Multi-Omics and Sensory Analysis of <i>Coffea canephora</i>: Assessing the Impact of Roasting Speed on Safety and Energy Efficiency by Sara Triachini, Pier Paolo Becchi, Terenzio Bertuzzi, Ettore Capri, Mario Gabrielli, Luigi Lucini, Fosca Vezzulli

“…The chemical fingerprint of coffee was initially investigated through an untargeted metabolomics approach based on high-resolution mass spectrometry (UHPLC-Q-Orbitrap-HRMS). …”
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DNA repair protein XPA is differentially expressed in colorectal cancer and predicts better prognosis by Xue Feng, Jingwei Liu, Yuehua Gong, Kaihua Gou, Huaiwei Yang, Yuan Yuan, Chengzhong Xing

“…Abstract As an indispensable factor in DNA damage recognition step of nucleotide excision repair, XPA interacts with a series of proteins to initiate repair process. The expression characteristics of XPA in colorectal cancer (CRC) and its influence on CRC prognosis remain elusive. …”
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Advancing Public Health in Rwanda through the Field Epidemiology Training Program by Mutabazi Vincent, Sinayobye Jean d’Amour

“…FETPs are competency-based workforce development training programs aimed at improving the epidemiology capacity of Ministry of Health staff at all levels to prevent, detect, investigate and respond to public health priority issues[1]. …”
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Restoring South African subtropical succulent thicket using Portulacaria afra: rooting variation across three soil types by Alastair J. Potts, Duncan Liddell, Catherine E. Clarke, Nicholas C. Galuszynski

“…Results Significant differences in root dry weight were detected (all tests: F5,74 = 4.11–11.45, p < 0.01). …”
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Screening and Risk Analysis of Atrial Fibrillation After Radiotherapy for Breast Cancer: Protocol for the Cross-Sectional Cohort Study “Watch Your Heart (WATCH)” by Laura Saint-Lary, Baptiste Pinel, Loic Panh, Gaelle Jimenez, Julien Geffrelot, Youlia Kirova, Jeremy Camilleri, David Broggio, Marie-Odile Bernier, Corinne Mandin, Christelle Levy, Serge Boveda, Juliette Thariat, Sophie Jacob

“…Identifying the dose-risk associations would improve RT delivery protocols to limit the occurrence of different forms of AF and, if necessary, initiate appropriate treatment. Trial RegistrationClinicalTrials.gov NCT06073509; clinicaltrials.gov/study/NCT06073509?…”
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Efficacy and safety of venetoclax in relapsed/refractory chronic lymphocytic leukemia in Russia routine clinical practice by E. A. Dmitrieva, S. V. Voloshin, K. D. Kaplanov, V. Touliet, V. V. Zasypkina, O. V. Magdych, E. F. Klinushkina

“…The primary endpoint was the overall response rate at 12 months after initiation of treatment.Results. The study included 71 previously treated patients with relapsed/refractory CLL. …”
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Prevalence, genotype diversity, and zoonotic potential of bovine rotavirus A in Amhara National Regional State, Ethiopia: A multicenter cross-sectional study by Debasu Damtie, Aschalew Gelaw, Yitayih Wondimeneh, Yetemwork Aleka, Zewdu Siyoum Tarekegn, Phillip Davis, Belay Tessema, Anastasia N. Vlasova

