Acute kidney injury and cardiogenic shock severity for mortality risk stratification in patients supported with VA ECMO by Chenglong Li, Yiwen Wang, Xiaomeng Wang, Chengcheng Shao, Meng Xin, Bo Xu, Xing Hao, Ming Jia, Feng Yang, Liangshan Wang, Hong Wang, Xiaotong Hou, Zhongtao Du

“…Methods ans results From January 2018 to December 2020, consecutive adult patients diagnosed with CS and received VA ECMO were retrospectively evaluated. The highest AKI stage within 48 h after ECMO initiation was assessed using the Kidney Disease: Improving Global Outcomes criteria. …”
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Assessment of Women’s Awareness of the Possible Risk of Stroke Associated with the Use of Oral Contraceptives Pills in Saudi Arabia: A Cross-Sectional Study by Fawaz E. Edris, Rehab Ahmed A. Alasiri, Abdullah Faisal Albukhari, Mohammed Arab Sadiq, Wojood Mubarak Alahmadi, Alhanouf Radhyan Alruwaili, Nojuod Fares Alhadidi, Iman Hamid Alenezi, Hussein Talal Sabban, Abdulrahim Gari, Mamdoh Eskandar, Umme Salma, Ahmed Baker A. Alshaikh

“…Addressing this knowledge gap through targeted educational initiatives could help mitigate the risks and improve overall public health outcomes.…”
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Mechanisms and genetic mutations of pyrethroid resistance in Aedes albopictus in the context of urbanization: a case study of Hangzhou, China by Binbin Jin, Binbin Jin, Lingya Wei, Lingya Wei, Tianxiao Duan, Yinghong Wang, Yinghong Wang, Huimin Wang, Huimin Wang, Hui Jin, Hui Jin

“…Resistance to beta-cypermethrin and permethrin were evaluated utilizing the World Health Organization (WHO) tube test methodology. …”
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Effect of chronic kidney disease on adverse drug reactions to anti-tubercular treatment: a retrospective cohort study by Divya Datta, Indu Ramachandra Rao, Attur Ravindra Prabhu, Shankar Prasad Nagaraju, Girish Thunga, Rahul Magazine, Shivashankar Kaniyoor Nagri, Raghavendra Shetty, Nisha Abdul Khader, Dharshan Rangaswamy, Srinivas Vinayak Shenoy, Mohan V. Bhojaraja, Asha Kamath

“…Optimal dosing of ATT in CKD needs to be further evaluated.…”
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Systematic use of protein free energy changes for classifying variants of uncertain significance: the case of IFT140 in Mainzer-Saldino Syndrome by Macarena Gajardo, José Luis Guerrero, Bárbara Poblete, Esperanza Bayyad, Ignacio Castro, Jorge Maturana, Jaime Tobar, Víctor Faúndes, Paola Krall, Paola Krall, Paola Krall

“…Specifically, we systematically analyzed the ΔΔG of MVs in IFT140 to identify those potentially pathogenic and associated with Mainzer-Saldino syndrome (MSS). To this end, we evaluated ΔΔG in IFT140 MVs sourced from ClinVar, gnomAD, and MSS patients, aiming to resolve the diagnosis of MSS in a child with a novel homozygous IFT140 variant, initially reported as a VUS.ResultsIFT140 MVs from MSS patients showed lower ΔΔG values than those reported in gnomAD individuals (−1.389 vs. −0.681 kcal/mol; p = 0.0031). …”
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A multi-omics strategy to understand PASC through the RECOVER cohorts: a paradigm for a systems biology approach to the study of chronic conditions by Jun Sun, Masanori Aikawa, Hassan Ashktorab, Noam D. Beckmann, Noam D. Beckmann, Michael L. Enger, Joaquin M. Espinosa, Xiaowu Gai, Xiaowu Gai, Benjamin D. Horne, Benjamin D. Horne, Paul Keim, Paul Keim, Paul Keim, Jessica Lasky-Su, Rebecca Letts, Cheryl L. Maier, Meisha Mandal, Lauren Nichols, Nadia R. Roan, Nadia R. Roan, Mark W. Russell, Jacqueline Rutter, George R. Saade, George R. Saade, Kumar Sharma, Kumar Sharma, Stephanie Shiau, Stephen N. Thibodeau, Samuel Yang, Lucio Miele, NIH Researching COVID to Enhance Recovery (RECOVER) Consortium

