Exposure to polyethylene and polyvinylchloride microplastics caused advanced puberty onset in females through promoting hypothalamic GnRH expression by Shaolian Zang, Fei Wang, Yang Ouyang, Weiwei Cheng, Pin Li, Xiaoqin Yin

“…These data suggested that MPs can be absorbed and accumulated in brain and gonad after gavage, and accelerate female pubertal initiation. This study provided valuable evidence that MPs threatened the normal progression of female pubertal development.…”
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A novel homozygous W99G mutation in CLDN-16 gene causing familial hypomagnesemic hypercalciuric nephrocalcinosis in Turkish siblings by Caner Alparslan, Elif Perihan Öncel, Sinem Akbay, Demet Alaygut, Fatma Mutlubaş, Mansur Tatlı, Martin Konrad, Önder Yavaşcan, Belde Kasap-Demir

“…Oral magnessium supplementation was initiated. Four years of follow-up has been completed uneventfully. …”
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Increasing polymyxin resistance in clinical carbapenem-resistant Klebsiella pneumoniae strains in China between 2000 and 2023 by Miaomiao Xie, Yanyan Zhang, Kaichao Chen, Ning Dong, Hongwei Zhou, Yonglu Huang, Congcong Liu, Edward Wai-Chi Chan, Sheng Chen, Rong Zhang

“…Results Here we show that polymyxin-resistant CRKP emerge initially in 2014, prevalence of such strains then increase steadily over the years, reaching a rate of 9.86% in 2023. …”
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Unveiling the Floral Scent Dynamics of Calamondin (<i>Citrus</i> × <i>microcarpa</i>) Across Developmental Stages by Yiwei Chen, Zhiqing Liang, Shiyu Chen, Fulong Yan, Jingjuan He, Yiwei Zhou, Ting Gao

“…The total VOC content increased initially and then decreased as the flowers developed, with terpenoids being the predominant compounds, accounting for over 90% of the total emissions at all stages. …”
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Itaconate suppresses neonatal intestinal inflammation via metabolic reprogramming of M1 macrophage by Shuchen Huangfu, Chaoting Lan, Sitao Li, Huijuan Wang, Chun Yan, Yuling Yang, Bowen Tian, Yide Mu, Peizhi Zhao, Yan Tian, Yijia Wang, Wei Zhong, Limei Zhong, Yongyan Shi, Yufeng Liu

“…Abstract Background Necrotizing enterocolitis (NEC) is a rapidly progressive and severe gastrointestinal disorder in neonates that is marked by an inflammatory cascade initiated by mechanisms that remain incompletely understood, resulting in intestinal necrosis and systemic infections. …”
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Descriptive analysis of the national drug adverse events (AEs) database in Lebanon by Rita Karam, Sarah Reda El Sayed, Aya Ibrahim, Joya-Maria Karam, Souheil Hallit, Abeer Zeitoun

“…The objective of this paper is to evaluate the prevalence of detected AEs within the Lebanese population in a descriptive analysis.Methods This is a retrospective analysis-based study that describes collected national AE cases for all marketed medications as well as medications in the pre-marketed phase as part of clinical studies in Lebanon, the LNPVP data system spontaneously received that from Marketing Authorisation Holders (MAHs) between 2018 and 2023.Results Since the initiation of the LNPVP programme, a total of 21,631 Individual Case Safety Reports (ICSRs) have been processed; 3,855 of which were excluded and the remaining 17,776 ICSRs are the subject of this paper and correspond to 37,768 AEs associated with medications authorised for use in Lebanon. …”
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Biological Traits and Isoenzymatic Characterization of <i>Triplophysa strauchii</i> from the Turks River by Gulden Serekbol, Chengxin Wang, Liting Yang, Huanhuan Wang, Jiaxuan Liu, Qiang Huo, Hao Xu, Yong Song, Daoquan Ren, Shengao Chen

“…This underscores the need for research and development initiatives aimed at supporting the recovery and sustainable management of the species. …”
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Characterizing Plasma-Based Metabolomic Signatures for Metastasis in Non-Small Cell Lung Cancer by Manlu Liu, Yanlong Zhu, Sean J. McIlwain, Haotian Deng, Allan R. Brasier, Ying Ge, Michelle E. Kimple, Andrew M. Baschnagel

“…<b>Background/Objectives</b>: The current staging of non-small cell lung cancer (NSCLC) relies on conventional imaging, which lacks the sensitivity to detect micrometastatic disease. The functional assessment of NSCLC progression may provide independent information to enhance the prediction of metastatic risk. …”
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Semi-elemental versus polymeric formula for enteral nutrition in critically ill patients: a secondary analysis of a multicenter cluster-randomized controlled trial by Wei Wei, Wen Lu, Guofeng Chen, Jindan Gao, Jun Zhang, Defeng Zhang, Ruiqin He, Jingjing Huang, Rong Cai, Rongrong Yuan, Xun Wang, Jinxia Yu, Zilong Li, Lu Ke, Lin Gao, Zhengquan Wang

“…Propensity score matching (PSM) was applied to control for the detected confounders. The primary outcome was the incidence of intolerance-related symptoms, including nausea/vomiting, aspiration, abdominal distension/pain, and diarrhea.ResultsPSM created 516 matched pairs from 1,548 eligible patients. …”
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Dust observation by a ground-based lidar network along the global dust belt by Huang Zhongwei, Huang Jianping, Bi Jianrong, Wang Tianhe, Zhou Tian, Dong Qingqing, Shi Jinsen, Liu Qiantao, Li Wuren, Li Ze, Song Xiaodong, Liu Wentao, Wang Huiyan, Niu Zuorong

