Long-Term Therapeutic Effects of ²²⁵Ac-DOTA-E[c(RGDfK)]₂ Induced by Radiosensitization via G2/M Arrest in Pancreatic Ductal Adenocarcinoma by Mitsuyoshi Yoshimoto, Kohshin Washiyama, Kazunobu Ohnuki, Ayano Doi, Miki Inokuchi, Motohiro Kojima, Brian W. Miller, Yukie Yoshii, Anri Inaki, Hirofumi Fujii

“…DNA damage responses (γH2AX and 53BP1) were detected using flowcytometry or immunohistochemistry analysis. …”
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Población reproductora de milano real Milvus milvus L., 1758 en Gipuzkoa en 2024 by Mikel Olano, Beñat Lardiazabal, Fermin Ansorregi, Jon Ugarte, Haritz Beñaran, Roberto Hurtado, Aitor Galdos, Olatz Anaya, Imanol Biain, Aitzol Urruzola, Tomás Aierbe, Egoitz Alkorta, Iker Novoa, Mari J. Azurmendi, Esteban Iriarte, Jose M. Olasagarre, Igor Elorza, Juan Arizaga

“…Overall, 61 territories (pairs) were detected, with a higher concentration found in the southeastern sector of the province. …”
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The antioxidant role of low molecular metabolites and polyphenol oxidase of bryophytes in post-technogenic territories by Oksana Baik, Roman Sokhanchak, Vasyl Humenyuk

“…Based on the research results, it can be assumed that the existence of P. imbricatulum and C. introflexus in post-technogenic territories initiates adaptogenesis and leads to the formation of mechanisms of moss resistance to the action of stress factors, which are based on nonspecific protective reactions that ensure the adaptation of the plant organism to changing environmental conditions.…”
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ON DISCRETE STRUCTURE OF GEOLOGIC MEDIUM AND CONTINUAL APPROACH TO MODELING ITS MOVEMENTS by Sh. A. Mukhamediev

“…Two basic opinions are considered in the framework of the discussion: (1) an initially homogeneous and continuous geologic medium acquires the structure composed of blocks in the process of the geologic medium’s deformation/destruction/degradation, and (2) a geologic medium is composed of blocks (and often has hierarchic, active, energy-saturated features), and the continuity model is thus not valid for describing the geologic medium’s deformation. …”
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Coronary atherosclerosis screening in asymptomatic adults using coronary artery calcium for cardiovascular prevention: a systematic review of randomised controlled trials and prosp... by Manuel R Blum, Nicolas Rodondi, Baris Gencer, Christoph Gräni, Victor Scheu, Louhai Alwan

“…Interventions following CACS were also heterogeneous, ranging from simply communicating results to participants to initiating statin therapy for detectable CACS. One RCT demonstrated improvement regarding blood pressure (BP) (n=2137; change in systolic BP: CACS: −5 mm Hg; control: −7 mm Hg; p=0.02), several an improvement in blood lipids between groups (five studies, n=3693; eg, low-density lipoprotein (LDL) cholesterol: range −6.0 to −4.9 mg/dL). …”
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Storage Stability and Lipidomic Analysis Reveal the Effect of Frozen Storage Temperature on Pacific Saury (<i>Cololabis saira</i>) by Ling Zhao, Shanyu Wang, Qi Liu, Rong Cao, Yating Zhang, Dong Su, Yueqin Yu

“…During the freezing process, TG expression was significantly down-regulated, and TG(18:4_14:0_20:5), TG(20:5_13:0_22:6), TG(22:6_14:1_22:6), and TG(18:4_13:0_22:6) were the most predominant individuals. The CK group was initially present in <i>C. saira</i> before storage. …”
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Immune response dynamics to SARS-CoV-2 in the Albanian population: A study on T-cell and antibody interactions during the transition from pandemic to endemic phase by Genc Sulcebe, Erkena Shyti, Jonida Dashi-Pasholli, Margarita Kurti, Haijuan Wang

“…IFN-γ positivity was detected in 95.1% (156/164), and anti-S1 IgG positivity in 93.3% (153/164). …”
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Frequency of hyperglycemia and polymorphism of TNF and TP53 genes in patients with acute pancreatitis, chronic pancreatitis, pancreatic cancer by I. N. Grigor’eva, O. V. Efimova, A. A. Gurazheva, V. N. Maksimov

“…BACKGROUND: «The vicious circle» of associations of diabetes mellitus (DM) with pancreatic pathology, when pancreatic diseases can initiate DM, and type 2 DM — cause functional and organic pancreatic pathology, determines the search for possible associations. …”
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Operationalizing Human Health Indicators to Link with Ecosystem Changes of Water Streams: An OneAquaHealth Protocol by Marilena ANASTASAKI, Catherine CHRONAKI, Anne MOEN, Eleni KOKINOU, Stratos KOKOLAKIS, Matenia KARAGIANNIDOU, May-Linn MØRK, Silje HENNI

