Point-Of-Care low-field MRI in acute Stroke (POCS): protocol for a multicentric prospective open-label study evaluating diagnostic accuracy by Mauro Silvestrini, Simona Sacco, Massimo Caulo, Simona Marcheselli, Carmine Marini, Sergio Lucio Vinci, Angelo Galante, Marco Colasurdo, Raffaele Ornello, Matteo Foschi, Stefano Necozione, Mario Muselli, Paola Olimpia Achard, Luciano Fratocchi, Marco Cavallaro, Gabriele Polonara, Laura Straffi, Luca Sorrentino, Enrico Franconi, Marcello Alecci

“…Low-field (LF) MRI (<0.5T) can detect several types of brain injury, including ischaemic and haemorrhagic stroke. …”
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Integrative Omics Analysis Reveals Mechanisms of Anthocyanin Biosynthesis in Djulis Spikes by Chunmei Zheng, Wenxuan Ge, Xueying Li, Xiuzhang Wang, Yanxia Sun, Xiaoyong Wu

“…However, the mechanisms underlying color variation in its spikes remain unexplored. This research initially detected the anthocyanin content at different developmental stages of the spike and subsequently utilized an integrative approach, combining targeted metabolomics, transcriptomics, and untargeted metabolomics analyses, to elucidate the mechanisms of anthocyanin biosynthesis in the spikes of djulis. …”
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Agricultural GDP exposure to drought and its machine learning-based prediction in the Jialing River Basin, China by Xinzhi Wang, Qingxia Lin, Zhiyong Wu, Yuliang Zhang, Changwen Li, Ji Liu, Shinan Zhang, Songyu Li

“…Initially, a soil moisture dataset with 0.083-degree resolution was generated using the Variable Infiltration Capacity (VIC) model. …”
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Prevalence, knowledge, attitudes, and practices regarding Chagas disease in Guanare, Venezuela: a cross-sectional study by Iván A. Escalante-Pérez, Ana A. Alviares, Óscar D. Omaña-Ávila, Fhabián S. Carrión-Nessi, Daniela L. Mendoza-Millán, Grecia de J. Erimee-Vieira, Juan M. Contreras-Rengifo, Vanessa C. Sande-Mujica, Mariana de J. de Marchis-Vento, Karim J. Gebran-Chedid, Mario A. Dubuc-Ponte, Daniela I. Castro-Betancourt, Vittoria F. Fuentes-Fiore, Rachell A. Molina-Mendoza, Alejandro M. Loreto-Rodrigues, Juan C. Gomes-González, Luciano Mauriello, Eyleen Moronta, Belkisyolé Alarcón de Noya, Zoraida Díaz-Bello, David A. Forero-Peña

“…Seroprevalence was determined by detecting anti-Trypanosoma cruzi IgG antibodies and assessing specific-IgG avidity enzyme-linked immunosorbent assay (ELISA). …”
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Safety and efficacy of different rotational speed during rotational atherectomy in coronary heart disease patients (RACE): study protocol for a randomized controlled trial by Jie Xu, Yu-wei Wang, Li-Kun Ma, Hao Hu, Hong-Wu Chen, Jing-Sheng Hua, Xiang-Yong Kong, Dan Li, Long-Wei Li, Jia-Wei Wu

“…Secondary outcomes encompass intravascular imaging (IVUS or OCT) assessments (detecting calcific ring disruption and measuring the target lesion’s minimum lumen area (MLA) and minimum lumen diameter (MLD)); in-hospital cardiac death, acute stent thrombosis, and heart failure occurrences; and the 1-year incidence of major adverse cardiovascular and cerebrovascular events (MACCE). …”
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Epidemiology of arboviruses in humans and livestock in Ethiopia: a systematic review and meta-analysis by Alemu Gedefie, Habtu Debash, Altaseb Beyene Kassaw, Gossa Mankelkl, Yeshi Metaferia, Melaku Ashagrie Belete, Sisay Desale, Saleamlak Sebsibe, Mihret Tilahun, Bruktawit Eshetu, Agumas Shibabaw, Yeshimebet Kassa, Hussen Ebrahim, Zewudu Mulatie, Ermiyas Alemayehu, Lebasie Woretaw, Berhanu Kebede, Minwuyelet Maru Temesgen, Natan Kassaye Msganew, Melkam Tesfaye

“…However, the surveillance system has been still challenged, and their burden and magnitude are not well estimated due to underestimates of true arbovirus burdens by passive case detections. To support targeted evidence-based public health decision-making, comprehensive evidence of arbovirus prevalence is crucial. …”
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Urinary DcR2/Cr level predicts renal outcomes in patients with diabetic kidney disease by Jia Chen, Weidong Wang, Fang Yu, Xiaoyue Wang, Yani He, Kehong Chen

