Efficacy and safety of TQB2450 combined with anlotinib as maintenance therapy for LS-SCLC after definitive concurrent or sequential chemoradiotherapy: a prospective phase Ib study by Xiaoli Liu, Xiaoyan Yin, Lulu Zhuang, Junxu Wen, Zhonghui Wei, Wenxing Cui, Minghao Yu, Kaikai Zhao, Lanping Liu, Lingling Kong, Liyang Jiang, Xuquan Jing, Hui Zhu, Xunqiang Wang, Xinjun Dong, Jinming Yu, Xiangjiao Meng

“…This prospective study aimed to evaluate the efficacy and safety of TQB2450 combined with Anlotinib as maintenance therapy for LS-SCLC following concurrent or sequential chemoradiotherapy (CCRT or SCRT). …”
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Impact of TNF inhibitors on inflammation-associated cognitive dysfunction in patients with rheumatoid arthritis: a prospective analysis by Natalia Mena-Vázquez, Natalia Mena-Vázquez, Fernando Ortiz-Márquez, Fernando Ortiz-Márquez, Fernando Ortiz-Márquez, Teresa Ramirez-García, Teresa Ramirez-García, Celia Gillis-Onieva, Pablo Cabezudo-García, Pablo Cabezudo-García, Aimara García-Studer, Aimara García-Studer, Aimara García-Studer, Arkaitz Mucientes, Arkaitz Mucientes, Jose Manuel Lisbona-Montañez, Jose Manuel Lisbona-Montañez, Jose Manuel Lisbona-Montañez, Paula Borregón-Garrido, Paula Borregón-Garrido, Patricia Ruiz-Limón, Patricia Ruiz-Limón, Patricia Ruiz-Limón, Sara Manrique-Arija, Sara Manrique-Arija, Sara Manrique-Arija, Laura Cano-García, Laura Cano-García, Pedro Jesús Serrano-Castro, Pedro Jesús Serrano-Castro, Pedro Jesús Serrano-Castro, Antonio Fernández-Nebro, Antonio Fernández-Nebro, Antonio Fernández-Nebro

“…ObjectivesTo evaluate cognitive improvement in patients with rheumatoid arthritis (RA) after 6 months of treatment with tumor necrosis factor (TNF) inhibitors, analyze associated factors, and determine the percentage of patients achieving cognitive improvement.MethodsThis was a single-center prospective observational study conducted over 12 months on 70 RA patients initiating their first biologic disease-modifying antirheumatic drug (bDMARD) with a TNF inhibitor. …”
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Synthesis of Iron-Based and Aluminum-Based Bimetals: A Systematic Review by Jeffrey Ken B. Balangao, Carlito Baltazar Tabelin, Theerayut Phengsaart, Joshua B. Zoleta, Takahiko Arima, Ilhwan Park, Walubita Mufalo, Mayumi Ito, Richard D. Alorro, Aileen H. Orbecido, Arnel B. Beltran, Michael Angelo B. Promentilla, Sanghee Jeon, Kazutoshi Haga, Vannie Joy T. Resabal

“…Additionally, a bibliometric analysis was performed to evaluate the research trends on the synthesis of Fe-based and Al-based bimetals. …”
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Targeting N4‐acetylcytidine suppresses hepatocellular carcinoma progression by repressing eEF2‐mediated HMGB2 mRNA translation by Hailing Liu, Lei Xu, Shiwei Yue, Hongfei Su, Xing Chen, Qiumeng Liu, Hui Li, Huifang Liang, Xiaoping Chen, Jiefeng He, Zeyang Ding, Bixiang Zhang

