Novel paradigm enables accurate monthly gestational screening to prevent congenital toxoplasmosis and more. by Ying Zhou, Karen Leahy, Andrew Grose, Joseph Lykins, Maryam Siddiqui, Nicole Leong, Perpetua Goodall, Shawn Withers, Kevin Ashi, Stephen Schrantz, Vera Tesic, Ana Precy Abeleda, Kathleen Beavis, Fatima Clouser, Mahmoud Ismail, Monica Christmas, Raphael Piarroux, Denis Limonne, Emmanuelle Chapey, Sylvie Abraham, Isabelle Baird, Juliette Thibodeau, Kenneth M Boyer, Elizabeth Torres, Shannon Conrey, Kanix Wang, Mary Allen Staat, Nancy Back, Coralie L'Ollivier, Caroline Mahinc, Pierre Flori, Jorge Gomez-Marin, Francois Peyron, Sandrine Houzé, Martine Wallon, Rima McLeod

“…However, in clinical trial, FDA-cleared-predicate tests initially caused practical, costly problems due to false-positive-IgM results. …”
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Association Between Shift Work and Acute Coronary Syndrome According to Alcohol Intake and Smoking by Seok-Jin Ryu, Sun-Min Kim, Hyun-Yi Kook, Eun-Young Park, Eujene Jung

“…Integrating these strategies into occupational health policies can contribute to the early detection and prevention of ACS, ultimately improving the cardiovascular health of shift workers.…”
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Deep Learning dengan Teknik Early Stopping untuk Mendeteksi Malware pada Perangkat IoT by Iwang Moeslem Andika Surya, Triawan Adi Cahyanto, Lutfi Ali Muharom

“…The use of Convolutional Neural Network (CNN) in classifying the IoT-23 dataset with the SMOTE (Synthetic Minority Oversampling Technique) data balancing technique and the Early Stopping function shows high results. Although CNN was initially designed for image processing, this algorithm also effectively detects complex patterns in non-image data, such as IoT network traffic, due to its ability to extract hierarchical features. …”
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Exploring care-seeking practices within a family mid-upper arm circumference approach in South Sudan: a mixed-methods prospective study by Sarah Bauler, Chiara Altare, Sule Ismail, Daniel Atem, Sandra Banks, Prachi Srivastava, Julia Hussian, Emily Lyles, Eva Leidman, Shannon Doocy

“…Abstract Background Despite the growing adoption of the Family Mid-Upper Arm Circumference (MUAC) approach to empower caregivers in detecting child malnutrition, limited evidence exists on whether caregivers act on identified cases by seeking care and factors influencing their decisions. …”
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Comparison of different intervention thresholds for the treatment of glucocorticoid-induced osteoporosis: a cross-sectional study by Kanchalee Puksun, Chatlert Pongchaiyakul, Rattapol Pakchotanon, Pongthorn Narongroeknawin, Pornsawan Leosuthamas, Thunyawarin Arunthanachaikul, Sumapa Chaiamnuay

“…Abstract Background Glucocorticoid-induced osteoporosis (GIO) is the most common drug-induced osteoporosis. Early detection and treatment may decrease the fragility fractures. …”
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Technologies for Interoperable Internet of Medical Things Platforms to Manage Medical Emergencies in Home and Prehospital Care: Scoping Review by Mattias Seth, Hoor Jalo, Åsa Högstedt, Otto Medin, Bengt Arne Sjöqvist, Stefan Candefjord

“…Recognizing the evident benefit of cross-domain interoperability, we advocate a stronger focus on collaborative initiatives and technologies to achieve higher levels of interoperability. …”
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Spotted! Remote camera traps used in a novel design reveal a perilous situation for the Critically Endangered Northwest African cheetah (Acinonyx jubatus hecki) in a conflict‐affec... by Marine Drouilly, Audrey Ipavec, Oksana Grente, Robin Horion, Aurlus Ouindeyama, Philipp Henschel, Vincent Lapeyre, Yekini Chabi N'Diaye, Ali Shams, Christine Breitenmoser, Sarah M. Durant

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Genetic mutations associated with rifampicin and isoniazid resistance in tuberculosis patients in Bhubaneswar, India by Dr Sidhartha Giri, Mr Sunil Swick Rout, Mr Satyanarayan Singh, Mr Prakasha Kumar Nayak, Mr Sudarshan Biswal, Mrs Kumari Shweta, Dr Sanghamitra Pati

