‘You adapt, and you try not to resent it’: a qualitative study exploring impacts of living with ticks and barriers to adopting preventive measures in Canada by Natasha Bowser, Catherine Bouchard, Madison Robertson, Valerie Hongoh, Lucie Richard, Patrick Leighton, Hélène Carabin, Cécile Aenishaenslin

“…Abstract Background Lyme disease (LD) is Canada’s most common tick-borne disease (TBD), with other tick-borne pathogens being detected with increasing frequency. Tick bite prevention remains the most effective preventive measure against TBDs, yet individual preventive behaviours are not always adopted by at-risk individuals. …”
Get full text

Global prevalence of Helicobacter pylori antibiotic resistance among children in the world health organization regions between 2000 and 2023: a systematic review and meta-analysis by Aryan Salahi-Niri, Ali Nabavi-Rad, Tanya Marie Monaghan, Theodore Rokkas, Michael Doulberis, Amir Sadeghi, Mohammad Reza Zali, Yoshio Yamaoka, Evelina Tacconelli, Abbas Yadegar

“…Results Among 1417 records obtained initially, 152 studies were selected for eligibility assessment after applying exclusion criteria in multiple steps. …”
Get full text

HIDDEN DANGER OF SARS-COV-2; MULTISYSTEM INFLAMMATORY SYNDROME IN ADULTS (MIS-A): FIRST CASE SERIES IN A SINGLE CENTER FROM TURKIYE by Aysun Benli, Yavuz Burak Tor, Serap Şimşek Yavuz, Seniha Başaran, Arif Atahan Çağatay, Halit Özsüt, Ahmet Gül, Haluk Eraksoy

“…Abnormal echocardiography findings were detected in five patients. Only one patient had multiple mucocutaneous findings. …”
Get full text

Negative correlation between relative fat mass and bone mineral density: NHANES 2011–2018 by Xing-An Jiang, Xing-An Jiang, Hong-Li Zhang, Bin-Tao Ye, Shao-Qi Fang, Jia-Jin Zhang, Hao-Lin Yu, Jun-Bo Liang, Jun-Bo Liang

“…Additionally, an inflection point was detected at RFM = 20.5847 (p < 0.001), with significantly distinct correlations between RFM and lumbar spine BMD when values were above or below this point. …”
Get full text

PCBP2 as an intrinsic agi ng factor regulates the senescence of hBMSCs through the ROS-FGF2 signaling axis by Pengbo Chen, Bo Li, Zeyu Lu, Qingyin Xu, Huoliang Zheng, Shengdan Jiang, Leisheng Jiang, Xinfeng Zheng

“…Conclusions: This study initially elucidates that PCBP2 as an intrinsic aging factor regulates the replicative senescence of hBMSCs through the ROS-FGF2 signaling axis. …”
Get full text

Predictive value of TGF-β1 and SMAD-7 expression at diagnosis for treatment response in low-risk myelodysplastic syndrome by Bedrettin Orhan, Hülya Öztürk Nazlıoğlu, Oğuzhan Dik, Büşra Gürbüz, Vildan Özkocaman, Tuba Ersal, İbrahim Ethem Pınar Pınar, Cumali Yalçın Yalçın, Sinem Çubukçu, Tuba Güllü Koca, Fazıl Çağrı Hunutlu, Şeyma Yavuz, Rıdvan Ali, Fahir Özkalemkaş

“…Strong TGF-β1 staining, alongside EPO levels, may influence the decision to initiate ESA therapy. …”
Get full text

The influence of adolescent nicotine exposure on ethanol intake and brain gene expression. by Constanza P Silva, William J Horton, Michael J Caruso, Aswathy Sebastian, Laura C Klein, Istvan Albert, Helen M Kamens

“…Adolescence is a vulnerable period for the initiation of both nicotine and alcohol use, which can lead to subsequent neurodevelopmental and behavioral alterations. …”
Get full text

Colchicine in patients with aortic stenosis undergoing transcatheter aortic valve replacement: a double-blind randomized trial by Christoph Ryffel, Jonas Lanz, Nicole Guntli, Daryoush Samim, Monika Fürholz, Stefan Stortecky, Daijiro Tomii, Dik Heg, Martina Boscolo Berto, Alan Arthur Peters, David Reineke, Tobias Reichlin, Christoph Gräni, Stephan Windecker, Thomas Pilgrim

“…The trial was an investigator-initiated study supported by dedicated grants from the Bangerter-Rhyner Foundation and the Swiss Life Foundation. …”
Get full text

Upregulation of TTYH3 by lncRNA LUCAT1 through interacting with ALYREF facilitates the metastasis in non-small cell lung cancer by Fang Fang, Mei Zhao, Jinming Meng, Jiaqi He, Chunlei Yang, Changhong Wang, Jiaxiao Wang, Sheng Xie, Xiaowei Jin, Wei Shi

“…Quantitative reverse transcription polymerase chain reaction (qRT-PCR) and western blot were initially employed to detect TTYH3 expression in NSCLC and normal lung epithelial cells. …”
Get full text

Infection length and host environment influence on Plasmodium falciparum dry season reservoir by Carolina M Andrade, Manuela Carrasquilla, Usama Dabbas, Jessica Briggs, Hannah van Dijk, Nikolay Sergeev, Awa Sissoko, Moussa Niangaly, Christina Ntalla, Emily LaVerriere, Jeff Skinner, Klara Golob, Jeremy Richter, Hamidou Cisse, Shanping Li, Jason A Hendry, Muhammad Asghar, Didier Doumtabe, Anna Farnert, Thomas Ruppert, Daniel E Neafsey, Kassoum Kayentao, Safiatou Doumbo, Aissata Ongoiba, Peter D Crompton, Boubacar Traore, Bryan Greenhouse, Silvia Portugal