“…Among the  aims of the OneAquaHealth project is to set up a framework to detect and monitor human health outcomes linked to ecosystem changes in urban streams in five European cities (Coimbra, Benevento, Toulouse, Ghent, Oslo, Heraklio). …”
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An integrated physiological indicator and transcriptomic analysis reveals the response of soybean buds to high-temperature stress by Jiajia Li, Meiyan Wu, Haoran Chen, Wei Liao, Shu Yao, Ying Wei, Heng Wang, Qun Long, Xiaoyu Hu, Wei Wang, Guoji Wang, Lijuan Qiu, Xiaobo Wang

“…After HT treatment, changes in physiological indicators including hypocotyl length, enzyme activity and hormone content were detected; at the same time, the cotyledons, hypocotyls, and main roots were collected for transcriptome sequencing analysis. …”
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Umbilical mesenchymal stem cells mitigate T-cell compartments shift and Th17/Treg imbalance in acute ischemic stroke via mitochondrial transfer by Shuna Chen, Chao Han, Zihan Shi, Xin Guan, Liyuan Cheng, Liang Wang, Wei Zou, Jing Liu

“…Abstract Background Acute ischemic stroke (AIS) initiates secondary injuries that worsen neurological damage and hinder recovery. …”
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SGLT2 inhibitor with and without ALDosterone AntagonIst for heart failure with preserved ejection fraction: Design paper by João Pedro Ferreira, Francisco Vasques‐Nóvoa, Francisca Saraiva, Ana C. Oliveira, Jorge Almeida, Ana Beatriz Batista, Arsénio Barbosa, Ana Filipa Ferreira, Cátia Costa, Diogo Santos‐Ferreira, Fernando Friões, Cândida Goncalves, João Tiago Guimarães, Marta Leite, Pedro Marques, Joana Mascarenhas, Maria Inês Matos, Catarina Pereira, Pedro Rodrigues, Abhinav Sharma, Gualter Silva, Inês Pereira‐Sousa, Carla Sousa, Faiez Zannad, Joana Pimenta, Ricardo Fontes‐Carvalho, Adelino Leite‐Moreira

“…A sample size of 108 patients was estimated to provide 80% power, at a 0.05 alfa level, to detect a 0.15 LogNT‐proBNP difference between the spironolactone/dapagliflozin combination and dapagliflozin alone sequence. …”
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In-depth characterization of vaccine-induced neoantigen-specific T cells in patients with IDH1-mutant glioma undergoing personalized peptide vaccination by Martin Glas, Florian Battke, Dirk Hadaschik, Martin Schulze, Saskia Biskup, David Reardon, Christina Kyzirakos, Simone Kayser, Oliver Bartsch, Armin Rabsteyn, Henning Zelba, Borong Shao, Annekathrin Reinhardt, Carsten Greve, Lisa Oenning, Pauline Latzer, Tabea Riedlinger, Julian Wünsche, Johannes Harter, Magdalena Feldhahn, Yannick Bantel, Janina Johänning, Jiri Ködding, Olga Maksimovic, Veit Scheble, Alexandra M Miller, Michael Castro, Deborah T Blumenthal

“…Subsequent T cell receptor (TCR) repertoire sequencing revealed that CD4+T cells reacting on mutIDH1 stimulation were polyclonal. Strikingly, we detected two mutIDH1-specific TCRβ candidate sequences in three different patients. …”
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Ibrutinib in the Treatment of Refractory Chronic Lymphocytic Leukemia by EA Nikitin, EA Dmitrieva, MA Panteleev, EI Emelina, VL Ivanova, YuB Kochkareva, EG Arshanskaya, IE Lazarev, EE Markova, LA Mukha, NG Novitskaya, MM Pankrashkina, VV Glazunova, AV Shubina, SA Chernysh, NK Khuazheva, EV Naumova, SA Lugovskaya, ME Pochtar’, TN Obukhova, OYu Vinogradova, GE Gendlin, VV Ptushkin

