COM-1 promotes homologous recombination during Caenorhabditis elegans meiosis by antagonizing Ku-mediated non-homologous end joining. by Bennie B L G Lemmens, Nicholas M Johnson, Marcel Tijsterman

“…In contrast to its yeast counterparts, COM-1 is not required for Spo11 removal and initiation of meiotic DSB repair, but instead promotes meiotic recombination by counteracting the NHEJ complex Ku. …”
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Developing self-assessment instruments to measure students’ performance characters in making dresses using a high order thinking skills approach by Emy Budiastuti, Sugiyem Sugiyem, Farah Najwa Ahmad Puad

“…This study reveals that self-assessment of work attitudes needs to be pursued during practical learning to enhance learning motivation and develop relevant competencies.…”
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Who Puts the ‘Open’ in Open Knowledge? by Montgomery Lucy, Neylon Cameron, Wilson Katie, Huang Chun-Kai (Karl), Hosking Richard, Ozaygen Alkim, Handcock Rebecca

“…As this paper discusses, the Curtin Open Knowledge Initiative, a major research project funded by Curtin University, is a deliberate effort to support the new forms of digital literacy needed to enable this shift.…”
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Ritshidze’s community-led monitoring system as a source of information on health system responsiveness in South Africa by P Barron, B Honermann, K Vallabhjee, K Govender, H Schneider

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Impact of the DEDICATED approach to optimizing palliative care for people with dementia: a multi-method study by Jesper M.A. Biesmans, Sascha R. Bolt, Niels Hameleers, Jos M.G.A. Schols, Jenny T. van der Steen, Sandra M.G. Zwakhalen, Daisy J.A. Janssen, Judith M.M. Meijers

“…However, nurses and other healthcare professionals often lack the confidence and skills to provide palliative care and struggle to initiate timely conversations about wishes and needs for palliative care. …”
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Systematic Literature Review of the Use of Computational Intelligence in the Routing and Spectrum Assignment Problem in Elastic Optical Networks by Renan V. B. Carvalho, Henrique A. Dinarte, Raul C. Almeida Jr., Carmelo J. A. Bastos-Filho

“…This study selects 40 primary studies for analysis and data extraction out of the 659 initially obtained papers. The main conclusions indicate that the community still needs to explore the RSA problem with the freedom to solve it without considering a fixed order of the two subproblems: routing and spectrum allocation. …”
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All arthroscopic management of an Hoffa fracture of the medial femoral condyle: case report by Catarina Silva Souto, Diana Bicas Machado, Nuno Rodrigues, Nuno Tavares

“…A posteromedial portal was needed to achieve anatomic reduction. Weight-bearing was allowed at 8 weeks and physical therapy initiated. …”
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A substance use relapse prevention programme for youth with substance use problems in Botswana by Wada Gaolaolwe, Miriam M. Moagi, Gaotswake P. Kovane, Leepile A. Sehularo

“…Results: The findings from the studies indicate that the programme for preventing substance use relapse among youth should focus more on aftercare initiatives such as tracking and assessment of those under this programme. …”
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Soluble αβ-tubulins reversibly sequester TTC5 to regulate tubulin mRNA decay by Alina Batiuk, Markus Höpfler, Ana C. Almeida, Deryn Teoh En-Jie, Oscar Vadas, Evangelia Vartholomaiou, Ramanujan S. Hegde, Zhewang Lin, Ivana Gasic

“…Our findings provide a paradigm for how cells regulate the activity of a specificity factor to adapt posttranscriptional regulation of gene expression to cellular needs.…”
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Lipid interactions and gating hysteresis suggest a physiological role for mechanosensitive channel YnaI by Nathan Will, Giorgos Hiotis, Yoshitaka Nakayama, Gabriella Angiulli, Zijing Zhou, Charles D. Cox, Boris Martinac, Thomas Walz

“…Unlike MscS, YnaI shows pronounced gating hysteresis and remains open to a substantially lower membrane tension than is needed to initially open the channel. Thus, at near-lytic membrane tension, both MscL and YnaI will open, but while MscL has a large pore and must close quickly to minimize loss of essential metabolites, YnaI only conducts ions and can thus remain open for longer to continue to facilitate pressure equilibration across the membrane.…”
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TB elimination in Southern Africa: overview and critical reflection by J. Boffa, D. Vambe, C. Khosa, B. José, N. Ndjeka, T. Nkomo, A.W. Kay, A.M. Mandalakas, L. Mvusi, S.V. Omar, S. Thi, K. Velen, S. Charalambous, M.X. Rangaka

