Comparison of two combined drug therapy regimens for renal damage in patients with metastatic kidney cancer after previously performed unilateral nephrectomy by K. S. Titov, M. V. Epifanova, A. A. Alimov, O. Yu. Nesterova, E. V. Shutov, S. S. Lebedev, G. M. Zapirov

“…Over the entire duration of therapy, urea in the ipilimumab + nivolumab group was 1.7 mmol/L higher (p = 0.010) than in the pembrolizumab + axitinib group with initially comparable parameters. The maximum difference in urea between the groups was observed after the 5th and 12th administration of the drugs, amounting to 2.6 mmol/l and 2.7 mmol/l, respectively (p = 0.009 and p = 0.032, respectively).Conclusion. …”
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Golden hour management in the patient with intraparenchymal cerebral hemorrhage: an Italian intersociety document by Gianluigi Morello, Daniela Alampi, Raffaele Aspide, Alessandra Beretta, Rita Bertuetti, Federico Bilotta, Etrusca Brogi, Giovanni Buscema, Anselmo Caricato, Davide Caruzzo, Carlo Alberto Castioni, Arturo Chieregato, Andrea Cortegiani, Alessandro De Cassai, Andrea Fabbri, Domenico Gelormini, Paolo Gritti, Lucrezia Guadrini, Alberto Librizzi, Nicola Latronico, Nicola Limbucci, Marina Munari, Edoardo Picetti, Giuseppina Pipitone, Gianluca Pucciarelli, Chiara Robba, Danilo Toni, Salvatore Sardo, Simone Maria Zerbi, Nicola Zugni, Frank Rasulo

“…Results Computer tomography (CT) angiography, with over 90% sensitivity and specificity, is a key tool for identifying macrovascular abnormalities and detecting active bleeding, a critical factor in poor outcomes. …”
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Plasma metabolomics of immune-related adverse events for patients with lung cancer treated with PD-1/PD-L1 inhibitors by Juan Chen, Jun-yan Liu, Fan Yang, Ting Zou, Zhan Wang, Jia-Si Liu, Lei She, Xiang-Ping Li, Zhaoqian Liu

“…Untargeted metabolomics analysis was used to identify the differential metabolites before initiating ICIs treatment and during the process that development of irAEs. …”
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Modelling the impact of climate and the environment on the spatiotemporal dynamics of Lyme borreliosis in GermanyResearch in context by Martín Lotto Batista, Bruno Carvalho, Rory Gibb, Balakrishnan Solaraju-Murali, Stefan Flasche, Stefanie Castell, Stéphane Ghozzi, Rachel Lowe

“…Funding: Helmholtz Association, Helmholtz Climate Initiative, Wellcome Trust, Royal Society, and Horizon Europe.…”
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Phase I, multicenter, open-label study of intravenous VCN-01 oncolytic adenovirus with or without nab-paclitaxel plus gemcitabine in patients with advanced solid tumors by Gabriel Capellá, Francisco X Real, Marta Gil-Martin, Rocio Garcia-Carbonero, Rafael Moreno, Ramon Alemany, Martí Farrera-Sal, Ramon Salazar, Teresa Macarulla, Jaime Martinez de Villarreal, Natalia del Pozo, Carmen Guillén-Ponce, Miriam Bazan-Peregrino, Rafael Álvarez, Ana Mato-Berciano, Emma Blasi, Carmen Blasco, Manel Cascallo, Maria C Riesco-Martinez, Helena Verdaguer, Maria Victoria Maliandi, Silvia Torres-Manjon, Marcel Costa, Noemí Vidal

“…VCN-01 viral genomes were detected in tumor tissue in five out of six biopsies (day 8). …”
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Evaluation of the sentinel surveillance system for influenza-like illness and severe acute respiratory infection in Ethiopia during the COVID-19 pandemic, 2021–2023 by Tsegaye Berkessa, Adamu Tayachew, Ayele Gebeyehu, Gizaw Teka, Wolde Shure, Admikew Agune, Adane Woldeab, Lehageru Gizachew, Ayinalem Alemu, Leuleseged Chekol, Melaku Gonta, Fetlework Kugna, Aster Hailemariam, Fekede Itefa, Ergetu Gedefaw, Mandefro Kebede, Zelalem Mekuria, Desalegne Mengesha, Mesay Hailu, Melkamu Abte, Mesfin Wossen