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Broad-line AGNs at 3.5 < z < 6: The Black Hole Mass Function and a Connection with Little Red Dots by Anthony J. Taylor, Steven L. Finkelstein, Dale D. Kocevski, Junehyoung Jeon, Volker Bromm, Ricardo O. Amorín, Pablo Arrabal Haro, Bren E. Backhaus, Micaela B. Bagley, Eduardo Banados, Rachana Bhatawdekar, Madisyn Brooks, Antonello Calabrò, Óscar A. Chávez Ortiz, Yingjie Cheng, Nikko J. Cleri, Justin W. Cole, Kelcey Davis, Mark Dickinson, Callum Donnan, James S. Dunlop, Richard S. Ellis, Vital Fernández, Adriano Fontana, Seiji Fujimoto, Mauro Giavalisco, Andrea Grazian, Jingsong Guo, Nimish P. Hathi, Benne W. Holwerda, Michaela Hirschmann, Kohei Inayoshi, Jeyhan S. Kartaltepe, Yana Khusanova, Anton M. Koekemoer, Vasily Kokorev, Rebecca L. Larson, Gene C. K. Leung, Ray A. Lucas, Derek J. McLeod, Lorenzo Napolitano, Masafusa Onoue, Fabio Pacucci, Casey Papovich, Pablo G. Pérez-González, Nor Pirzkal, Rachel S. Somerville, Jonathan R. Trump, Stephen M. Wilkins, L. Y. Aaron Yung, Haowen Zhang

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Investigating the relationship between the Khami reservoir horizon in the Chilingar and Garangan oilfields in the Southern Dezful Embayment using surface geochemistry by Bahram Alizadeh, Arman Salehipour Bavarsad

“…In Iran, surface geochemistry was initiated in 2014 by the Energy Researchers Ariana (ERA) company. …”
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A validated heart-specific model for splice-disrupting variants in childhood heart disease by Robert Lesurf, Jeroen Breckpot, Jade Bouwmeester, Nour Hanafi, Anjali Jain, Yijing Liang, Tanya Papaz, Jane Lougheed, Tapas Mondal, Mahmoud Alsalehi, Luis Altamirano-Diaz, Erwin Oechslin, Enrique Audain, Gregor Dombrowsky, Alex V. Postma, Odilia I. Woudstra, Berto J. Bouma, Marc-Phillip Hitz, Connie R. Bezzina, Gillian M. Blue, David S. Winlaw, Seema Mital

“…Results Of 8583 rare DNA splice-disrupting variants initially identified using SpliceAI, 100 were associated with altered splice junctions in the corresponding patient myocardium affecting 95 genes. …”
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Rearrangement of 11q23 Chromosome Region in Acute Myeloid Leukemias in Children by EV Fleishman, OI Sokova, AV Popa, GA Tsaur, LN Konstantinova, OM Plekhanova, MV Strigaleva, ES Nokhrina, VS Nemirovchenko, OR Arakaev

“…The chromosomal analysis of bone marrow and peripheral blood cells has been performed prior to initiation of treatment in 395 children with primary AML aged from 0 to 16 years. …”
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Hypometabolism and atrophy patterns associated with Niemann-Pick type C by Jesús Silva-Rodríguez, Cristina Castro, Julia Cortés, Manuel Arias, Virginia Pubul, Alexis Moscoso, Michel J. Grothe, Gabriel Reynes-Llompart, Laura Rodríguez-Bel, Jordi Gascon-Bayarri, María Jesús Sobrido, Pablo Aguiar

“…Early diagnosis is critical for initiating treatment with miglustat, which can decelerate disease progression. …”
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Role of stimulated by retinoic acid 6 in 46 children of coarctation of the aorta by Xin Jin, Zhengxia Pan, Zhenjiang Zhao, Da Ouyang, Jinjie Qin, Jie Tian

“…STRA6 knockout, a gene that initiates the retinoic acid pathway, may lead to CoA.…”
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Sirtuin 5 inhibits mitochondrial metabolism in liver cancer cells and promotes apoptosis by mediating the desuccinylation of CS by Huimin Cao, Dongsheng Wei, Dongsheng Wei, Han Li, Mei Zhao, Yixin Ma, Liang Kong, Guoyuan Sui, Lianqun Jia

“…The aim of this study is to elucidate the role of CS and its post-translational modifications (PTMs) in the initiation and progression of hepatocellular carcinoma (HCC).MethodsLiquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to detect protein lysine succinylation in human liver cancer and adjacent non-cancerous tissues. …”
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The Effects of <i>Lactobacillus plantarum</i>, <i>Bacillus subtilis</i>, a Lignocellulolytic Enzyme System, and Their Combination on the Fermentation Profiles, Chemical Composition... by Jiaqi Su, Ye Xue, Kunlun Zhang, Zihan Liu, Jingyi Lv, Qi Yang, Zhongqiu Li, Chunlong Liu, Hangshu Xin

