Emerging evidence to reduce the burden of tuberculosis in children and young people by Julie Huynh, Yara-Natalie Abo, Rina Triasih, Varinder Singh, Gordon Pukai, Pauline Masta, Bazarragchaa Tsogt, Boi Khanh Luu, Felisia Felisia, Naomi Pank, Aung Aung, Alison Morton, Pete Azzopardi, Raspati C. Koesoemadinata, Bachti Alisjahbana, Philip C. Hill, Ben J. Marais, Silvia S. Chiang, Stephen M. Graham

“…This narrative review discusses the progress and identifies potential solutions with insights from the Asia-Pacific region to ongoing challenges in TB detection, treatment, and prevention in children and young people, with a view to TB elimination.…”
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Multimodal versus non-contrast computed tomography for assessment of acute ischaemic stroke: the PRACTISE RCT by Keith W Muir, Salwa El Tawil, Alex McConnachie, Alicia Murray, Ian Ford, Grant Mair, Joanna Wardlaw

“…This difference could be detected with 80% power at p = 0.05 with 152 subjects per group. …”
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Regional Design by Verena Balz

“…The chapter presents an initial review of a regional-design practice that was conducted between 2005 and 2007 by South Wing Studio (Atelier Zuidvleugel). …”
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Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults by Jose Bernal, Inga Menze, Renat Yakupov, Oliver Peters, Julian Hellmann-Regen, Silka Dawn Freiesleben, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Björn H. Schott, Frank Jessen, Ayda Rostamzadeh, Wenzel Glanz, Enise I. Incesoy, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Sebastian Sodenkamp, Annika Spottke, Anna Esser, Falk Lüsebrink, Peter Dechent, Stefan Hetzer, Klaus Scheffler, Stefanie Schreiber, Emrah Düzel, Gabriel Ziegler

“…Similarly, those with lower initial cortical thickness had faster WMH progression (σ = -0.141, SE = 0.060, Z = -2.336, P = 0.009), with this effect being most pronounced in temporal, cingulate, and insular cortices. …”
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The relationship of arterial hypertension, elevated low-density lipoprotein cholesterol and their combination with the occurrence of new cases of cardiovascular diseases in men and... by S. A. Shalnova, E. B. Yarovaya, V. A. Metelskaya, E. M. Filichkina, A. V. Kapustina, V. A. Kutsenko, Yu. A. Balanova, A. E. Imaeva, G. A. Muromtseva, S. E. Evstifeeva, S. A. Maksimov, N. V. Kulakova, O. N. Kalachikova, T. M. Chernykh, O. A. Belova, G. V. Artamonova, Yu. I. Grinshtein, R. A. Libis, O. P Rotar, I. A. Trubacheva, A. Yu. Efanov, S. S. Yakushin, A. N. Redko, I. A. Viktorova, N. N. Prishchepa, A. O. Konradi, S. A. Boytsov, E. V Shlyakhto, O. M. Drapkina

“…Prospective monitoring of new cases was carried out in the initial sample without patients with coronary artery disease, MI, and stroke. …”
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Paroxysmal Nocturnal Hemoglobinuria in Patients with Aplastic Anemia: Challenges, Characteristics, and Analysis of Clinical Experience by ER Shilova, TV Glazanova, ZhV Chubukina, OE Rozanova, MN Zenina, AV Seltser, VI Rugal, VA Balashova, VA Kobilyanskaya, II Krobinets, VYu Udal’eva, II Zotova, LV Stelmashenko, NA Romanenko, TB Zamotina, IV Khorsheva, SV Voloshin

“…A female patient born in 1964, with initial diagnosis of AA was followed-up from 1989 till present at the Russian Research Institute of Hematology and Transfusiology. …”
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High anal swab viral load predisposes adverse clinical outcomes in severe COVID-19 patients by Haibo Li, Lili Ren, Lulu Zhang, Yeming Wang, Li Guo, Conghui Wang, Yan Xiao, Ying Wang, Jian Rao, Xinming Wang, Ying Liu, Chaolin Huang, Xiaoying Gu, Guohui Fan, Hui Li, Binghuai Lu, Bin Cao, Jianwei Wang

