MPRIP::PDGFRB Fusion Gene: A Rare Case Report of Adult Myeloid/Lymphoid Neoplasm With Eosinophilia and Tyrosine Kinase Gene Fusions by Taksin Ukkahad, Tanapun Thamgrang

“…Further targeted RNA analysis using next-generation sequencing (NGS) detected a fusion gene involving MPRIP::PDGFRB. The patient was diagnosed with myeloid/lymphoid neoplasms with eosinophilia and MPRIP::PDGFRB rearrangement in the chronic-phase disease and was initiated on oral imatinib at a daily dose of 100 mg. …”
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High-throughput analysis of calcium signalling kinetics in astrocytes stimulated with different neurotransmitters. by Laura R James, Simon Andrews, Simon Walker, Paula R S de Sousa, Aaron Ray, Noah A Russell, Tomas C Bellamy

“…Astrocytes express a wide range of receptors for neurotransmitters and hormones that are coupled to increases in intracellular Ca(2+) concentration, enabling them to detect activity in both neuronal and vascular networks. …”
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Successful treatment of a CLL associated IgM hyper-viscosity syndrome: A rare case by Toufic Tannous, Gil Hevroni, Raiyan Islam, Georgios Pongas

“…Our case underscores the significance of swiftly identifying HVS when IgM hyperparaproteinemia is detected in CLL patients. Notably, our patient not only achieved successful treatment for the acute presentation but also initiated second-line therapy for relapsed disease. …”
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Cryptic absence and genetic variation of Plasmodium falciparum PfHRP2 and PfHRP3 from isolates in Papua, Indonesia by Agatha Mia Puspitasari, Edwin Sutanto, Khilal Syauqi, Ristya Amalia, Fahira Ainun Nisa, Leily Trianty, Elizabeth Sidhartha, Enny Kenangalem, Jeanne Rini Poespoprodjo, Rukhsana Ahmed, Ewurama Owusu, Lise Carlier, Kevin K. A. Tetteh, Qin Cheng, Rintis Noviyanti

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Early cardio-oncology intervention in thoracic radiotherapy: prospective single-arm pilot study by Samuel C. Zhang, Jordan O. Gasho, Celeste Eno, Katrina D. Silos, Felicity Pendergast, Wenjuan Zhang, Eric Vail, Mitchell Kamrava, Behrooz Hakimian, Amin Mirhadi, Raymond H. Mak, Andriana P. Nikolova, Katelyn M. Atkins

“…Conclusions We observe that early cardio-oncology consultation is feasible, leads to cardiovascular medication optimization in the majority (>60%) of participants, most commonly to initiate or intensify statin therapy. New clonal hematopoiesis variants are detectable early after radiotherapy and the impact on post-treatment cardiovascular risk is worthy of further study.…”
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Connectivity guided intermittent theta burst stimulation versus repetitive transcranial magnetic stimulation in moderately severe treatment resistant depression by Richard Morriss, Lucy Webster, Luke Ingram, Mohamed Abdelghani, Adriana Anton, Shaun Barber, Peter Bates, Paul Briley, Clement Boutry, Cassandra Brookes, Edward Cox, Beth Hall, Marilyn James, Matthew Keane, Micheal Kurkar, Sudheer Lankappa, Peter Liddle, Hamish McAllister-Williams, Hyerin Oh, Alexander O’Neill-Kerr, Jehill Parikh, Stefan Pszczolkowski, Ana Suazo Di Paola, Louise Thomson, Yvette Walters, Dorothee Auer

“…Results Baseline characteristics and flow into the study Completion of initial telephone screening was undertaken with 685 individuals: 317 consented to the trial, 39 were excluded and 23 withdrew from baseline to first randomisation. …”
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Doxycycline post-exposure prophylaxis in China: current utilized situation among men who have sex with men in a cross-sectional online survey from two cites by Xu Zhang, Fang-Zhi Du, Xiao-Li Zheng, Rui-Li Zhang, Qian-Qiu Wang

“…Most of them under 35 years of age (79.55%), had college degrees (70.61%) and worked in private institutions (36.42%) or were freelancers (24.28%). 34.2% had heard of Doxy-PEP and 12.1% had used it, while 8.31% were self-initiated users. Doxy-PEP self-initiated use behavior was found to be associated with multiple sexual partners (P = 0.013) and HIV PrEP/PEP experience (P < 0.001). 89.47% of the Doxy-PEP users showed interest in promoting it to others in the future. …”
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Evaluating the efficacy of Terminalia chebula Retz. 5% cream compared to hydroquinone 2% cream in the treatment of melasma by Amir Emad Kheirieh, Fariba Sharififar, Mehdi Ansari Dogaheh, Fatemeh Dabaghzadeh, Simin Shamsi Meymandi, Behnoush Bakhshoudeh

“…Modified Melasma Area and Severity Index (mMASI) scores were recorded for all the participants at the baseline and 4, 8, and 12 weeks after initiating the study.Results: No statistically significant differences regarding mMASI scores were detected between T. chebula and hydroquinone groups at each time point. …”
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Microwave-Assisted Synthesis of Corn Husk-Based Hydrogels Grafted with Acrylamide by Ginanjar Penata Aji, Mahira Noor Syevarani Arifandi, Sperisa Distantina, Mujtahid Kaavessina

