Comprehensive genomic profiling reveals a unique genomic landscape in solid tumors in an Indian cancer cohort of 1000 patients: a single institutional experience by Mithua Ghosh, Sheela Mysore Lingaraju, Krishna C.R, Gautam Balaram, Ramya Kodandapani, Vijay E, Vijay K, Suhas N, Devika H, Shekar Patil, Satheesh Chiradoni Thungappa, Somorat Bhattacharjee, Sridhar P.S, Roshni Dasgupta, Mohammed Naseer, Srinivas B.J, Vishal Rao, Veena Ramaswamy, Radheshyam Naik, Govind Babu, Aarthi Ravichandran, Urvashi Bahadur, Krithika Murugan, Mahesh B, Lohith Reddy, Ajaikumar Basavalinga S

“…Tumor-agnostic markers for immunotherapy (IO) were observed in 16% of the current cohort, based on which IO was initiated. In 13.5% of the cohort, alterations in the HRR pathway including sBRCA (5.5%) were detected providing an option for treatment with platinum or PARP inhibitors. …”
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Changes in macrobenthos communities during the invasive Spartina alterniflora removal and mangrove restoration by Lin Lin, Yuqing Guo, Guangzhao Wang, Shilong Feng, Kai Liu, Mingcheng Hu, Mouxin Ye, Chunxi Cao, Ruohai Chen, Silong Ding, Zenghui Peng, Fenfen Ji, Yi-Jia Shih

“…Additionally, the results suggested that after the removal of S. alterniflora, macrobenthos diversity initially declined but gradually recovered, and long-term monitoring is warranted in order to better understand the changes in macrobenthos diversity with planting of mangroves.…”
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Phylogenomic analysis reveals exceptions to the co-evolution of ZAR1 and ZRK immune gene families in plants by Li Yang, Shengyi Liu, M. Eric Schranz, Klaas Bouwmeester

“…Abstract Background HOPZ-ACTIVATED RESISTANCE 1 (ZAR1) is a nucleotide-binding leucine-rich repeat (NLR) protein functioning as a recognition hub to initiate effector-triggered immunity against bacterial pathogens. …”
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Evidence for in vivo resistance against allopurinol in a dog infected with Leishmania infantum by reduction in copy numbers of the S-adenosylmethionine synthetase (METK) gene by Ingo Schäfer, Mathieu Faucher, Yaarit Nachum-Biala, Lluís Ferrer, Marina Carrasco, Alexandra Kehl, Elisabeth Müller, Torsten J. Naucke, Gad Baneth

“…Immunosuppressive treatment was initiated, and the dog was referred for a second opinion to the Clinique Veterinaire Alliance in France. …”
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THE NEPSKY-1 IMPACT CRATER AND ITS FILL DEPOSITS ON THE BASEMENT ROOF OF THE SIBERIAN PLATFORM by M. I. Gyokche, A. V. Plyusnin

“…In the area around the crater, fault systems are detected. Based on the core sample analysis, we identified the lithological members of the crater and its rim and described them in detail. …”
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Cerebral Oxygenation Monitoring During Coronary Artery Bypass Grafting and Its Correlation with Hematocrit, Mean arterial pressure, and Partial pressure of Oxygen in Arterial Blood by Jai Sharma, Indu Verma, Swati Agarwal, Nivedita Dagar

“…It offers real-time rSO2 assessment, detecting critical thresholds and reducing risks during cardiopulmonary bypass (CPB). …”
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Viral infections and related fatal adverse events associated with complement inhibitors for PNH: a real-world pharmacovigilance analysis in FAERS by Jinman Zhong, Chang Chen, Yunman Xu, Yueping He, Jiewen Tan, Dan Xiong

“…Pharmacovigilance analyses (including Reporting Odds Ratio [ROR] and multiple other metrics) were employed to detect signals for adverse events, including viral infection. …”
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Serous retinal detachment secondary to bilateral choroidal osteoma successfully treated with subscleral sclerectomy: A case report by Satoko Fujimoto, Kazuichi Maruyama, Takuya Shunto, Kohji Nishida

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Final analysis of ArtemisR, a European real-world retrospective study of apalutamide for the treatment of patients with metastatic hormone-sensitive prostate cancer by Martin Boegemann, Mostefa Bennamoun, Louis Marie Dourthe, Juan Antonio Encarnacion, Axel Hegele, Eva Hellmis, Igor Latorzeff, Wolfgang Leicht, Julián Oñate-Celdrán, Antonio Rosino-Sánchez, Krystelle Hanna, Joana Lencart, Martin Lukac, Claudio A. Schioppa, Suzy Van Sanden, Gero Kramer

“…Median follow-up was 25.5 months from treatment initiation. Within 12 months of apalutamide initiation, 96% of patients achieved PSA50, 82% achieved PSA90, and 61% achieved uPSA. …”
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Low-Grade Endometrial Stromal Sarcoma with Intravenous and Intracardiac Extension: A Multidisciplinary Approach by Wataru Kudaka, Hitoshi Inafuku, Yuko Iraha, Tomoko Nakamoto, Yusuke Taira, Rie Taira, Hisashi Kamiya, Maho Tsubakimoto, Yuichi Totsuka, Yukio Kuniyoshi, Tomoko Tamaki, Hajime Aoyama, Masanao Saio, Naoki Yoshimi, Yoichi Aoki

