Prevention of mother-to-child transmission of hepatitis B virus: protocol for a one-arm, open-label intervention study to estimate the optimal timing of tenofovir in pregnancy by François Nosten, Rose McGready, Verena Carrara, Stephan Ehrhardt, Chaisiri Angkurawaranon, Nan Guo, Yuanxi Jia, Marieke Bierhoff, Kenrad E Nelson, Podjanee Jittamala, Wanitda Watthanaworawit, Clare Ling, Fuanglada Tongprasert, Michele van Vugt, Marcus Rijken, Chloe Lynne Thio

“…Measurement of tenofovir concentrations in maternal and cord plasma is anticipated in 10–15 women who have detectable HBV DNA at delivery and matched to 20–30 women with no detectable HBV DNA. …”
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Prevalence and spatial distributions of trachomatous inflammation-follicular among children aged 1–9 years in rural areas of Yilmana Densa and Gonji Kolela districts, Northwestern... by Misganaw Alelign, Asmamaw Malede, Eshetu Shifaw, Tesfahun Taddege, Yideg Abinew, Metadel Adane

“…In hot spot spatial analysis, fourteen hot spot clusters were detected. Eight clusters were detected as significantly clustered from those fourteen hot spot areas at the 99% confidence level. …”
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MoHiPr-TB: A Monthly Gridded Multi-Source Merged Precipitation Dataset for the Tarim Basin Based on Machine Learning by Ping Chen, Junqiang Yao, Jing Chen, Mengying Yao, Liyun Ma, Weiyi Mao, Bo Sun

“…Moreover, MoHiPr-TB is capable of detecting the precipitation–elevation relationship in the Pamir Plateau, where precipitation initially increases and then decreases with elevation, as well as the synchronous variation of precipitation and elevation in the Tianshan region. …”
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Prevention of respiratory syncytial virus disease across the lifespan in Italy by Paolo Manzoni, Eugenio Baraldi, Irene Cetin, Stefania Maggi, Matteo Riccò, Roberta Siliquini, Giovanni Sotgiu, Elsa Viora

“…Policies are needed to support these preventive measures in the Italian healthcare system, and access must be accompanied by educational initiatives and advocacy to promote acceptance by HCPs and the target population.…”
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Unconventional low temperature decomposition of a saturated hydrocarbon over atomically-dispersed titanium-aluminum-boron catalyst by Souvick Biswas, Jack Cokas, Winston Gee, Dababrata Paul, Nureshan Dias, Harry W. T. Morgan, Matthew T. Finn, Bethany M. Hudak, Perrin M. Godbold, Christopher A. Klug, Albert Epshteyn, Anastassia N. Alexandrova, Musahid Ahmed, Ralf I. Kaiser

“…Here, the model saturated hydrocarbon, exo-tetrahydrodicyclopentadiene (C10H16), undergoes catalytic decomposition on TiAlB NPs in a chemical microreactor to produce 1,3-cyclopentadiene (c-C5H6), cyclopentene (c-C5H8), and molecular hydrogen (H2) as detected in situ via isomer-selective, single-photon ionization time-of-flight mass spectrometry. …”
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Comparative structural insights and functional analysis for the distinct unbound states of Human AGO proteins by Panos Kakoulidis, Eleni I. Theotoki, Vasiliki I. Pantazopoulou, Ioannis S. Vlachos, Ioannis Z. Emiris, Dimitrios J. Stravopodis, Ema Anastasiadou

“…Additionally, we suggest that AGOs interact with a mitosis initiator, zinc ion, by predicting potential binding sites and detecting structurally similar proteins with the same function. …”
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Tradeoffs When Building and Running Cohort and Patient-Level Markov Simulation Models by Balázs Nagy, Ahmad Nader Fasseeh, Jonathan D. Campbell, Zoltán Kaló, Kareem Ahmed El-Fass, Rok Hren, Bertalan Németh

“…CH modeling faced more challenges when extensive structural changes were initiated. Choosing between CH and PL modeling techniques involves the careful assessment of trade-offs between the need for a flexible and informed model and the optimization of human and computational resources.…”
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Accurate scoliosis vertebral landmark localization on X-ray images via shape-constrained multi-stage cascaded CNNs by Zhiwei Wang, Jinxin Lv, Yunqiao Yang, Yi Lin, Qiang Li, Xin Li, Xin Yang

“…The landmarks in each step were located gradually from a set of initialized points by regressing offsets using cascaded CNNs. …”
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Systematic review and meta-analysis of cardiovascular event risk prediction models in maintenance hemodialysis patients by Yaping Zhou, Yining He, Peiqi Zhu, Ruxue Yan, Ruijie Tang, Lanhui Wang, Weiming He

“…Through systematic literature searching, the titles and abstracts of 23,707 related papers were initially screened, ultimately including 16 papers covering 17 prediction models. …”
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USP5 Promotes Ripretinib Resistance in Gastrointestinal Stromal Tumors by MDH2 Deubiquition by Haoyu Sun, Zhiwei Cui, Chao Li, Zhishuang Gao, Jun Xu, Yibo Bian, Tianhao Gu, Jianan Zhang, Tengyun Li, Qianzheng Zhou, Dinghua Yang, Zhongyuan He, Bowen Li, Fengyuan Li, Zekuan Xu, Hao Xu