“…FTIR analysis confirmed the successful grafting of acrylamide onto corn husk cellulose by detecting changes in the infrared spectrum. Based on FTIR and swelling capacity data, it was concluded that the grafting process was completed using the microwave method with PPD as the initiator.…”
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MicroRNA-223-3p inhibits human bladder cancer cell migration and invasion by Ju Guo, Runfu Cao, Xingwei Yu, Zewen Xiao, Zhiwen Chen

“…The regulation of initiation and progression during carcinogenesis of bladder carcinoma is not completely elucidated. …”
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INFLAMMATION AND IMMUNITY: A ROLE OF PATHOGENESIS OF OSTEOARTHRITIS by V. S. Shirinsky, E. V. Kazygasheva, I. V. Shirinsky

“…In addition, some authors detected IL-5, IL-13, IL-19, IL-21, IL-26, IL-32, and TGFb. …”
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Macrotroponin interference and association with cardiotoxicity in patients receiving cardiotoxic breast cancer therapy: a pilot study by Andrea Soosaipillai, Inbar Nardi-Agmon, Davor Brinc, Anselmo Fabros, Peter A. Kavsak, Paaladinesh Thavendiranathan, Ashley Di Meo

“…We aimed to assess whether macrotroponin is detectable in women with ERBB2 + breast cancer receiving sequential therapy with anthracyclines and trastuzumab. …”
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Retinoic Acid signalling and the control of meiotic entry in the human fetal gonad. by Andrew J Childs, Gillian Cowan, Hazel L Kinnell, Richard A Anderson, Philippa T K Saunders

“…Germ cells in the fetal testis enter mitotic arrest, whilst those in the fetal ovary undergo sex-specific entry into meiosis, the initiation of which is thought to be mediated by selective exposure of fetal ovarian germ cells to mesonephros-derived retinoic acid (RA). …”
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Cell cycle-dependent TICRR/TRESLIN and MTBP chromatin binding mechanisms and patterns by Tyler D. Noble, Courtney G. Sansam, Kimberlie A. Wittig, Blanka Majchrzycka, Christopher L. Sansam

“…Results We examine genomic binding locations for TICRR/TRESLIN and MTBP, the human orthologs for the yeast replication initiation factors Sld3 and Sld7. TRESLIN and MTBP binding patterns are detectable in a G1 synchronized population and have a higher binding signal compared to asynchronously cycling cells. …”
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A Practical Alternative? KardiaMobile to Improve Uptake of ECGs on Psychiatric Wards by Emily Pettifor, Faizaan Syed, Obumneme Chinweuba, Suresh Thapaliya, Mudasir Firdosi

“…Aims: ECGs on psychiatric wards are crucial for detecting cardiac side effects of psychotropics and identifying patients with underlying cardiac conditions. …”
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From Global Insights to National Impact: Advancing Cardio-Oncology in Iraq by Mustafa H. Ajlan, Hasan A. Farhan, Zainab A. Dakhil

“…These intersecting burdens highlight the growing need to prevent, detect, and manage cardiovascular complications in cancer care pathways and call for important initiatives in establishing cardio-oncology services globally. …”
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Drawback of chimerism analysis by XY-fluorescence in situ hybridization: Deception of a relapse by D VS Kiran Kumar, Jayachandran Perumal Kalaiyarasi

“…The relapse of the disease initially happens in the marrow and then spreads to the peripheral blood. …”
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Postzone Phenomenon: A False-Negative Cryptococcal Antigen Assay in a Patient With Cryptococcemia and Meningoencephalitis by Tin Lynn Han, Raphael Shaw, Vibhuti Krishna, Vel Sivapalan

“…Rapid diagnosis and early initiation of antifungal therapy effectively reduce cryptococcal infection-related mortality. …”
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CERTOLIZUMAB PEGOL IN THE TREATMENT OF AXIAL SPONDYLOARTHRITIS by Sh. F. Erdes

“…CZP was shown to be effective in all forms of axSpA, whether radiographically detected sacroiliitis was present or absent. This study has also demonstrated for the first time the long-term efficacy of TNF-α inhibitors in patients with initially high C-reactive protein level and/or signs of active sacroiliitis by magnetic resonance imaging.…”
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BRCA1 promoter methylation predicts PARPi response in ovarian cancer: insights from the KOMET study by Léna Nougarede, Florence Hazane-Puch, Florence de Fraipont, Emmanuelle Jacquet, Marie Bidart

“…Results A methylated BRCA1 promoter was detected in 17 out of 88 (19%) tumor tissues. Statistically, PFS from PARPi initiation was significantly different between the BRCA1 methylated promoter (BRCA1mp) group and the BRCA1 unmethylated promoter and HRD negative (BRCA1up HRD−) group (p value = 0.0003 log rank test; Hazard Ratio (HR), 95% CI 0.04–0.40). …”
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