Effectiveness of a specialist palliative home care nurse–patient consultation followed by an interprofessional telephone case conference compared with usual care among patients wit... by Judith Dams, Hans-Helmut König, Tim Friede, Nils Schneider, Stephanie Stiel, Martin Scherer, Silke Böttcher, Gabriella Marx, Ingmar Schäfer, Nadine Janis Pohontsch, Hendrik van den Bussche, Friedemann Nauck, Michael Freitag, Eva Hummers, Tina Mallon, Franziska Schade, Manuel Zimansky, Thomas Asendorf, Christiane A Mueller

“…Intervention will be evaluated after the observation period using qualitative methods.Ethics and dissemination The responsible ethics committees of the cooperating centres approved the study. …”
Get full text

Patient knowledge, attitudes and behaviors related to antimicrobial use in South African primary healthcare settings: development and testing of the CAMUS and its implications by Nishana Ramdas, Thobani Biyela, Mapula Thema, Mncengeli Sibanda, Tiyani Milta Sono, Tiyani Milta Sono, Stephen M. Campbell, Stephen M. Campbell, Natalie Schellack, Brian Godman, Brian Godman, Brian Godman, Johanna C. Meyer, Johanna C. Meyer

“…A feasibility assessment was also conducted to evaluate the practical use of CAMUS in PHC settings.ResultsParticipants demonstrated varied knowledge of antimicrobial use. …”
Get full text

SNRPB/CCNB1 axis promotes hepatocellular carcinoma progression and cisplatin resistance through enhancing lipid metabolism reprogramming by Xin Jin, Xigan He, Runze Huang, Qinyu Liu, Lei Wang, Xuanci Bai, Yibin Wu, Yixiu Wang, Ziting Jiang, Yi Shi, Gautam Sethi, Lu Wang, Weiping Zhu

“…Complementary in vivo experiments and metabolic assays were conducted to explore the relationship between tumor growth and lipid metabolism further. Additionally, evaluations of cisplatin sensitivity were performed, providing an in-depth analysis of influence of SNRPB on HCC. …”
Get full text

Spatiotemporal Dynamic Changes of Cropland in Rich and Coarse Sediment Areas of Middle Yellow River Basin Based on Multi-source Data Fusion Products by LI Shuchang, GUO Zheng, ZHANG Fengbao, LUO Jiaru, LI Xuantian, SHEN Nan, YANG Mingyi

“…Accurately quantifying the spatiotemporal dynamic changes of cropland in this region is crucial for evaluating regional food security, ecological restoration benefits, soil erosion conditions, and the downstream tranquility of the Yellow River. …”
Get full text

Diagnostic value of the wnt target and cancer-associated blood biomarker hPG80: ONCOPRO case-control prospective study by Benoit You, Sebastien Couraud, Philippe Ceruse, Lionel Badet, Philippe Paparel, Alice Durand, Marielle Guillet, Philippe Merle, Gaelle Lescuyer, Charles-André Philip, Francois Ducray, Mathieu Pioche, Lionel Karlin, Jean-Christophe Lifante, Olivier Glehen, Pierre-Adrien Bolze, Marion Chauvenet, Carole Langlois-Jacques, Fabien Subtil, Marie Piecyk, Aurore Carrot, Dominique Joubert, Alexandre Prieur, Berengere Vire, Sara Calattini, Lea Payen

“…Abstract Background hPG80 (circulating progastrin), initially recognized for its oncogenic properties due to its direct link to the Wnt signaling pathway, is secreted by cancer cells and detectable in the blood of cancer patients. …”
Get full text

The effect of mepolizumab dosage form on treatment outcomes in severe asthma by Martina Vetchá, Kateřina Kubová, Constantinos Glynos, Sylvie Pavloková, Irena Krčmová, Irena Krčmová, Eva Voláková, Eva Voláková, Ondřej Fibigr, Ondřej Fibigr, Beáta Hutyrová, Beáta Hutyrová, Alena Vlachová, Jiří Zeman, David Vetchý

“…The results were statistically evaluated using exacerbation rate (ER), asthma control test, forced expiratory volume, blood eosinophil count, and required systemic oral corticosteroid (OCS) daily dose.ResultsThree months after initiation of administration, all methods showed improvement compared to the values at the beginning of treatment, with ER decreasing from a median of 4 to 0. …”
Get full text

Lack of canonical activities of connexins in highly aggressive human prostate cancer cells by Catalina Asencio, Loreto Véliz, Emilia Flores-Faúndez, Lorena Azócar, Carolina E. Echeverría, Verónica Torres-Estay, Viviana Orellana, Catalina Ramírez-Santelices, Paula Sotomayor, Jorge Cancino, Bredford Kerr, Ainoa Fernandez-Olivares, Mauricio A. Retamal, Juan C. Sáez, Alejandro S. Godoy

“…In addition, GJ and HC activities were evaluated in the PCa cell lines using dye coupling and dye uptake assays, respectively. …”
Get full text

