Contrast‐enhanced point of care ultrasound for the evaluation of stable blunt abdominal trauma by the emergency physician: A prospective diagnostic study by Viviane Donner, Julian Thaler, Wolf E Hautz, Thomas Christian Sauter, Daniel Ott, Karsten Klingberg, Aristomenis K Exadaktylos, Beat Lehmann

“…Conclusions A FOCUS examination shows limited sensitivity and specificity to detect positive abdominal CT in stable adults with abdominal trauma. …”
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The association between chronic underlying diseases and the clinical characteristics in adult patients infected with Omicron BA.1 by Jingyu Wang, Yuechuan Cui, Henan Dong, Jie Zhao, Meng Wang, Chunlei Zhou, Hong Mu

“…Methods: We performed an analysis on 320 individuals who were admitted to Tianjin First Central Hospital for treatment in the initial largest outbreak of the Omicron variant BA.1 infection between January and February 2022 in Tianjin, China. …”
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The Volatile Composition and Activity Evolution of Main-belt Comet 358P/PANSTARRS by Henry H. Hsieh, John W. Noonan, Michael S. P. Kelley, Dennis Bodewits, Jana Pittichová, Audrey Thirouin, Marco Micheli, Matthew M. Knight, Michele T. Bannister, Colin O. Chandler, Carrie E. Holt, Matthew J. Hopkins, Yaeji Kim, Nicholas A. Moskovitz, William J. Oldroyd, Jack Patterson, Scott S. Sheppard, Nicole Tan, Chadwick A. Trujillo, Quanzhi Ye

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Loss of stimulator of interferon genes (STING) promotes accumulation of cholesterol and triglycerides throughout life in mice by Ian Riquelme, Daniela Carrillanca, Camila Sánchez-Pérez, Andrea Monterroza, Bairon Hernández-Rojas, Gonzalo Riadi, Gonzalo I. Cancino, Paola Murgas

“…Abstract Background The Stimulator of Interferon Genes (STING) pathway is pivotal in innate immunity, facilitating the detection of cytosolic DNA and initiating type I interferon-dependent responses. …”
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Invasion dynamics and ecological impacts of Anisakis typica in commercial fish from the Western Pacific Ocean by Dhito Dwi Pramardika, Fadjar Satrija, Sulistiono Sulistiono, Risa Tiuria, Arifin Budiman Nugraha

“…Enhanced inspection practices and public awareness initiatives are crucial to mitigate the zoonotic risks posed by consuming infected fish.…”
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The Role of HMGB1 in Infection-Related Cognitive Deficits by Fathima Ijaza Irzan, Thaarvena Retinasamy, Wong Ruo Wen, Edward Ting Ming Sheng, Mohd. Farooq Shaikh, Alina Arulsamy

“…These mechanisms are spearheaded by inflammatory markers that are released/initiated by the pathogens over the course of the infection. …”
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Dose-intensive therapy (DIT) for infantile Pompe disease: A pilot study by Jeanine R. Jarnes, Nishitha R. Pillai, Alia Ahmed, Sofia Shrestha, Molly Stark, Chester B. Whitley

“…Background: The current standard of care for infantile-onset Pompe disease (IOPD), a severe form of acid α-glucosidase enzyme activity deficiency is: (1) detection by newborn screening, (2) early initiation of intravenous enzyme replacement therapy (ERT) using recombinant human acid alpha-glucosidase (rhGAA), with higher doses of rhGAA increasingly used to improve clinical outcomes, and (3) immune tolerization induction (ITI) using to prevent anti-rhGAA antibody formation, with methotrexate (MTX), rituximab, and IVIG used for patients who are cross-reactive immunologic material negative (CRIM-) and monotherapy with MTX used in patients who are cross-reactive immunologic material positive (CRIM+). …”
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Alpha-lipoic acid on intermediate disease markers in overweight or obese adults: a systematic review and meta-analysis by Yao Luo, Jizhen Zhang, Hongxia Guo

“…Publication bias was assessed using Begg’s test, while funnel plots and Egger’s test were applied to outcomes with 10 or more studies.Results This meta-analysis included 11 RCTs from an initial screening of 431 studies, encompassing a total of 704 adults. …”
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Anti-idiotypic antibodies specific to steroid hormones and proliferative activity of tumor in breast cancer patients by A. N. Glushkov, E. G. Polenok, S. A. Mun, L. A. Gordeeva, A. V. Antonov, P. V. Bairamov, N. E. Verzhbitskaya, G. I. Kolpinsky

“…Ki-67, ER and PR were detected by immunohistochemical methods. High levels of IgG2-E2 in stage I BCP were detected more frequently than in healthy women (63.9% vs 40.2%, р < 0.001), being more common in cases with Ki-67 > 14, than with tumors with Ki-67 ≤ 14 (63.9% vs 56.9%, р = 0.03). …”
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Super-high tumor mutational burden predicts complete remission following immunotherapy: from Peto’s paradox to druggable cancer hallmark by Ming Zheng

“…By proposing a universal framework—“cancer disease continuum”—unified by mutational burden as a shared hallmark across tumor initiation, progression, and immunogenicity, this study recasts mutational burden as both a biological price of longevity and an Achilles’ heel exploitable for durable, complete tumor remission in personalized medicine.…”
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Clinical Characteristics and Treatment Outcomes of Colorectal Cancer in Jordan, a Resource-Restricted Country by Hikmat Abdel-Razeq, Maha Barbar, Sarah Abdel-Razeq, Fawzi Abuhijla, Issa Mohamad, Kamal Al-Rabi, Akram Al-Ibraheem, Hazem Hammad, Asem Mansour

