ROLE OF GENETIC VARIABILITY IN METABOLIC PATHWAYS ON CISPLATIN-INDUCED KIDNEY INJURY IN HEAD AND NECK CANCER PATIENTS by Ericka Francislaine Dias Costa, Ana Maria Castro Ferreira, Marilda Mazzali, Gustavo Jacob Lourenço, Carmen Silvia Passos Lima

“…Patients with the GSTP1 c.313AG or GG and ERCC1 c.354CT or TTC>T (17.57%), MLH1 c.93GA or A (12.49%), or MSH3 c.3133AG or GG (12.19%) combined genotypes showed a reduction in renal function after CDDP treatment. Renal function declines of 18.85% and 13.38% were observed in patients with ERCC1 c.354CT or TT and MLH1 c.93GA or AA or MSH3 c.3133AG or GG combined genotypes, respectively. …”
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Intention to Use Pre-Exposure Prophylaxis Among Age Groups of Brazilian Men Who Have Sex With Men: National Cross-Sectional Study by Alvaro Francisco Lopes de Sousa, Caique Jordan Nunes Ribeiro, Guilherme Reis de Santana Santos, Emerson Lucas Silva Camargo, Herica Emilia Félix de Carvalho, Guilherme Schneider, Leticia Genova Vieira, Liliane Moretti Carneiro, Ana Paula Morais Fernandes, Talita Morais Fernandes, Márcio Bezerra-Santos, Rita de Cassia Dias Nascimento, Lucas Almeida Andrade, Anderson Reis de Sousa, Inês Fronteira, Isabel Amélia Costa Mendes

“…By addressing these nuances, public health initiatives can more effectively promote PrEP use, catering to the diverse needs of the MSM community and contributing to the reduction of HIV infection rates.…”
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Impact Response of Dam Affected by Landslide Surge Based on Improved SPH Method by Shuai HUANG, Zhonggen WANG, Yu LI, Yuxiang FENG

“…Subsequently, the wave undergoes fragmentation, leading to a reduction in the dam’s deformation under the effect of the fragmented wave. …”
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Cytokine status in posttraumatic synovitis on the background of systemic and intra-articular use of NSAID and ozone by G. V. Poryadin, A. N. Zakhvatov, T. V. Tarasova, D. A. Khaydar, V. O. Timoshkin

“…Joint  damage  initiates aseptic  self-sustaining inflammation, which  contributes the  progression of post-traumatic destruction of tissues  not  only  in the  pathological focus,  but  also outside  it,  significantly expanding the zone of degenerative changes due to secondary alterations. …”
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Impact of strategic public health interventions to reduce tuberculosis incidence in Brazil: a Bayesian structural time-series scenario analysisResearch in context by Klauss Villalva-Serra, Beatriz Barreto-Duarte, Moreno M. Rodrigues, Artur T.L. Queiroz, Leonardo Martinez, Julio Croda, Valeria C. Rolla, Afrânio L. Kritski, Marcelo Cordeiro-Santos, Timothy R. Sterling, Mariana Araújo-Pereira, Bruno B. Andrade

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A very early clinical response to treatment with the Janus kinase inhibitor tofacitinib in patients with active rheumatoid arthritis: the dynamics of pain and central sensitization... by A. E. Karateev, E. S. Filatova, E. Yu. Pogozheva, V. N. Amirdzhanova, E. L. Nasonov, A. M. Lila, V. I. Mazurov, A. Yu. De, A. A. Baranov, N. A. Lapkina, G. V. Lukina, N. A. Kiryukhina, S. Yu. Davidyan, T. S. Salnikova, R. R. Samigullina, D. S. Chakieva, I. M. Marusenko, O. V. Semagina, M. Yu. Semchenkova, A. F. Davydova, E. V. Kalinina

