High-resolution profile of neoantigen-specific TCR activation links moderate stimulation to increased resilience of engineered TCR-T cells by Franziska Füchsl, Johannes Untch, Vladyslav Kavaka, Gabriela Zuleger, Sarah Braun, Antonia Schwanzer, Sebastian Jarosch, Carolin Vogelsang, Niklas de Andrade Krätzig, Dario Gosmann, Rupert Öllinger, Piero Giansanti, Michael Hiltensperger, Roland Rad, Dirk H. Busch, Eduardo Beltrán, Eva Bräunlein, Angela M. Krackhardt

“…We describe a heterogeneous spectrum of TCR-intrinsic activation patterns in response to a shared neoepitope ranging from previously detected more highly frequent neoTCRs with moderate activation to rare ones with initially stronger activation. …”
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A Study on the Energy Condition and Quantitative Analysis of the Occurrence of a Coal and Gas Outburst by Linchao Dai, Yanbao Liu, Jie Cao, Xuelin Yang, Haitao Sun, Guangcai Wen, Bo Wang

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Sustainable Development Goals in academic publishing: impacts of SDG Publishers Compact and EASE Environmental Manifesto by Nikita Lad, Iva Grabarić Andonovski, Dana Compton, Jo Wixon, Mary Hodgson

“…It is important to monitor the impact of these initiatives on journal policies for developing future recommendations.Objectives: The EASE and the Higher Education Sustainability Initiative (HESI) SDG Publishers Compact Fellows developed a survey to assess the progress made by signatories to the SDG Publishers Compact, detect obstacles that prevent other publishers or journals from signing the compact, assess awareness and implementation of the EASE Environmental Manifesto, and identify other initiatives that promote SDGs.Methods: A multi-stakeholder group was formed, which included editors and both commercial and non-profit publishers, to design questions suited to journals and organizations at different stages of sustainability action. …”
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Novel Polymorphism in a Promoter of MBL2 Gene Result in Lower MBL Expression in Chronic Infection Caused by HCV by Paywast Jamal Jalal

“…The level of these proteins was measured by ELISA method and compared with each other based on the detected SNPs by PCR and sequencing methods in the responsible genes. …”
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Disparities in dolutegravir utilisation in children, adolescents and young adults (0–24 years) living with HIV. An analysis of the IeDEA Pediatric West African cohort by Valériane Leroy, Anandi Sheth, Julie Jesson, Jean Jacques Koffi, Antoine Jaquet, François Dabis, Didier Koumavi Ekouevi, Karen Malateste, Olivia Keiser, Lehila Bagnan, Simon Boni, Madeleine Amorissani Folquet, Mariam Sylla, Olivier Marcy, Raoul Moh, Gildas Boris Hedible, Sophie Desmonde, Joycelyn Dame, Agatha David, Madeleine Amorissani-Folquet, Sylvie N'Gbeche, Elom Takassi, François Tanoh Eboua, Kouadio Kouakou, Lehila Bagnan Tossa, Caroline Yonaba, Jocelyn Dame, Sylvie Marie N’Gbeche, Fatoumata Dicko Traore, Oliver Ezchechi, Rosemary Audu, Charlotte Bernard, Caroline Couturier, Marie Kerbie Plaisy, Elodie Rabourdin, Thierry Tiendrebeogo, Désiré Dahourou, Emile Sodinyessi, Jean-Claude Azani, Kadidja Diarra, Maika Bengali, Abdoulaye Cissé, Guy Gnepa, Eric Komena, Séverin Lenaud, Eulalie Kangah, Igho Ofotokun, Cecile Delille Lahiri, Noëlle Benzekri, Geoffrey Gottlieb

“…Adjusted on ART line and available viral load (VL) at baseline, females aged >10 years were less likely to initiate DTG compared with males of the same age (adjusted HR among 10–14 years: 0.62, 95% CI 0.54 to 0.72; among ≥15 years: 0.43, 95% CI 0.36 to 0.50), as were those with detectable VL (>50 copies/mL) compared with those in viral suppression (aHR 0.86, 95% CI 0.77 to 0.97) and those on PIs compared with those on non-nucleoside reverse-transcriptase inhibitors (aHR after 12 months of roll-out: 0.75, 95% CI 0.65 to 0.86).Conclusion Paediatric DTG uptake was incomplete and unequitable in west African settings: DTG use was least likely in children <5 years, females ≥10 years and those with detectable VL. …”
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Diagnostics to support the eradication of yaws-Development of two target product profiles. by Noah Fongwen, Becca L Handley, Diana L Martin, Camila Beiras, Louise Dyson, Michael Frimpong, Oriol Mitja, Kingsley Asiedu, Michael Marks

“…The test to detect azithromycin resistance should be able to detect known genetic resistance mutations with a minimum sensitivity and specificity of 95%, with the caveat that all patients with suspected treatment failure should be treated as having resistant yaws and offered alternative treatment.…”
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Study on the infection characteristics and pathogenesis of duck circovirus 1 in Cherry Valley meat ducks by Hanqing Li, Guige Xu, Hui Yan, Lei Bei, Mingrui Zhao, Ruihua Zhang, Yu Meng, Yanli Zhu, Liangmeng Wei, Zhijing Xie, Shijin Jiang

