Design and Implementation of a Deep Learning-Based Hand Gesture Recognition System for Rehabilitation Internet-of-Things (RIoT) Environments Using MediaPipe by Nurul Hanis Mohd Dhuzuki, Ahmad Anwar Zainuddin, Nur Anis Sofea Kamarul Zaman, Alin Nur Maisarah Ahmad Razmi, Wonderful Shammah Kaitane, Asmarani Ahmad Puzi, Mohd Naqiuddin Johar, Maslina Yazid, Nor Azlin Mohd Nordin, Shahrul Naim Sidek, Hasan Firdaus Mohd Zaki

“…The methodology involves the integration of MediaPipe for detecting hand landmarks and adaptive sensitivity algorithms to ensure reliable recognition across different environments, such as varying lighting and hand positions. …”
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A Digital Home-Based Health Care Center for Remote Monitoring of Side Effects During Breast Cancer Therapy: Prospective, Single-Arm, Monocentric Feasibility Study by Hanna Huebner, Lena A Wurmthaler, Chloë Goossens, Mathias Ernst, Alexander Mocker, Annika Krückel, Maximilian Kallert, Jürgen Geck, Milena Limpert, Katharina Seitz, Matthias Ruebner, Philipp Kreis, Felix Heindl, Manuel Hörner, Bernhard Volz, Eduard Roth, Carolin C Hack, Matthias W Beckmann, Sabrina Uhrig, Peter A Fasching

“…The prevalence of reported adverse events was comparable to existing literature, suggesting clinical potential. This initial feasibility study highlights the potential of the DHHC.…”
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International society of liquid biopsy (ISLB) perspective on minimal requirements for ctDNA testing in solid tumors by Nicola Fusco, Konstantinos Venetis, Francesco Pepe, Omshree Shetty, Silvia Calabuig Farinas, Simon Heeke, Julia V. Burnier, Simon J. Patton, Ellen Heitzer, Giovanni Nigita, Paul Hofman, Maria Jose Serrano, Massimo Cristofanilli, Eloisa Jantus-Lewintre, David R. Gandara, Christian Rolfo, Umberto Malapelle

“…Circulating tumor DNA (ctDNA) testing has transformed precision oncology by enabling the non-invasive detection of actionable mutations. To facilitate broader clinical adoption and improve testing accuracy, standardized quality criteria must be clearly defined and universally implemented. …”
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INnovative Steroid Treatment to reduce Asthma development in children after first-time Rhinovirus-induced wheezing (INSTAR): protocol for a randomised placebo-controlled trial by Maria Vollsæter, Knut Øymar, Svein Arne Nordbø, Tytti Vuorinen, Kari Risnes, Claus Klingenberg, Tuomas Jartti, Henrik Døllner, Anna Partty, Håvard Ove Skjerven, Turid Follestad, Trude Elvebakk, Heidi Jartti, Silje Nerheim, Nina Moe, Johanna Koski, Anita Hofstad, Carina Bjørkvoll Leknessund, Cilla Söderhäll, Erle Sissener, Christopher Stephen Inchley, Jon R Konradsen

“…Asthma is defined as fulfilment of the 2007 National Asthma Education and Prevention Program—criteria for initiating asthma controller medication in children aged 0–4 years. …”
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Cardiovascular toxicities in cancer patients treated with immune checkpoint inhibitors: multicenter study using natural language processing on Belgian hospital data by D. Delombaerde, C.L. Oeste, V. Geldhof, L. Croes, I. Bassez, A. Verbiest, L. Tack, D. Hens, C. Franssen, P.R. Debruyne, H. Prenen, M. Peeters, J. De Sutter, C. Vulsteke

“…We analyzed CV events from first ICI administration until last follow-up, identifying and validating the first detection of a CV event at the patient level. Results: We included 1571 patients (66% male, median age 67 years); CV events were detected in 196 (12.5%) patients [median (min-max) follow-up: 8 (0-63) months]. …”
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Patterns of Opportunistic Infections and Antiretroviral Therapy Efficacy in Newly Diagnosed Human Immunodeficiency Virus-1 Patients: A Descriptive Study in India by N Kisenjang, Sumit Arora, Pooja Sangwan, Imam D Khan, Charu Mohan, Anmol Sharma, Vikram Sharma, Ankit Rao, Aditya Puniyani, Shivani Sangwan, Alisha Sharma, Swati Jain, Anuradha Makkar, Preeti Badhan, H Vanalahruaii

“…Conclusion: The study highlights the challenges of early HIV detection and the effectiveness of ART in controlling viral load. …”
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Tracking acute flaccid paralysis in Niger: a half-decade epidemiological portrait (2016–2021) by El Khalef Ishagh, Marc Talatou Ouédraogo, Batouré Oumarou, Mutenda Sheria Kaya, Gbaguidi Aichatou Diawara, Abdoulaye Macire Camara, Seyni Moussa, Kuyangisa Bienvenu, Joseph Toko, Hamidou Harouna, Haladou Moussa, N.’Zue Kofi, Jacques L. Tamuzi, Patrick D. M. C. Katoto, Charles S. Wiysonge, Blanche-Philomene Melanga Anya, Manengu Casimir Tshikolasoni