“…On 28 days, the effect became better: there was a reduction in the level of NRS pain to 2.32±1.57 (p<0.001), in pain according to the patient's assessment of the analgesic effect of therapy to 43.6±29.6%; in the median PainDETECT score to 2.5 [0; 8.7] (p<0.001); and in CSI scores to an average of 26.4±13.9 (p <0.001). …”
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Spatio-temporal Coupling of Ecological Service Value and Human Activity Intensity in the Central Urban Area of Lhasa City by Jiarui ZHANG, Wangdwei MIGMAR, Li CHENG, Liyuan QIAN

“…Ecosystem service value (ESV) initially decreased before a partial recovery, with an overall decline of 46.28 million CNY. …”
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LRP6 regulates growth in Litopenaeus vannamei via the Wnt/β-catenin signaling pathway by Sheng Wang, Xiaodi Wang, Hao Yang, Xuanzheng Di, Haoyang Li, Bin Yin, Ziwei Liu, Chaozheng Li, Jianguo He

“…Functional investigations via RNAi technology revealed that silencing LvLRP6 via dsRNA injection resulted in a significant reduction in shrimp growth, as indicated by lower weight gain than that in the control group. …”
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Supporting antiretroviral therapy uptake and adherence: the SUPA research programme and RCT by Rob Horne, Caroline Sabin, Trudie Chalder, Vanessa Cooper, Lucy Campbell, Elizabeth Glendinning, Iris Mosweu, Paul McCrone

“…Conclusions Patients who received the Supporting UPtake and Adherence to antiretroviral therapy service intervention benefited from a reduction in antiretroviral therapy concerns, a reduction in antiretroviral therapy intrusiveness and reduced depressive symptoms, and from improved quality of life. …”
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Lefitolimod in Combination with Ipilimumab in Patients with Advanced Solid Tumors: A Phase I Trial by Mirella Nardo, Mohamed A. Gouda, Matthew J. Reilley, Amadeo B. Biter, Joann Lim, Stacie A. Bean, Ly M. Nguyen, Priya R. Bhosale, Casey R. Ager, Coline A. Couillault, Sarina A. Piha-Paul, Siqing Fu, Apostolia M. Tsimberidou, Timothy A. Yap, Aung Naing, Jordi Rodon, Vivek Subbiah, Daniel D. Karp, Michael A. Curran, David S. Hong

“…No grade 4 or 5 AEs occurred, and no patients required dose reduction or treatment discontinuation due to AEs. …”
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STEREOTACTIC RADIOTHERAPY AND RADIOSURGERY IN THE TREATMENT OF PATIENTS WITH BRAIN PILOID ASTROCYTOMAS OF DEEP LOCATION by Yu. Yu. Trunin, A. V. Golanov, A. N. Konovalov, L. V. Shishkina, G. E. Gorlachev, S. K. Gorelyshev, I. N. Pronin, E. A. Khukhlayeva, N. K. Serova, A. G. Korshunov, A. Kh. Bekyashev, M. V. Ryzhova, M. V. Galkin, Sh. U. Kadyrov, V. S. Sorokin, N. A. Mazerkina, S. A. Maryashev, E. R. Vetlova, N. A. Antipina, V. V. Kostyuchenko, A. S. Pankova

“…The median follow-up from the initiation of radiotherapy was 22.7 months (range 6–60 months). …”
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Study protocol for a randomized double-blinded placebo-controlled trial on ASA therapy for patients with chronic rhinosinusitis with nasal polyps, NSAID-exacerbated respiratory dis... by Sanna Toppila-Salmi, Sanna Toppila-Salmi, Sanna Toppila-Salmi, Annina Lyly, Annina Lyly, Viljami Salmi, Viljami Salmi, Mikko Nuutinen, Mikko Nuutinen, Michael Kilpiö, Michael Kilpiö, Tanzeela Hanif, Tanzeela Hanif, Tanzeela Hanif, Mikko Niemi, Mikko Niemi, Mikko Niemi, Anu Laulajainen-Hongisto, Lena Hafrén, Mika Mäkelä, Paula Kauppi, Paula Virkkula, Alma Helevä, Alma Helevä