“…The NIH-sponsored “Researching COVID to Enhance Recovery” (RECOVER) initiative includes several retrospective/prospective observational cohort studies enrolling adult, pregnant adult and pediatric patients respectively. …”
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Development of an extended full-time equivalent framework: A workforce metric for the beedi rolling industry in India by Eshwari Kundangar, Muralidhar M. Kulkarni, Yash Alok, Ambigai Rajendran, Satish Kumar, Praveen Kumar, Priyanka Bantwal, Rohith Bhagawath, Ashwath Naik, Praveen Sinha, Mark Goodchild

“…Conclusions The study presents a pilot-tested framework to evaluate beedi rollers’ workload and advocates for improved working conditions. …”
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A novel patient-derived cutaneous melanoma cell line reveals key features of metastatic melanoma by Ana Tomás, Ana Tomás, Lúcia Roque, Inês Francisco, Ana Luísa Silva, Hugo Nunes, Emanuel Gouveia, Elisabete Carvalho, Victor Farricha, Cecília Moura, Joaninha Costa Rosa, Pedro Miguel Garrido, Cristina Albuquerque, Patrícia M. Pereira, M. Guadalupe Cabral, Marta Pojo

“…Gene and protein expression were evaluated by RT-qPCR and immunofluorescence, and cell proliferation was assessed using trypan blue exclusion and BrdU incorporation assays. …”
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Effects of innovative modular prone positioning tools in patients with acute respiratory distress syndrome due to COVID-19 during awake prone position: a prospective randomized con... by Dunbing Huang, Huan Tian, Wei Song, Jiaqi Wang, Zizhe Yao, Lize Xiong, Cai Jiang, Anren Zhang, Xiaohua Ke

“…Methods This prospective randomized controlled study initially enrolled 168 patients with COVID-19 due to ARDS. …”
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Exploring the active ingredients of Banzhilian and its mechanism of action on diabetic Gastric cancer based on network pharmacology by Haikun Cao, Hui Song, Weiguo Zhou, Xiaohu Lv, Xinlei Liu, Zheng Xiang, Rui Fu, Yixian Cheng, Junjie Chen, Shengwei Wang, Yvbo Hu, Huayue Yan, Wenlong You, Changqian Guo, Bo Chen, Guodong Cao, Wei Wang, Jianguang Jia

“…This study aims to explore the mechanism of quercetin, a key component of Banzhilian, through network pharmacology, molecular docking, molecular dynamics (MD) simulation, bioinformatics, and in vitro and in vivo experiments. Initially, core targets and key pathways involved in the treatment of diabetes-associated GC (GC-diabetes) were identified using public databases. …”
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Comparative performance and age dependence of tuberculin and defined antigen bovine tuberculosis skin tests assessed with Bayesian latent class analysis by Matios Lakew, Andrew J. K. Conlan, Biniam Tadesse, Sreenidhi Srinivasan, Bekele Yalew, Teferi Benti, Abebe Olani, Getachew Kinfe, Tigist Ashagrie, Ashebir Abebe, Abebe Fromsa, Musse Girma Abdela, Berecha Bayissa, Solomon Gebre, Adane Mihret, Getnet Abie Mekonnen, Gobena Ameni, Hagos Ashenafi, James L. N. Wood, Balako Gumi, Vivek Kapur

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Assessing HIV-1 subtype C infection dynamics, therapeutic responses and reservoir distribution using a humanized mouse model by Snehal Kaginkar, Leila Remling-Mulder, Ashashree Sahoo, Tejaswini Pandey, Pranay Gurav, Jyoti Sutar, Amit Kumar Singh, Ella Barnett, Sivasankar Panickan, Ramesh Akkina, Vainav Patel

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Viral dynamics and factors associated with duration of COVID-19 positivity: evidence from the first-three epidemiological waves in Cameroon by Joseph Fokam, Aurelie Minelle Kengni Ngueko, Alex Durand Nka, Collins Ambe Chenwi, Ezechiel Ngoufack Jagni Semengue, Yagai Bouba, Désiré Takou, Nadine Fainguem, Michel Carlos Tommo Tchouaket, Aude Christelle Ka’e, Grace Angong Beloumou, Sandrine Claire Djupsa Ndjeyep, Willy Leroi Togna Pabo, Davy-Hyacinthe Gouissi Anguechia, Naomi-Karell Etame, Evariste Molimbou, Rachel Audrey Nayang Mundo, Aissatou Abba, Samuel Martin Sosso, John Otshudiema Otokoye, Christian Ngongang Ouankou, Claudia Alteri, Luna Colagrossi, Maria-Mercedes Santoro, Francesca Ceccherini-Silberstein, Yap Boum, Edie Gregory Halle Ekane, Alfred K. Njamnshi, Vittorio Colizzi, Nicaise Ndembi, Alexis Ndjolo, Carlo-Federico Perno