“…Renal DcR2 mRNA and protein expression were detected using in situ hybridization and immunohistochemical staining. …”
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Hepatitis B Virus-KMT2B Integration Drives Hepatic Oncogenic Processes in a Human Gene-edited Induced Pluripotent Stem Cells-derived ModelSummary by Jun Tsuchiya, Masato Miyoshi, Sei Kakinuma, Fukiko Kawai-Kitahata, Akihide Kamiya, Taro Shimizu, Ayako Sato, Keiya Watakabe, Tomohiro Mochida, Kento Inada, Rion Kamimae, Shun Kaneko, Miyako Murakawa, Sayuri Nitta, Mina Nakagawa, Mamoru Watanabe, Yasuhiro Asahina, Ryuichi Okamoto

“…Long-read RNA-sequence detected the common KMT2B transcript variants in the HCC sample and HPCs. …”
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The Role of Atrial Fibrillation and Oral Anticoagulation Status in Health‐Related Quality of Life 12 Months After Ischemic Stroke or TIA by Manuel C. Olma, Lena Steindorf‐Sabath, Serdar Tütüncü, Claudia Kunze, Cornelia Fiessler, Paulus Kirchhof, Joanna Dietzel, Johannes Schurig, Patrick Oschmann, Ludwig Niehaus, Christian Urbanek, Götz Thomalla, Darius G. Nabavi, Joachim Röther, Ulrich Laufs, Roland Veltkamp, Peter U. Heuschmann, Karl Georg Haeusler, Matthias Endres, for the MonDAFIS Investigators

“…Results A first episode of AF was detected in 261/2927 (8.9%) patients within 12 months after the index stroke and 227/2920 (7.8%) patients had AF and were anticoagulated at 12 months. …”
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Isolation, Antibacterial Activity and Molecular Identification of Avocado Rhizosphere Actinobacteria as Potential Biocontrol Agents of <i>Xanthomonas</i> sp. by Jesús Rafael Trinidad-Cruz, Gabriel Rincón-Enríquez, Zahaed Evangelista-Martínez, Luis López-Pérez, Evangelina Esmeralda Quiñones-Aguilar

“…An increment for the AA was registered for isolates cultured on PDA and YME, with an IZ from 21.1 to 80.2 mm and 14.1 to 69.6 mm, respectively. A lower AA was detected when isolates were cultured on OA media (15.0 to 38.1 mm). …”
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Experimental medicine study with stabilised native-like HIV-1 Env immunogens drives long-term antibody responses, but lacks neutralising breadthResearch in context by Katrina M. Pollock, Hannah M. Cheeseman, Leon R. McFarlane, Suzanne Day, Monica Tolazzi, Hannah L. Turner, Jennifer Joypooranachandran, Katsiaryna Shramko, Stefania Dispinseri, Philipp Mundsperger, Ilja Bontjer, Nana-Marie Lemm, Sofia Coelho, Maniola Tanaka, Tom Cole, Bette Korber, Dietmar Katinger, Quentin J. Sattentau, Andrew B. Ward, Gabriella Scarlatti, Rogier W. Sanders, Robin J. Shattock

“…Funding: European Aids Vaccine initiative (EAVI2020) received funding from EU Horizon 2020, grant number 681137. …”
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Prevalence of heart failure among hospitalized patient with T2D: results of a prospective observational multicenter study (CREDO) by M. B. Antsiferov, Zh. D. Kobalava, T. Y. Demidova, T. N. Markova, V. V. Tolkacheva, L. Y. Morgunov, A. V. Andreeva, Е. Y. Pashkova, M. R. Khaziakhmetova, E. S. Samburova, S. G. Vedyashkina, A. M. Mkrtumyan, N. А. Petunina, A. N. Serebrov, T. M. Deeva, A. Y. Karaeva

“…The results obtained confirm the possibility of detecting HF and initiating cardioprotective therapy at the hospital stage, using inpatient clinical diagnostic examination, and patients with type 2 diabetes lasting more than 3 years and aged over 50 years can be classified as a high risk group for developing HF.…”
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Cardioprotective Effect of Growth Differentiation Factor 15 Against Isoproterenol-Induced Cardiomyocyte Apoptosis via Regulation of the Mitochondrial Fusion by Yan Zhang, Zhu Mei, Xiaodong Jia, Haixu Song, Jing Liu, Xiaoxiang Tian, Tianyu Xu, Xiaoxia Fu