“…The study explores various outcomes, including reduction in polyp burden, improvement in QoL, treatment-related side effects, and biomarker analyses derived from nasal swabs, blood, and urine samples.MethodsAirGOs Medical is an investigator-initiated RDBCT conducted at Helsinki University Hospital. …”
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Monoclonal antibodies in severe asthma: outcomes from real-world data by Silvia del-Barrio-Buesa, Silvia del-Barrio-Buesa, Álvaro Narrillos-Moraza, Álvaro Narrillos-Moraza, Julia García-de-Pedro, Julia García-de-Pedro, Julia García-de-Pedro, Francisco Javier de-Castro-Martínez, Francisco Javier de-Castro-Martínez, María Esther Durán-García, María Esther Durán-García, Vicente Escudero-Vilaplana, Vicente Escudero-Vilaplana, Elena Lobato-Matilla, Elena Lobato-Matilla, Rosa Romero-Jimenez, Rosa Romero-Jimenez, Esther Chamorro-de-Vega, Esther Chamorro-de-Vega, Paula Ruiz-Briones, Paula Ruiz-Briones, Félix Jesús Garcia-Moreno, Félix Jesús Garcia-Moreno, María Martín-Bartolomé, María Martín-Bartolomé, Ana Herranz, Ana Herranz, María Sanjurjo, María Sanjurjo

“…Overall, 42% of patients discontinued treatment, mainly due to insufficient clinical response (48.4%) or drug supply issues (42.2%).ConclusionIn routine clinical practice, benralizumab, mepolizumab, omalizumab, and reslizumab were associated with improvements in asthma control, lung function, and reduction in exacerbations over 12 months. Benralizumab and reslizumab were associated with the greatest reductions in eosinophil counts. …”
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Impact of COVID-19 pandemic on non-communicable diseases care and service deliveries in Sub-Saharan Africa: A systematic review by Yordanos Tadesse Kidanemariam, Finina Abebe, Eshetu Girma, Adamu Addisse, Zewdie Birhanu, Kalkidan Hassen, Abonesh Taye, Demuma Amdisa, Eyasu Alem Lake, Mistire Teshome Guta, Sudhakar Morankar, Kiya Kedir, Firaol Mesfin, Fiseha Wadilo, Elifaged Hailemeskel, Melat Dereje, Eskedar Hailegebrel, Rawleigh Howe, Minyahil Tadesse Boltena, Hailemicheal Getachew, Endalkachew Worku Mengesha, Tadesse Dagget Tesfaye, Netsanet Fentahun, Bereket Damtew, Adisalem Debebe, Zerihun Tariku, Addisu worku, Yoseph Gebreyohannes Abraha, Sabit Ababor Ababulgu

“…It include substantial reduction in outpatient attendance, delayed or cancelled diagnostic service and compromised disease management. …”
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Efficacy and Safety of Rituximab in Antiglomerular Basement Membrane Disease by Vanja Ivković, Ingeborg Bajema, Annette Bruchfeld, Stephen McAdoo, Asheesh Kumar, Richard Klaus, Nele Kanzelmeyer, Maxime Touzot, Georgina Maalouf, Ajay Jaryal, Sanjay Vikrant, Dieter Haffner, Bärbel Lange-Sperandio, David Saadoun, Mårten Segelmark, Andreas Kronbichler

“…Kidney survival was lower in initially dialysis-dependent patients (34% vs. 81%, P < 0.001). …”
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<i>Morinda citrifolia</i> Essential Oil in the Control of Banana Anthracnose: Impacts on Phytotoxicity, Preventive and Curative Effects and Fruit Quality by Maysa C. Santos, Luis O. Viteri, Paulo R. Fernandes, Rosilene C. Carvalho, Manuel A. Gonzalez, Osmany M. Herrera, Pedro R. Osório, Dalmarcia S. C. Mourão, Sabrina H. Araujo, Cristiano B. Moraes, Marcos V. Giongo, Wellington S. Moura, Marcos P. Camara, Alex Sander R. Cangussu, Raimundo W. S. Aguiar, Eugênio E. Oliveira, Gil R. Santos

