A novel high-throughput screen identifies phenazine-1-carboxylic acid as an inhibitor of African swine fever virus replication in primary porcine alveolar macrophages by Jing Lan, Rui Luo, Di Liu, Changxing Qi, Xin Song, Zhanhao Lu, Ruojia Huang, Yuying Yang, Yuan Sun, Yonghui Zhang, Tao Wang, Hua-Ji Qiu

“…Thus, the development of effective and readily available therapeutics for ASF is urgently needed. To conduct high-throughput screening (HTS) for anti-ASFV drugs, we initially developed a recombinant dual-reporter virus (rASFV-Gluc/EGFP) using the virulent strain ASFV HLJ/18 (ASFV-WT). …”
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Guiding transdisciplinary synthesis processes for social-ecological policy decisions by Jean Paul Metzger, Carlos Joly, Gerd Sparovek, Renata Pardini, Patricia Ruggiero, Gabriela di Giulio, Cristina Azevedo, Danilo Boscolo, Pedro H.S. Brancalion, Helena Carrascosa, Raquel Carvalho, Luciana Schwandner Ferreira, Alexandre Gerard, Camila Hohlenwerger, Alexandre Igari, Pedro Medrado Krainovic, Eduardo Freitas Moreira, Nathalia Nascimento, Juliana Ortega, Marco Aurelio Nalon, Adriano Pinter, Paula Prist, Ricardo Ribeiro Rodrigues, Lucia Sousa e Silva, Fernando Henrique de Sousa, Luara Tourinho, Rodrigo A.B.M. Victor, Rafael B. Chaves

“…Flexibility is also required to adjust to political circumstances, acknowledging that there are trade-offs between responding to urgent political needs and creating novel ideas, knowledge and outputs (3). …”
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Assessment of effectiveness and impact of universal prophylaxis with nirsevimab for prevention of hospitalizations due to respiratory syncytial virus in infants. The NIRSE-GAL stud... by Narmeen Mallah, Sonia Ares-Gómez, Jacobo Pardo-Seco, Alberto Malvar-Pintos, María-Isolina Santiago-Pérez, Olaia Pérez-Martínez, María-Teresa Otero-Barrós, Nuria Suárez-Gaiche, Rolf Kramer, Jing Jin, Leticia Platero-Alonso, Rosa-María Alvárez-Gil, Olga-María Ces-Ozores, Victoria Nartallo-Penas, Susana Mirás-Carballal, Marta Piñeiro-Sotelo, Juan-Manuel González-Pérez, Carmen Rodríguez-Tenreiro, Irene Rivero-Calle, Antonio Salas, Carmen Durán-Parrondo, Federico Martinón-Torres

“…The number of averted cases and the number needed to immunize will be estimated. Immunization failure and nirsevimab safety will be monitored. …”
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SBRT in recurrent oligometastatic ovarian cancer: An EORTC Y-ECI GCG systematic review by Constance Huck, Melpomeni Kountouri, Ramon Yarza, Gloria Marquina, Manuel Espantaleon, Judith Kroep, Fernanda Herrera, Ainhoa Madariaga, Noelia Sanmamed

“…SBRT delayed systemic therapy initiation, with a median time of 9.45 months, and was well tolerated, with mostly mild toxicities (CTCAE grade ≤ 2). …”
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Radiotherapy Increases Carotid Intima-Media Thickness in Patients with Nasopharyngeal Carcinoma Compared to a Healthy Control Group: A 6-Year Follow-Up Study by Yun-Fan Yvonne Chu, Ya-Yuan Hou, Wan-Chen Tsai, Chih-Cheng Huang, Hung-Chen Wang, Yu-Jih Su, Wei-Che Lin, Cheng-Hsien Lu, Nai-Wen Tsai

“…An increased carotid IMT may be correlated to an increased mortality rate and needs to be explored in future studies. Consequently, we recommend regular follow-up carotid ultrasonography for NPC patients undergoing radiation therapy.…”
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Malaria Vaccines and Global Equity: A Scoping Review of Current Progress and Future Directions by Rajesh Perumbilavil Kaithamanakallam, Tirath Patel, Bharati Balachandran, Neville Fernandez, Joseph Jillwin, Dharambir Kashyap, Aparna Shivaprasad, Uttam Udayan, Pragnesh Kalyandrug, Aakanksha Aakanksha, Prasanna Honnavar

