Agricultural GDP exposure to drought and its machine learning-based prediction in the Jialing River Basin, China by Xinzhi Wang, Qingxia Lin, Zhiyong Wu, Yuliang Zhang, Changwen Li, Ji Liu, Shinan Zhang, Songyu Li

“…Additionally, cropland exposure to drought was evaluated using gridded agricultural GDP data derived from pixel interpolation. …”
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HGF decreases ANIT-induced liver damage through modulation of redox status. by Maricruz García-Barrera, Genaro J. Rosales-Muñoz, Alejandro Escobedo-Calvario, Roberto C. Lazzarini-Lechuga, Natalia Nuño-Lámbarri, Luis E. Gómez-Quiroz, Leticia Bucio-Ortiz

“…Mice were sacrificed at 30 h, 36 h, and 48 h post-treatment initiation for liver tissue and serum collection. The collected samples were used for biochemical assays, Western Blot, TBARS, and H&E staining. …”
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Sea ice and mixed layer depth influence on nitrate depletion and associated isotopic effects in the Drake Passage–Weddell Sea region, Southern Ocean by A. P. M. Servettaz, A. P. M. Servettaz, Y. Isaji, C. Yoshikawa, Y. Jang, B.-K. Khim, Y. Ryu, D. M. Sigman, N. O. Ogawa, F. J. Jiménez-Espejo, F. J. Jiménez-Espejo, N. Ohkouchi

“…The timing of sea ice melt date conditions the initiation of nitrate drawdown, but the annual minimum of nitrate only weakly correlates with sea ice concentration. …”
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The bioinformatics analysis and experimental validation of the carcinogenic role of EXO1 in lung adenocarcinoma by Bohao Sun, Jing Zhang, Nan Wang, Zhirong Zhang, Yichen Wu, Mengzhen Xie, Yanmei Peng, Yifan Ye, Zhaochang Jiang, Shumei Wei

“…This study seeks to elucidate the functional significance of EXO1 in LUAD and evaluate its potential as a therapeutic target.Materials and methodsPatient RNA-seq and clinical data were acquired from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. …”
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Methane abatement in Malaysia’s upstream oil and gas sector: A marginal cost analysis for supporting long-term energy transition by Jaya Prasanth Rajakal, Adeline Shu Ting Tan, Mark Lunt, Shareen Yawanarajah, Emily Yen Tse Oi, Viknesh Andiappan, Bing Shen How

“…In support of Malaysia’s net-zero 2050 target and Global Methane Pledge commitment, this study developed a marginal abatement cost (MAC) analysis to evaluate the techno-economic feasibility of methane mitigation strategies across key emission sources. …”
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Neurodegenerative and neuroinflammatory changes in SOD1-ALS patients receiving tofersen by Cecilia Simonini, Elisabetta Zucchi, Ilaria Martinelli, Giulia Gianferrari, Christian Lunetta, Gianni Sorarù, Francesca Trojsi, Roberta Pepe, Rachele Piras, Matteo Giacchino, Federico Banchelli, Jessica Mandrioli

“…Abstract The initiation of tofersen, a new specific antisense oligonucleotide (ASO) for SOD1 pathology, marked a significant turning point for SOD1-ALS patients. …”
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Prevalence, knowledge, attitudes, and practices regarding Chagas disease in Guanare, Venezuela: a cross-sectional study by Iván A. Escalante-Pérez, Ana A. Alviares, Óscar D. Omaña-Ávila, Fhabián S. Carrión-Nessi, Daniela L. Mendoza-Millán, Grecia de J. Erimee-Vieira, Juan M. Contreras-Rengifo, Vanessa C. Sande-Mujica, Mariana de J. de Marchis-Vento, Karim J. Gebran-Chedid, Mario A. Dubuc-Ponte, Daniela I. Castro-Betancourt, Vittoria F. Fuentes-Fiore, Rachell A. Molina-Mendoza, Alejandro M. Loreto-Rodrigues, Juan C. Gomes-González, Luciano Mauriello, Eyleen Moronta, Belkisyolé Alarcón de Noya, Zoraida Díaz-Bello, David A. Forero-Peña

“…Seroprevalence was determined by detecting anti-Trypanosoma cruzi IgG antibodies and assessing specific-IgG avidity enzyme-linked immunosorbent assay (ELISA). Additionally, we evaluated knowledge, attitudes, and practices (KAPs) regarding CD in the region. …”
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A single-institution experience with intraoperative in vivo confocal laser endomicroscopy for brain tumors in 50 patients by Yuan Xu, Thomas J. On, Irakliy Abramov, Oscar Alcantar-Garibay, Joelle N. Hartke, Jennifer M. Eschbacher, Kivanc Yangi, Michael T. Lawton, Kris A. Smith, Randall W. Porter, Mark C. Preul

