Chronic insomnia disorder as risk factor for stroke: a systematic review by Luiz Augusto Soares Silva, Mateus Molin do Amaral, Vanise Grassi, André Luiz Rodrigues Palmeira

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Economic analysis of hemodialysis and urgent-start peritoneal dialysis therapies by Alexandre Minetto Brabo, Dayana Bitencourt Dias, Everton Nunes da Silva, Daniela Ponce

“…In planned RRT, the costs of PD are lower than those of HD; however, the literature lacks such analyses when initiation is urgent. Objective: To clinically and economically evaluate, from the perspective of the Unified Health System (SUS, Sistema Único de Saúde), the strategy of initiating unplanned RRT using HD or PD in patients during their first year of therapy. …”
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A mixed methods feasibility study of a ketogenic diet as treatment for Parkinson’s disease by Kate Worster, Dana Colgan, Dana Colgan, Alexandra Vita, Alexandra Vita, Christine McClure, Lita Buttolph, Lita Buttolph, Romilly Hodges, Romilly Hodges, Angela Senders, Andy Erlandsen, Fawzy Elbarbry, Heather Zwickey

“…Quality of life and functional movements were also evaluated.MethodsTwelve people with PD followed a modified, low dairy KD for 12 weeks. …”
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Exploring colorectal cancer patients’ diagnostic pathways and general practitioners’ assessment of the diagnostic processes: a Danish survey study by Dorte E. Jarbøl, Sanne Rasmussen, Kirubakaran Balasubramaniam, Jesper Lykkegaard, Linda Juel Ahrenfeldt, Gitte B. Lauridsen, Peter Haastrup

“…Although many cases are diagnosed swiftly, there is still room for improvement.Aim We aimed to explore CRC diagnostic pathways, encompassing (1) place of initial contact; (2) associations with symptom presentations, sex, and age with events in the diagnostic process and initial referrals and (3) the general practitioner’s (GP’s) evaluation of the diagnostic processes.Methods All GPs in North-, Central-, and Southern Denmark were invited to fill in questionnaires for their listed patients diagnosed with cancer during the past two years.Results Among 1,032 recorded CRC patients, 65% had their initial contact in general practice, 5% within the out-of hours service, 10% in the hospital, and 20% were diagnosed based on screening. …”
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Impact of the time of initiation and line of biologic therapy on the retention rate of secukinumab in axial spondyloarthritis (axSpA): data from the French multicentre retrospectiv... by Maxime Dougados, Pascal Claudepierre, Philippe Goupille, Alain Saraux, Anne Tournadre, Daniel Wendling, Cédric Lukas, Adeline Ryussen-Witrand, Emilie Desfleurs, Audrey Lardy-Cleaud

“…Study periods: Two cohorts were evaluated regarding the time of initiation of secukinumab: cohort 1 (C1)—between 16 August 2016 and 31 August 2018—and cohort 2 (C2)—between 1 September 2018 and 13 November 2020. …”
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Effectiveness and Safety of the TRIO Optimal Health Management Program in Patients With Type 2 Diabetes Mellitus Initiating Basal Insulin Therapy: Prospective Observational Real-Wo... by Chenxi Li, Lixin Guo, Lixin Shi, Li Chen, Liming Chen, Yaoming Xue, Hong Li, Yuzhen Liang, Jing Yang, Weimin Wang, Dalong Zhu

“…ObjectiveThis prospective observational study evaluated the effectiveness and safety of the TRIO optimal health management program for patients with T2DM initiating BI therapy in a real-world setting. …”
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Two-year follow-up of gait and postural control following initiation of recombinant human tripeptidyl intracerebroventricular enzyme replacement therapy in two atypical CLN2 patien... by Rahul Soangra, Marybeth Grant-Beuttler, Harriet Chang, Raymond Y. Wang

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Conversion surgery for metastatic gastric cancer at 2 years after initial diagnosis of cancer of unknown primary with metastasis of cervical lymph nodes and ovary: a case report by Masaki Suzuki, Hisashi Hosaka, Yasuyuki Fukai, Yasushi Mochida, Daigo Ozawa, Norimichi Kogure, Kazunosuke Yamada, Hitoshi Ojima

“…At about 2 years after the initial diagnosis, an esophagogastroduodenoscopy revealed evidence of gastric cancer. …”
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The initial clinical application of standard PCNL combined with visual needle nephroscope in the treatment of complex renal calculi by holmium YAG laser: a retrospective case serie... by Engo Ovone Yanne, Bai Lin Wu, Cong Li, Jiaqiao Zhang, Xiao Yu, Xiaolin Guo, Lei Cui, Huan Yang

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Colon cancer exosome-associated HSP90B1 initiates pre-metastatic niche formation in the liver by polarizing M1 macrophage into M2 phenotype by ShuJie Li, Xue Fu, Deng Ning, QiuMeng Liu, JunFang Zhao, Qi Cheng, XiaoPing Chen, Li Jiang