“…The journey toward a viable malaria vaccine, initiated in 1965, reached a major milestone in 2021 with the WHO’s endorsement of RTS,S/AS01, a recombinant protein-based malaria vaccine. …”
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A role of CD20+ T cells in early multiple sclerosis by Marina Rode von Essen, Marie Mathilde Hansen, Sahla El Mahdaoui, Victoria Hyslop Hvalkof, Rikke Holm Hansen, Jørgen E. Nielsen, Jørgen E. Nielsen, Jette Frederiksen, Jette Frederiksen, Finn Sellebjerg, Finn Sellebjerg

“…As CD8+CD20+ T cells are present in the CNS before inflammation and are highly enriched in MS lesions once the disease is initiated, they may be among the first effector cells in RRMS. …”
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Quantifying Joystick Interactions and Movement Patterns of Toddlers With Disabilities Using Powered Mobility With an Instrumented Explorer Mini by Kimberly A. Ingraham, Nicole L. Zaino, Claire Feddema, Mia E. Hoffman, Liesbeth Gijbels, Alexis Sinclair, Andrew N. Meltzoff, Patricia K. Kuhl, Heather A. Feldner, Katherine M. Steele

“…Powered mobility technology can be a powerful tool to facilitate self-initiated exploration and play for toddlers with motor disabilities. …”
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Macrophage infiltration promotes regrowth in MYCN-amplified neuroblastoma after chemotherapy by Anders Valind, Bronte Manouk Verhoeven, Jens Enoksson, Jenny Karlsson, Gustav Christensson, Adriana Mañas, Kristina Aaltonen, Caroline Jansson, Daniel Bexell, Ninib Baryawno, David Gisselsson, Catharina Hagerling

“…While most high-risk neuroblastoma patients initially respond to treatment, often with complete clinical remission, many eventually relapse with therapy-resistant tumors. …”
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An efficient strategy to promote food waste composting by adding black soldier fly (Hermetia illucens) larvae during the compost maturation phase by Jiawei Quan, Yumei Wang, Yu Wang, Chunxing Li, Zengwei Yuan

“…Composting is an effective way to recycle FW, while the disease risk of immature compost and the long durations needed for mature compost restrict the application. …”
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Clinical profile of an unselected population with heart failure treated with vericiguat in real life: differences with the VICTORIA trial by Alberto Esteban-Fernández, Alberto Esteban-Fernández, Alejandro Recio-Mayoral, Raquel López-Vilella, Raquel López-Vilella, Gregorio de Lara, Moisés Barrantes-Castillo, Inés Gómez-Otero, Inés Gómez-Otero, Julio Nuñez-Villota, Julio Nuñez-Villota, Julio Nuñez-Villota, Julio Nuñez-Villota, Carolina Robles-Gamboa, José López-Aguilera, Ángel Iniesta-Manjavacas, Paula Fluviá, Francisco Pastor-Pérez, Laia Belarte-Tornero, Gonzalo Alonso-Salinas, Pablo Díez-Villanueva

“…Further research is needed to identify which patients may benefit the most from vericiguat treatment.…”
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Emergency Identification of Endotracheal Tube Tip via Ultrasonography Used by Trained Nurse in the Neonatal Intensive Care Unit (NICU) by Athanasia Voulgaridou, Savas Deftereos, Pelagia Chloropoulou, Konstantina Bekiaridou, Emmanouela Tsouvala, Rozita Meziridou, Soultana Foutzitzi, Christos Kaselas, Xenophon Sinopidis, Elpis Mantadakis, Katerina Kambouri

“…Further studies with more patients and additional studied factors are needed to fully assess US’s reliability in determining ETT positioning.…”
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Care management staff perspectives on stigma and barriers to substance use treatment experienced by latine adults who use substances by Christina S. Lee, Erika G. Cordova-Ramos, Damaris J. Rohsenow, Kim T. Mueser, Christine A. Pace, Rosemarie Martin, Suzanne M. Colby, Victoria Lopez, Melanie Morris, Jake R. Morgan, Ari Kriegsman, Mari-Lynn Drainoni

“…Stigma processes may discourage the initiation of needed substance use care among Latine persons experiencing oppression.…”
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Successful Management of Refractory Chylothorax in Preterm Infants Using Hypertonic Glucose Pleurodesis by Young Seok Do, Euiseok Jung, Sung Hyeon Park, Jeong Min Lee, Ha Na Lee, Jiyoon Jeong, Soo Hyun Kim, Byong Sop Lee, Ki Soo Kim, Ellen Ai-Rhan Kim

