Assessment of Circulating Tumor Cells in Colorectal Cancer as an Adjunctive Non-invasive Diagnostic Method by Saskia Aziza Nursyirwan, Murdani Abdullah, Andri Sanityoso Sulaiman, Ikhwan Rinaldi, Dadang Makmun, Marcellus Simadibrata, Dimas Ramadhian Noor, Agustinus Wiraatmadja, Wifanto Saditya Jeo, Nur Rahadiani, Diah Rini Handjari, Hamzah Shatri

“…Biopsy remains the gold standard for CRC diagnosis, but invasive testing may not be preferred as an initial diagnostic procedure. Therefore, alternative non-invasive approaches are needed. …”
Get full text

Improving SARS-CoV-2 variants monitoring in the absence of genomic surveillance capabilities: a serological study in Bolivian blood donors in October 2021 and June 2022 by Lucia Inchauste, Elif Nurtop, Lissete Bautista Machicado, Yanine Leigue Roth, Shirley Lenz Gonzales, Maria Luisa Herrera, Katty Mina Villafan, Pedro Mamani Mamani, Marcelo Ramos Espinoza, Juan Carlos Pavel Suarez, Juan Cansio Garcia Copa, Yitzhak Leigue Zabala, Etzel Arancibia Cardozo, Pierre Gallian, Xavier de Lamballerie, Stéphane Priet

“…In 2022, Gamma continued to circulate in southernmost departments of the country, and the emergence of Omicron BA.1 was detected. These trends align with publicly available genomic data from neighboring countries. …”
Get full text

The Excretion Period of Triclabendazole Residual and it's Metabolites after Triclafascid Application on Sheep by M. B. Musaev, I. E. Shumakovich, M. S. Khalikov, N. B. Emelyanova, P. P. Kochetkov, N. E. Patyukov, V. E. Abramov

“…After animals dehelminthization with triclafascid at a therapeutic dose of 2.0 mg/kg, no drug residual and its metabolites were detected in muscles, fat, lungs, spleen, kidneys on the 7th day. …”
Get full text

Multiplex immunophenotyping of human acute myeloid leukemia patients revealed single -cell heterogeneity with special attention on therapy sensitive and therapy resistant subpopula... by Nikolett Gémes, Benedek Rónaszéki, Szabolcs Modok, Zita Borbényi, Imre Földesi, Éva Trucza, Blanka Godza, Zsuzsanna László, Balázs Csernus, László Krenács, Enikő Bagdi, Enikő Szabó, László G. Puskás, László G. Puskás, Valeria Bertagnolo, Gábor J. Szebeni, Gábor J. Szebeni, Gábor J. Szebeni

“…The follow-up of AML samples revealed four MCs of therapy sensitive cells, and one MC composed of therapeutic resistant cells (MC12: CD3-CD7-CD33-CD38- CD64- HLA-DR- CD117- CD135-) identified by the FlowSOM analysis. The initial AML blasts in the MRD gate (CD19-, CD45+, CD3-, CD38+/CD34±, CD7+/CD117+, CD117+/CD135+) were detectable at the lowest frequency in our current study at 22 cells per 100,000 (0.022%) CD45+CD3- living singlet parental population. …”
Get full text

Multimorbidity and mortality in an older, rural black South African population cohort with high prevalence of HIV findings from the HAALSI Study by Stephen Tollman, Kathleen Kahn, F Xavier Gómez-Olivé, Justine Davies, Chodziwadziwa Kabudula, Joshua A Salomon, Collin F Payne, Alisha N Wade, Lisa Berkman, Miles Witham, Angela Chang

“…HIV multimorbidity was associated with increased risk of death compared with non-HIV multimorbidity in men (HR 1.93; 95% CI: 1.05 to 3.54), but was not statistically significant in women (HR 1.85; 95% CI: 0.85 to 4.04); when detectable, HIV viral loads were higher in men (p=0.021). …”
Get full text

Image analysis: 68Ga-FAPI-46 PET derived texture parameters improve the differentiation of malignant and benign pulmonary lesions by Joel Wessendorf, Anna-Maria Spektor, Brahim Aboulmaouahib, Johanna Daum, Frederik M. Glatting, Kai Schlamp, Matthias Grott, Florian Eichhorn, Claus Peter Heußel, Hans Ulrich Kauczor, Michael Kreuter, Mathias Schreckenberger, Hauke Winter, Uwe Haberkorn, Manuel Röhrich