“…The counts of lactic acid bacteria, yeast, and mold declined over the fermentation period, dropping below detectable levels on the seventh and fifth days, respectively. …”
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Cloning and Bioinformatics Analysis of Vitellogenin Genes and Its Receptor Genes in Thalassodes immissaria by Guolin ZHU, Qiong YAO, Wenjing LI, Shu XU, Kai LIU, Shuanggang DUAN

“…【Result】The open reading frames (ORFs) of TiVg and TiVgR span 5 343 and 5 250 bp respectively, encoding polypeptides of 1 780 and 1 749 amino acids, with predicted molecular weights of 202.403 and 196.248 kDa.Both TiVg and TiVgR are water-soluble, exhibiting hydropathicity index of-0.681 and-0.329, respectively.The N-termini of TiVg and TiVgR contain signal peptide regions composed of 16 and 14 amino acid residues, respectively.The phylogenetic analysis suggested that TiVg clusters within the Operophtera brumata ObVg clade, while TiVgR aligns closely with Helicoverpa armigera HaVgR orthologs.The expression pattern results with TPM value showed that TiVg expression initiated at the pupal stage and peaked in adult females, whereas TiVgR exhibited maximal expression in adult females with minimal levels detected in eggs.Tissue expression pattern suggested that TiVg was highly expressed in fat body of adult females and TiVgR was highly expressed in ovary of adult females, respectively.…”
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Comparison of the STANDARD M10 C. difficile, Xpert C. difficile, and BD MAX Cdiff assays as confirmatory tests in a two-step algorithm for diagnosing Clostridioides difficile infec... by Hyunseul Choi, Minhee Kang, Sun Ae Yun, Hui-Jin Yu, Eunsang Suh, Tae Yeul Kim, Hee Jae Huh, Nam Yong Lee

“…This algorithm starts with enzyme immunoassay (EIA) for detecting glutamate dehydrogenase (GDH) and toxins A/B, followed by nucleic acid amplification test (NAAT) for GDH-positive but toxin-negative cases. …”
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IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury by Hongshuang Su, Xiaoxi Lin, Ayinuer Paredong, Ayinuer Paredong, Congcong Yao, Yan Zhang, Mengke Geng, Yuqian Guan, Lichao Gong, Feng Jiang, Qi Lv, Songtao Shou, Heng Jin

“…Additionally, the levels of IL-6 were detected by employing ELISA kits. RNA sequencing analysis was performed on cells treated with myoglobin and tocilizumab. …”
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Centre-level fluid management practices in the BISTRO trial and their lack of association with participant fluid status and blood pressure in non-anuric haemodialysis patients by Neena Johal, Radha Sharma, John Belcher, David Coyle, Elizabeth J. Lindley, David Keane, Fergus J. Caskey, Indranil Dasgupta, Andrew Davenport, Ken Farrington, Sandip Mitra, Paula Ormandy, Martin Wilkie, Jamie Macdonald, Ivonne Solis-Trapala, Julius Sim, Simon J. Davies

“…Conclusions Centre-level fluid management practices were stable over the course of the BISTRO trial, and in contrast to patient-level factors, no centre-level associations were detected with fluid status or blood pressure. This may be because the trial imposed a standardised approach to fluid assessment in all trial participants who at least initially had residual kidney function, potentially over-riding the effects of other centre practices. …”
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Identification and validation of diagnostic biomarkers and immune cell abundance characteristics in Staphylococcus aureus bloodstream infection by integrative bioinformatics analys... by Junhong Shi, Li Shen, Yanghua Xiao, Cailing Wan, Bingjie Wang, Peiyao Zhou, Jiao Zhang, Weihua Han, Rongrong Hu, Fangyou Yu, Hongxiu Wang

“…Overall, three candidate hub genes (DRAM1, PSTPIP2, and UPP1) were identified initially for S. aureus bloodstream infection diagnosis. …”
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