“…LPA is a qualitative in-vitro test for the detection of Mycobacterium tuberculosis (M.tb) complex, along with resistance to RIF and INH. …”
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Neonatal Screening for Spinal Muscular Atrophy and Severe T- and B-Cell Lymphopenias in Andalusia: A Prospective Study by Beatriz De Felipe, Carmen Delgado-Pecellin, Mercedes Lopez-Lobato, Peter Olbrich, Pilar Blanco-Lobo, Josefina Marquez-Fernandez, Carmen Salamanca, Beatriz Mendoza, Rocio Castro-Serrano, Cristina Duque, Mariana Moreno-Prieto, Marcos Madruga-Garrido, Jose M. Lucena, Raquel M. Fernandez, Maria Ruiz-Camacho, Alberto Varona, Olaf Neth

“…In January 2021, we initiated the first pilot study in Spain to evaluate the efficacy of a very early detection technique for SMA and SCID. …”
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Pre-treatment Drug Resistance Could Impact the 96-Week Antiretroviral Efficacy in Treatment-Naive HIV-1–Infected Patients in Guangdong, China by Pengle Guo, Yun Lan, Quanmin Li, Xuemei Ling, Junbin Li, Xiaoping Tang, Fengyu Hu, Weiping Cai, Linghua Li

“…Pretreatment drug resistance was detected in 125 cases (6.46%) from the 1936 enrolled participants, most of which were resistant to non-nucleoside reverse transcriptase inhibitors (64.00%, 80/125). …”
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Improved Sixty-Day Mortality in Candidemia with Antifungal Treatment Within 72 Hours of Fever Onset: A Single-Center Retrospective Study in Rural Japan by Koji Hayashi, Chizuru Hashimoto, Kohei Ueda, Yuka Nakaya, Asuka Suzuki, Maho Hayashi, Mamiko Sato, Yasutaka Kobayashi

“…In departments that provide aggressive chemotherapy or transplantation, candidiasis markers are regularly evaluated, and preemptive treatments may be initiated. However, in resource-limited facilities, candidemia detection largely relies on vital signs like fever and blood cultures. …”
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Case Report: Acute polymorphic psychosis and NMDA-R IgG antibodies in serum: a follow-up case study by Katharina von Zedtwitz, Judith Weiser, Raphael J. Dressle, Simon J. Maier, Bernd Feige, Kathrin Nickel, Nils Venhoff, Katharina Domschke, Katharina Domschke, Joachim Brumberg, Sebastian Rauer, Ludger Tebartz van Elst, Luciana Hannibal, Harald Prüss, Harald Prüss, Alexander Rau, Dominique Endres

“…Immunotherapy (performed after the initial assumption of an autoimmune cause) with steroids led to clinical improvement of residual symptoms. …”
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Clinical characteristics, time course, treatment and outcomes of patients with immune checkpoint inhibitor-associated myocarditis by Edward J Spangenthal, Igor Puzanov, Marc S Ernstoff, Pankit Vachhani, Fumito Ito, Ankita Kapoor, Benjamin Switzer, Poornima Subramanian, Yan V Yatsynovich, David M Jacobs, Maya R Chilbert, Umesh C Sharma, Steven G Feuerstein, Filip Stefanovic, Mark D Hicar, Anne B Curtis, Grace K Dy, Brian J Page, Nikhil Agrawal, Arjun Khunger, Alexander Hattoum, Jerome J Schentag

“…Early detection of troponin elevation is associated with earlier intervention and improved outcomes in ICI-associated myocarditis. …”
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Radiomic Feature Characteristics of Ovine Pulmonary Adenocarcinoma by David Collie, Ziyuan Chang, James Meehan, Steven H. Wright, Chris Cousens, Jo Moore, Helen Todd, Jennifer Savage, Helen Brown, Calum D. Gray, Tom J. MacGillivray, David J. Griffiths, Chad E. Eckert, Nicole Storer, Mark Gray