“…Methods The ac4C levels were evaluated by dot blot and ultra‐performance liquid chromatography‐tandem mass spectrometry with harvested HCC tissues. …”
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Adverse fetal and perinatal outcomes associated with Zika virus infection during pregnancy: an individual participant data meta-analysisResearch in context by Edna Acosta Pérez, Juan Aguilar Ticona, Jackeline Alger, Celia Alpuche Aranda, Angélica Amado Niño, Emily Ansusinha, Thalia Araújo, Juan Arias, Lumumba Arriaga Nieto, Marcos Ávila, Azucena Bardají, Carlos Becerra Mojica, Andrea Benedetti, Ana Bertozzi, Sarah Bethencourt, Karen Blackmon, Victor Borja Aburto, Patrícia Brasil, Elizabeth Brickley, William Britt, Nathalie Broutet, Pierre Buekens, André Cabié, David Alejandro Cabrera-Gaytán, Rodrigo Cachay, Maria Luisa Cafferata, Isaac Caicedo-Castro, Juan Calle, Guilherme Calvet, Harlan Campbell, Maribel Campos, Mabel Carabali, Helen Cerigo, Celia Cordon, Juliana Silva Corrêa, Federico Costa, Conrado Coutinho, Antonio Cunha, Carlos Cure Cure, Johanna Damen, Marcela Daza, Ilich De la Hoz Siegler, Roberta DeBiasi, Thomas Debray, Valentijn de Jong, Camille Delgado-López, Geraldo Duarte, Gabriella Duarte Miranda, Valorie Eckert, Sophie Eickmann, Esther Ellis, Cassia Estofolete, Lester Figueroa Bolaños, Olivier Fléchelles, Kirsten Fong, Maria Barbara Franco Gomes, Trevon Fuller, Victoria Fumadó, Anna Funk, Luis Galvão, Gabriela Lopes Gama, Patrick Gérardin, Luz Gibbons, Anna Goncé, Amy Gonzalez, Eduardo Gotuzzo, Concepción Grajales-Muñiz, Paul Gustafson, Tahani Hamdan, Eva Harris, Cosme Harrison, Najeh Hcini, Cristina Hofer, Natanaël Holband, Claudia Hormiga Sánchez, Ivonne Huerta, Isabel Hurtado, Irene Inwani, David Cruvinel Isaac, Thomas Jaenisch, Esaú João, Amadu Juliana, Jose Paulo Pereira Junior, Edna Kara, Caron Kim, Albert Ko, Nancy Krebs, Angelle Desiree LaBeaud, Heather Lake-Burger, Jill Lebov, Yee-Sin Leo, Brooke Levis, Talita Lima, Simon Ling, Eduardo Lopez-Medina, Cynthia Lorenzo, Calum Macpherson, Olivia Manders, Elena Marbán-Castro, Ernesto Torres de Azevedo Marques, Celina Turchi Martelli, Flor Martinez-Espinosa, Gloria Martinó González, Gustavo Matta, Salim Máttar, Lauren Maxwell, John McCracken, Adriana Melo, Clara Menéndez, Marcela Mercado Reyes, María Consuelo Miranda Montoya, Demócrito de Barros Miranda-Filho, Ulisses Montarroyos, Karel Moons, Maria Elisabeth Moreira, Jack Moye, Sarah Mulkey, José Muñoz-Medina, Johanna Munoz, Marisa Mussi-Pinhata, Silvia Negrini, Nivison Nery, Jurg Niederbacher Velásquez, Karin Nielsen, M. Kariuki Njenga, Trevor Noël, Mauricio Nogueira, Theresa Ochoa, Consuelo Oliveira, Eric Osoro, Ester Paiva Souto, Miguel Parra-Saavedra, Saulo Passos, Luiza Pela Rosado, Bernadete Perez Coêlho, Priscila Cardia Petra, Léo Pomar, Arnaldo Prata-Barbosa, Ingrid Rabe, Mitermayer G. Reis, Ana Maria Rivera Casas, Diana Rojas, Kerstin Daniela Rosenberger, Paola Mariela Saba Villarroel, Nuria Sanchez Clemente, Magda Sanz Cortes, Janet Sayers, Deolinda Scalabrin, Lavinia Schuler-Faccini, Stacey Schultz-Cherry, Aluisio Segurado, Kirstin Short, Priya Shreedhar, Antônio Silva, Ronaldo Silva, Vivian Avelino Silva, Isadora Cristina de Siqueira, Karen Sohan, Antoni Soriano-Arandes, Carmen Soria-Segarra, Paulo Sucasas da Costa, Adriana Tami, Jousilene Tavares, Maria Benamor Teixeira, Robert F. Terry, Tun-Linn Thein, Soe Soe Thwin, Frank Tobian, Vivian Torres Rodríguez, Isabel Trejos, Marilia Dalva Turchi, César Ugarte-Gil, Miguel Valencia-Prado, Alfonso Vallejos-Parás, Zilton Vasconselos, Ana Beatriz Gorini da Veiga, Carmen Viñuela-Benéitez, Manon Vouga, Yinghui Wei, Jamie Westcott, Marc-Alain Widdowson, Ricardo Ximenes, Carmen Zorrilla

