Global, regional, and national trends in colorectal cancer burden from 1990 to 2021 and projections to 2040 by Tao Zhang, Yuchen Guo, Binxu Qiu, Xianyu Dai, Yifei Wang, Xueyuan Cao

“…Initially, a series of descriptive statistics were performed on the incident cases, deaths, disability-adjusted life years (DALYs), and age-standardized rates (ASRs) of CRC. …”
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Congenital Bullous Syphilis: A Case Report from Italy and a Comprehensive Literature Review by Edoardo Cammarata, Elia Esposto, Nunzia Di Cristo, Chiara Airoldi, Elena Bernascone, Valentina Burzio, Paola Savoia

“…Although many infants appear asymptomatic at birth, subtle clinical signs—including bullous lesions (congenital bullous syphilis, also known as pemphigus syphiliticus)—may facilitate early detection. Recognizing this rare manifestation is crucial for timely intervention, reducing serious outcomes. …”
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A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose. by Fumihiko Takeuchi, Ralph McGinnis, Stephane Bourgeois, Chris Barnes, Niclas Eriksson, Nicole Soranzo, Pamela Whittaker, Venkatesh Ranganath, Vasudev Kumanduri, William McLaren, Lennart Holm, Jonatan Lindh, Anders Rane, Mia Wadelius, Panos Deloukas

“…We report the first genome-wide association study (GWAS) whose sample size (1,053 Swedish subjects) is sufficiently powered to detect genome-wide significance (p<1.5 x 10(-7)) for polymorphisms that modestly alter therapeutic warfarin dose. …”
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HIV-associated B-cell lymphoma of a patient with multiresistant tuberculosis (clinical case) by O. M. Raznatovska, A. V. Fedorets, M. S. Potapenko, I. V. Pashchenko, I. M. Voitiuk, S. I. Zakharchuk

“…In the modern context, there is an increase in the detection of HIV/tuberculosis co-infection, which makes it difficult to timely diagnose and treat complications of HIV infection and, as a result, it is the cause of death. …”
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Predictive value of systemic immune inflammation index combined with coagulation index in traumatic coagulopathy in patients with severe trauma by Chen Wang, Yongyong Huang, Shiyun Liao, Jiming Song

“…Here, this study aimed to evaluate the predictive value of combining SII with coagulation indices for TIC in severe trauma patients, with the goal of enhancing early detection and guiding prompt therapeutic strategies. …”
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Early Diagnosis of Upper Extremity Deep Venous Thrombosis Using Emergency Department Point-of-Care Ultrasound: A Case Report by Tasnim Ahmed, Martin Joseph

“…Despite the proven effectiveness of point-of-care ultrasonography (POCUS) in detecting UEDVT, it is rarely utilized in the Emergency Department (ED). …”
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Characteristics and dynamics of cognitive impairment in patients with primary and recurrent cerebral ischemic hemispheric stroke by A. A. Kozyolkin, А. А. Kuznietsov, L. V. Novikova

“…The groups were matched by age, sex, localization of the lesion and the initial level of neurological deficit. All patients underwent physical examination, neurological examination. …”
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Bariatric Surgery in the United Kingdom: A Cohort Study of Weight Loss and Clinical Outcomes in Routine Clinical Care. by Ian J Douglas, Krishnan Bhaskaran, Rachel L Batterham, Liam Smeeth

“…Gastric bypass (6.56 kg/mo) and sleeve gastrectomy (6.29 kg/mo) were associated with greater initial weight reduction than gastric banding (2.77 kg/mo). …”
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Value of serum-free light chain measurements in response and progression assessment in multiple myeloma with monoclonal protein measurable by electrophoresis by Elham Askari, Angela Dispenzieri, Francis K. Buadi, Suzanne R. Hayman, Morie A. Gertz, Prashant Kapoor, Wilson Gonsalves, Taxiarchis Kourelis, David Dingli, Rahma Warsame, Nelson Leung, Yi Lin, Eli Muchtar, Joselle Cook, Moritz Binder, Nadine Abdallah, Lisa Hwa, Miriam Hobbs, Amie Fonder, David Murray, Robert. A. Kyle, S. Vincent Rajkumar, Shaji K. Kumar

“…Among patients with PD, 12% had sFLC as the only detectable tumor marker at the time of second-line therapy. …”
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The presence of multiple variants of IncF plasmid alleles in a single genome sequence can hinder accurate replicon sequence typing using in silico pMLST tools by Michaela Ruzickova, Jana Palkovicova, Ivo Papousek, Max L. Cummins, Steven P. Djordjevic, Monika Dolejska