“…Texture parameters with significant (P < 0.05) differences between lung cancer and benign lesions were detected by the Mann-Whitney U test. Boxplots and a scatter plot matrix were created. …”
Get full text

Combination of Silicate-Based Soil Conditioners with Plant Growth-Promoting Microorganisms to Improve Drought Stress Resilience in Potato by Abdullah Al Mamun, Günter Neumann, Narges Moradtalab, Aneesh Ahmed, Fahim Nawaz, Timotheus Tenbohlen, Jingyu Feng, Yongbin Zhang, Xiaochan Xie, Li Zhifang, Uwe Ludewig, Klára Bradáčová, Markus Weinmann

“…Although no significant SC effects on WHC and total plant biomass were detectable, the SC-inoculant combinations increased the proportion of leaf biomass not affected by drought stress symptoms (chlorosis, necrosis) by 66% (SP) and 91% (GH). …”
Get full text

Diagnostic performance of plasma p-tau217 in a memory clinic cohort using the Lumipulse automated platform by Francisco Martínez-Dubarbie, Armando Guerra-Ruiz, Sara López-García, Carmen Lage, Marta Fernández-Matarrubia, Álvaro Nevado-Cáceres, María Rivera-Sánchez, Andrea Valera-Barrero, Ana Pozueta-Cantudo, María García-Martínez, Andrea Corrales-Pardo, María Bravo, Marcos López-Hoyos, Juan Irure-Ventura, Enrique Marco de Lucas, Marta Drake-Pérez, Nancy Heidy Cahuana-Santamaría, María Teresa García-Unzueta, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez

“…Conclusion Plasma p-tau217 shows excellent results for detecting amyloid pathology at brain level in a clinical setting with an AUC of 0.95. …”
Get full text

Dalpiciclib combined with pyrotinib and endocrine therapy in women with ER-positive, HER2-positive advanced breast cancer: A prospective, multicenter, single-arm, phase 2 trial. by Jian Zhang, Yanchun Meng, Biyun Wang, Xinhong Wu, Hongmei Zheng, Jing Hu, Wei Liu, Wenyan Chen, Leiping Wang, Jun Cao, Zhonghua Tao, Ting Li, Sujie Ni, Zhengyan Yu, Lichun Sun, Yun Wang, Qiang Peng, Song Wang, Xin Hu, Jianfei Wang, Yijia Wu, Xichun Hu

“…Of interest, no objective response was observed in three patients with detected BRCA mutations (n = 2) or increased 68Ga-HER2 affibody uptake over the initial two cycles (n = 2). …”
Get full text

Genomic analyses reveal presence of extensively drug-resistant Salmonella enterica serovars isolated from clinical samples in Guizhou province, China, 2019–2023 by Yongxian Wen, Jingtong Wu, Lv You, Xiaoyu Wei, Junhua Wang, Shijun Li

“…Highly prevalent point mutations in gyrA (D87 and S83) and parC (S80I) were detected, along with eight plasmid-mediated quinolone resistance (PMQR) genes. …”
Get full text

CO34 | Evaluation of emicizumab concentration and thrombin generation in a cohort of severe hemophilia A patients with and without inhibitor

“…At FU, 18/29 (62.1%) pts were getting lower doses than initial maintenance dose, with a median reduction of 26.7% (range 3.3 - 33.3%) - dosage had not been adjusted to increasing weight in pts without clinical issues. …”
Get full text

Mixed nontuberculous mycobacteria in an immunocompromised patient with progressive multifocal leukoencephalopathy by Dr Christoffel Opperman, Dr Janet Scott, Dr Aliasgar Esmail, Dr Sarishna Singh, Mr Yonas Ghebrekristos, Prof Rob warren, Dr Wynand Goosen

“…The commonly used GenoType Mycobacterium CM (Common mycobacteria) line probe assay (LPA) failed to detect mixed NTM in the same sample. Subsequently, management was changed to rifabutin, ethambutol, azithromycin, and isoniazid. …”
Get full text