“…Frequentist and Bayesian regression methods were applied to estimate outcome prevalence and evaluate the association between maternal ZIKV infection and fetal loss, microcephaly and congenital zika syndrome as primary outcomes. …”
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Impact of select actionable genomic alterations on efficacy of neoadjuvant immunotherapy in resectable non-small cell lung cancer by Charles Lu, Mehmet Altan, Apar Pataer, Tina Cascone, Annikka Weissferdt, Jianjun Zhang, Boris Sepesi, Ara A Vaporciyan, Marcelo V Negrao, Hai T Tran, Stephen G Swisher, John V Heymach, Don L Gibbons, Brett W Carter, Jack A Roth, Ferdinandos Skoulidis, Yasir Y Elamin, Xiuning Le, Wayne L Hofstetter, J Jack Lee, Bonnie S Glisson, Myrna C B Godoy, Garrett L Walsh, Jia Wu, Humam Kadara, George R Blumenschein, Heather Y Lin, Nicolas Zhou, William N William, Cheuk H Leung, Frank V Fossella, Anne S Tsao, Jonathan M Kurie, Lauren A Byers, Reza J Mehran, David C Rice, Luisa M Solis Soto

“…The suboptimal efficacy of neoadjuvant chemotherapy-sparing, ICI-based regimens in this patient subset underscores the importance of tumor molecular testing prior to initiation of neoadjuvant ICI therapy in patients with resectable NSCLC.…”
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PSMB10 maintains the stemness of chemotherapeutic drug-resistant leukemia cells by inhibiting senescence and cytotoxic T lymphocyte-mediated killing in a ubiquitinated degradation... by Xiao Ma, Yingnan Li, Di Wang, Jialan Niu, Qian Li, Ying Chen, Mengyuan Wang, Jin Wen, Chenxi Liao, Nan Wang, Xiaolan Zhang, Jiwei Chang, Jiayi Yang, Lei Li, Jing Zou, Danyue Peng, Lingbo Liu

“…The cellular senescence was evaluated by the assays of cell proliferation, cell cycle, senescence-associated β-galactosidase activity, and senescence-associated secretory phenotype factors. …”
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Home Blood Pressure Control and Drug Prescription Patterns among Thai Hypertensives: A 1-Year Analysis of Telehealth Assisted Instrument in Home Blood Pressure Monitoring Nationwid... by Anut Sakulsupsiri, Pairoj Chattranukulchai, Sarawut Siwamogsatham, Patchaya Boonchayaanant, Witthawat Naeowong, Aekarach Ariyachaipanich, Vorarit Lertsuwunseri, Voravut Rungpradubvong, Sudarat Satitthummanid, Sarinya Puwanant, Suphot Srimahachota, Wacin Buddhari, Smonporn Boonyaratavej, Surapun Sitthisook, Prapimporn Shantavasinkul, Peera Buranakitjaroen, Apichard Sukonthasarn, Somkiat Sangwatanaroj

“…However, the enhancement of blood pressure (BP) control with HBP telemonitoring technology has yet to be studied in Thailand. Objective. To evaluate the attainment of HBP control and drug prescription patterns in Thai hypertensives at one year after initiating the TeleHealth Assisted Instrument in Home Blood Pressure Monitoring (THAI HBPM) nationwide pilot project. …”
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Human PrP E219K: a new and promising substrate for robust RT-QuIC amplification of human prions with potential for strain discrimination by A. Marín-Moreno, F. Reine, F. Jaffrézic, L. Herzog, H. Rezaei, I. Quadrio, S. Haïk, V. Béringue, D. Martin

