle Proteome Analysis Improves Diagnosis of Recurrence in Triple‐Negative Breast Cancer by Ju‐Yong Hyon, Min Woo Kim, Kyung‐A Hyun, Yeji Yang, Seongmin Ha, Jee Ye Kim, Young Kim, Sunyoung Park, Hogyeong Gawk, Heaji Lee, Suji Lee, Sol Moon, Eun Hee Han, Jin Young Kim, Ji Yeong Yang, Hyo‐Il Jung, Seung Il Kim, Young‐Ho Chung

“…To enhance biomarker selection robustness, we implemented a hybrid machine learning framework integrating LsBoost, convolutional neural networks, and support vector machines. …”
Get full text

<i>Lactobacillus rhamnosus</i> Sepsis in a Preterm Infant Following Probiotic Administration: Challenges in Diagnosis by Ilaria Farella, Maria Fortunato, Domenico Martinelli, Carmela De Carlo, Eleonora Sparapano, Stefania Stolfa, Federica Romanelli, Vittoriana De Laurentiis, Stefano Martinotti, Loredana Capozzi, Stefano Castellana, Antonio Parisi, Giuseppe Latorre

“…In this case, accurately identifying the <i>Lactobacillus rhamnosus</i> strain proved challenging, as initial analyses using the Vitek 2 system yielded incorrect identifications. …”
Get full text

Identifying lifelong factors that impact brain health and functional outcomes in adults with childhood-onset type 1 diabetes: the cognition and longitudinal assessments of risk fac... by Velandai K Srikanth, Eva L Feldman, Chris Moran, Lili Zhao, Amy Brown, Richard Beare, Elisabeth A Northam, Emily J Koubek, Stacey A Sakowski, Taya Collyer, Chris L. Adamson, Fergus J. Cameron

“…Additionally, linear mixed-effects regression (Aim 2) will identify T1D-related metabolic factors affecting brain outcomes, with covariate selection informed by the construction of directed acyclic graphs (DAGs).Ethics and dissemination The study was approved by the Royal Children’s Hospital Human Research Ethics Committee (HREC 35 240F and 2019.065). …”
Get full text

Normalization of elevated preoperative serum creatinine and acute kidney injury after cardiac surgery: a retrospective cohort study by Bo Jiang, Genshen Zhen, Haiping Yang, Yi Hao, Meiping Wang, Zhenhua Zhang, Lin Chen, Ning He, Yueling Chen, Li Jiang

“…Normalization of preoperative sCr following an initial elevation was associated with higher risks of AKI, as well as AKI severity and duration.…”
Get full text

Experimental study of electrostatic ignition of nylon 1010 material under high pressure and pure oxygen environment by Wei Yan, Shanliang Qiu, Xiaoliang Si, Minglei Qu, Zhibao Li, Bo Zhang, Zemin Duan

“…Experimental analyses revealed a pronounced initial flame phase during the ignition of nylon 1010, with its duration influenced by spark energy and oxygen pressure. …”
Get full text

Stability Assessment of Furosemide Oral Suspension in Hospital Extemporaneous Preparations by Fai Alkathiri, Omamah Eid, Njoud Altuwaijri, Rihaf Alfaraj, Eram K. Eltahir, Hend Alsabbagh, Shamma Bin Shoia, Mashal Aljead, Haya H. Alnufaie, Ghadah AlToum

“…These findings underscore the importance of vehicle selection and regular stability monitoring in compounded formulations to ensure therapeutic reliability and patient safety.…”
Get full text

Prognostic factors of thalamic and thalamopeduncular low-grade gliomas in children: A systematic review and recommendations for surgical management by Jana Táborská, Adéla Bubeníková, Petr Skalický, Jakub Táborský, David Horváth, Michal Zápotocký, Ondřej Bradáč, Vladimír Beneš, 3rd

“…The risk of bias and applicability were assessed using The Quality Assessment of Prognostic Accuracy Studies criteria. Results: The study selection process resulted in the inclusion of 14 articles out of the initial pool of 876 references. …”
Get full text

The response to anti-seizure medications and the development of pharmacoresistant epilepsy in malformations of cortical development by Pu Miao, Meiping Ying, Ruotong Chen, Yuyu Yang, Yao Ding, Junming Zhu, Jianhua Feng, Jin Wang, Thandar Aung, Shuang Wang, Bo Jin

“…Sodium channel blockers (SCBs) were the most prescribed initial ASMs and demonstrated a higher response rate than other ASMs. …”
Get full text

Identification of potential prognostic biomarkers of thymoma with myasthenia gravis based on serum proteomics by Xiaoting Lin, Xiaoting Lin, Xiaoting Lin, Xiaoting Lin, Peng Liu, Peng Liu, Peng Liu, Peng Liu, Guoyan Qi, Guoyan Qi, Guoyan Qi, Guoyan Qi

“…This study may provide a more accurate prognostic risk assessment of TMG patients to help clinicians better individualize the initial treatment regimen for patients with different risk stratification, plan a more reasonable frequency of follow-up visits, and make more precise maintenance treatment decisions, thereby improving the overall prognosis of TMG patients.…”
Get full text