“…Aiming to obtain the vertical distribution of dust aerosol and clouds, we have initiated a ground-based lidar network along the dust belt since 2018. …”
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Newborn screening for congenital hypothyroidism: worldwide coverage 50 years after its start by Marta Arrigoni, Nitash Zwaveling-Soonawala, Stephen H LaFranchi, A S Paul van Trotsenburg, Christiaan F Mooij

“…Background: Congenital hypothyroidism (CH) is a preventable cause of neurodevelopmental delay in children, detectable by newborn screening (NBS) programs for CH. …”
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Preterm infants at low risk for early-onset sepsis differ in early fecal microbiome assembly by Sagori Mukhopadhyay, Jung-Jin Lee, Erica Hartman, Emily Woodford, Miren B. Dhudasia, Lisa M. Mattei, Scott G. Daniel, Kelly C. Wade, Mark A. Underwood, Kyle Bittinger

“…Species isolated from the blood culture was detected in the pre-antibiotic fecal samples of the infant for all episodes, though these species were also found in infants without bacteremia. …”
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Impact of liver-specific survival motor neuron (SMN) depletion on central nervous system and peripheral tissue pathology by Monique Marylin Alves de Almeida, Yves De Repentigny, Sabrina Gagnon, Emma R Sutton, Rashmi Kothary

“…To address this, we developed a mouse model with a liver-specific depletion of SMN by utilizing an Alb-Cre transgene together with one Smn2B allele and one Smn1 exon 7 allele flanked by loxP sites. Initially, we evaluated phenotypic changes in these mice at postnatal day 19 (P19), when the severe model of SMA, the Smn2B/- mice, exhibit many symptoms of the disease. …”
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Effect of physical and occupational therapy on delirium duration in older emergency department patients who are hospitalized by James O. Jordano, Eduard E. Vasilevskis, Maria C. Duggan, Sarah A. Welch, John F. Schnelle, Sandra F. Simmons, E. Wesley Ely, Jin H. Han

“…ED delirium duration was defined as the duration of delirium detected in the ED using the Brief Confusion Assessment Method. …”
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Influence of cardiopulmonary bypass on the erythrocyte membranes and the method of its protection by V.І. Cherniy, L.O. Sobanska, P.O. Topolov, T.V. Сherniy

“…Вefore cardiac surgery hypophosphatemia was detected in 18% out of 150 and in 32% out of 150 patients – a lower limit of normal phosphorus content in the blood. …”
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Characterization of the Blood Bacterial Microbiota in Lowland Tapirs (<i>Tapirus terrestris</i>), a Vulnerable Species in Brazil by Anna Claudia Baumel Mongruel, Emília Patrícia Medici, Rosangela Zacarias Machado, Keith Clay, Marcos Rogério André

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Clinical and epidemiological characteristics of influenza and SARS-CoV-2 virus among patients with acute febrile illness in selected sites of Ethiopia 2021–2022 by Musse Tadesse Chekol, Musse Tadesse Chekol, David Sugerman, Adamu Tayachew, Adamu Tayachew, Zelalem Mekuria, Neamin Tesfay, Aynalem Alemu, Aynalem Alemu, Andargachew Gashu, Andargachew Gashu, Wolde Shura, Melaku Gonta, Admikew Agune, Aster Hailemariam, Yonas Assefa, Mesfin Wossen, Abdulhafiz Hassen, Parsons Michele, Rachel Silver, Hulemenaw Delelegn, Lozano Briana, Tesfu Kasa, Nigatu Kebede

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Component-resolved Diagnostics in Allergy Practice Focusing on Food Allergy: A Systematic Review by Shambo S Samajdar, Shatavisa Mukherjee, Sourya Ghosh, Santanu Munshi, Santanu K Tripathi, Saibal Moitra, Pudupakkam Vedanthan

“…Further research and initiatives are necessary to address these gaps and improve the use of CRD in food allergy diagnosis.…”
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Rapid recovery of postnivolumab vemurafenib-induced Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome after tocilizumab and infliximab administration by Davide Zanon, Natalia Maximova, Alessandra Maestro, Annalisa Marcuzzi

“…On the third day of anti-BRAF therapy, profound lymphopenia was detected, and maculopapular eruption appeared afterward. …”
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Dynamic conduction and repolarisation changes in early arrhythmogenic right ventricular cardiomyopathy versus benign outflow tract ectopy demonstrated by high density mapping &amp;... by Malcolm C Finlay, Akbar K Ahmed, Alan Sugrue, Justine Bhar-Amato, Giovanni Quarta, Antonis Pantazis, Edward J Ciaccio, Petros Syrris, Srijita Sen-Chowdhry, Ron Ben-Simon, Anthony W Chow, Martin D Lowe, Oliver R Segal, William J McKenna, Pier D Lambiase

“…<h4>Aims</h4>The concealed phase of arrhythmogenic right ventricular cardiomyopathy (ARVC) may initially manifest electrophysiologically. No studies have examined dynamic conduction/repolarization kinetics to distinguish benign right ventricular outflow tract ectopy (RVOT ectopy) from ARVC's early phase. …”
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