“…Here, we investigated whether seasonality affects plasma composition so that P. falciparum can detect and adjust to changing serological cues; or if alternatively, parasite infection length dictates clinical presentation and persistency. …”
Get full text

Association of Central Precocious Puberty with a Rare Presentation of Schimmelpenning–Feuerstein–Mims Syndrome in a Peruvian Girl by Miguel Angel De los Santos-La Torre, Carlos Manuel Del Águila-Villar, Luis Rómulo Lu-de Lama, Oswaldo Nuñez-Almache, Eliana Manuela Chávez-Tejada, Oscar Antonio Espinoza-Robles, Paola Marianella Pinto-Ibárcena, Martha Rosario Calagua-Quispe

“…Analyses of the H-RAS, K-RAS, and N-RAS genes in the blood and in the skin were performed, and a missense mutation in exon 2 of the gene, H-RAS c37G > C (p.G13R), was detected in the latter. Treatment with triptorelin, a GnRH analog, was initiated, and it gave good clinical response. …”
Get full text

Influence of High Temperature and Ammonia and Nitrite Accumulation on the Physiological, Structural, and Genetic Aspects of the Biology of Largemouth Bass (<i>Micropterus salmoides... by Yuexing Zhang, Hui Qiao, Leyang Peng, Yujie Meng, Guili Song, Cheng Luo, Yong Long

“…Nitrite levels remained low initially and increased rapidly along with the reduction in ammonia levels at both temperatures. …”
Get full text

An intracellular bacterial pathogen triggers RIG-I/MDA5-dependent necroptosis by Hang Xu, Huili Li, Boguang Sun, Li Sun

“…RIG-I and MDA5 are members of RIG-I-like receptors (RLRs) that detect viral RNA within the cytoplasm and subsequently initiate antiviral immune responses. …”
Get full text

Automated Pixel Purification for Delineating Pervious and Impervious Surfaces in a City Using Advanced Hyperspectral Imagery Techniques by Payam Sajadi, Mehdi Gholamnia, Stefania Bonafoni, Gerald Mills, Yan-Fang Sang, Zeting Li, Salman Khan, Jiazheng Han, Francesco Pilla

“…Conventional urbanization transforms natural into paved landscapes, posing a significant environmental challenge. Detecting the changes in (im)pervious surfaces in cities, where patches are small and intermingled, is particularly challenging. …”
Get full text

Application and interpretation of core elements of the 2015 NMOSD diagnostic criteria in routine clinical practice by Edgar Carnero Contentti, Edgar Carnero Contentti, Juan I. Rojas, Ricardo Alonso, Michael R. Yeaman, Michael R. Yeaman, Brian G. Weinshenker

“…Implementing collaborative educational initiatives could improve NMOSD diagnosis and raise patient care standards.…”
Get full text

Coexistence of Sympatric Large Carnivores: Spatio‐Temporal Interactions Between Tigers and Leopards in Parsa National Park, Nepal by Dol Raj Thanet, Pramod Raj Regmi, Babu Ram Lamichhane, Dipanjan Naha, Caitlin Kupferman, James C. Beasley, Mandip Pangeni, Anil Shrestha, Saneer Lamichhane, Haribhadra Acharya, Bed Kumar Dhakal, Bhagawan Raj Dahal, Chiranjibi Prasad Pokheral, Naresh Subedi

“…In general, our findings indicate that both species co‐detected at 44 camera locations, demonstrating that they spatially share habitats inside the park. …”
Get full text

The clinical significance of T cell infiltration and immune checkpoint expression in central nervous system germ cell tumors by Jiajun Zhou, Jiajun Zhou, Wenhao An, Lei Guan, Lei Guan, Jinyu Shi, Qiaozhen Qin, Shuai Zhong, Zheng Huang, Rui Liu, Chenxing Wu, Zhong Ma, Xueling Qi, Xiaoxia Jiang, Yan Wang, Shouwei Li

“…Additionally, CTLA-4 expression was detected in 58.06% of cases, while PD-1 and PD-L1 were expressed in over 90%, with higher CTLA-4 levels in germinomas and elevated PD-L1 levels in NGGCTs. …”
Get full text

Helicobacter mastomyrinus infection induces autoimmune hepatitis in mice by Liqi Zhu, Yuanyuan Liang, Linghan Yang, Qihui Yang, Jun Yin, Tao Wang, Xiangming Xu, Quan Zhang

“…The serum was collected for detecting a number of AIH indicators, including the aminotransferases level, IgG content and autoantibody level. …”
Get full text

Regional patterns of genetic variants in expanded carrier screening: a next-generation sequencing pilot study in Fujian Province, China by Danhua Guo, Danhua Guo, Nani Zhou, Qianqian He, Qianqian He, Na Lin, Na Lin, Shuqiong He, Shuqiong He, Deqin He, Deqin He, Yifang Dai, Yifang Dai, Ying Li, Ying Li, Xuemei Chen, Xuemei Chen, Hailong Huang, Hailong Huang, Jia Jia, Hua Cao, Liangpu Xu, Liangpu Xu

“…However, before integrating ECS into regional public health initiatives, the development of a region-specific, curated disease panel is necessary to optimize screening efficacy and clinical utility.…”
Get full text

Gradual changes within long-lived influenza virus-specific CD8+ T cells are associated with the loss of public TCR clonotypes in older adultsResearch in context by Carolien E. van de Sandt, Hayley A. McQuilten, Malet Aban, Thi H.O. Nguyen, Sophie A. Valkenburg, Emma J. Grant, Sneha Sant, Jamie Rossjohn, Stephanie Gras, Jane Crowe, Katherine Kedzierska

“…Loss of public clonotypes was initially compensated by expansions of clonotypes expressing public-associated features. …”
Get full text