Efficacy and safety of Tofacitinib in patients with active rheumatoid arthritis resistant to conventional therapy: Preliminary results of an open-label clinical trial by E. L. Luchikhina, D. E. Karateev, N. V. Demidova, A. S. Musiyuk, E. N. Aleksandrova, A. A. Novikov, A. V. Smirnov, E. L. Nasonov

“…The dose was escalated to 10 mg BID in 13 (31.2%) patients, on the average, 11.2±1.7 weeks after treatment initiation. TOFA was not discontinued in the reporting period. …”
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The State of Artificial Intelligence and its Prospects in Pakistan's Medical Sector by Rohail Akhtar Habib, Yumna Sattar Khan

“…AI helps predict the possibility of diseases by evaluating patient data, which enables focused preventive actions and individualized healthcare interventions. …”
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Patient satisfaction with ambulatory care services delivery and respect for patient rights: findings from 2022 national survey in Rwanda by Corneille Killy Ntihabose, Stephenson Musiime, Joy Atwine, Viateur Kalinda, Jean Marie Vianney Nkurikiyintwali, Bienvenu Niyongabo, Kara L. Neil

“…Abstract Background This study evaluated the factors influencing patient satisfaction with hospital services and respect for patient rights in outpatient consultation in Rwanda, aiming to provide insights into improving the overall quality of care. …”
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PHASE 2 MULTICENTER RANDOMIZED CLINICAL TRIAL: NEOADJUVANT CHEMORADIOTHERAPY FOLLOWED BY D2 GASTRECTOMY AND ADJUVANT CHEMOTHERAPY IN PATIENTS WITH LOCALLY ADVANCED GASTRIC CANCER by V. Yu. Skoropad, S. G. Afanasyev, S. V. Gamayunov, N. K. Silanteva, T. A. Agababyan, P. V. Sokolov, S. A. Ivanov, A. D. Kaprin

“…To objectify the results, a multicenter randomized trial was initiated in 2016. the main objective of the study was to assess the immediate efficacy and safety of neoadjuvant chemoradiotherapy using pathological response criteria and to evaluate the frequency/severity of toxic reactions and postoperative complications. …”
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Pre-pregnancy body mass index and risk of macrosomia: glycemic status-specific thresholds and subgroup interactions in a prospective cohort by Yuhang Wu, Hanyu Xiao, Lizhang Chen, Lizhang Chen, Jiabi Qin, Tingting Wang, Tingting Wang

“…This study aimed to quantify glycemic status-specific risk thresholds and explore subgroup interactions in a large prospective cohort.MethodsIn this prospective cohort study, 34,031 women initiating antenatal care before 14 weeks of gestation were enrolled at a tertiary hospital in Central China (2013–2019). …”
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Análisis de la actividad física y la alimentación en estudiantes de Ecuador y la influencia del apoyo familiar e institucional (Analysis of physical activity and nutrition in stude... by Ángel-Freddy Rodríguez-Torres, José-Antonio Marín-Marín, Jesús López-Belmonte, Santiago Pozo-Sánchez

“…The participation of families and educational centers, through specific programs and school policies, is essential to address sedentary lifestyle. Continuously evaluating these initiatives is essential to measure their impact. …”
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Pan-drug, colistin, streptomycin, erythromycin, clindamycin resistant Salmonella enterica serovars isolated from slaughtered cattle and human in mansoura, Egypt by Shimaa El Baz, Hanan Ahmed Zaher, Wafaa Ragab

“…Salmonella isolation was done following standard microbiological techniques. Initially, pre-enrichment of the samples was conducted using buffered peptone water. …”
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Capacitação de agentes comunitários de saúde para a detecção da demência na fase leve [Capacitating community health workers to detect dementia at the mild stage ] [Capacitación de... by Emanuela Bezerra Torres Mattos, Mariana de Castro Barbosa, Rosilda Mendes

“…ABSTRACT Objective: to evaluate the continuing professional development (CPD) process in capacitation of community health workers (CHWs) to detect early dementias. …”
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INVESTIGATION OF THE GENETIC ALTERATIONS IN CDKN2A/B AND IL7R IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA by RMB Lemos, ES Costa, T Ferraz, MT Schramm, MM Lins, MCN Fagundes, ALT Maciel, M Emerenciano

“…Thus, IL7R activation is a crucial event in T-ALL initiation, but its transcriptional profile and prognostic role are still unclear. …”
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Population structure, floral diversity, habitat geography, and conservation status of Himalayan horse chestnut (Aesculus indica) in western Himalayan moist temperate forest ecosyst... by Urwa Irfan, Hamayun Shaheen, Muhammad Manzoor, Muhammad Manzoor, Sidra Nasar, Raja Waqar Ahmed Khan, Syed Waseem Gillani, Syed Waseem Gillani, Abdulwahed Fahad Alrefaei, Arbaz Attique, Asif Kamal, Sarah Abdul Razak, Malik Talha Riaz

“…This study was designed to investigate distribution patterns, community structure, floristic diversity, and phytosociological attributes of A. indica forests, as well as evaluate the habitat geography of species by using GIS analysis. …”
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Prevalence and associated factors of HIV among female sex workers in Eastern and Southern Africa: Systematic review and meta-analysis. by Tigabu Kidie Tesfie, Getaneh Awoke Yismaw, Bantie Getnet Yirsaw, Habtamu Wagnew Abuhay, Meron Asmamaw Alemayehu, Nebiyu Mekonnen Derseh, Gebrie Getu Alemu, Muluken Chanie Agimas