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Population profile and glycemic control following initiation or switch of injectable therapies in Tianjin, China: A real‐world retrospective cohort study of adults with type 2 diab... by Qiumei Zhang, Yaqing Fan, Xixi Liu, Minlu Zhang, Jiewen Zhang, Qin Du, Lei Kang, Liming Chen

“…ABSTRACT Aims To evaluate characteristics and glycemic outcomes in individuals with type 2 diabetes using injectable therapies in real‐world clinical practice in Tianjin, China. …”
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Desregulación emocional en la formación inicial de profesores de Pedagogía en Educación Física (Emotional dysregulation in the initial teacher training of Physical Education Pedag... by Gerardo Fuentes-Vilugrón, Esteban Saavedra-Vallejos, Noemi Salvador-Soler

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An antibiotic stewardship initiative focused on community-acquired bacterial pneumonia (CABP) in outpatient clinics and urgent care centers: a 2023–2024 community health system exp... by Tomefa E. Asempa, Tyler Ackley, Kristin E. Linder, Cara D. Riddle, Eric Walsh, David P. Nicolau

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Crescimento inicial do cafeeiro irrigado com água salina e salinização do solo Initial growth of coffee plants irrigated with saline water and soil salinization by Vladimir B. Figueirêdo, Manoel A. de Faria, Elio L. da Silva

“…<br>The coffee crop is expanding to new areas with not enough studies about its response to saline irrigation water. The initial growth of coffee plant was evaluated, in greenhouse at the Engineering Department of the Federal University of Lavras (UFLA), under different levels of irrigation water salinity. …”
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Early re-examination of chest CT may be unnecessary when patients with psittaci pneumonia at low and intermediate risk on Pneumonia Severity Index present with response to initial... by Ming Chen, Shu Ying Zeng, Sheng Jia Lu, Miao Shi, Qing Qian Zhang

“…All patients had improved clinical symptoms and inflammatory markers after receiving antibiotic treatment, and chest CT was reexamined within 5-12 days. Evaluate the correlation between imaging changes before and after treatment and clinical symptoms and inflammatory indicators (CRP, PCT, WBC, etc.).ResultsAfter treatment, the patient’s body temperature, CRP, PCT and other indicators decreased significantly (P &lt; 0.05). …”
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Prevalence and drivers of nurse and physician distress in cardiovascular and oncology programmes at a Canadian quaternary hospital network during the COVID-19 pandemic: a quality i... by Gary Rodin, Kenneth Mah, Monika K Krzyzanowska, Ahlexxi Jelen, Leanna Graham, Rebecca Goldfarb, Daniel V Satele, Mary Elliot, Barry B Rubin

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Association between ventilation–perfusion matching improvement during initial prone positioning and ICU mortality in patients with moderate to severe ARDS: a prospective two-center... by Rui Wang, Wancong Wang, Xiao Tang, Zhenyuan Qi, Ting Li, Yalan Liu, Hongju Li, Jican Yan, Hua Yang, Wenrui Lyu, Zhaohong Li, Bing Sun, Guifen Gan

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Genetic subtype-guided immunochemotherapy in relapsed and refractory diffuse large B cell lymphoma: a phase 2 investigator-initiated nonrandomized clinical trial (GUIDANCE-06) by Yi-Ge Shen, Qing Shi, Wei Tang, Peng-Peng Xu, Yi-Wen Cao, Meng-Meng Ji, Zhong Zheng, Shu Cheng, Li Wang, Wei-Li Zhao

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Antiretroviral therapy initiated during acute infection in women with HIV-1 clade C reduces anti-Tat antibody production and lowers CD8+ T cell activation by Thandeka I. Kubheka, Kewreshini Naidoo, Kavidha Reddy, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Nompumelelo P. Mkhwanazi

“…In this study, we investigate the effect of initiating ART in acute phase infection on the production of anti-Tat antibodies and on T-cell activation.MethodsAnti-Tat IgA, IgG, and IgM titres were evaluated longitudinally by enzyme-linked immunosorbent assay in plasma samples collected from 34 women who started ART immediately following the detection of acute HIV-1 infection. …”
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Low CD4 count was characterized in recent HIV CRF01_AE infection and it rapidly increased to reach a peak in the first year since ART initiation by Xue-Ying Zhang, Li Wang, Yue Jiang, Si-Miao Huang, Hong-Rui Zhu, Wei Liu, Jia-Ye Wang, Xiang-Hui WEI, Yi-Lin Zhao, Wen-Juan Wei, Teng Fei, Xiao-Hong Chen, Dan Wang, Jin-Liang Li, Hong Ling, Min Zhuang

“…The infection status of 402 newly diagnosed and ART-naïve PLWH from a cohort of men who have sex with men (MSM) in China was evaluated using diagnosis records and LAg-Avidity EIA. …”
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