“…Abstract Background Recently, a total of 74 circulating vaccine-derived poliovirus (cVDPV) outbreaks were detected in 39 countries, with 672 confirmed Acute Flaccid Paralysis (AFP) cases identified in 27 countries. …”
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Critical care nurses’ knowledge regarding prevention of central venous catheter-related infection in Saudi Arabia: A cross-sectional study by Bassam Shyhan Alshammari, Salman Hamdan Alsaqri, Sameer A. Alkubati, Jordan H. Llego, Ahmad K. Al-Sadi, Aziza Z. Ali, Wessam A. Elsayed, Anas Mahmoud Balawi, Shaimaa Mohamed Nageeb, Laila A. Hamed

“…Nurses play a crucial role in preventing these infections through proper catheter care, adherence to aseptic techniques, and early detection of complications. However, knowledge gaps may hinder effective infection prevention and patient outcomes. …”
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An effective multistage mouse model of esophageal carcinogenesis for preclinical and computational pathology applications by Yuxia Fu, Guoqing Zhang, Yue Liu, Lei Xu, Yuanyuan Hu, Liyan Xue, Huiqin Guo, Yan Fu, Yigang Cen, Xiao Li, Wei Jiang, Xiying Yu

“…Since the CIMCM of ESCC provides valuable samples from different stages of tumor initiation and progression, the pathological whole slide images of the CIMCM of ESCC are applied to the computational pathology, which enables the detection, segmentation and annotation of the ESCC initiation and progression with pathologist-level accuracy. …”
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Peripheral blood mitochondrial DNA copy number as a predictor of steatotic liver disease development: insights from epidemiological and experimental studies by Genki Mizuno, Atsushi Teshigawara, Hiroya Yamada, Eiji Munetsuna, Yoshiki Tsuboi, Yuji Hattori, Mirai Yamazaki, Yoshitaka Ando, Itsuki Kageyama, Takuya Wakasugi, Naohiro Ichino, Keisuke Osakabe, Keiko Sugimoto, Ryosuke Fujii, Hiroaki Ishikawa, Nobutaka Ohgami, Koji Ohashi, Koji Suzuki

“…Conclusions: Our findings suggest that reduced mtDNA-CN may contribute causally to SLD development and could serve as a convenient, noninvasive biomarker for early detection and risk assessment.…”
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Resting Cysts of the Toxic Dinoflagellate <i>Gymnodinium catenatum</i> (Dinophyceae) Ubiquitously Distribute along the Entire Coast of China, with Higher Abundance in Bloom-Prone A... by Xiaohan Liu, Zhe Tao, Yuyang Liu, Zhangxi Hu, Yunyan Deng, Lixia Shang, Po-Teen Lim, Zhaoyang Chai, Ying-Zhong Tang

“…The detection revealed that <i>G. catenatum</i> cysts were widely present in the sediments (126 of the 199 samples), with 93.55%, 74.65%, 42.37%, and 50% of the samples detected positively from the BS, YS, ECS and SCS, respectively, and covering the vast sea area from Nansha Islands to the Beidaihe area. …”
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Research on navigation method in closed-canopy orchard based on 3D LiDAR by Zhigang ZHANG, Kaiyuan BAO, Wenyu ZHANG, Fan DING, Zongyi TONG, Fukang ZHOU

“…MethodA navigation method based on three-dimensional light detection and ranging (3D LiDAR) was proposed, taking the wheeled spray robot as the research platform and the canopy mango orchard as the experimental environment. …”
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Use of an extended KDIGO definition to diagnose acute kidney injury in patients with COVID-19: A multinational study using the ISARIC-WHO clinical characterisation protocol. by Marina Wainstein, Samual MacDonald, Daniel Fryer, Kyle Young, Valeria Balan, Husna Begum, Aidan Burrell, Barbara Wanjiru Citarella, J Perren Cobb, Sadie Kelly, Kalynn Kennon, James Lee, James Lee, Laura Merson, Srinivas Murthy, Alistair Nichol, Malcolm G Semple, Samantha Strudwick, Steven A Webb, Patrick Rossignol, Rolando Claure-Del Granado, Sally Shrapnel, ISARIC Clinical Characterisation Group

“…Limitations include ad hoc sCr sampling, exclusion of patients with less than two sCr measurements, and limited availability of sCr measurements prior to initiation of acute dialysis.<h4>Conclusions</h4>An extended KDIGO definition of AKI resulted in a significantly higher detection rate in this population. …”
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Effect of Ciprofol on Postoperative Delirium in Elderly Patients Undergoing Hip Surgery: A Randomized Controlled Trial by Chen Z, Liu YY, Hu Q, Wang JS, Cao RY, Yu ST, Lu F, Zhong ML, Liang WD, Wang L