“…The first informative images were acquired within 10.5 s after the initiation of CLE imaging for each ROI. Mean CLE imaging time per case was 8.6 min. …”
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The use of cannabidiol in patients with Lennox-Gastaut syndrome and Dravet syndrome in the UK Early Access Program: A retrospective chart review study by Christin Eltze, Shaikha Alshehhi, Aisha Al Ghfeli, Kishan Vyas, Seeta Saravanai-Prabu, Gaelle Gusto, Artak Khachatryan, Marta Martinez, Archana Desurkar

“…Purpose: To evaluate clinical outcomes from the UK Early Access Program in patients aged 2–17 years with Lennox-Gastaut syndrome (LGS) or Dravet syndrome (DS) treated with plant-derived highly purified cannabidiol (CBD; Epidyolex®; 100 mg/mL oral solution). …”
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Integrating Body Composition and Nutritional Indices: A Novel Prognostic Tool for Survival in Pancreatic Cancer by Yiting Xu, Yang Chen, Gaowei Jin, Chenrui Yao, Yangyang Wang, Ziyang Wei, Zhihang Cai, Xuanhao Gu, Binbin Deng, Peilu Wang, Yuxiong Feng, Qi Zhang, Tingbo Liang

“…This study aimed to systematically evaluate the synergistic effects of body composition parameters and nutritional index as prognostic indicators in patients with PDAC. …”
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Enhancing early detection of neurological and developmental disorders and provision of intervention in low-resource settings in Uttar Pradesh, India: study protocol of the G.A.N.E.... by Moreno Toldo, Swami Varishthananda, Christa Einspieler, Neeraj Tripathi, Anshu Singh, Surendra K Verma, Kanchan Vishwakarma, Dajie Zhang, Agyeya Dwivedi, Ritika Gupta, Sanjay Karn, Nirmal Kerketta, Ram Narayan, Karuna Nikam Singh, Sumitra Rani, Akanksha Singh, Divyanshu Singh, Krishna Pratap Singh, Navin Singh, Neeraj Singh, Rishi Singh, Shyam P Singh, Rakesh Srivastava, Sandeep Srivastava, Sanjeev Srivastava, Gopal Yadav, Preeti Yadav, Sheshnath Yadav, Sujata Yadav, Peter B Marschik

“…Research objective (3): to evaluate the interscorer agreement of GMA.Ethics and dissemination G.A.N.E.S.H. received ethics approval from the Indian Government Chief Medical Officers of Varanasi and Mirzapur and from the Ramakrishna Mission Home of Service in Varanasi. …”
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Insights from expert elicitation: prioritising pathogens for genome sequencing for Australian public health responseResearch in context by Tehzeeb Zulfiqar, Angeline Ferdinand, Danielle Cribb, Patiyan Andersson, Alireza Zahedi, Kathryn Glass, Son Nghiem, Susan Trevenar, Nhung Mai, Benjamin P. Howden, Martyn D. Kirk

“…Methods: We conducted a modified Delphi study with experts in public health, infection prevention, and pathogen genomics to examine both prioritisation mechanisms, selection criteria and specific pathogen rankings across surveillance contexts. Initially, 38 experts evaluated 89 statements on a 5-point Likert scale with accompanying feedback. …”
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Urinary DcR2/Cr level predicts renal outcomes in patients with diabetic kidney disease by Jia Chen, Weidong Wang, Fang Yu, Xiaoyue Wang, Yani He, Kehong Chen

“…Kaplan–Meier survival analysis and multifactorial Cox regression models evaluated the association between uDcR2 levels and renal outcomes. …”
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Cladribine tablets as therapy for advanced relapsing-remitting multiple sclerosis: a 4-year follow-up real-world, multi-center, retrospective, cohort study by Aleksandra Pogoda-Wesołowska, Adam Stępień, Marcin Wnuk, Monika Marona, Elżbieta Tokarz-Kupczyk, Karolina Piasecka-Stryczyńska, Konrad Rejdak, Anna Jamroz-Wiśniewska, Monika Adamczyk-Sowa, Katarzyna Kubicka-Bączyk, Iwona Kurkowska-Jastrzębska, Katarzyna Kurowska, Przemysław Puz, Alina Kułakowska, Monika Chorąży, Waldemar Brola, Halina Bartosik-Psujek