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Rh-relaxin-2 attenuates oxidative stress and neuronal apoptosis via ERK-nNOS-NO pathway after germinal matrix hemorrhage in rats by Jun Liu, Yonghua Cai, Khalil ur Rahman, Qixiong Zhou, Guangjie Liu, Huibin Kang, Mingzhou Li, Shichao Zhang, Gang Wang, Wenfeng Feng, Xi’an Zhang, Guozhong Zhang, Ye Song, Peng Li

“…Previously study have indicated that relaxin 2 receptor activation initiates anti-oxidative stress and anti-apoptosis in ischemia-reperfusion injury. …”
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Optimizing Nutrition Protocols for Improved Rice Yield, Quality, and Nitrogen Use Efficiency in Coastal Saline Soils by Xiang Zhang, Xiaoyu Geng, Yang Liu, Lulu Wang, Jizou Zhu, Weiyi Ma, Xiaozhou Sheng, Lei Shi, Yinglong Chen, Pinglei Gao, Huanhe Wei, Qigen Dai

“…This study evaluated the effects of one-time application of controlled-release fertilizer (CRF) on rice (<i>Oryza sativa</i> L.) grain yield, grain quality, and agronomic nitrogen use efficiency (ANUE, ANUE (kg/kg) = (Grain yield with N application − grain yield without N application)/N application amount) in coastal saline soils. …”
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Influence of Lifestyle Factors on Ocular Surface Parameters in Relation to Age by Jacobo Garcia-Queiruga, Hugo Pena-Verdeal, Belen Sabucedo-Villamarin, Veronica Noya-Padin, Maria J. Giraldez, Eva Yebra-Pimentel

“…Purpose: To evaluate how Video Display Terminal (VDT) use, Contact Lens (CL) wear, and eyedrop use affect ocular surface parameters in participants with ocular discomfort and how these factors may vary across different age groups. …”
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Impact of the first year of COVID-19 vaccination strategy in Brazil: an ecological study by Fernando A Bozza, Paulo Simões, Silvio Hamacher, Soraida Aguilar, Leonardo S L Bastos, Paula Maçaira, Fernanda Baião, José Cerbino-Neto, Otavio Ranzani

“…Brazil adopted an age-based calendar strategy to reduce mortality and the burden on the healthcare system. This study evaluates the impact of the vaccination campaign in Brazil on the progression of the reported COVID-19 deaths.Methods This ecological study analyses the dynamic of vaccination coverage and COVID-19 deaths in hospitalised adults (≥20 years) during the first year of the COVID-19 vaccination roll-out (January to December 2021) using nationwide data (DATASUS). …”
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Efficacy and safety of modified bleomycin administration with EP chemotherapy in adult male patients with germ cell tumors: a retrospective study by Ditian Shu, Riqing Huang, Meiting Chen, Haifeng Li, Xin An, Cong Xue, Anqi Hu, Fangjian Zhou, Kai Yao, Zhuowei Liu, Yanxia Shi

“…Abstract Background Given the substantial inconvenience caused by weekly bleomycin administration, we initiated a study to evaluate the efficacy and toxicity of the modified bleomycin combined with EP (modified-BEP) regimen in Chinese adult male patients with germ cell tumors (GCTs). …”
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Soil humus and aluminum—iron interactions enhance carbon sequestration and yield sustainability after long-term fertilization in three different soils by Philip T. Singbah, Jing Huang, Imtiaz Ahmed, Mahmoud Abdelaziz, Kiya Adare Tadesse, Nano Alemu Daba, Jiwen Li, Jun Yan, Shujun Liu, Lisheng Liu, Huimin Zhang

“…Methods: A long-term field experiment initiated in 1982 at Qiyang Red Soil Experimental Station in southern China was selected. …”
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MiR-7 inhibits progression of glioblastoma by impairing autophagy resolution, energy metabolism and ECM remodeling by Marta Torrecilla-Parra, Virginia Pardo-Marqués, Antonio C. Fuentes-Fayos, Miguel E. G-García, Mario Fernández-de Frutos, José L. López-Aceituno, Cristina Puigdueta, Carmen Zamora, Ana Pérez-García, Juan F. Aranda, Rebeca Busto, Manuel D. Gahete, Raúl M. Luque, Cristina M. Ramírez

“…In vivo, miR-7 levels were restored in a mouse GBM xenograft model to evaluate its potential therapeutic effect in already established tumors. …”
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