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Integrating hepatitis C testing and treatment into routine HIV care in Cameroon is feasible by Mathurin Pierre Kowo, Liza Coyer, Victor Sini, Carole Assontsa Kafack, Gabriella Yelheen Metomo, Guy S. Wafeu, Richard Njouom, Alexander Boers, Roel Coutinho, Oudou Njoya, Charles Kouanfack, the DHEPC project team

“…Among 286 sampled, 251 (87.8%) had detectable HCV RNA. Of these, 173 (68.9%) enrolled for treatment, 55 (21.9%) were eligible but not enrolled (49 lost‐to‐follow‐up, 6 denied) and 23 (9.2%) were ineligible. …”
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A case-control study on Chlamydia psittaci pneumonia and legionella pneumonia by Ying Gao, Yuan-jie Lin, Wen-long Zhang, Jian-ming Ni, Shu-guang Han, Liang Bao

“…PurposeAtypical pathogens (Chlamydia psittaci and Legionella) are often detected by metagenomic next-generation sequencing (mNGS). …”
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The Role of Intestinal Translocation in the Pathogenesis of Pneumonia in Acute Poisoning and the Contribution of Intestinal Lavage to Its Prevention and Resolution by V. A. Matkevich, T. T. Tkeshelashvili, A. G. Vorobyova, N. E. Stolbova, M. M. Potskhveriya, Yu. S. Goldfarb

“…Patients in the comparison groups (469) received standard therapy.   RESULTS. Initially detected: intestinal dysbiosis of II–III degree, increased permeability of the intestinal barrier — 3.8–4.9 times higher than normal, a tenfold increase in the content of endotoxin in the blood and a 6-fold increase in the leukocyte index of intoxication. …”
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Prevalence of Staphylococcus aureus Isolated from Clinical Samples that Exhibits Inducible Clindamycin Resistance: A Cross-sectional Study by Akansha Goyal, Akansha Arya, Kajal Rajput, Sapna Chauhan

“…Identifying iMLSB resistance is crucial for effectively managing S. aureus. Aim: To detect the prevalence of inducible CLI resistance in S. aureus isolates from various clinical samples and to determine the association between methicillin resistance and inducible CLI resistance in S. aureus isolates. …”
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Resveratrol contributes to NK cell-mediated breast cancer cytotoxicity by upregulating ULBP2 through miR-17-5p downmodulation and activation of MINK1/JNK/c-Jun signaling by Bisha Ding, Jie Li, Jia-Lin Yan, Chun-Yan Jiang, Ling-Bo Qian, Jie Pan

“…ULBP2-NKG2D ligation initiates NK cell activation and subsequent targeted elimination of cancer cells. …”
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Analysis of molecular resistance and associated risk factors in tuberculosis by Zhenzhen Wang, Tengfei Guo, Liyang Xu, Jinwei Liu, Long Li, Junrong Jin, Qing Zhang, Tao Jiang, Zhanqin Zhao, Yun Xue

“…Abstract Background Local surveillance of molecular resistance to first-line anti-tuberculosis (TB) drugs and fluoroquinolones (FQs) was initiated in 2019, but existing reports remain limited, hindering effective TB prevention and control efforts. …”
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The Role of Tumor Necrosis Factor and ITS Soluble Receptors in Myelosuppression Developing in B-Cell Chronic Lymphocytic Leukemia by Barilka V., Matlan V., Prymak S., Vygovska O., Shalay O.