Análisis comparativo de los perfiles motivacionales y el Estado de Flow entre una metodología tradicional y la metodología Flipped Classroom en estudiantes de Educación Física (Co... by Pablo Cuenca Ruano, Salvador García Martínez, Alberto Ferriz Valero, Juan Tortosa Martínez

“…To determine if there are initial and final differences between the groups, the T-Student test was performed on independent samples. …”
Get full text

Invasive pulmonary aspergillosis after heart transplantation by M. A. Simonenko, M. Yu. Sitnikova, P. A. Fedotov, Yu. V. Sazonova, M. A. Bortsova, K. I. Monosova, L. A. Vasilievna, L. B. Mitrofanova, G. V. Nikolaev, M. L. Gordeev, M. A. Karpenko

“…In the majority of recipients, the disease was detected at the early stages; diagnosis required surgical intervention in 12% of cases. …”
Get full text

Characterization of a novel covS SNP identified in Australian group A Streptococcus isolates derived from the M1UK lineage by Johanna Richter, Amanda J. Cork, Yvette Ong, Nadia Keller, Andrew J. Hayes, Mark A. Schembri, Amy V. Jennison, Mark R. Davies, Kate Schroder, Mark J. Walker, Stephan Brouwer

“…In this study, we identified and characterized a novel covS single nucleotide polymorphism detected in three separate invasive M1UK isolates. …”
Get full text

Plasma microRNA signatures of aging and their links to health outcomes and mortality: findings from a population-based cohort study by Lieke M. Kuiper, Michelle M. J. Mens, Julia W. Wu, Jaap Goudsmit, Yuan Ma, Liming Liang, Albert Hofman, Trudy Voortman, M. Arfan Ikram, Jeroen G. J. van Rooij, Joyce B. J. van Meurs, Mohsen Ghanbari

“…Abstract Background MicroRNAs are small non-coding RNAs that regulate gene expression post-transcriptionally and show differential expression in various tissues with aging phenotypes. Detectable in circulation, extracellular microRNAs reflect (patho)physiological processes and hold promise as biomarkers for healthy aging and age-related diseases. …”
Get full text

Association between the early or late onset of gestational diabetes mellitus with neonatal adverse outcomes: a retrospective cohort study by Fabiana Vieira Duarte de Souza Reis, Carlos Izaias Sartorão Filho, Luis Sobrevia, Caroline Baldini Prudencio, Bruna Bologna, Luana Favaro Iamundo, Adriely Magyori, Luiz Takano, Raissa Escandiussi Avramidis, Rafael Guilen de Oliveira, Marilza Vieira Cunha Rudge, Angélica Mércia Pascon Barbosa, Diamater Study Group

“…The criteria for late-onset GDM, involving a negative initial screening and a positive OGTT at 24–28 weeks, align with the standard diagnostic timeframe when insulin resistance typically peaks due to placental hormone secretion. …”
Get full text

Blood lactate as a predictor of clinical outcomes and health-care resource needs in combat abdominal injuries by І.В. Собко, О.В. Рабощук, А.В. Верба, С.А. Асланян, Г.П. Хитрий, В.М. Мошківський, І.П. Кураченко, Т.С. Бордюг

“…The low sensitivity of commonly used cardiovascular parameters to detect the initial manifestations of tissue hypoperfusion induced by blood loss dictates the need to use more effective markers that reflect metabolic changes in tissues. …”
Get full text

A comprehensive, population level evaluation of previously reported drug triggers of pemphigus highlights immunomodulatory capacity as a common characteristic by Justin Baroukhian, Kristina Seiffert-Sinha, Animesh A. Sinha

“…Associations for other previously reported drugs (25/36) were not detected.Conclusions and relevanceThis study represents a comprehensive evaluation of suspected drug triggers of pemphigus using real-world data. …”
Get full text

Retrospective Analysis of the Pattern, Causes and Variants of Ocular Herpes Severity by G. M. Chernakova, G. Sh. Arzhimatova, E. V. Shirshova, A. V. Andrianova, E. A. Kleshcheva, N. V. Mel’nikova

“…In the majority of cases (n = 799; 70 %) patients had a history of recurrent course of keratitis (keratouveitis) by the time of initial examination, whereas first detected ophthalmic herpes was noted in 343 (30 %) cases. …”
Get full text