“…The virus was initially detected in the liver and the organ with the highest viral titer was the thymus. …”
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FLORA: a novel method to predict protein function from structure in diverse superfamilies. by Oliver C Redfern, Benoît H Dessailly, Timothy J Dallman, Ian Sillitoe, Christine A Orengo

“…We also provide novel predictions of enzymatic activity for a large number of structures solved by the Protein Structure Initiative. Overall, we show that FLORA is able to effectively detect functionally similar protein domain structures by purely using patterns of structural conservation of all residues.…”
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Monitoring the rate and variability of somatic genomic alterations using long-read sequencing by Xingyao Chen, Hagai Ligumsky, Charlie Ambrose, Denisse Sibrian, Brian Tran, Daoud Arif, Olga Castellanos, Darren Kessner, Hanyi Luo, Mukta Ubale, Abigail Coleman, Vaidhyanathan Mahaganapathy, Thomas J. Jönsson, Reva K. Basho, Jerry S. H. Lee, Naim Matasci, David B. Agus

“…Here we show that the number of somatic single nucleotide variants detected increases with their age and that for specific mutational processes, changes can be detected within months. …”
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Developing a language screening scale that considers linguistic diversity in pre-school children by Antri Kanikli, George Charilaos Spanoudis, Elena Theodorou

“…The evaluation demonstrates the SSLD's reliability as an instrument for assessing language growth in Greek Cypriot children. The SSLD initiative not only provides a robust tool backed by strong psychometric foundations, but also empowers professionals to confidently detect language difficulties in a diverse linguistic context. …”
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Predicting and comparing transcription start sites in single cell populations. by Shiwei Fu, Wei Vivian Li

“…It employs a Binomial generalized linear mixed model to accurately and efficiently detect differential TSS usage. We demonstrate the utility of scTSS through its application in analyzing transcriptional initiation from single-cell data of two distinct diseases. …”
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Palliatives for Low Velocity Impact Damage in Composite Laminates by Mubarak Ali, S. C. Joshi, Mohamed Thariq Hameed Sultan

“…This damage is generally difficult to detect and repair. This makes it important to find a preventive solution. …”
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Nigral volume loss in prodromal, early, and moderate Parkinson’s disease by Jason Langley, Kristy S. Hwang, Daniel E. Huddleston, Xiaoping P. Hu, On behalf of the Parkinson’s Progression Marker Initiative

“…This study shows that nigral depigmentation can be robustly detected in prodromal and overt PD populations.…”
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Unsupervised deep learning of electrocardiograms enables scalable human disease profiling by Sam F. Friedman, Shaan Khurshid, Rachael A. Venn, Xin Wang, Nate Diamant, Paolo Di Achille, Lu-Chen Weng, Seung Hoan Choi, Christopher Reeder, James P. Pirruccello, Pulkit Singh, Emily S. Lau, Anthony Philippakis, Christopher D. Anderson, Mahnaz Maddah, Puneet Batra, Patrick T. Ellinor, Jennifer E. Ho, Steven A. Lubitz

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Reducing red blood cell folate testing: a case study in utilisation management by Alan Gob, Ian Chin-Yee, Ola Ismail, Vipin Bhayana, Angela Rutledge

“…Joseph’s Healthcare London (SJHC) without any folate deficiency detected. We implemented a quality improvement initiative to reduce RBC folate testing at LHSC/SJHC. …”
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POST-VACCINATION IMMUNE RESPONCE IN SERONEGATIVE TO INFLUENZA VIRUS HIV-INFECTED PATIENTS by R. G. Yapparov, D. A. Lioznov, E. Yu. Karnaukhova, V. A. Larionov, T. L. Galankin

“…To evaluate immunogenicity of influenza vaccination in HIV-infected adults initially seronegative to influenza virus.Materials and methods. …”
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Different clinical presentation in a patient with two novel pathogenic variants of the FBXL4 gene by Engin Köse, Melis Köse, Selvinaz Edizer, Zeynep Akışın, Zehra Burcu Yılmaz, Ahmet Şahin, Ferah Genel

“…Conclusion. We detected two novel variants of the FBXL4 gene. To the best of our knowledge, this is the first case in the literature that presented with gastrointestinal bleeding as an encephalomyopathic form of mitochondrial DNA depletion syndromes and for whom ketogenic diet was initiated due to intractable epilepsy, which was not reported in previous cases. …”
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Exploring the role of infected keratinocytes during rabies virus infection by Keshia Kroh, Redwan Rahmat, Lineke Begeman, Lars W. van Greuningen, Debby Schipper, Matthijs F. Ravensberg, Stefan Finke, Claude Sabeta, Thijs Kuiken, Corine H. GeurtsvanKessel, Carmen W. E. Embregts

“…Thus, it remains unclear whether keratinocytes are initially infected or become infected later due to centrifugal spread of RABV. …”
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Host blood transcriptomic biomarkers of tuberculosis disease in people living with HIV: a systematic review protocol by Mary Shelton, Humphrey Mulenga, Stanley Kimbung Mbandi, Simon C Mendelsohn, Mark Hatherill, Fatoumatta Darboe, Thomas J Scriba

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Essential Thrombocytosis: A Rare Entity by Parimi Ram Shashank, Intikabur Rahman

“…We present the case of a 40-year-old female patient, who came with complaints of excessive tiredness, infrequent tingling sensation at the tip of her fingers, and generalized body ache, and was initially detected to have extreme thrombocytosis of 1,775,000/mm3. …”
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