“…Pressure overload-induced myocardial apoptosis is a critical pathologically initiated process leading to heart failure (HF). Growth differentiation factor 15 (GDF15) dramatically increases during cardiac hypertrophy and dysfunction, but its functions and mechanisms are barely known. …”
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Elemental analysis in the scales of commercially important coastal fishes and their connections with fish feeding habits and habitats by Md. Sohel Parvez, Md. Sohel Parvez, Md. Sohel Parvez, Md. Imdadul Hoque, Md. Nurul Momen Siddique, Mohammad Mizanur Rahman, Edina Baranyai, Zsófi Sajtos, Boglárka Döncző, Haithem Aib, Haithem Aib, Md. Abdul Kader, Edina Simon, Edina Simon, Herta Czédli

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A model-based approach to estimating the prevalence of disease combinations in South Africa by Naomi S Levitt, Sarah Bennett, Kirsty Bobrow, Lara R Fairall, Rifqah A Roomaney, Max O Bachmann, Andrew Boulle, Robyn Curran, Leigh F Johnson, Reshma Kassanjee, Naomi Folb

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Moxibustion regulates KDM4D expression and modulates lipid metabolism to inhibit tumor proliferation in CAC mice by Guona Li, Jindan Ma, Luyi Wu, Hanxiao Zhang, Yaying Lin, Hongxiao Xu, Muen Gu, Kunshan Li, Hongsheng Dong, Yan Huang, Huangan Wu

“…Using kdm4d knockout technology, it was initially confirmed that kdm4d is a key gene affecting CAC tumor proliferation. …”
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Triage test for all-oral drug-resistant tuberculosis (DR-TB) regimen: a phase IV study to assess effectiveness, feasibility, acceptability and cost-effectiveness of the Xpert MTB/X... by Kogieleum Naidoo, Derek J Sloan, Wilber Sabiiti, Bariki Mtafya, Stephen H Gillespie, Aderonke Agbaje, Nyanda Elias Ntinginya, Morten Ruhwald, Agnes Gebhard, Anushka Naidoo, Rubeshan Perumal, Getachew Tollera, Evaezi Okpokoro, Alash'le G Abimiku, Everdina W Tiemersma, Sabine M Hermans, Sophia B Georghiou, Kalkidan Yae, Shewki Moga, Hannelise Feyt, Takondwa Kachoka, Marothi P Letsoalo, Andrea M Cabibbe, Letitia Shunmugam, Daniela M Cirillo, Salah Foraida

“…The primary study outcomes include time to initiation of an appropriate treatment regimen by resistance profile and the proportion of patients with favourable treatment outcomes compared with historical cohorts from each of the implementing sites. …”
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Prolonged storage reduces viability of Peptacetobacter (Clostridium) hiranonis and core intestinal bacteria in fecal microbiota transplantation preparations for dogs by Bruna Correa Lopes, Jonathan Turck, M. Katherine Tolbert, Paula R. Giaretta, Jan S. Suchodolski, Rachel Pilla, Rachel Pilla

“…The higher bacterial viability detected in fecal samples preserved with glycerol confirms the use of this cryoprotectant as a reliable method to keep bacteria alive in the presence of fecal matrix for FMT purposes.…”
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Case Report: Rhabdomyolysis and Flare-up of Lupus Erythematosus as Complications of Tuberculostatic Drug Therapy in a Pakistani Patient with Mycobacterium africanum Infection by Dr Markus Zettler, Mr Christoph Zacher, Prof. Dr. Benjamin Wilde, Mr Jan Kehrmann, Prof. Dr. Oliver Witzke, PD Dr. Hana Rohn, Prof. Dr. Sebastian Dolff, Prof. Dr. Dr. h.c. Christoph Lange, Dr. med. Markus Zettler

“…In patients with concomitant autoimmune diseases, regular clinical and laboratory monitoring are essential to promptly detect flares and other serious adverse reactions.…”
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Electrocardiographic signs of cardiac ischemia at rest and during exercise in patients with COPD traveling to 3,100 m: data from a randomized trial of acetazolamide by Marla Christen, Marla Christen, Aline Buergin, Aline Buergin, Maamed Mademilov, Maamed Mademilov, Laura Mayer, Laura Mayer, Simon R. Schneider, Simon R. Schneider, Mona Lichtblau, Mona Lichtblau, Talant M. Sooronbaev, Talant M. Sooronbaev, Silvia Ulrich, Silvia Ulrich, Konrad E. Bloch, Konrad E. Bloch, Michael Furian, Michael Furian

“…We assessed electrocardiogram (ECG)-derived signs of cardiac ischemia and the effects of preventive acetazolamide therapy in COPD patients traveling to high altitudes.MethodsPatients with COPD [Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) grades 2–3] and a predicted forced expiratory volume in 1 s (FEV1) of 66 ± 11% (mean ± SD), aged 57 ± 8 years, and living &lt;1,000 m were included in this analysis of secondary outcomes from a randomized placebo-controlled double-blind trial (www.clinicaltrials.gov, NCT03156231). …”
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