“…Accurate identification of plasmid STs is useful as it enables an assessment of IncF plasmid lineages associated with pandemic enterobacterial STs. Our initial observations showed discrepancies in IncF allele variants reported by pMLST in a collection of 898 Escherichia coli ST131 genomes. …”
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Clinicopathological analysis of adrenal intravascular large B-cell lymphoma by LIN Jiaxin, WEI Ran, SHUI Ruohong, LU Hongfen, LI Xiaoqiu, YU Baohua

“…The molecular genetic characteristics were detected using next-generation sequencing (NGS). This study was approved by the Ethics Committee of Fudan University Shanghai Cancer Center (Ethics number: 050432-4-2307E). …”
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Better the devil you know: sympatric fish host copes better than allopatric with a myxozoan parasite by Itziar Estensoro, Beatriz López-Gurillo, Carolina Tafalla, Ryan Craig, Stephen Atkinson, Ariadna Sitjà-Bobadilla, Jerri Bartholomew

“…Specific circulating IgM was detected much later in both fish strains, only at 57 and 183 days post exposure. …”
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The association between dolutegravir based first-line antiretroviral regimens and dyslipidemia among adults living with HIV on follow-up at health facilities in Hawassa city admini... by Agete Tadewos Hirigo, Alemayehu Abera, Daniel Yilma, Ayalew Astatkie, Zelalem Debebe

“…This study aimed to assess the association between DTG-based regimens and dyslipidemia among adults initiated on ART after the test-and-treat implementation in Ethiopia. …”
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Essential role of community health workers in promoting oral health in Africa by Morenike O. Folayan, Ahmed Bhayat, Nicaise Ndembi, Adeyinka G. Ishola, Maha El Tantawi

“…By providing basic dental care, education and facilitating access to professional services, CHWs contribute to the prevention and early detection of oral diseases. The research draws on case studies, programme evaluations and field reports to highlight the effectiveness of CHW-led initiatives. …”
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Artificial Intelligence in Health Promotion and Disease Reduction: Rapid Review by Farzaneh Yousefi, Florian Naye, Steven Ouellet, Achille-Roghemrazangba Yameogo, Maxime Sasseville, Frédéric Bergeron, Marianne Ozkan, Martin Cousineau, Samira Amil, Caroline Rhéaume, Marie-Pierre Gagnon

“…Artificial intelligence (AI) has transformed health promotion and disease reduction through improved early detection, encouraging healthy lifestyle modifications, and mitigating the economic strain on health systems. …”
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CRIM-negative infantile Pompe disease, long-term observation of the effect of enzyme replacement therapy: a clinical case by D. R. Sabirova, D. I. Sadykova, A. A. Kucheryavaya, A. A. Kashina, L. A. Sabirova

“…It was decided to initiate specific enzyme replacement therapy by intravenous administration of a recombinant form of human acidic alpha-glucosidase (alglucosidase alfa) at a dose of 20 mg/kg/injection in a frequency of once every 2 weeks. …”
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SLAM-based localization method of coal mine underground robot with adaptability to dark illumination environment by Song JIANG, Zhixiang CUI, Bibo DAI, Binjian RAO, Runfeng HE, Haoyu WANG

“…Based on the ORB–SLAM3 framework, the whole local image detection is introduced to screen the input image, and an improved IMU initialization strategy based on analytical solution is introduced to improve the initialization speed, and the improved image enhancement network is transplanted to enhance the low illumination and uneven illumination images. …”
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Kidney dysfunction and associated factors among adults living with human immuno-deficiency virus in Africa: a systematic review and meta-analysis by Worku Chekol Tassew, Agerie Mengistie Zeleke, Yeshiwas Ayale Ferede, Girum Meseret Ayenew

“…Publication bias was detected by the visual inspection of the funnel plot and statistical Egger’s test. …”
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A clinical case of transthyretin amyloidosis with manifestations of seronegative arthritis by V. A. Mareeva, A. A. Klimenko, E. R. Moskalets, P. A. Glazunov, N. A. Shostak, E. V. Zhilyaev

“…The variety of amyloid tropicity to various organs and tissues leads to it phenotypic heterogeneity, which makes it difficult to make a diagnosis on early stages. However, the detection of «red flags» symptoms signaling the presence of transthyretin amyloidosis can shorten the time before initiation of targeted treatment, contributing to the improvement of the patient’s quality of life.…”
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Audit of antenatal care in a rural district of KZN, South Africa by Monjurul Hoque, Ehsanul Hoque, Suriya Kader

“…Thus strategies are urgently needed to improve antenatal care through a quality improving initiative.…”
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