“…After a median follow-up of 49 months, the 5-year OS for the whole group was 53.9% (95% CI, 52.0% to 55.8%) and varied by disease stage; 87.7% (95% CI, 80.3% to 93.5%) for stage I, 84.7% (95% CI, 81.3% to 87.9%) for stage II, 69.9% (95% CI, 67.0% to 72.8%) for stage 3, and only 14.5% (95% CI, 12.2% to 16.9%) for patients with stage IV disease, P < .0001.CONCLUSIONOne third of all patients with colorectal cancer are diagnosed with metastatic disease, which explains the lower survival rates observed compared with Western countries. Programs and initiatives focused on the prevention and early detection of colorectal cancer should be a national priority.…”
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An enhanced fusion of transfer learning models with optimization based clinical diagnosis of lung and colon cancer using biomedical imaging by N. A. S. Vinoth, J. Kalaivani, R. Madonna Arieth, S. Sivasakthiselvan, Gi-Cheon Park, Gyanendra Prasad Joshi, Woong Cho

“…The main objective of the FTLMO-BILCCD technique is to develop an efficient method for LCC detection using clinical biomedical imaging. Initially, the image pre-processing stage applies the median filter (MF) model to eliminate the unwanted noise from the input image data. …”
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Potential value of urine lateral-flow lipoarabinomannan (LAM) test for diagnosing tuberculosis among severely acute malnourished children. by Birgit Schramm, Rodrigue C Nganaboy, Piex Uwiragiye, Didier Mukeba, Aboubacar Abdoubara, Illa Abdou, Jean-Claude Nshimiymana, Seyni Sounna, Laurent Hiffler, Laurence Flevaud, Helena Huerga

“…We explored whether, in a low HIV-prevalence setting, the detection of mycobacterial lipoarabinomannan (LAM) antigen in urine may assist TB diagnosis in SAM children, a pediatric population currently not included in LAM-testing recommendations. …”
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Current status and developmental trend on leakage and dispersion research for hydrogen-blended natural gas pipeline by Hongye JIANG, Mingyue KOU, Kexi LIAO, Taolong XU, Youlyu LI, Guoxi HE

“…Results Despite a delayed initiation, research on the leakage and dispersion of hydrogen-blended natural gas pipelines in China has progressed rapidly. …”
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Clinical and laboratory characterictic of acute HIV-infection in adult residents of Novosibirsk region by Ya. S. Ulyanova, N. M. Gashnikova, V. V. Ivlev, E. I. Krasnova, N. I. Khokhlova, A. V. Totmenin, O. V. Melnikova, M. V. Vorotova, I. R. Glushko, V. V. Ulyanov

“…Early initiation of antiretroviral therapy with the appointment of well-tolerated regimens contributes to the formation of a high commitment to therapy.…”
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Abscence of specific humoral response in three dogs with clinical leishmaniosis by Sergio Villanueva-Saz, Diana Marteles, Ámparo Ortuñez, María C. Aceña, Janine E. Davies, Cristina Riera, María Borobia, Maite Verde, Álex Gómez

“…Conclusions These findings highlight the diagnostic challenges in detecting clinical leishmaniosis in seronegative dogs. …”
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Systematic review of the performance of HIV viral load technologies on plasma samples. by Kimberly A Sollis, Pieter W Smit, Susan Fiscus, Nathan Ford, Marco Vitoria, Shaffiq Essajee, David Barnett, Ben Cheng, Suzanne M Crowe, Thomas Denny, Alan Landay, Wendy Stevens, Vincent Habiyambere, Jos Perrins, Rosanna W Peeling

“…<h4>Conclusions</h4>This review found that all currently available HIV VL assays are of sufficient sensitivity to detect plasma VL of 1,000 copies/mL as a threshold to initiate investigations of treatment adherence or possible treatment failure. …”
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Transforming Breast Cancer Care: Overcoming Rural Challenges in Pakistan by Syeda Huda Fatima, Syeda Jazilah Faisal

“…Initiatives by NGOs like Pink Ribbon1 and Rehmat Medical Aid, such as free mobile mammography and diagnostic services, have successfully decreased costs, and corporate entities like Meezan Bank have programs to provide financial relief,5 yet rural awareness remains low. …”
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Chemotherapy-related adverse drug reaction and associated factors among adult cancer patient attending Jimma medical center oncology unit, Southwest Ethiopia. by Mukerem Sultan Shrmeka, Mubarik Fetu Semman, Biruk Tafese Moges, Feki Nekir Dereja, Aster Wakjira Garedo

“…Implement protocols for risk assessment before initiating chemotherapy.…”
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Partnering RemoTe monitoring of Implanted Cardiac devices with Intelligent PATient Engagement – PARTICIPATE trial: a protocol for a randomised controlled trial by Tim Shaw, Liliana Laranjo, Clara K Chow, Aravinda Thiagalingam, Brodie Sheahen, Gopal Sivagangabalan

“…The intervention group will receive regular SMS communication with a range of educational and self-efficacy resources, in conjunction with engagement initiatives following CIED clinical issue detection. …”
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