“…In addition, any changes were detected in TNF, sTNFRI and sTNFRII concentrations in patients with thrombocytopenia. …”
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Rifampicin-resistant tuberculosis in Fujian Province, Southeast China: a retrospective analysis of drug resistance screening and treatment outcomes, 2019–2024 by Yinfa Zhou, Zhisong Dai, Zhisong Dai, Shufang Lin, Shufang Lin, Daiquan Chen, Jian Lin, Kun Chen, Yongming Lin, Yanqin Deng, Yanqin Deng

“…Of 1,056 RR-TB patients initiated on treatment, 720 had outcome data, revealing a low success rate (58.6%) due to high loss to follow-up (31.1%) and mortality (9.3%). …”
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Impact of positive end-expiratory pressure and recruitment maneuver on healthy lungs in dogs assessed by functional and anatomical monitoring methods by Martina Mosing, Martina Mosing, Andreas D. Waldmann, Thom C. Gent, Giselle Hosgood, Nadja S. Sieber-Ruckstuhl, Matthias Dennler, Peter Herrmann, Karin Unger

“…Thereafter, either (1) ZEEP was continued, (2) PEEP initiated or (3) an RM was performed followed by PEEP. …”
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Shared decision-making for pediatric acute otitis media in the United States: a randomized emergency department trial by Jana L. Anderson, Lucas Oliveira J. E. Silva, Erik P. Hess, Derek E. Vanmeter, Aidan Mullan, Juan P. Brito, Ian G. Hargraves, Fernanda Bellolio

“…UC 3.0 min (2.4, 4.4), p = 0.059. No difference was detected in immediate antibiotic prescriptions: EPDA 36% vs. …”
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PREDİCTİON OF THE RİSK OF LEUKEMİA DEVELOPMENT İN AGED HEALTHY POPULATİON: IMPLEMENTATİON İN THE PUBLİC HEALTH SYSTEM by Francesco Frassoni, Roberto Tedone, Emanuela Marcenaro, Giorgio Piastra, Davide Guerr

“…(Nature. 2018) these mutations are detectable many years before the clinical onset of Acute Myeloid Leukemia (AML) and are potentially linked to its subsequent evolution. …”
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Results of asciminib therapy as part of managed access program in patients with chronic myeloid leukemia with T315I mutation by A. N. Petrova, E. G. Lomaia, E. V. Morozova, O. A. Shukhov, E. Yu. Chelysheva, Yu. Yu. Vlasova, E. A. Kuzmina, O. V. Kulemina, I. S. Nemchenko, A. V. Bykova, A. B. Sudarikov, A. V. Kokhno, A. G. Turkina

“…The therapy results of patients in initially unfavorable 2Cp / Cp ACA+ group were comparable with Cp group in terms of both survival rates and probability of achieving responses. …”
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Multiple molecular diagnoses identified through genome sequencing in individuals with suspected rare disease by Alka Malhotra, Erin Thorpe, Alison J. Coffey, Revathi Rajkumar, Josephine Adjeman, Naomi Dianne Naa Adjeley Adjetey, Sharron Aglobitse, Felix Allotey, Todor Arsov, Joyce Ashong, Ebenezer Vincent Badoe, Donald Basel, Yvonne Brew, Chester Brown, Kerri Bosfield, Kari Casas, Mario Cornejo-Olivas, Laura Davis-Keppen, Abbey Freed, Kate Gibson, Parul Jayakar, Marilyn C. Jones, Martina Kawome, Aimé Lumaka, Ursula Maier, Prince Makay, Gioconda Manassero, Marilyn Marbell-Wilson, Charles Marcuccilli, Diane Masser-Frye, Julie McCarrier, Hannah-Sharon Mills, Jeny Balazar Montoya, Gerrye Mubungu, Mamy Ngole, Jorge Perez, Eniko Pivnick, Milagros M. Duenas-Roque, Hildegard Pena Salguero, Arturo Serize, Marwan Shinawi, Fabio Sirchia, Claudia Soler-Alfonso, Alan Taylor, Lauren Thompson, Gail Vance, Adeline Vanderver, Keith Vaux, Danita Velasco, Samuel Wiafe, Ryan J. Taft, Denise L. Perry, Akanchha Kesari

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Response to amoxicillin and perampanel in infantile Alexander disease by Susana Boronat, Eulalia Turon‐Viñas, Noel Mac Manus, Asuncion Diaz‐Gomez, Mónica Vicente, Victoria Ros‐Castelló, Alba Sierra‐Marcos

“…We describe a patient presenting with irritability starting at 2 months of age, initially attributed to gastroesophageal reflux. A ventriculoperitoneal shunt was placed at 3 months of age due to hydrocephalus secondary to aqueduct stenosis detected through an MRI scan, but the irritability persisted. …”
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