“…This study is aimed to evaluate the long-term efficacy of CladT in population of Polish RRMS patients, with more advanced disease.MethodsThis retrospective observational study included patients with RRMS who started CladT treatment between December 2019 and November 2023. …”
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Trigonella foenum-graecum L. protects against renal function decline in a mouse model of type 2 diabetic nephropathy by modulating the PI3K-Akt-ERK signaling pathway by Yang Niu, Hongjuan Niu, Luxuan Chi, Peihang Li, Jiyang Du, Xiaoqian Wang, Xu He, Binan Lu, Zongran Pang

“…This study aims to enhance the understanding of HLB’s pharmacodynamic effects and elucidate the mechanisms underlying its therapeutic potential in DN.MethodsThe pharmacodynamic effects of HLB were initially evaluated in a murine DN model through the oral administration of an aqueous extract of HLB. …”
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Epidemiological investigation of venomous snakebites in Yunnan Province by Qinfen Gao, Yajun Teng, Chao Xiao, Rui Zeng, Bin Han, Hong Gao, Jianhai Wang, Xiaoyan Li, Canju Yang, Jianneng Dai, Chunxi Li, Qunyan Huang, Zengzheng Li, Wei Zhang

“…Yunnan Province, The lack of comprehensive epidemiological data on snakebite in Yunnan affects research, diagnostic, and treatment advancements. This research evaluates patient demographics, seasonal patterns, snake species associated with the disease, and treatment approaches to guide preventative and therapeutic initiatives in the province.MethodsThis retrospective analysis reviewed clinical records of venomous snakebite cases admitted to hospitals in 16 cities within Yunnan Province from January 2022 to November 2024. …”
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Patterns of Opportunistic Infections and Antiretroviral Therapy Efficacy in Newly Diagnosed Human Immunodeficiency Virus-1 Patients: A Descriptive Study in India by N Kisenjang, Sumit Arora, Pooja Sangwan, Imam D Khan, Charu Mohan, Anmol Sharma, Vikram Sharma, Ankit Rao, Aditya Puniyani, Shivani Sangwan, Alisha Sharma, Swati Jain, Anuradha Makkar, Preeti Badhan, H Vanalahruaii

“…This study investigates the clinical presentation, management, and outcomes of HIV patients with OIs and evaluates the effectiveness of antiretroviral therapy (ART). …”
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Insights into the transformations, antimicrobial activity, and degradation efficiency of a representative carbapenem antibiotic by high-frequency ultrasound hybridized with the (ph... by Efraím A. Serna-Galvis, Kevin P. Celis-Llamoca, Ingrit E. Collantes-Díaz, Ricardo A. Torres-Palma, Jessica I. Nieto-Juárez

“…Afterward, the MERO treatment by the hybridized sono-photo-Fenton process (i.e., ultrasound combined with Fe2+ and UVA light) was evaluated, showing that the degradation efficiency was higher than by the sono-Fenton or photolysis (indeed, a synergistic index of 1.11 was obtained). …”
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Targeting DNA helicase CMG complex and NFκB2-driven drug-resistant transcriptional axis to effectively treat KRASG12D-mutated pancreatic cancer by Jeffrey Xiao, Joshua Kim, Brandon Park, David J. Baylink, Cedric Kwon, Victoria Tran, Scott Lee, Kevin Codorniz, Laren Tan, Pamela Lobo Moreno, Amy Schill-Depew, Saied Mirshahidi, David De Semir, Diana Hanna, Kiran Naqvi, Huynh Cao, Chien-Shing Chen, Joanne Xiu, Heinz-Josef Lenz, Hamid Mirshahidi, Mark E Reeves, Yi Xu

“…To address reported resistance to MRTX, we adapted our anti-leukemia co-targeting strategy and evaluated a combination of MRTX and Bedaquiline (BED), an FDA-approved inhibitor of mitochondrial ATP production, in in vitro human PDAC models. …”
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Mesenchymal stromal cells promote the formation of lung cancer organoids via Kindlin-2 by Zhilin Sui, Xianxian Wu, Jiaxin Wang, ShihJye Tan, Chao Zhao, Zhentao Yu, Chuanyue Wu, Xiaoxiao Wang, Ling Guo

“…Results Our findings demonstrate that the addition of MSCs/fibroblasts to three tumor samples, initially incapable of forming organoids by traditional methods, successfully facilitated the cultivation of tumor organoids. …”
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