Longitudinal Immunological Analysis of Portuguese Healthcare Workers Across the COVID-19 Pandemic Reveals Differences in the Humoral Immune Response to Vaccines by Luísa Vilela, Anabela Silva, Alberta Cruz, Madalena Sousa, Margarida Costa, Fernando Fonseca, Susana Campino, Taane G. Clark, Anabela Miranda

“…The kinetics of anti-spike antibody production were evaluated until 56 days on average after the third dose (booster). …”
Get full text

In Vitro Efficacy of Ceftazidime-avibactam Against blaOXA-48-producing Klebsiella pneumoniae Isolates by Yasemin ÇAĞ, Mücahide Esra KOÇOĞLU, Hülya ÇAŞKURLU, Demet HACISEYİTOĞLU, Hasan Cenk MİRZA, Aylin ÜSKÜDAR GÜÇLÜ, Rıza Aytaç ÇETİNKAYA, Haluk VAHABOĞLU

“…Ceftazidime-avibactam time-kill kinetics were evaluated in multiples of MIC. There was a decrease of ≥3-log10 in CFU/ml count at a concentration of 8, 16, and 32 MIC at 6 hours. …”
Get full text

Predicting postoperative malnutrition in patients with oral cancer: development of an XGBoost model with SHAP analysis and web-based application by Lixia Kuang, Lixia Kuang, Jingya Yu, Yunyu Zhou, Yu Zhang, Yu Zhang, Guangman Wang, Guangman Wang, Fangmin Zhang, Grace Paka Lubamba, Grace Paka Lubamba, Xiaoqin Bi, Xiaoqin Bi

“…Nutritional risk was assessed via the Nutritional Risk Screening 2002 (NRS-2002) tool and diagnosed via the Global Leadership Initiative on Malnutrition (GLIM) criteria. Model performance was evaluated on the basis of discrimination, calibration, and clinical applicability, with SHAP analysis used for interpretability. …”
Get full text

Lefitolimod in Combination with Ipilimumab in Patients with Advanced Solid Tumors: A Phase I Trial by Mirella Nardo, Mohamed A. Gouda, Matthew J. Reilley, Amadeo B. Biter, Joann Lim, Stacie A. Bean, Ly M. Nguyen, Priya R. Bhosale, Casey R. Ager, Coline A. Couillault, Sarina A. Piha-Paul, Siqing Fu, Apostolia M. Tsimberidou, Timothy A. Yap, Aung Naing, Jordi Rodon, Vivek Subbiah, Daniel D. Karp, Michael A. Curran, David S. Hong

“…Methods This was a single-center, open-label, investigator-initiated phase I trial conducted at The University of Texas MD Anderson Cancer Center. …”
Get full text

Trial to compare mixed-use (multi-use and single-use) intermittent catheter management with single-use management over 12 months (The MultICath Trial): protocol for a non-inferiori... by Isabel Reading, Jeremy Jones, Gillian Watson, Paul Little, Michael Moore, Carl R May, Suzanne Hagen, Doreen McClurg, Karen Guerrero, Jacqui Prieto, Nina Wilson, Carol Shields, Mandy Fader, Bridget Clancy, Margaret Macaulay, Thomas J Chadwick, Brian S Buckley, Rajvinder Khasriya, Alaa Abouhajar, Catherine P James, Nicola Goudie, Sylvia Dickson, Miriam R Avery, Jackie Broadbridge, Alan Cottenden, Cathy Murphy, Anthony Timoney, Sandra A Wilks

“…Introduction Evaluating the safety and acceptability of reusing catheters for intermittent catheterisation (IC) is one of the top 10 continence research priorities identified by the UK James Lind Alliance Priority Setting Partnership in 2008. …”
Get full text

Adaptation of the ‘’Food Allergy Self-Efficacy Scale for Parents’’(FASE-P) to Turkish: a validity and reliability study by Nilay Çalışkan, Şeyma Genç, Güler Yıldırım, Hamit Bologur, Hilal Güngör, Merve Karaca Şahin, Muhammed Fatih Erbay, Şefika İlknur Kökcü Karadağ, Özlem Terzi, Deniz Özçeker

“…Results. T-FASE-P scale initially contained 21 items, and the Cronbach’s alpha coefficient (α) calculated in this form was found to be 0.89. …”
Get full text

The role of heparan sulfate in enhancing the chemotherapeutic response in triple-negative breast cancer by Jasmine M. Manouchehri, Jharna Datta, Lynn M. Marcho, Jesse J. Reardon, Daniel Stover, Robert Wesolowski, Uma Borate, Ting-Yuan David Cheng, Patrick M. Schnell, Bhuvaneswari Ramaswamy, Gina M. Sizemore, Mark P. Rubinstein, Mathew A. Cherian

“…In addition, we examined breast-cancer-initiating cell populations using tumorsphere formation efficiency assays on treated cells. …”
Get full text