“…Successful TB elimination will depend on simple, low-cost prevention, testing and treatment options, tailored to each country’s specific needs. All of which will require sustained political commitment, innovation and strategic investments in health system strengthening and community-based care.…”
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Design and Implementation MPPT Improved Whale Optimization Algorithm to Overcome Partial Shading Condition on Solar Panel by Muhammad Nizar Habibi, Rifqi Noviantono Prakoso, Ahmad Firyal Adila, Moh. Zaenal Efendi, Novie Ayub Windarko, Rachma Prilian Eviningsih

“…So, MPPT optimization method is needed, one of which is the Improved Whale Optimization Algorithm (IWOA). …”
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High diversity of Coxiella burnetii genotypes in Q fever human cases from Spain, 2012-2024 by Judit Gil-Zamorano, Daniel Cifo, María Teresa Llorente, Manuela Rodríguez-Vargas, Rosa Estévez-Reboredo, Diana Gómez-Barroso, David González-Barrio, Isabel Jado

“…Results: Six different genotypes (SNP1–SNP3, SNP6, SNP8, and SNP9) were correctly identified in 52 out of 66 initially analyzed samples, revealing high genetic variability in human clinical samples. …”
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Overview of the Surgical Management of Liver Oligometastatic Disease in Colorectal Cancer by Anca Monica Oprescu Macovei, Dana Paula Venter, Bogdan Dumitriu, Constantin Oprescu, Mircea Dan Venter, Gabriel-Nicolae Andrei, Mures Sebastian Valcea Precup, Bogdan Socea, Mihai Stefan

“…This review aims to clarify how and when liver resection can first be chosen; when preoperative systemic treatment is needed; and if this is chosen, what is the best approach.…”
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First case report in China of Gitelman syndrome associated with ileocecal polyps in a child: a case report by Yue Wang, Haiyan Lei, Haibin Wang, Jun Yang, Hongxi Guo

“…Imaging revealed a 4 cm × 3 cm × 3 cm ileocecal mass, initially suspected as lymphoma. Colonoscopy identified a pedunculated polyp, excised via electrocoagulation. …”
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Letter from a teacher: A plea for school-university partners to rethink educator burnout and attrition through an ethic of care by Sally Valentino Drew, Kate Atwood Heyboer, Betsy J. Paddock, William Michael McLachlan, Joan Nicoll-Senft

“…Many schools are operating under anti-care practices which directly undermine teacher wellness in part due to secondary traumatic stress, rising workload demands and intensive student needs. Design/methodology/approach – Reflecting a compilation of teacher voices, including participants from three research studies and the collective decades-worth experience of educator scholars, this paper presents a synthesis of educator burnout and the role of educator wellness within trauma-informed social emotional learning initiatives. …”
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Advancements in Sustainable Prestressed Concrete Bridge Technologies: A Comprehensive Review by Seyedmilad Komarizadehasl, Al-Amin, Ye Xia, Jose Turmo

“…Sustainable prestressing techniques, including the use of fiber-reinforced polymer (FRP) tendons and shape memory alloys (SMAs), increase the durability of prestressed concrete bridges, extend service life, and minimize maintenance needs, thereby reducing environmental impact. Key methodologies, such as lifecycle assessment (LCA) and performance-based design, are highlighted for their roles in optimizing structural performance while reducing the ecological footprint. …”
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Retreatment With Nivolumab and Ipilimumab in Pleural Mesothelioma Following Disease Progression After a Durable Response: Case Series by Illaa Smesseim, MD, Paul Baas, MD, PhD, Jacobus A. Burgers, MD, PhD

“…We report two cases of patients with pleural mesothelioma (epithelioid subtype) initially treated with nivolumab-ipilimumab, achieving prolonged disease control. …”
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Availability and funding of clinical genomic sequencing globally by Sarah Wordsworth, Deborah A Marshall, Kathryn A Phillips, Michael P Douglas, James Buchanan

“…We conclude by assessing what type of data and initiatives will be needed to better track and understand the use of NGS around the world as such testing continues to expand.…”
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New Generation Agricultural Cooperatives: Towards a Sustainable Model Serving Ecology and Environmental Preservation by Benjaafar Hasnae, Berrichi Abdelbasset, El Jai Fadwa, Arabi Mourad

“…These cooperatives stand out for their democratic governance, adoption of modern technologies and strong local roots, all of which enhance their competitiveness while meeting local needs and protecting the environment.…”
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