“…In tg650-passaged prions, amplification reactions were initiated between 3 and 36 hours for sCJD prions and between 11 and 31 hours for vCJD prions, covering a 5- to 7-log dilution range depending on the strain. …”
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Long-term outcomes in leucine-rich glioma inactivated-1 autoimmune encephalitis and associated biomarkers of inflammation and neuronal and glial injury by Tyler L. Borko, Tyler L. Borko, Phillip Winters, Kelli M. Money, Stefan Sillau, Sadie Eggmann, Sean Selva, Alanna Ritchie, Ryan Kammeyer, Ryan Kammeyer, Gregory P. Owens, Jeffrey L. Bennett, Jeffrey L. Bennett, Amanda L. Piquet

“…Blood-based biomarkers for inflammation and neuronal and glial injury have been evaluated as potential markers of disease severity and prognosis in AE.MethodsPatients diagnosed with LGI1 AE, confirmed by cell-based assay, were enrolled and followed prospectively to gather plasma samples for biomarker testing. …”
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Global perspectives on challenges, coping strategies, and future preparedness of nursing home staff during COVID-19: a systematic review and meta-synthesis by Xiu-fen Yang, Jia-yi Guo, Wei-si Peng, Bing-dong Wang, Chao-ran Qv, Si-jia Zhou, Rui Sun, Lulu Liao, Wei-wei Zhang, Ling-Yan Liu, Lian-chi Ren, Lin Zou, Shi-hai Xu

“…Two reviewers used the Joanna Briggs Institute's (JBI) qualitative research checklist to evaluate each manuscript. The findings were synthesized using pragmatic meta-aggregators. …”
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NeoTRACK trial: Neoadjuvant TiRagolumab, Atezolizumab and Chemotherapy – dissection of IO- efficacy in NSCLC by longitudinal tracKing – protocol of a non-randomised, open-label, si... by Albrecht Stenzinger, Farastuk Bozorgmehr, Michael Thomas, Hauke Winter, Michael Allgäeuer, Alexander Schramm, Servet Bolukbas, Marietta Kirchner, Martin Schuler, Petros Christopoulos, Marc Schneider, Romina M Roesch, Johannes Schnorbach, Laura V Klotz, Raffaella Griffo, Marcel Wiesweg, Fabian Doerr, Balazs Hegedüs, Jelena Cvetkovic, Martin E Eichhorn, Florian Eichhorn

“…Several trials are currently investigating the combination of neoadjuvant platinum-based chemotherapy and dual checkpoint inhibition prior to curative surgery. The investigator-initiated NeoTRACK trial (EU CT number: 2022-501322-38-00; ClinicalTrials.gov identifier: NCT05825625; IKF056) aims to evaluate the feasibility and safety of perioperative anti-PD-L1 (by atezolizumab) and anti-TIGIT (by tiragolumab) treatment in combination with chemotherapy in patients with early stage NSCLC.Methods and analysis NeoTRACK is an open-label, single-arm, prospective, bicentric phase II trial. …”
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Phase I study of a recombinant attenuated oncolytic virus, MEDI5395 (NDV–GM-CSF), administered systemically in combination with durvalumab in patients with advanced solid tumors by Dmitriy Zamarin, Diwakar Davar, Adel Samson, Kevin J Harrington, Siddharth Sheth, Eric Tu, Mitesh J Borad, Grace K Dy, Evanthia Galanis, Fernanda Arnaldez, Sandip P Patel, Nicholas Durham, Benedito A Carneiro, Sonia Agrawal, Zhongying Chen, Chunling Fan, Maozhen Gong, Jenny Burton, Kevin Laubscher