Citizen science platforms can effectively support early detection of invasive alien species according to species traits by Pablo González‐Moreno, Ana A. Anđelković, Tim Adriaens, Christophe Botella, Jakovos Demetriou, Rita Bastos, Sandro Bertolino, Celia López‐Cañizares, Franz Essl, Živa Fišer, Milka Glavendekić, Marc Herremans, Philip E. Hulme, Viola Jani, Dimitra Katsada, Periklis Kleitou, Nicola La Porta, Katharina Lapin, Marta López‐Darias, Vanessa Lozano, Angeliki F. Martinou, Damiano Oldoni, Esra Per, Stephanie Rorke, Helen E. Roy, Karl‐Manfred Schweinzer, Kristijn Swinnen, Elena Tricarico, Joana R. Vicente, Maarten de Groot, Michael J. O. Pocock

“…We recommend that IAS surveillance programmes should be better connected with citizen science platforms, including greater acknowledgement of the role of citizen scientists and better data flow from smaller citizen science initiatives into global databases, to support efficient early detection. …”
Get full text

Updating the genomic and clinicopathologic features of thoracic SMARCA4-deficient undifferentiated tumor: a mini-series including a long-term survivor by Kenneth Ofori, Carlos Pagan, Marie C. Smithgall, Asma Salah Jadalla, Swikrity Upadhyay Baskota, John P. Crapanzano, Susan Hsiao, Mahesh M. Mansukhani

“…We sought to update the literature on the clinicopathologic and genomic characteristics of thoracic SMARCA4- dUT.MethodsWe searched for cases diagnosed in our institution, reviewed clinical data, performed comprehensive genomic analysis, and evaluated immunomorphologic features.ResultsFour cases (three males and one female) were identified at a median age of 61.5 years (range, 49–72 years), all with smoking history. …”
Get full text

QTL Mapping and Candidate Gene Analysis for Cotton Fiber Quality and Early Maturity Using F₂ and F₃ Generations by Xiaoyun Jia, Jijie Zhu, Hongxia Zhao, Linglei Kong, Shijie Wang, Miao Li, Guoyin Wang

“…Three genes located in the QTL regions were identified based on their high expression levels in the three evaluated RNA-seq datasets. <i>Ghir_A04G014830.1</i>, covered by qHNFFB-A4-1 and qFU-A4-1, encoded ACLA-1. …”
Get full text

Long‐term interventions by conservation and development projects support successful recovery of tropical peatlands in Amazonia by Eurídice N. Honorio Coronado, Julio Grández Rios, Jhon delÁguila Pasquel, Gerardo Flores Llampazo, Cesar J. Córdova Oroche, José Reyna Huaymacari, C. Gabriel Hidalgo Pizango, Luis Freitas Alvarado, Ulises Pipa Murayari, Gonzalo Isla Reátegui, Chris López Álvarez, Eva Loja Aleman, Emiliana Isasi‐Catalá, Joaquín Gutierrez‐Sotelo, Frederick C. Draper, Margarita delAguila Villacorta, Timothy R. Baker, Dennis delCastillo Torres, Kenton de laCruz Gamarra, Daniel Escobedo Guerra, Ian T. Lawson, Manuel Martín Brañas, Estela P. Martinez Gonzales, Jacqueline Ramirez Chávez, Katherine H. Roucoux

“…We demonstrate how long‐term conservation and development initiatives can lead to successful outcomes for rural communities and peatland ecosystems. …”
Get full text

Real-World Validity of Tissue-Agnostic Circulating Tumor DNA Response Monitoring in Lung Cancers Treated With Chemotherapy, Immunotherapy, or Targeted Agents by Anne C. Chiang, MD, PhD, Russell W. Madison, MS, Zoe June Assaf, PhD, Alexander Fine, PhD, Yi Cao, PhD, Ole Gjoerup, PhD, Yanmei Huang, PhD, Dexter X. Jin, PhD, Jason Hughes, PhD, Vladan Antic, MD, PhD, Amanda Young, PhD, David Fabrizio, MS, David Shames, PhD, Sophia Maund, PhD, Alexia Exarchos, MPH, Shailendra Lakhanpal, MD, Richard Zuniga, MD, Lincoln W. Pasquina, PhD, Katja Schulze, PhD

“…Introduction: Circulating tumor DNA (ctDNA) monitoring is emerging as a minimally invasive complement to tumor imaging. We evaluated the validity of tissue-agnostic ctDNA quantification across four treatment modalities in NSCLC and SCLC. …”
Get full text

Study of the immunological efficacy and safety of a candidate vaccine against Lassa hemorrhagic fever by O. Popova, O. V. Zubkova, T. A. Ozharovskaia, D. I. Zrelkin, D. V. Voronina, P. P. Goldovskaya, V. Yu. Kan, I. V. Dolzhikova, A. V. Kovyrshina, D. M. Grousova, I. A. Ermolova, D. V. Shcheblyakov, D. Yu. Logunov, A. L. Gintsburg

“…The aim of this study was to develop and evaluate the immunobiological properties and preclinical safety of a candidate vaccine for the prevention of Lassa hemorrhagic fever (LHF) based on recombinant human adenoviral vectors. …”
Get full text