“…Deletion of 17p/TP53 mutations were detected in 29 (33 %) of 87 patients. Seventy patients had refractory CLL. …”
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Pulmonary and functional hallmarks after SARS-CoV-2 infection across three WHO severity level-groups: an observational study by Patrícia Blau Margosian Conti, Maria Ângela Gonçalves Oliveira Ribeiro, Carla Cristina Souza Gomez, Aline Priscila Souza, Daniela Souza Paiva Borgli, Eulália Sakano, Mauro Alexandre Pascoa, Silvana Dalge Severino, Tayná Castilho, Fernando Augusto Lima Marson, Fernando Augusto Lima Marson, Fernando Augusto Lima Marson, José Dirceu Ribeiro, UNICOVID Study Group, Adyléia Aparecida Dalbo Contrera Toro, Aline Cristina Gonçalves, Andrea de Melo Alexandre Fraga, André Moreno Morcillo, Andressa Oliveira Peixoto, Andrei Carvalho Sposito, Bianca Aparecida Siqueira, Emília Silva Gonçalves, Emília Raposo Nascimento, Gil Guerra Junior, Jenniffer Tayna Orzechowski Furtado, Lucas Rodrigues de Moraes, Maria de Fatima Corrêa Pimenta Servidoni, Mariana Zorron, Marcos Tadeu Nolasco da Silva, Maíra Seabra Assumpção, Milena Baptistela Grotta, Renan Marrichi Mauch, Simone Appenzeller, Thiago Luís Infanger Serrano

“…The consequences of this inflammatory process impact overall function, which can be detected through both short- to long-term assessments. …”
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Long-term results of a randomized controlled trial of biosimilar CT-P16 and reference bevacizumab in patients with metastatic or recurrent non-small cell lung cancer by Zoran Andric, Fedor Moiseenko, Tamta Makharadze, Alona Oleksiienko, Eduardo Yañez Ruiz, SungHyun Kim, KeumYoung Ahn, TaeHong Park, Hana Ju, Eric Hyungseok Baek, Soonbum Kwon, IlSung Chang, SinHye Kim, HyunAh Kim, EunKyung Lee, Claire Verschraegen

“…No new safety signals were detected. Conclusions: Long-term results of the CT-P16 3.1 study confirm equivalent efficacy of CT-P16 and EU-bevacizumab in patients with metastatic or recurrent non-squamous NSCLC. …”
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Immunotherapy combining tumor and endothelium cell lysis with immune enforcement by recombinant MIP-3α Newcastle disease virus in a vessel-targeting liposome enhances antitumor imm... by Lei Li, Feng-Ying Huang, Jin-Yan Wang, Shu-Zhen Dai, Ying-Ying Lin, Guang-Hong Tan, Hengyu Chen, Cai-Chun Wang, Wu-Ping Zheng

“…MIP-3α, HMGB1, IgG, and ATP were detected by western blotting or ELISA. The chemotaxis of DCs was examined by Transwell chambers. …”
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Preferential transmission of minority and drug-resistant clones in polyclonal infections in Mali by Leen N. Vanheer, Emilia Manko, Almahamoudou Mahamar, Jody Phelan, Koualy Sanogo, Youssouf Sinaba, Sidi M. Niambele, Adama Sacko, Sekouba Keita, Ahamadou Youssouf, Makonon Diallo, Harouna M. Soumare, Kjerstin Lanke, Djibrilla Issiaka, Halimatou Diawara, Sekou F. Traore, Lynn Grignard, Alassane Dicko, Chris Drakeley, Susana Campino, William Stone

“…These observations mirror the rapid decline in asexual parasite density that occurs after ACT initiation, and the more persistent circulation of gametocytes. …”
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Fertility programs for lactating dairy cows: A novel presynch + timed artificial insemination program (Double E-Synch) produces similar ovarian dynamics, synchronization, and ferti... by Carlos E.C. Consentini, Tattiany Abadia, Juan P.A. Galindez, Ana L.M. Lopes, Pedro P.C. Ferro, Yasmim E. Pazini, Natalia V. Faria, Fernando Machado, Tuanne Capella, Tiago N. dos Santos, Marcelo Duarte, Paulo P. Ferreira, Luiz M.F. Matos, Danilo R. Ferreira, Ernane Campos, Alexandre Prata, Leonardo F. Melo, Milo C. Wiltbank, Roberto Sartori

“…The PreP4/E2 presynch was initiated on d −17 with a used 2-g progesterone (P4) insert, which was removed on d −10, together with 0.5 mg of PGF and 1 mg of estradiol (E2) cypionate (EC). …”
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The Abundance and Properties of Barred Galaxies out to z ∼ 4 Using JWST CEERS Data by Yuchen Guo, Shardha Jogee, Eden Wise, Keith Pritchett Jr., Elizabeth J. McGrath, Steven L. Finkelstein, Kartheik G. Iyer, Pablo Arrabal Haro, Micaela B. Bagley, Mark Dickinson, Jeyhan S. Kartaltepe, Anton M. Koekemoer, Casey Papovich, Nor Pirzkal, L. Y. Aaron Yung, Bren E. Backhaus, Eric F. Bell, Rachana Bhatawdekar, Yingjie Cheng, Luca Costantin, Alexander de la Vega, Mauro Giavalisco, Nimish P. Hathi, Benne W. Holwerda, Peter Kurczynski, Ray A. Lucas, Bahram Mobasher, Pablo G. Pérez-González, Fabio Pacucci

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