“…Such characteristics suggest that radiomic analysis offers potential for the early detection and management of JSRV-related lung tumours. …”
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Impact of norepinephrine versus phenylephrine on brain circulation, organ blood flow and tissue oxygenation in anaesthetised patients with brain tumours: study protocol for a rando... by Mads Rasmussen, Lingzhong Meng, Klaus Ulrik Koch, Joel Aanerud, Niels Juul, Kaare Meier, Per Borghammer, Stig Dyrskog, Anders Rosendal Korshoej, Niwar Faisal Mohamad, Irene Klærke Mikkelsen, Ulrick S Espelund, Christian Fenger Eriksen, Karen Baden Alstrup, Bo Jespersen, Lene Marie Fries, Alp Tankisi, Søren Ole Stigaard Cortnum, Ann Katrine Sindby, Lars Poulsen Tolbod

“…The study also explores the impact of the vasopressor agents on the distribution of cardiac output between various organs.Methods and analysis This is an investigator-initiated, double-blinded, randomised clinical trial including 32 patients scheduled for supratentorial brain tumour surgery. …”
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CLINICAL EVALUATION OF RESTORATIONS OF ENDODONTICALLY TREATED TEETH by O.A. Udod, R.S. Kostenko

“…During both terms with impairments, we detected 32 direct photocomposite restorations (36.0%), 12 indirect ceramic restorations (14.8%) and only 5 indirect ceramic restorations (6.3%) made with additional retention elements. …”
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Effect of rituximab on the manifestations of activity and pulmonary function in patients with systemic sclerosis: one-year follow-up evaluation by L. P. Ananyeva, O. A. Koneva, O. V. Desinova, L. A. Garzanova, S. I. Glukhova, M. N. Starovoitova, O. B. Ovsyannikova, A. V. Volkov, A. P. Aleksankin, E. L. Nasonov

“…The presence of anti-Scl-70 antibodies was detected in 73% of patients. The mean cumulative dose of RTM was 1.43±0.6 g; 48 patients in Group 1 received ≤2 g of RTM (the mean dose, 1.1±0.1 g) and 23 patients in Group 2 took ≥2 g of RTM (mean dose, 2±0.6 g). …”
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Risk assessment of 2024 cattle H5N1 using age-stratified serosurveillance data by Lin-Lei Chen, Xiaojuan Zhang, Kang Zhang, Brian Pui-Chun Chan, Jacqueline Kwan Yuk Yuen, Kwok-Yung Yuen, Pui Wang, Yuhe R. Yang, Honglin Chen, Kelvin Kai-Wang To

“…Here, we conducted a serosurveillance study to determine the risk of A(H5N1) clade 2.3.4.4b (2024 cattle H5N1) to general population. In the initial screening of 180 serum specimens encompassing all age groups, 2.2% (4/180) had detectable neutralizing antibody (nAb) titres against reverse genetics-derived 2024 cattle H5N1, with all collected from older adults aged ≥60 years old. …”
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Human immunodeficiency virus prevention and testing strategies among men who have sex with men in the UK: the PANTHEON research programme including the SELPHI RCT by Janey Sewell, T Charles Witzel, David Dunn, Fiona Lampe, Fiona Burns, Peter Weatherburn, Sheena McCormack, Leanne McCabe, Alec Miners, Valentina Cambiano, Roger Pebody, Roy Trevelion, Nadia Hanum, Andrew Phillips, Alison Rodger

“…It was also unclear whether other HIV prevention initiatives in addition to self-testing could offer value for money. …”
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AI-driven healthcare innovations for enhancing clinical services during mass gatherings (Hajj): task force insights and future directions by Ala’a Alquayt, Ohoud Aljuhani, Abdullah F. Alharthi, Rahaf Alqahtani, Anas Khan, Ahmed Al-jedai, Abdulqader Almoeen, Mohammed Alshennawi, Hisham A. Badreldin, Abdulrhman Aljouie, Lubna A. Alnasser, Abdulmajeed M. Alshehri, Mohammed Y. Alzahrani, Haifa A. Alhaidal, Raghad Alhajaji, Salman Alotaibi, Esraa Z. Redhwan, Fahad Alharthi, Badr G. Alghamdi, Khalid Al Sulaiman

“…Results The task force identified key focus areas: (1) Patient Care: AI tools for predictive analytics, triage, resource management, and virtual healthcare. (2) Healthcare Providers: AI in medical imaging, care delivery, provider-patient communication, and training. (3) Operational Management: AI for healthcare documentation and reducing administrative burden. (4) Healthcare Systems: AI for early detection and automation during Hajj. The task force constructed ten statements to guide future initiatives. …”
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