“…The first case was that of a female infant born at 24+5 weeks of gestation (585 g) and diagnosed with postsurgical chylothorax at 68 days of life. Even after the initiation of fasting and intravenous octreotide administration, pleural drainage did not reduce. …”
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Analysis of the Molecular Profile of Melanoma Brain Metastases using Immunohistochemistry by Shiro Manoel Shimoakoishi de Arruda, Sergio Hideki Suzuki, Jose Erasmo Dal Col Lucio, Robson Tadashi Saruwatari, Vinicius Trindade Gomes da Silva, Raphael Esteves Veiga, Anibal Rodrigues Neto, Eloah Silva Marcilio

“…Further investigations are needed to validate these findings and elucidate their clinical applicability.…”
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Bioactive peptides and proteins for tissue repair: microenvironment modulation, rational delivery, and clinical potential by Zhuo-Wen Hao, Zhe-Yuan Zhang, Ze-Pu Wang, Ying Wang, Jia-Yao Chen, Tian-Hong Chen, Guang Shi, Han-Ke Li, Jun-Wu Wang, Min-Chao Dong, Li Hong, Jing-Feng Li

“…Investigating the fundamental mechanisms by which BAPPs modulate the microenvironment and developing rational delivery strategies are essential for optimizing their administration in distinct tissue repairs and facilitating clinical translation. This review initially focuses on the mechanisms through which BAPPs influence the microenvironment for tissue repair via reactive oxygen species, blood and lymphatic vessels, immune cells, and repair cells. …”
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Optimizing oral 3-hydroxybutyrate dosage using pharmacokinetic model to improve cognitive function and mood in healthy subjects by Kentaro Nishioka, Kentaro Nishioka, Kentaro Nishioka, Takahiro Ishimoto, Mariko Sato, Ruki Yasuda, Yumi Nakamura, Hiroshi Watanabe, Toshihide Suzuki, Yudai Araragi, Yukio Kato, Ken-ichi Yoshida, Norihito Murayama

“…The model principally reflected the observed serum 3-HB concentrations profiles and predicted a minimum dose of 3.5 g needed to achieve the target Cmax. In the efficacy study, although no significant difference was observed in any cognitive domains assessed by the Cognitrax, total responses and correct answers in the SAT were significantly improved in the active group receiving 3.5 g of 3-HB compared to the placebo group. …”
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Methodology for the Positive Voices 2022 Survey of People With HIV Accessing Care in England, Wales, and Scotland: Cross-Sectional Questionnaire Study by Janey Sewell, Carole Kelly, Adamma Aghaizu, Hannah Kitt, Annegret Pelchen-Matthews, Veronique Martin, Amal Farah, Colette Smith, Alison Brown, Clare Humphreys, Alex Sparrowhawk, Valerie Delpech, Alison Rodger, Fiona Lampe, Meaghan Kall

“…It monitors the physical, mental, and social health, well-being, and needs of this population so that they can be addressed. …”
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From warehouse to ward: applying implementation research methods to the device identification, qualification, distribution, and management process within the Newborn Essential Solu... by Kylie Dougherty, Rebecca P. Kirby, Katerina Claud, Kara M. Palamountain, Elizabeth Asma, Millicent Alooh, Danica Kumara, Vince Gate, Ali Khalid, George Banda, Hope David Peter, Charles Osuagwu, Rebecca Richards-Kortum, Z. Maria Oden, Christine A. Bohne, Lisa R. Hirschhorn

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“Crying in the Wilderness”—The Use of Web-Based Support in Telomere Biology Disorders: Thematic Analysis by Emily Eidenier Pearce, Alina Majid, Toniya Brown, Rowan Forbes Shepherd, Camella Rising, Catherine Wilsnack, Ashley S Thompson, Melissa B Gilkey, Kurt M Ribisl, Allison J Lazard, Paul KJ Han, Allison Werner-Lin, Sadie P Hutson, Sharon A Savage

“…Our findings suggest web-based psychosocial support should target long-term and multifaceted informational and emotional needs, be user-initiated, be offered alongside in-person formats, provide expert-informed information, and be attentive to personal privacy and evolving support needs of the TBD community. …”
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