“…The dose-expansion phase was not initiated. The primary objectives were to evaluate safety and tolerability, dose-limiting toxicities (DLTs) and the dose and schedule of MEDI5395 plus durvalumab administration. …”
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Ibrutinib in the Treatment of Refractory Chronic Lymphocytic Leukemia by EA Nikitin, EA Dmitrieva, MA Panteleev, EI Emelina, VL Ivanova, YuB Kochkareva, EG Arshanskaya, IE Lazarev, EE Markova, LA Mukha, NG Novitskaya, MM Pankrashkina, VV Glazunova, AV Shubina, SA Chernysh, NK Khuazheva, EV Naumova, SA Lugovskaya, ME Pochtar’, TN Obukhova, OYu Vinogradova, GE Gendlin, VV Ptushkin

“…Atrial fibrillation was registered in 5 patients, who initially had sinus rhythm. The total of 144 infections were diagnosed in 64 (66 %) patients. …”
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Long-term results of a randomized controlled trial of biosimilar CT-P16 and reference bevacizumab in patients with metastatic or recurrent non-small cell lung cancer by Zoran Andric, Fedor Moiseenko, Tamta Makharadze, Alona Oleksiienko, Eduardo Yañez Ruiz, SungHyun Kim, KeumYoung Ahn, TaeHong Park, Hana Ju, Eric Hyungseok Baek, Soonbum Kwon, IlSung Chang, SinHye Kim, HyunAh Kim, EunKyung Lee, Claire Verschraegen

“…They were then followed up every 9 weeks until death or end of study. Outcomes were evaluated ≤3 years after the last patient enrollment. …”
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HELLO: a protocol for a cluster randomized controlled trial to enhance interpersonal relationships and team cohesion among ICU healthcare professionals by Elie Azoulay, Nancy Kentish Barnes, Sheila Nainan Myatra, Maria-Cruz Martin Delgado, Yaseen Arabi, Carole Boulanger, Giovanni Mistraletti, Maria Theodorakopoulou, Vernon Van Heerden, José-Artur Paiva, Oktay Demirkýran, Gabriel Heras La Calle, Abdulrahman Al Fares, Gaston Burghi, Guy Francois, Anita Barth, Jan De Waele, Samir Jaber, Michael Darmon, Maurizio Cecconi

“…The six components include: Hello campaign posters, email reminders, integrating greetings in morning huddles, hello jars, lead-by-example initiatives, and a daily updated hello board in each ICU. …”
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Stillbirth increase long-term health risks of diabetes, CVD, CVD mortality, and all-cause mortality by Yi Shen, JiaLyu Huang, Yan Chen, Yang Zhao, Zhaochen Sun, Ping Sun, Kaihong Zeng, Ping Shuai, Yuping Liu, Lei Yuan, Xiangzhi Li, Zhengwei Wan

“…Multivariate Cox regressions were used to evaluate associations of stillbirths with diabetes, CVD, all-cause mortality, and CVD mortality utilizing hazard ratios (HRs) and 95% confidence intervals (CIs). …”
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Stability of non-fullerene acceptor-based organic solar cells: chemical and physical properties at the interfaces and active layer by Ian C Flores, Yenny L Casallas-Moreno, Ángel Sacramento, Magali Ramírez-Como, Marlene Camacho-Reynoso, Víctor Cabrera, Yuriy Kudriavtsev, Carlos Rivera-Rodríguez, Luis M Reséndiz

“…The TOF-SIMS and XPS analyses confirmed that oxygen did not diffuse into the layers where it was initially absent, thereby ensuring chemical stability. …”
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The brainstem BBSome regulates glucose homeostasis and lean mass in a state-dependent manner by Connor Laule, Deng-Fu Guo, Yuying Zhao, Paul A. Williams, Donald A. Morgan, Younes Rouabhi, Miriam McDonough, Trevor Butler, Jon Resch, Kamal Rahmouni

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Community engagement and chronic viral hepatitis public health interventions: a systematic review, meta-analysis, and complementary crowdsourcing open callResearch in context by Yifan Li, Eneyi Kpokiri, Dalia Elasi, Rongrong Sheng, Keying Wang, Hayley Conyers, Ye Zhang, Danjuma K. Adda, Philippa C. Matthews, Thomas Fitzpatrick, Joseph D. Tucker, Dan Wu

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