“…In non-survivors, the viral RNA in AS was detected earlier than that in survivors (median of 14 days vs 19 days, P = 0.007). …”
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Immune memory reactivation and T cell dynamics following 12-month homologous CoronaVac booster: a longitudinal cohort study by Xinran Song, Xinran Song, Weixin Chen, Weixin Chen, Shuang Bai, Shuang Bai, Min Lv, Min Lv, Jian Wang, Jian Wang, Ao Zhang, Ao Zhang, Jiang Wu, Jiang Wu, Wei Zhao, Wei Zhao, Wei Zhao

“…Anti-receptor-binding domain immunoglobulin subclasses (IgG1, IgG2, IgG3, IgG4) were detected using enzyme-linked immunosorbent assay. Cytokine secretion (interferon [IFN]-γ/interleukin [IL]-2/IL-4/IL-5) was assessed using enzyme-linked immunospot assay. …”
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Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis. by Madushi Wanaguru, David J Barry, Donald J Benton, Nicola J O'Reilly, Kate N Bishop

“…We propose that p12 is acting in a similar capacity to CPSF6 in HIV-1 infection by facilitating initial chromatin targeting of CA-containing PICs prior to integration.…”
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Habitat conditions of reef-forming corals directly affect the spatial distribution and stability in fish and macroinvertebrate communities: A case study of Mischief Reef by Peng Xu, Jianfeng Gan, Lintao Huang, Danping Xie, Feilong Li, Hui Huang

“…We utilized eDNA baseline data from Mischief Reef to investigate changes in community structure and their underlying drivers within a small-scale habitat model. Our initial analysis identified 178 species of fish and macroinvertebrates (including crustaceans and mollusks) through eDNA. …”
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Psychometric property of the Japanese version of self-efficacy for managing chronic disease scale in individuals with chronic diseases by Megumi Hazumi, Mayumi Kataoka, Ayako Nakashita, Kentaro Usuda, Michi Miyake, Chiaki Kamikawa, Daisuke Nishi, Naoaki Kuroda

“…Test-retest reliability was assessed two weeks after the initial measurement. Results: Of 500 participants, 494 were analyzed and 149 were analyzed for test-retest reliability. …”
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Machine Learning for Monoclonal Gammopathies of Renal Significance Risk Stratification Using Clinical and Pathology Data by Giorgio Cazzaniga, Giulia Capitoli, Raffaella Barretta, Andrew Smith, Gisella Vischini, Giuliana Papalia, Federico Alberici, Federica Mescia, Albino Eccher, Jan Ulrich Becker, Maarten Naesens, Lucrezia Furian, Bernd Schröppel, Stefania Galimberti, Fabio Pagni, Vincenzo L'Imperio

“…Introduction: The prompt detection of monoclonal gammopathies of renal significance (MGRS) is clinically relevant for the initiation of chemotherapy. …”
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Study of height-spread sporadic-E layers observed in the South American Magnetic Anomaly by Juliano Moro, Juliano Moro, Jiyao Xu, José Valentin Bageston, Lígia Alves da Silva, Lígia Alves da Silva, Laysa Cristina Araújo Resende, Laysa Cristina Araújo Resende, Clezio Marcos De Nardin, Vânia Fátima Andrioli, Vânia Fátima Andrioli, Angela Machado Santos, Angela Machado Santos, Giorgio Arlan da Silva Picanço, Hui Li, Liu Zhengkuan, Chi Wang, Nelson Jorge Schuch

“…These layers have also been detected in nighttime ionograms collected at some ionospheric stations in the South American Magnetic Anomaly (SAMA) region in Brazil during the recovery phases of geomagnetic storms. …”
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International Survey on Phenylketonuria Newborn Screening by Domen Trampuž, Peter C. J. I. Schielen, Rolf H. Zetterström, Maurizio Scarpa, François Feillet, Viktor Kožich, Trine Tangeraas, Ana Drole Torkar, Matej Mlinarič, Daša Perko, Žiga Iztok Remec, Barbka Repič Lampret, Tadej Battelino, ISNS Study Group on PKU, Francjan J. van Spronsen, James R. Bonham, Urh Grošelj