“…Posttranslational modifications (PTMs) such as ubiquitination, in conjunction with its interplay with other modifications, play a collective role in regulating tumor initiation and progression. However, the specific association between ubiquitination and ripretinib resistance is not reported. …”
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Imprint of a quasi-16-day period in boreal summer through modulation of quasi-2-day wave implying interhemispheric coupling by Gourav Mitra, Amitava Guharay, P. P. Batista, R. A. Buriti, Toralf Renkwitz, J. F. Conte

“…Notably, while no significant Q16DW wave is detected in the boreal summer middle atmospheric winds, the primary Q2DWW3 mode (with amplitudes reaching ~8 m s−1) play a crucial role in carrying the Q16DW signature from the winter to the summer hemisphere. …”
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Immune microenvironment heterogeneity characterizes biologically distinct KRASmut/SPOPmut and KRASmut/PIK3CAmut mesonephric-like adenocarcinoma subtypes revealed by integrated whol... by Jing Zeng, Jing Zeng, Qingli Li, Qingli Li, Kemin Li, Kemin Li, Lu Yang, Lu Yang, Lian Xu, Lian Xu, Wei Wang, Wei Wang, Kaixuan Yang, Kaixuan Yang, Qingbo Wei, Jin Wang, Changbin Zhu, Rutie Yin, Rutie Yin

“…KRAS_SPOP mutant MLAs, exhibited reduced immune infiltration in their tumor microenvironment.ConclusionThis is the first study to demonstrate the comprehensive molecular characteristics of MLA and detect biologically distinct subtypes of KRASmut/SPOPmut and KRASmut/PIK3CAmut MLAs.…”
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Potential role of matrix metalloproteinase-8 as a predictive marker for peri-implant mucositis progress by Noor I Dhaidan, Ghada I Taha, Maher AL Shayeb

“…The purpose of this study was to detect the role of MMP-8 as a biomarker of active and aggressive peri-implant mucositis. …”
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Comparing 2D and 3D Feature Extraction Methods for Lung Adenocarcinoma Prediction Using CT Scans: A Cross-Cohort Study by Margarida Gouveia, Tânia Mendes, Eduardo M. Rodrigues, Hélder P. Oliveira, Tania Pereira

“…Computed Tomography (CT) is widely used for detecting tumours and their phenotype characteristics, for an early and accurate diagnosis that impacts patient outcomes. …”
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A Patient with Uncontrollable Belching: What to Do? by I. V. Maev, Yu. A. Kucheryaviy, E. V. Barkalova, M. A. Ovsepyan

“…Gastric belching occurs reflexively at the moment of stomach stretching by excess air trapped during swallowing, which initiates the transient relaxation of the lower esophageal sphincter. …”
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Tau‐targeting nanoparticles for treatment of Alzheimer's disease by Shreya Pawar, Mohd Ahmar Rauf, Hosam Abdelhady, Arun K. Iyer

“…Diagnosis involves computed tomography (CT) scans, Magnetic resonance imaging (MRIs), Positron emission tomography (PET) scans, and lumbar punctures to detect brain abnormalities, protein deposits, and cerebrospinal fluid biomarkers. …”
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Bundling gold nanorods with RCA-produced DNA tape into an intelligently reconfigurable nanocluster bomb for multimodal precision cancer therapy by Qian Gao, Weijun Wang, Shujuan Sun, Ya Yang, Kaili Mao, Yuxi Yang, Zai-Sheng Wu

“…The external stimuli (laser irradiation) promotes the release of chemotherapeutic agents and initiates the PTT/chemotherapy outcome, while endogenous stimuli (intracellular biomarkers) causes almost 100 % release of siRNA-Plk1 species and induces RNA interference therapy, completely inhibiting tumor growth without detectable off-target toxicity.…”
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Females with Fabry disease: an expert opinion on diagnosis, clinical management, current challenges and unmet needs by Antonino Tuttolomondo, Cristina Chimenti, Vittoria Cianci, Maurizio Gallieni, Chiara Lanzillo, Antonella La Russa, Giuseppe Limongelli, Renzo Mignani, Renzo Mignani, Iacopo Olivotto, Federico Pieruzzi, Federico Pieruzzi, Antonio Pisani

“…Female patients usually underwent cardiac, renal, and neurologic monitoring, and measurement of plasma lyso-globotriaosylsphingosine (Gb3) levels at 6- or 12-month intervals. Treatment was initiated in 54%, mostly enzyme replacement therapy. …”
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Host personality and seasonal parasitism risk do not account for egg rejection behavior in the azure-winged magpie by Xingyi Jiang, Wei Liang, Yanyun Zhang

“…In addition, no significant difference was detected in the proportion of egg rejection between bold individuals (shorter flight initiation distance, FID) and shy individuals (longer FID). …”
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Relict charcoal hearth magnetic fingerprints in the forest topsoil by Marcin Szuszkiewicz, Jarosław Lasota, Maria Magdalena Szuszkiewicz, Ewa Błońska

“…The preliminary research was aimed at verifying the possibility of using some environmental magnetism parameters to detect differences in the soil magnetic signal with and without relict charcoal hearth (RCH). …”
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