“…This significantly reduced the Area Under the Disease Progress Curve without affecting the fruit weight, although there was a slight reduction in °Brix. The growth of non-target organisms, such as <i>T. asperellum</i> and the insect predators <i>Co. maculata</i> and <i>E. connexa</i>, was not affected. …”
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Outcomes of transcatheter aortic valve replacement in younger low-risk patients: a comprehensive meta-analysis of efficacy and safety by António Rocha de Almeida, António Rocha de Almeida, António Rocha de Almeida, Maria Rita Lima, Maria Rita Lima, Daniel A. Gomes, Renato Fernandes, Eduardo Infante Oliveira, Eduardo Infante Oliveira, Pedro Araújo Gonçalves, Pedro Araújo Gonçalves, Rui Campante Teles, Rui Campante Teles, Manuel de Sousa Almeida, Manuel de Sousa Almeida, Lino Patrício

“…At a mean follow-up of 16 ± 5 months, TAVI showed a non-significant reduction in the composite of death or disabling stroke [2.8% vs. 5.1% risk ratio (RR) 0.98, 95% confidence interval (CI) (0.96–1.00), p = 0.11] and all-cause mortality [2.1% vs. 3.7%, RR 0.99, 95% CI (0.97–1.00), p = 0.15]. …”
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Assessment of the Prevalence of Markers of Monoinfection with Hepatitis C Virus and Coinfection with Hepatitis C and B Viruses among the Personnel of Medical Institutions of an End... by M. P. Kostinov, N. A. Magomedova, I. A. Khrapunova, A. V. Linok, E. Yu. Malinnikova, G. I. Alatortseva, L. N. Pritvorova, L. N. Nesterenko, I. I. Amiantova, V. V. Dotsenko, V. Yu. Kabargina, V. B. Polishchuk, M. N. Loktionova, A. A. Besshaposhnikova

“…Parenteral viral hepatitis B (HBV) and C (HCV) affect not only millions of people, but also healthcare workers due to professional contacts, which lead to the progression of liver pathology and a reduction in medical activity. Numerous studies have shown that patients with double infection are at greater risk of developing progressive liver disease, cirrhosis, and hepatocellular carcinoma compared to monoinfected patients.Aim. …”
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The added value of coupling anti-dsDNA and anti-chromatin antibodies in follow-up monitoring of systemic lupus erythematosus patients by Caroline Carlé, Françoise Fortenfant, Chloé Bost, Julie Belliere, Stanislas Faguer, Dominique Chauveau, Antoine Huart, David Ribes, Laurent Alric, Gregory Pugnet, Laurent Sailler, Yves Renaudineau

“…Following therapy introduction, Ab reduction occurred in all patients from the DP + group with a more pronounced effect reported in complete responders. …”
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Impact of Low-Dose Amino Acid-Chelated Trace Minerals on Performance, Antioxidant Capacity, and Fecal Excretion in Growing-Finishing Pigs by Yunxia Xiong, Fei Zhao, Yaojie Li, Qiwen Wu, Huaqin Xiao, Shuting Cao, Xuefen Yang, Kaiguo Gao, Zongyong Jiang, Shenglan Hu, Li Wang

“…Both LITM and LOTM significantly reduced fecal emissions of Fe, Cu, Zn, and Mn compared with HITM (<i>p</i> < 0.05), with greater reductions in Cu, Zn, and Mn in LOTM. In conclusion, low-dose substitution of inorganic or organic trace minerals did not negatively affect growth, carcass traits, meat quality, or nutrient digestibility in growing-finishing pigs, while it effectively reduced fecal heavy metal emissions. …”
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