“…Silent information regulator factor 3(SIRT3) could regulate mitochondrial function, initiate mitochondrial autophagy, and has played an important role in maintaining normal neuronal cell function. …”
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Interferon gamma inhibits CXCL8–CXCR2 axis mediated tumor-associated macrophages tumor trafficking and enhances anti-PD1 efficacy in pancreatic cancer by Mingjie Zhang, Lifeng Huang, Guoping Ding, Huilian Huang, Guoliang Cao, Xu Sun, Neng Lou, Qiang Wei, Tao Shen, Xiaodong Xu, Liping Cao, Qiang Yan

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Development and Validation of a Brain Aging Biomarker in Middle-Aged and Older Adults: Deep Learning Approach by Zihan Li, Jun Li, Jiahui Li, Mengying Wang, Andi Xu, Yushu Huang, Qi Yu, Lingzhi Zhang, Yingjun Li, Zilin Li, Xifeng Wu, Jiajun Bu, Wenyuan Li

“… BackgroundPrecise assessment of brain aging is crucial for early detection of neurodegenerative disorders and aiding clinical practice. …”
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PI-RADSv2.1 combined with PSA density for optimizing prostate biopsy decisions: a retrospective analysis by Yuchun Li, Siran Wang, Jianqiu Wang, Xin Qi, Tianran Liu, Xiaodong He, Yu Zhang, Yi Zhu, Yunfu Zeng

“…Similarly, for patients with a PI-RADS v2.1 score of 3 and PSAD &lt; 0.15 ng/(mL·cm³), the csPCa detection rate was also zero, supporting biopsy avoidance in these cases.ConclusionThe use of the PI-RADS v2.1 score combined with PSAD is recommended as an indication for prostate biopsy: (1) For patients with PI-RADS scores of 1-2, biopsy can be avoided if PSAD is &lt; 0.30 ng/(mL·cm³), whereas biopsy is recommended if PSAD is ≥ 0.30 ng/(mL·cm³). (2) For patients with a PI-RADS score of 3, biopsy can be avoided if PSAD is &lt; 0.15 ng/(mL·cm³), but it is recommended if PSAD is ≥ 0.15 ng/(mL·cm³). (3) Patients with a PI-RADS score of 4 are recommended for biopsy in all cases. (4) For patients with a PI-RADS score of 5, biopsy is recommended if PSAD is &lt; 2.00 ng/(mL·cm³), but empirical initiation of treatment without biopsy may be considered if PSAD ≥ 2.00 ng/(mL·cm³), subject to ethics committee approval. …”
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ENABLE—App-Based Digital Capture and Intervention of Patient-Reported Quality of Life, Adverse Events, and Treatment Satisfaction in Breast Cancer: Protocol for a Randomized Contro... by Thomas M Deutsch, Léa L Volmer, Manuel Feisst, Laura Bodenbeck, Kathrin Hassdenteufel, Lara Tretschock, Christiane Breit, Stefan Stefanovic, Armin Bauer, Carolin Anders, Lina Weinert, Tobias Engler, Andreas D Hartkopf, Nico Pfeifer, Pascal Escher, Marc Mausch, Oliver Heinze, Marc Suetterlin, Sara Y Brucker, Andreas Schneeweiss, Markus Wallwiener

“…ConclusionsParticipation in the intervention group is expected to improve treatment satisfaction, adherence, detection, and timely treatment of critical AEs. The close-meshed, weekly, brief HRQoL assessment will also be tested as a screening tool to detect relevant side effects during therapy. …”
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Congenital cytomegalovirus infection and brain injury in a newborn following maternal non-primary infection: case report of an unexpected diagnosis by Gregorio Serra, Ettore Piro, Deborah Bacile, Laura Antonella Canduscio, Claudia Colomba, Mario Giuffrè, Sergio Salerno, Ingrid Anne Mandy Schierz, Giovanni Corsello

“…Although such diagnostic hypothesis was unsuspected (in light of the association of clinical manifestations with perinatal sepsis and the misleading maternal serology), however CMV DNA detection on blood and urine was carried out, giving positive results in both samples for connatal infection diagnosis. …”
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Diagnostic potential of miRNA-135A1 in human papillomavirus associated cervical lesions by D. S. Elkin, M. I. Taubinskaya, N. V. Elkina, R. S. Faskhutdinov, M. D. Fedorova, A. N. Katargin, K. I. Zhordania, E. A. Mustafina, E. A. Grivachev, L. S. Pavlova, S. V. Vinokurova

“…The mechanisms leading to disruption of viral oncogene expression and initiation of epithelial cell transformation are poorly understood. …”
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