Dual objective multimodal transportation path optimization based on different carbon tax mechanisms under uncertain demand by Xu Zhang, Hongzhu Chen, Haiyan Zhang, Xumei Yuan

“…The findings indicate that companies can achieve emission reductions with minimal cost increases under dual-target cost scenarios, ideal for dual carbon transportation contexts. …”
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The role of myeloid cell heterogeneity during spontaneous choroidal neovascularization in Vldlr knockout mice by Amrita Rajesh, Joyce Gong, Kyle S Chan, Ritvik Viniak, Steven Droho, David Kachar, Joshua Y Strauss, Andrew L. Wang, Jeremy A. Lavine

“…DT-treated mice showed dramatic reductions in macrophage counts, CNV number, and total lesion area. …”
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Telerehabilitation of Chronic Obstructive Pulmonary Disease Patients in a Tertiary Care Hospital in Western India: A 3-month Follow-up Study by T. K. Abins, Ravi Gaur, Nitesh Manohar Gonnade, Nagma Sheenam, Chinchu Kolakkanni, T. K. Adharshna, A. P. Sangeeth

“…HRQoL, assessed by SGRQ-C, showed an overall improvement, with statistically significant reductions in total scores (42.15 ± 3.52–39.54 ± 3.41, P < 0.001) and in each domain (symptom, impact and activity). …”
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LOW DOSE CYTARABINE PLUS SORAFENIB IN AN ELDERLY PATIENT WITH ACUTE MYELOID LEUKEMIA by Tural Mahmudov

“…Given the patient’s overall health status, a treatment regimen of low-dose Ara-C (20 mg BID on days 1–10) and sorafenib (400 mg on days 11–28) was initiated. Due to hematologic toxicity, dose reductions were necessary during treatment. …”
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Blockade of de novo dNTP biosynthesis pathway delays HIV-1 early life cycle kinetics and dynamics by Mohammad Anwar Siddique, Michael D. McRaven, Muhammad Shoaib Arif, Edward J. Allen, Charia McKee, Shravya Honne, Tahmina Sultana, Baek Kim, Ann M. Carias, João I. Mamede, Thomas J. Hope

“…We find that RNR inhibition slows reverse transcription kinetics and delays the initiation of uncoating in both the capsid integrity and TRIM-CypA restriction assays. …”
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The symbiont Wolbachia increases resistance to bifenthrin in Ectropis grisescens by regulating the host detoxification function by Tian Gao, Yong Zhang, Wanpeng Sun, Qiangkun Li, Xueyu Huang, Dian Zhi, Huabin Zi, Ruijie Ji, Yanhua Long, Chunmei Gong, Yunqiu Yang

“…Moreover, the population treated with 2.5 mg ml−1 tetracycline exhibited even greater reductions in these parameters than the 300 μg ml−1 tetracycline-treated group. …”
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Genomic insights about the effect of sodium-glucose cotransporter 2 inhibitors: a systematic review by Pavitraa Saravana Kumar, Yogapriya Chidambaram, G. Shree Devi, Vettriselvi Venkatesan, Ramesh Sankaran, Nagendra Boopathy Senguttuvan, Thanikachalam Sadagopan, Dorairaj Prabhakaran

“…Sodium-glucose cotransporter 2 (SGLT2) inhibitors, initially developed for diabetes management, have demonstrated cardiovascular benefits, including reductions in HF hospitalizations and mortality. …”
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Impact of COVID-19 on disease-specific mortality, healthcare resource utilization, and disease burden across a population over 1 billion in 31 countries: an interrupted time-series... by Kyungseon Choi, Minseol Jang, Siin Kim, Sang Jun Park, Hae Sun Suh

“…Although changes in total direct medical costs varied by disease, per capita costs initially increased despite a decrease in the number of patients. …”
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Single-atom nanozyme-mediated dihydroartemisinin delivery for self-enhanced chemodynamic therapy and ferroptosis by Yuanlong Zhang, Binghong Chen, Penghui Wei, Zhongyuan Shen, Xiyue Wu, Wenzhong Mei, Yang Zhu, Yuanxiang Lin

“…Additionally, Fe-SAE@D demonstrates glutathione oxidase-like activity, oxidizing reductive GSH to glutathione disulfide and promoting GPX4 inactivation. …”
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Postoperative Radiologic Changes in Early Recurrent Lumbar Foraminal Stenosis After Transforaminal Endoscopic Lumbar Foraminotomy for Lower Lumbar Segments by Chi-Ho Kim, Pius Kim, Chang-Il Ju, Jong-Hun Seo

“…The study included 11 recurrent patients who initially experienced symptomatic improvement and sufficient neural decompression on radiological evaluation, but exhibited recurrent radicular pain and radiological restenosis within six months postoperatively. …”
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Impact of rapid blood culture identification PCR panel on optimal antibiotic use in methicillin-susceptible Staphylococcus aureus bacteremia by Jahnavi Yetukuri, Dimple Patel, Aiman Bandali, Pamela Giordano, Robert Roland, Jason Kessler