“…The I2 statistic was used to evaluate heterogeneity. Funnel plot and Egger's regression test were utilized to assess the small study effect. …”
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Use of a multidimensional RAPID3 questionnaire to assess the achievement of remission and minimal disease activity in patients with early psoriatic arthritis treated according to T... by E. Yu. Loginova, T. V. Korotaeva, A. D. Koltakova

“…Joint pain measurement, patient (PGA) and physician (PhGA) global assessment on visual analog scale (VAS) was performed, the serum level of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were evaluated. DAS and DAS28, HAQ and RAPID3 functional index were estimated. …”
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Clinical, microbiologic, and immunologic determinants of mortality in hospitalized patients with HIV-associated tuberculosis: A prospective cohort study. by Charlotte Schutz, David Barr, Bruno B Andrade, Muki Shey, Amy Ward, Saskia Janssen, Rosie Burton, Katalin A Wilkinson, Bianca Sossen, Kiyoshi F Fukutani, Mark Nicol, Gary Maartens, Robert J Wilkinson, Graeme Meintjes

“…Antituberculosis therapy was initiated in 566/576 (98.3%) and 487/576 (84.5%) started therapy within 48 hours of enrolment. …”
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Acute pericarditis: features of diagnosis and treatment in real practice by K. M. Beseliia, A. V. Alabushev, S. А. Koroleva, L. L. Opieva, F. A. Eldzharkieva, M. S. Dolgaya, А. R. Gainutdinova, D. G. Gognieva

“…In the discussed study, therapy with NSAIDs, GCS and colchicine was initiated only when antibiotic therapy was ineffective, which is not in accordance with clinical guidelines. …”
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Educational Needs in Geriatric Medicine Among Health Care Professionals and Medical Students in COST Action 21122 PROGRAMMING: Mixed-Methods Survey Protocol by Giulia Ogliari, Tahir Masud, Anna Marie Herghelegiu, Tajana Pavic, Anne Wissendorff Ekdahl, Karolina Piotrowicz, Sofia Duque, Athanase Benetos, Nenad Bogdanovic, Sylvie Bonin-Guillaume, Rachael Frost, Meltem Koca, Anastassia Kossioni, Evrydiki Kravvariti, Nicolas Martínez-Velilla, William McKeown, Regina Roller-Wirnsberger, Sumru Savas, Michael Vassallo, Tamar Yellon, Mirko Petrovic, Marina Kotsani

“…MethodsThe mixed methods electronic survey, initially developed in English through a cocreation process with key stakeholders, was subsequently translated into 24 languages. …”
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Integrative metabolomics and genomics reveal molecular signatures for type 2 diabetes and its cardiovascular complications by Chunxiao Cheng, Yuanjiao Liu, Lingyun Sun, Jiayao Fan, Xiaohui Sun, Ju-Sheng Zheng, Lin Zheng, Yimin Zhu, Dan Zhou

“…Nevertheless, their contributions to these diseases have not been comprehensively evaluated, particularly in East Asian ancestry. This study aims to elucidate the metabolic underpinnings of T2D and its cardiovascular complications and leverage multi-omics integration to uncover the molecular pathways involved. …”
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EFFICACY AND SAFETY OF LUSPATERCEPT IN MYELODYSPLASTIC SYNDROME/NEOPLASM WITH VERY LOW/LOW/INTERMEDIATE RISK REQUIRED TRANSFUSION: A SYSTEMATIC REVIEW AND SINGLEARM META-ANALYSIS by VC Monici, AS Alves, JVM Cunha, DS Ribeiro, AAS Lima, ARR Souto, FS Oliveira, HLRVMD Reis, VC Destefani

“…Luspatercept has been evaluated in several retrospective studies and randomized controlled trials as a promising treatment. …”
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Wildlife law and policy by S. Bertouille

“…Finally, the effectiveness of the regulations should be evaluated in light of their objectives, and where necessary, the regulations should be strengthened or adapted to improve their performance (Van Gossum et al., 2010). …”
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Efficacy and safety of epaminurad, a potent hURAT1 inhibitor, in patients with gout: a randomized, placebo-controlled, dose-finding study by Jae-Bum Jun, Hye-Soon Lee, Sang-Hyon Kim, Seung-Geun Lee, Doo-Ho Lim, Jinhyun Kim, Yong-Beom Park, Mie Jin Lim, Seung-Jae Hong, Hyo-Jin Choi, Shin-Seok Lee, Hyun Ah Kim, Jiwon Hwang, Chang-Hee Suh, Seungwoo Han, Jung-Yoon Choe, Wan-Hee Yoo, Jung Soo Song

“…The aims of the current study were to evaluate the urate-lowering efficacy and safety of epaminurad compared with placebo in patients with gout, and to determine the optimal dose. …”
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Efficacy and safety of anlotinib in combination with ¹³¹I therapy in the treatment of distant metastatic differentiated thyroid cancer: a single-arm, phase II study by Yan Li, Jianjing Liu, Jianjing Liu, Qian Su, Xueyao Liu, Zhen Yang, Zhao Yang, Jie Fu, Yan Zhang, Lina Tong, Fang Yang, Dong Dai, Dong Dai

“…When confirmed iodine uptake in metastatic lesions, anlotinib would be given at 12 mg (QD, 2 weeks on/1 week off, Q3W) initially. One combination treatment cycle consisted of 12 weeks of anlotinib and 1 dose of iodine-131. …”
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