“…Newborn screening for Phenylketonuria enables early detection and timely treatment with a phenylalanine-restricted diet to prevent severe neurological impairment. …”
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Better models, better treatment? a systematic review of current three dimensional (3D) in vitro models for implant-associated infections by Neele Brümmer, Neele Brümmer, Katharina Doll-Nikutta, Katharina Doll-Nikutta, Patrik Schadzek, Patrik Schadzek, Carina Mikolai, Carina Mikolai, Andreas Kampmann, Andreas Kampmann, Dagmar Wirth, Dagmar Wirth, Andrea Hoffmann, Andrea Hoffmann, Philipp-Cornelius Pott, Philipp-Cornelius Pott, Oliver Karras, Sören Auer, Meike Stiesch, Meike Stiesch

“…IntroductionUnderstanding the biology of implant-associated infections is essential in order to provide adequate detection, prevention and therapeutic strategies. Advanced 3D in vitro models offer valuable insights into the complex interactions between cells and bacteria in the presence of implant materials. …”
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A Near-infrared Search for Helium in the Superluminous Supernova SN 2024ahr by Harsh Kumar, Edo Berger, Peter K. Blanchard, Sebastian Gomez, Daichi Hiramatsu, Moira Andrews, K. Azalee Bostroem, Yize Dong, Joseph Farah, Estefania Padilla Gonzalez, D. Andrew Howell, Curtis McCully, Darshana Mehta, Megan Newsome, Aravind P. Ravi, Giacomo Terreran

“…We detect broad features of Mg i λ 1.575 μ m and Mg ii λ 2.136 μ m, which are typical of Type Ic SNe, but with higher velocities. …”
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Invasive urodynamic investigations in the management of women with refractory overactive bladder symptoms: FUTURE, a superiority RCT and economic evaluation by Mohamed Abdel-Fattah, Christopher Chapple, Suzanne Breeman, David Cooper, Helen Bell-Gorrod, Preksha Kuppanda, Karen Guerrero, Simon Dixon, Nikki Cotterill, Karen Ward, Hashim Hashim, Ash Monga, Karen Brown, Marcus Drake, Andrew Gammie, Alyaa Mostafa, Rebecca Bruce, Victoria Bell, Christine Kennedy, Suzanne Evans, Graeme MacLennan, John Norrie

“…Symptoms include urinary urgency, with or without urgency incontinence, increased daytime urinary frequency and nocturia. Initial conservative treatments for overactive bladder are unsuccessful in 25–40% of women (refractory overactive bladder). …”
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Clinical and hematological factors predicting the effectiveness of ruxolitinib in primary and secondary myelofibrosis. Results of a prospective single-center study by O. Yu. Vinogradova, M. M. Pankraskina, A. L. Neverova, D. I. Shikhbabaeva, M. A. Murzabekova, M. V. Chernikov, A. V. Popova, V. P. Kosenkova, L. B. Egoryan, V. V. Ptushkin

“…The median allele burden of JAK2 V617F during observation decreased more than twice from the initial value in half of the patients. The median of progression-free survival (PFS) from the start of ruxolitinib therapy was 28 months, the median of overall survival (OS) has not been achieved. …”
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复合塑料泡罩包装浓香葵花籽油加速氧化期间 风味品质变化Flavor quality changes of composite plastic blister packaged fragrant sunflower seed oil during accelerated oxidation... by 李颖，李思，郑绣蒨，刘昌树 LI Ying, LI Si, ZHENG Xiuqian, LIU Changshu

“…The results of sensory evaluations differential test showed that the accelerated oxidation samples showed significant differences compared with the initial fragrant sunflower seed oil. In conclusion, the flavor quality of composite plastic blister packaged fragrant sunflower seed oil has changed significantly during accelerated oxidation storage.…”
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Integrated Early CRP Kinetics and Plasma EBV DNA Clearance as Prognostic Biomarkers in De Novo Metastatic Nasopharyngeal Carcinoma Treated with First-Line Chemoimmunotherapy by Fang M, Hu Y, Wang T, Su Y, Lu T, Zhang H, Li J, Xie C, Gong X

“…In subgroup analysis, patients with undetectable EBV DNA after three immunotherapy cycles showed higher median PFS among CRP responders compared to non-responders (28 vs 21 months, P=0.014), whereas no significant difference was observed in patients with detectable EBV DNA levels (13 vs 8 months, P=0.142).Conclusion: CRP responders are associated with improved survival outcomes, particularly in patients achieving early EBV DNA clearance. …”
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