“…PCR implementation was associated with significant reductions in the initiation of empiric anti-MRSA antibiotic therapy (98% vs 84%, P = 0.001), duration of empiric anti-MRSA antibiotic use (44.2 vs 20.9 hours, P < 0.001), and duration of bacteremia (68.6 vs 47.3 hours, P = 0.015). …”
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Variability in Response to Valsartan and Its Relationship With AGT M235T Genotype and Other Nongenetic Parameters Among a Sample of Hypertensive Individuals in Jordan: A Prospectiv... by Hussein Alhawari, Yazun Jarrar, Malek Zihlif, Ayman Wahbeh, Sameeha Alshelleh, Khaled Ojjoh, Dalia Abdelrazaq, Hussam Alhawari

“…Systolic (SBP) and diastolic blood pressure (DBP) measurements were taken at the initiation of 160 mg valsartan and after 1 month of treatment, assessing the valsartan response for each patient. …”
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Epidemiological Impact of Increasing Vaccination Coverage Rate and Re-Vaccination on Pneumococcal Disease in Older Adults in Germany by Oluwaseun Sharomi, Marion de Lepper, Sarah Mihm-Sippel, Thorsten Reuter, Claudia Solleder, Giulio Meleleo, Tufail M. Malik, Kevin M. Bakker, Rachel J. Oidtman

“…Results: Vaccination with PCV20 and V116 initially decreased PD incidence, but incidence returned to pre-vaccine levels after five and eight years, respectively. …”
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Effectiveness and sustainability of peer support interventions for patients with obesity: a realist synthesis protocol by Jing Hu, Haoyang Li, Donghong Wang, Lizhe Huang, Xuejuan Li, Youmei Su, Rixiao Liang

“…However, recent systematic reviews and meta-analyses have suggested a potential association between peer support and reductions in both weight and body mass index. In response to these emerging findings, the present study employs a realist synthesis approach to elucidate the context–mechanism–outcome (CMO) configurations identified in literature that meets stringent inclusion and exclusion criteria, thereby addressing the pivotal question: under what conditions can peer support effectively mitigate obesity? …”
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A Comparative Study on Two Innovative Solutions for Non-Invasive Phosphorus Removal from Aquatic Ecosystems by Agnieszka Bańkowska-Sobczak, Dorota Pryputniewicz-Flis, Dorota Burska, Jakub Idźkowski, Łukasz Kozłowicz, Wiktoria Leśniewska, Grzegorz Brenk

“…Both techniques enable reductions in the orthophosphate (OP) availability in lake water, and its removal from the ecosystem, without the permanent deposition of the P binding agent in the environment. …”
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Regional Development Assessment and Policy Perspectives on Urban Residential Energy Efficiency Program in Morocco by 2030 by Fatima Zohra Gargab, Samir Idrissi Kaitouni, Abdelmajid Jamil, Padmanathan Kasinathan, Rachid Saadani, Miloud Rahmoune

“…Although specific numerical outcomes are not discussed herein, the implementation of these regulations is observed to yield notable benefits, including reductions in energy bills and gains in annual primary energy. …”
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Effect of biological agents on B-lymphocyte subpopulations in patients with systemic lupus erythematosus by A. A. Mesnyankina, S. K. Solovyev, E. A. Aseeva, A. P. Aleksankin, E. N. Aleksandrova, E. L. Nasonov

“…BLM therapy resulted in a decrease in PCs and plasmablasts (PBs) to the point of their complete depletion. There were reductions in total CD19+ B-lym-phocytes and naive B lymphocytes. …”
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Lipodystrophy induced by combination antiretroviral therapy in HIV/AIDS patients: A Belgrade cohort study by Dragović Gordana, Danilović Dragana, Dimić Aleksandra, Jevtović Đorđe

“…Highly active antiretroviral therapy (HAART) has led to dramatic reductions in mortality and morbidity of HIV/AIDS-patients. …”
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A 3D Printing-Based Transcatheter Pulmonary Valve Replacement Simulator: Development and Validation by Yuanzhang Liu, Yu Mao, Yiwei Wang, Ping Jin, Mengen Zhai, Yang Liu, Jian Yang

“…Conclusions: The reliability and validity of the TPVR simulator was initially demonstrated and has the potential to be a teaching and training tool for surgeons.…”
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Congenital Anomalies in Children of Mothers Taking Antiepileptic Drugs with and without Periconceptional High Dose Folic Acid Use: A Population-Based Cohort Study. by Lu Ban, Kate M Fleming, Pat Doyle, Liam Smeeth, Richard B Hubbard, Linda Fiaschi, Laila J Tata

“…Stratification by folic acid supplementation did not show marked reductions in AED-associated risks (e.g. for CAs overall aOR 1.75, 1.01-3.03 in the high dose folic acid group and 1.94, 95%CI 1.21-3.13 in the low dose or no folic acid group); however, the majority of mothers taking AEDs only initiated high dose folic acid from the second month of pregnancy.…”
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