“…A 40-year-old woman had IVC tumor, which was incidentally detected by abdominal ultrasonography during a routine medical checkup. …”
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Experimental and Numerical Investigation of Reinforcement Sheet Effect on the Bending Strength of Corrugated Composite Panels by Ali Hemmatian Soorki, Abdulreza Kabiri Ataabadi, Mohsen Loh-Mousavi

“…In the numerical analysis, Hashin failure criterion was used to detect the failure, and an instantaneous material properties degradation model via a VUSDFLD subroutine developed in the commercial software ABAQUS was employed to simulate the behavior of the panel after damage initiation. …”
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Occurrence of Polycyclic Aromatic Hydrocarbons (PAHs) in Pyrochar and Hydrochar during Thermal and Hydrothermal Processes by Hwang-Ju Jeon, Donghyeon Kim, Fabiano B. Scheufele, Kyoung S. Ro, Judy A. Libra, Nader Marzban, Huan Chen, Caroline Ribeiro, Changyoon Jeong

“…They ranged from 131 to 9358 µg·kg⁻¹ in the seven pyrochars and from not detected to 333 µg·kg⁻¹ for the fourteen hydrochars. …”
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Sodium glucose co-transporter 2 inhibitors (SGLT2i) for pediatric kidney disease: the future is near by Gilda M. Portalatin, Irene Hong-McAtee, Irene Hong-McAtee, Anna M. Burgner, Edward R. Gould, Tracy E. Hunley, Tracy E. Hunley

“…Regulatory guidance mandated adequately powered studies to detect increased cardiovascular risk from emerging hypoglycemic medications. …”
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Serological and genetic analysis of a novel 27delC variant in A subgroup: a case report by ZHANG Yingjun, ZHU Yuli, FENG Zhihui, YU Shuhong

“…Monoclonal sequencing was used to detect the haplotypes of the DNA sequence, and bioinformatics analysis was applied to predict the possible translation outcomes of the mutated DNA sequence. …”
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Behavioral adaptations of Caenorhabditis elegans against pathogenic threats by Xin Zhao, Xinyu Li, Jiayi Gao, Shi Shen, Wei Zou

“…It systematically explores how mechanisms such as avoidance behavior, transgenerational learning, and forgetting enable C. elegans to optimize its survival and reproductive strategies within dynamic microbial environments. C. elegans detects harmful signals through chemosensation and initiates avoidance behaviors. …”
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Extrahepatic malignancies in a liver transplant recipient from a living related donor by I. Yu. Kolyshev, S. E. Voskanyan, M. V. Shabalin, A. I. Artemyev, V. S. Rudakov, A. P. Maltseva, A. N. Bashkov, V. E. Syutkin, K. K. Gubarev, D. S. Svetlakova, M. V. Popov, A. I. Sushkov, Z. A. Sadykhov

“…Cancer occurring in recipients of living donor liver transplantation may be characterized by a progressive course requiring an immediate specialized treatment initiation and adjustment of immunosuppression regimen. …”
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A Case of Granulomatous Interstitial Nephritis Associated with <i>Mycobacterium chimaera</i> Disseminated Infection by Martina Cacciapuoti, Maria Mazzitelli, Elena Naso, Maria Loreta De Giorgi, Giovanni Samassa, Valentina Di Vico, Serena Marinello, Lucia Federica Stefanelli, Lorenzo Calò, Annamaria Cattelan, Federico Nalesso

“…A kidney biopsy revealed non-caseating necrotizing granulomatous interstitial nephritis, which was initially diagnosed as idiopathic granulomatous interstitial nephritis. …”
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Single‐Cell Metabolic Labeling Probe for Diagnosing Tuberculous Meningitis: A Case Report by Jiahao Wang, Guiqin Dai, Pengfei Zhao, Mingbin Zheng, Li Wei, Hongzhou Lu

“…SCMLP‐TB successfully detected Mycobacterium tuberculosis in cerebrospinal fluid within 2 h in this case of clinically suspected TBM. …”
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Design of a risk matrix to assess sterile formulations at health care facilities by A. M.ª Martín de Rosales Cabrera, C. López Cabezas, P. García Salom

“…Material and methods: i) Literature search and critical appraisalof the model proposed by the European Resolution CM/ResAp(2011)1, ii) Identification of the risk associated to the elaborationprocess by means of the AMFE methodology (ModalAnalysis of Failures and Effects), iii) estimation of the severityassociated to the risks detected. After initially trying a model ofnumeric scoring, the classification matrix was changed to analphabetical classification, grading each criterion from A to D.Each preparation assessed is given a 6-letter combination withthree possible risk levels: low, intermediate, and high. …”
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A neglected cause of recurrent rhabdomyolysis, LPIN1 gene defect: a rare case from Turkey by Sevgi Topal, Melis Demir Köse, Hasan Ağın, Ferhat Sarı, Mustafa Çolak, Gülhan Atakul, Utku Karaarslan, Rana İşgüder

“…(Asp566His)] mutation was detected on LPIN1 gene. This variant has not been described previously, however, when examined with programs such as SIFT and Mutation taster, it has been considered as pathogenic. …”
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